-
2
-
-
0029921232
-
The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts
-
BERNHARD, E.J., KAO, G., COX., A.D , SEBTI, S M., HAMILTON, A.D., MUSCHEL, R J. & MCKENNA, W.G (1996). The farnesyltransferase inhibitor FTI-277 radiosensitizes H-ras-transformed rat embryo fibroblasts. Cancer Research, 56, 1727.
-
(1996)
Cancer Research
, vol.56
, pp. 1727
-
-
Bernhard, E.J.1
Kao, G.2
Cox, A.D.3
Sebti, S.M.4
Hamilton, A.D.5
Muschel, R.J.6
Mckenna, W.G.7
-
3
-
-
0027989834
-
Rational design of potent carboxylic acid based bisubstrate inhibitors of Ras farnesyl protein transferase
-
BHIDE, R S , PATEL, D V , PATEL, M M., ROBINSON, S.P., HUNIHAN, L.W & GORDON, E.M. (1994). Rational design Of potent carboxylic acid based bisubstrate inhibitors of Ras farnesyl protein transferase. Bioorganic and Medicinal Chemistry Letters, 4, 2107.
-
(1994)
Bioorganic and Medicinal Chemistry Letters
, vol.4
, pp. 2107
-
-
Bhide, R.S.1
Patel, D.V.2
Patel, M.M.3
Robinson, S.P.4
Hunihan, L.W.5
Gordon, E.M.6
-
4
-
-
0029586503
-
Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells
-
BISHOP, W.R., BOND, R., PETRIN, J., WANG, L., PATTON, R., DOLL, R., NJOROGE, G., CATINO, J., SCHWARTZ, J. & WINDSOR, W. (1995). Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells. Journal of Biological Chemistry, 270, 30611.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 30611
-
-
Bishop, W.R.1
Bond, R.2
Petrin, J.3
Wang, L.4
Patton, R.5
Doll, R.6
Njoroge, G.7
Catino, J.8
Schwartz, J.9
Windsor, W.10
-
5
-
-
0029613291
-
Farnesyltransferase inhibitors: The successes and surprises of a new class of potential cancer chemotherapeutics
-
BUSS, J.E. & MARSTERS, J C., JR (1995). Farnesyltransferase inhibitors: the successes and surprises of a new class of potential cancer chemotherapeutics. Chemical Biology, 2, 787.
-
(1995)
Chemical Biology
, vol.2
, pp. 787
-
-
Buss, J.E.1
Marsters Jr., J.C.2
-
6
-
-
0027050783
-
Biochemistry of protein prenylation
-
CASEY, P. J. (1992). Biochemistry of protein prenylation. Journal of Lipid Research, 33, 1731.
-
(1992)
Journal of Lipid Research
, vol.33
, pp. 1731
-
-
Casey, P.J.1
-
7
-
-
0012698942
-
P21ras is modified by a farnesyl isoprenoid
-
CASEY P.J., SOLSKI, P.A., DER, C.J & BUSS, J E. (1989). P21ras is modified by a farnesyl isoprenoid. Proceedings of the National Academy of Sciences, USA, 86, 8323.
