Inhibitors of farnesylation of Ras from a microbial natural products screening program

Journal of Industrial Microbiology and Biotechnology

Volumn 25, Issue 6, 2000, Pages 315-327

  Vilella, D ^a   Sanchez M ^a   Platas, G ^a   Salazar, O ^a   Genilloud, O ^a   Royo, I ^a   Cascales, C ^a   Martin I ^a   Diez T ^a   Silverman, K C ^b   Lingham, R B ^b   Singh, S B ^b   Jayasuriya, H ^b   Pelaez F ^a  

^a Medical affairs Merck sharp and Dohme ltd   (Spain)

^b MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Cancer; Farnesyl protein transferase inhibitors; Natural products; Ras; Screening

Indexed keywords

ACTINOPLANIC ACID A; ACTINOPLANIC ACID B; BARCELONEIC ACID A; CHAETOMELLIC ACID A; CHAETOMELLIC ACID B; CLAVARIC ACID; CYLINDROL A; DEOXYPREUSSOMERIN A; DEOXYPREUSSOMERIN B; FUSIDIENOL; FUSIDIENOL A; KOMPANOL A; KOMPANOL B; NATURAL PRODUCT; OREGANIC ACID; PREUSSOMERIN G; PREUSSOMERIN H; PREUSSOMERIN I; PROTEIN FARNESYLTRANSFERASE INHIBITOR; RAS PROTEIN; UNCLASSIFIED DRUG; ZARAGOZIC ACID D; ZARAGOZIC ACID D2;

ACTINOMYCES; ARTICLE; CANCER; CHEMOTAXONOMY; DRUG ACTIVITY; DRUG IDENTIFICATION; DRUG POTENCY; ENZYME INHIBITION; FUNGUS; NONHUMAN; NUCLEOTIDE SEQUENCE; ONCOGENE RAS; PHYLOGENY; PRENYLATION; SCREENING;

ACTINOBACTERIA (CLASS); ACTINOMYCES; FUNGI;

EID: 17744400777     PISSN: 13675435     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.jim.7000085     Document Type: Article

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