3α-Hydroxy-3β-(phenylethynyl)-5β-pregnan-20-ones: Synthesis and pharmacological activity of neuroactive steroids with high affinity for GABA(A) receptors

Journal of Medicinal Chemistry

Volumn 40, Issue 1, 1997, Pages 73-84

  Upasani, Ravindra B ^a   Yang, Kevin C ^a   Acosta Burruel, Manuel ^a   Konkoy, Chris S ^a   McLellan, James A ^a   Woodward, Richard M ^a   Lan, Nancy C ^a   Carter, Richard B ^a   Hawkinson, Jon E ^a  

^a Department of Pharmacokinetics and Drug Metabolism   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3BETA [(4 ACETYLPHENYL)ETHYNYL] 3ALPHA HYDROXY 5BETA 19 NORPREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ANTICONVULSIVE AGENT; PENTETRAZOLE; UNCLASSIFIED DRUG;

ALLOSTERISM; ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; ELECTRIC SHOCK; MALE; MOUSE; NONHUMAN; RAT; RECEPTOR AFFINITY; STEROID METABOLISM; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTICONVULSANTS; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN; ELECTROPHYSIOLOGY; ELECTROSHOCK; FEMALE; GABA MODULATORS; HUMANS; ISOMERISM; MICE; OOCYTES; PREGNANOLONE; RATS; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP; XENOPUS;

EID: 0031022082     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm9605344     Document Type: Article

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