Neurosteroid modulation of native and recombinant GABAA receptors

Cellular and Molecular Neurobiology

Volumn 16, Issue 2, 1996, Pages 155-174

  Lambert, Jeremy J ^a   Belelli, Delia ^a   Hill Venning, Claire ^a   Callachan, Helen ^a   Peters, John A ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Anesthetic; GABAA receptor; Ligand gated ion channel; Neurosteroids; Neurotransmitter receptor; Nongenomic steroid effects; Pregnane steroids; Whole cell patch clamp; Xenopus laevis oocyte

Indexed keywords

4 AMINOBUTYRIC ACID RECEPTOR; ION CHANNEL; PREGNANEDIONE;

ANIMAL CELL; BINDING SITE; CENTRAL NERVOUS SYSTEM; HORMONE ACTION; MOLECULAR INTERACTION; NEUROMODULATION; NEUROTRANSMITTER RELEASE; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; REVIEW; STEROID BINDING; STEROID METABOLISM; XENOPUS LAEVIS;

ANIMALS; RECEPTORS, GABA-A; RECOMBINANT PROTEINS; STEROIDS; SYNAPTIC TRANSMISSION;

EID: 0029892673     PISSN: 02724340     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF02088174     Document Type: Article

References (23)

1. A receptor deduced from mutation-induced rectification. NeuroReport 5:285-288.
2. Barker, J. L., Harrison, N. L., Lange, G. D., and Owen, D. G. (1987). Potentiation of γ-aminobutyric-acid-activated chloride conductance by a steroid anaesthetic in cultured rat spinal neurones. J. Physiol. 386:485-501.
3. A receptors by the neurosteroid 5α-pregnan-3α,20α-diol. Br. J. Pharmacol. 111:182P.
4. A receptors by pregnanediols. Can. J. Physiol. Pharmacol. 72:339.
5. Belelli, D., Callachan, H., Lambert, J. Peters, J. A., Hill-Venning, C., and Lan, N. C. (1994c), A comparative study of the influence of allosieric modulators upon human (α3β1γ2L) and Drosophila recombinant GABA receptors. Br. J. Pharmacol. 112:257P.
6. Bertrand, P. P., and Galligan, J. J. (1992). Alfaxalone, pentobarbital and diazepam potentiate γ-aminobutyric acid-induced depolarizations in single myenteric neurons of guinea-pig intestine. J. Pharmacol. Exp. Ther. 262:677-682.
7. B receptor subtypes. Trends Neurosci. 11:112-116.
8. Bormann, J., and Clapham, D. E. (1985). γ-Aminobutyric acid receptor channels in adrenal chromaffin cells: A patch-clamp study. Proc. Natl. Acad. Sci. USA 82:2168-2172.
9. Bureau, M., and Olsen, R. W. (1990). Multiple distinct subunits of the γ-aminobutyric acid-A receptor protein show different ligand binding affinities. Mol. Pharmacol. 37:497-502.
10. A receptor by progesterone metabolites. Proc. R. Soc. Land. B 231:359-369.
11. Carboni, E., Wieland, S., Lan, N. C., and Gee, K. W. (1994). Effect of endogenously occurring pregnandiols in animal models of anxiety. Can. J. Physiol. Pharmacol. 72:449.
12. Carl, P., Høgskilde, S., Lang-Jensen, T., Bach, V., Jacobsen, J., Sorensen, M. B., Gralls, M., and Widlund, L. (1994). Pharmacokinetics and pharamcodynamics of eltanolone (pregnanolone), a new steroid intravenous anaesthetic, in humans. Acta Anaesthesiol. Scand. 38:734-741.
13. Celotti, F., Melcangi, R. C., and Martini, L. (1992). The 5α-reductase in the brain: Molecular aspects and relation to brain function. From. Neuroendocrinol. 13:163-215.
14. Chen, R., Belelli, D., Lambert, J. J., Peters, J. A., Reyes, A., and Lan, N. C. (1994). Cloning and functional expression of a Drosophila γ-aminobutyric acid receptor. Proc. Natl. Acad. Sci. USA 91:6069-6074.
15. Chvátal, A., and Kettenman, H. (1991). Effects of steroids on γ-aminobutyrate-induced currents in cultured rat astrocytes. Pflugers Arch. 419:263-266.
16. A receptor activity by alphaxalone. Br. J. Pharmacol. 90:491-501.
17. Ebert, B., Wafford, K. A., Whiting, P. J., Krogsgaard-Larsen, P., and Kemp, J. A. (1994). Molecular pharmacology of γ-aminobutyric acid type A receptor agonists and partial agonists in ooctyes injected with different α, β and γ receptor subunit combinations. Mol. Pharmacol. 46:957-963.
18. A-like autoreceptor by barbiturates but not by steroids. Neuropharmacolagy 32:355-357.
19. ffrench-Constant, R. H., Rocheleau, T. A., Steichen, J. C., and Chalmers, A. E. (1993). A point mutation in a Drosophila GABA receptor confers insecticide resistance. Nature 363:449-451.
20. ffrench-Mullen, J. M. H., Danks, P., and Spence, K. (1994). Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism. J. Neurosci. 14:1963-1977.
21. Figdor, S. K., Kodet, M. T., Bloom, B. M., Agnello, E. J., P'An, S. Y., and Laubach, G. D. (1957). Central activity and structure in a series of water soluble steroids. J. Pharmacol. Exp. Ther. 119:299-309.
22. Galzi, J.-L., and Changeux, J.-P. (1994). Neurotransmitter-gated ion channels as unconventional allosteric proteins. Current Opin. Struct. Biol. 4:554-565.
23. Gee, K. W., Bolger, M. B., Brinton, R. E., Coirini, H., and McEwen, B. S. (1988). Steroid regulation of the chloride ionophore in rat brain: Structure activity requirements, regional dependence and mechanism of action. J. Pharmacol. Exp. Ther. 241:346-353.