3α-hydroxy-3β-trifluoromethyl-5α-pregnan-20-one (Co 2-1970): A partial agonist at the neuroactive steroid site of the γ-Aminobutyric acidA receptor

Molecular Pharmacology

Volumn 49, Issue 5, 1996, Pages 897-906

  Hawkinson, Jon E ^a   Drewe, John A ^a   Kimbrough, Catherine L ^a   Chen, Jie Sheng ^a   Hogenkamp, Derk J ^a   Lan, Nancy C ^a   Gee, Kelvin W ^b   Shen, Ke Zhong ^a,c   Whittemore, Edward R ^a   Woodward, Richard M ^a  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3ALPHA HYDROXY 3BETA TRIFLUOROMETHYL 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR STIMULATING AGENT; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; BENZODIAZEPINE DERIVATIVE; CO 2 1970; FLUNITRAZEPAM; MUSCIMOL; TERT BUTYLBICYCLOPHOSPHOROTHIOATE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ARTICLE; BRAIN MEMBRANE; CHLORIDE CURRENT; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DRUG INHIBITION; DRUG POTENCY; DRUG RECEPTOR BINDING; HUMAN; HUMAN CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SEDATION; STRUCTURE ACTIVITY RELATION; TRANQUILIZING ACTIVITY;

ALLOSTERIC REGULATION; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; CELL MEMBRANE; CEREBRAL CORTEX; CONVULSANTS; GABA AGONISTS; HUMANS; ION CHANNEL GATING; PREGNANOLONE; RADIOLIGAND ASSAY; RATS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; RNA, MESSENGER; XENOPUS LAEVIS;

EID: 0029920459     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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