Manumycin and gliotoxin derivative KT7595 block Ras farnesylation and cell growth but do not disturb lamin farnesylation and localization in human tumour cells

British Journal of Cancer

Volumn 76, Issue 8, 1997, Pages 1001-1010

  Nagase, T ^a   Kawata, S ^a   Tamura, S ^a   Matsuda, Y ^a   Inui, Y ^a   Yamasaki, E ^a   Ishiguro, H ^a   Ito, T ^a   Miyagawa, J ^a   Mitsui, H ^a   Yamamoto, K ^a   Kinoshita, M ^b   Matsuzawa, Y ^a  

^a OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^b OTSUKA PHARMACEUTICAL CO LTD   (Japan)

Author keywords

Cell growth; Farnesyl protein transferase; Gliotoxin derivative; Manumycin; Nuclear lamin; Ras

Indexed keywords

CELL DNA; GLIOTOXIN; KT 7595; LAMIN; MANUMYCIN; PROTEIN FARNESYLTRANSFERASE; TRANSFERASE INHIBITOR; UNCLASSIFIED DRUG;

ANCHORAGE INDEPENDENT GROWTH; ARTICLE; CELL GROWTH; CELL TRANSFORMATION; COLON CARCINOMA; CONTROLLED STUDY; DNA SYNTHESIS; DNA SYNTHESIS INHIBITION; DRUG EFFECT; GENE ACTIVATION; GENE SEQUENCE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOFLUORESCENCE; LIVER CELL CARCINOMA; ONCOGENE RAS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTEIN PROCESSING; STOMACH CARCINOMA; TUMOR CELL;

EID: 9844247549     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/bjc.1997.499     Document Type: Article

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