-
(1989)
Proceedings of the National Academy of Sciences, USA
, vol.86
, pp. 8323
-
-
Casey, P.J.1
Solski, P.A.2
Der, C.J.3
Buss, J.E.4
-
8
-
-
0027998986
-
The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic Ras signaling and transformation
-
COX, A.D., GARCIA, A.M., WESTWICK, J.K., KOWALCZYK, J.J., LEWIS, M D., BRENNER, D.A. & DER, C.J. (1994). The CAAX peptidomimetic compound B581 specifically blocks farnesylated, but not geranylgeranylated or myristylated, oncogenic Ras signaling and transformation. Journal of Biological Chemistry, 269, 19203.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 19203
-
-
Cox, A.D.1
Garcia, A.M.2
Westwick, J.K.3
Kowalczyk, J.J.4
Lewis, M.D.5
Brenner, D.A.6
Der, C.J.7
-
9
-
-
0027320616
-
Peptidomimetic inhibitors of Ras farnesylation and function in whole cells
-
GARCIA, A.M., ROWELL, C., ACKERMANN, K., KOWALCZYK, J.J & LEWIS, M.D. (1993). Peptidomimetic inhibitors of Ras farnesylation and function in whole cells. Journal of Biological Chemistry, 268, 18415.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 18415
-
-
Garcia, A.M.1
Rowell, C.2
Ackermann, K.3
Kowalczyk, J.J.4
Lewis, M.D.5
-
10
-
-
0028331587
-
Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic
-
GIBBS, J.B., OLIFF, A. & KOHL, N E (1994). Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic. Cell, 77, 175.
-
(1994)
Cell
, vol.77
, pp. 175
-
-
Gibbs, J.B.1
Oliff, A.2
Kohl, N.E.3
-
11
-
-
0028211246
-
Pseudopeptide inhibitors of Ras farnesyl-protein transferase
-
GRAHAM, S.L., DESOLMS, S.J., GIULIANI, E.A., KOHL, N.E., MOSSER, S.D., OLIFF, A.I., POMPLIANO, D.L., RANDS, E., BRESLIN, M J , DEANA, A A., GARSKY, V M., SCHOLZ, T.H., GIBBS, J.B & SMITH, R.L (1994). Pseudopeptide inhibitors of Ras farnesyl-protein transferase. Journal of Medicinal Chemistry, 37, 725.
-
(1994)
Journal of Medicinal Chemistry
, vol.37
, pp. 725
-
-
Graham, S.L.1
Desolms, S.J.2
Giuliani, E.A.3
Kohl, N.E.4
Mosser, S.D.5
Oliff, A.I.6
Pompliano, D.L.7
Rands, E.8
Breslin, M.J.9
Deana, A.A.10
Garsky, V.M.11
Scholz, T.H.12
Gibbs, J.B.13
Smith, R.L.14
-
12
-
-
0024406286
-
All Ras proteins are polyisoprenylated but only some are palmitoylated
-
HANCOCK, J.F., MAGEE, A.I., CHILDS, J.E. & MARSHALL, C.J. (1989). All Ras proteins are polyisoprenylated but only some are palmitoylated. Cell, 57, 1167.
-
(1989)
Cell
, vol.57
, pp. 1167
-
-
Hancock, J.F.1
Magee, A.I.2
Childs, J.E.3
Marshall, C.J.4
-
13
-
-
0025013547
-
A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane
-
HANCOCK, J.F., PATERSON, H. & MARSHALL, C.J. (1990). A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane. Cell, 63, 133.
-
(1990)
Cell
, vol.63
, pp. 133
-
-
Hancock, J.F.1
Paterson, H.2
Marshall, C.J.3
-
14
-
-
0028152440
-
Cysteine and methionine linked by carbon pseudopeptides inhibit farnesyl transferase
-
HARRINGTON, E M., KOWALCZYK, J.J , PINNOW, S.L., ACKERMANN, K., GARCIA, A M. & LEWIS, M.D. (1994). Cysteine and methionine linked by carbon pseudopeptides inhibit farnesyl transferase. Bioorganic and Medicinal Chemistry Letters, 4, 2775.
-
(1994)
Bioorganic and Medicinal Chemistry Letters
, vol.4
, pp. 2775
-
-
Harrington, E.M.1
Kowalczyk, J.J.2
Pinnow, S.L.3
Ackermann, K.4
Garcia, A.M.5
Lewis, M.D.6
-
15
-
-
0030034763
-
Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase
-
HUNT, J T., LEE, V.G , LEFTHERIS, K., SEIZINGER, B., CARBONI, J , MABUS, J., RICCA, C., YAN, N. & MANNE, V. (1996). Potent, cell active, non-thiol tetrapeptide inhibitors of farnesyltransferase. Journal of Medicinal Chemistry, 39, 353.
