The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with GABA(A) receptors

European Journal of Pharmacology

Volumn 325, Issue 1, 1997, Pages 1-7

  Brot, Michelle D ^a,b   Akwa, Yvette ^a,b   Purdy, Robert H ^a,b   Koob, George F ^a,b   Britton, Karen T ^a,b  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b VA SAN DIEGO HEALTHCARE SYSTEM   (United States)

Author keywords

3 Hydroxy 5 pregnan 20 one; Anxiety; Benzodiazepine; Conflict; GABA(A) receptor; Neurosteroid

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; ALCOHOL; BENZODIAZEPINE RECEPTOR INVERSE STIMULATING AGENT; FLUMAZENIL; NEUROSTEROID; PICROTOXININ;

ANIMAL MODEL; ANXIETY; ARTICLE; CONTROLLED STUDY; FEMALE; INTRAPERITONEAL DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION;

AFFINITY LABELS; ANIMALS; ANTI-ANXIETY AGENTS; ANXIETY; AZIDES; BEHAVIOR, ANIMAL; BENZODIAZEPINES; BINDING SITES; CHLORIDE CHANNELS; CONFLICT (PSYCHOLOGY); DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FEMALE; FLUMAZENIL; GABA MODULATORS; ORGANOPHOSPHORUS COMPOUNDS; PREGNANOLONE; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 0030968281     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(97)00096-4     Document Type: Article

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