Pharmacological characterisation of multiple components in the enhancement by pregnanolone and propofol of [3H]flunitrazepam binding to GABA(A) receptors

Neuropharmacology

Volumn 35, Issue 9-10, 1996, Pages 1193-1198

  Zhong, Yu ^a   Simmonds, M A ^a  

^a UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

11 Ketoprogesterone; 3H flunitrazepam binding; Bicuculline; GABA(A) receptors; Pregnanolone; Propofol

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; BICUCULLINE; ELTANOLONE; FLUNITRAZEPAM; MUSCIMOL; PREGN 4 ENE 3,11,20 TRIONE; PROPOFOL; RADIOLIGAND; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN HOMOGENATE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG POTENTIATION; DRUG SENSITIVITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR BINDING;

ANESTHETICS, INTRAVENOUS; ANIMALS; BICUCULLINE; FLUNITRAZEPAM; GABA AGONISTS; GABA MODULATORS; MALE; MUSCIMOL; PREGNANOLONE; PROGESTERONE; PROPOFOL; RATS; RATS, WISTAR; RECEPTORS, GABA-A; SYNAPTIC MEMBRANES;

EID: 0030459354     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(96)00056-1     Document Type: Article

References (13)

1. A receptors. Brain Res. 542:1991;225-232.
2. Hales T.G., Lambert J.J. The actions of propofol on inhibitory amino acid receptors of bovine adrenomedullary chromaffin cells and rodent central neurones. Br. J. Pharmacol. 104:1991;619-628.
3. A receptor complex. J. Pharmacol. Exp. Ther. 241:1987;346-353.
4. Harrison N.L., Simmonds M.A. Modulation of the GABA receptor complex by a steroid anaesthetic. Brain. Res. 323:1984;287-292.
5. A receptor. Eur. J. Pharmacol. Molec. Pharmacol. Sect. 269:1994;157-163.
6. A receptor function. Trends Pharmacol. Sci. 16:1995;295-303.
7. Morrow A.L., Pace J.R., Purdy R.H., Paul S.M. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: evidence for multiple steroid recognition sites. Molec. Pharmacol. 37:1990;263-270.
8. Prince R.J., Simmonds M.A. Temperature and anion dependence of allosteric interaction at the γ-aminobutyric acid-benzodiazepine receptor. Biochem. Pharmacol. 44:1992;1297-1302.
9. A receptor complex. Brain. Res. 596:1992;238-242.
10. A receptors. Neuron. 4:1990;759-765.
11. 1 γ-aminobutyric acid type A receptors: actions of the anesthetics propofol and pentobarbital. Molec. Pharmacol. 47:1995;213-217.
12. - ion channels modulated by multiple drug-binding sites. Trends Pharmacol. Sci. 13:1992;446-450.
13. A receptor by steroids. Seminars Neurosci. 3:1991;231-239.