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, pp. 353
-
-
Hunt, J.T.1
Lee, V.G.2
Leftheris, K.3
Seizinger, B.4
Carboni, J.5
Mabus, J.6
Ricca, C.7
Yan, N.8
Manne, V.9
-
16
-
-
0025212684
-
Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation
-
JACKSON, J H , COCHRANE, C.G., BOURNE, J.R., SOLSKI, P.A., BUSS, J E & DER, C J (1990). Farnesol modification of Kirsten-ras exon 4B protein is essential for transformation. Proceedings of the National Academy of Sciences, USA, 87, 3042.
-
(1990)
Proceedings of the National Academy of Sciences, USA
, vol.87
, pp. 3042
-
-
Jackson, J.H.1
Cochrane, C.G.2
Bourne, J.R.3
Solski, P.A.4
Buss, J.E.5
Der, C.J.6
-
17
-
-
0027323459
-
Benzodiazepine peptidomimetics: Potent inhibitors of Ras farnesylation in animal cells
-
JAMES, G.L., GOLDSTEIN, J.L., BROWN, M.S., RAWSON, T.E , SOMERS, T.C., MCDOWELL, R S., CROWLEY, C.W., LUCAS, B K , LEVINSON, A.D. & MARSTERS, J.C , JR (1993). Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells. Science, 60, 1937.
-
(1993)
Science
, vol.60
, pp. 1937
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
Rawson, T.E.4
Somers, T.C.5
Mcdowell, R.S.6
Crowley, C.W.7
Lucas, B.K.8
Levinson, A.D.9
Marsters Jr., J.C.10
-
18
-
-
0028063058
-
Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-ras-transformed rat-1 cells, but not in untransformed cells
-
JAMES, G.L., BROWN, M S., COBE, M.H. & GOLDSTEIN, G.L (1994). Benzodiazepine peptidomimetic BZA-5B interrupts the MAP kinase activation pathway in H-ras-transformed rat-1 cells, but not in untransformed cells. Journal of Biological Chemistry, 269, 27705.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 27705
-
-
James, G.L.1
Brown, M.S.2
Cobe, M.H.3
Goldstein, G.L.4
-
19
-
-
0028958919
-
Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro
-
JAMES, G L., GOLDSTEIN, J.L. & BROWN, M S (1995). Polylysine and CVIM sequences of K-RasB dictate specificity of prenylation and confer resistance to benzodiazepine peptidomimetic in vitro. Journal of Biological Chemistry, 270, 6221.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 6221
-
-
James, G.L.1
Goldstein, J.L.2
Brown, M.S.3
-
20
-
-
0026747866
-
Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity
-
KATO, K., COX., A.D., HISAKA, M.M , GRAHAM, S M , BUSS, J.E. & DER, C J (1992). Isoprenoid addition to Ras protein is the critical modification for its membrane association and transforming activity. Proceedings of the National Academy of Sciences, USA, 89, 6403.
-
(1992)
Proceedings of the National Academy of Sciences, USA
, vol.89
, pp. 6403
-
-
Kato, K.1
Cox, A.D.2
Hisaka, M.M.3
Graham, S.M.4
Buss, J.E.5
Der, C.J.6
-
21
-
-
0028868945
-
Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors
-
KAUFFMANN, R.C , QIAN, Y., VOGT, A., SEBTI, S.M., HAMILTON, A D. & CARTHEW, R W (1995). Activated Drosophila Ras1 is selectively suppressed by isoprenyl transferase inhibitors. Proceedings of the National Academy of Sciences, USA, 92, 10919.
-
(1995)
Proceedings of the National Academy of Sciences, USA
, vol.92
, pp. 10919
-
-
Kauffmann, R.C.1
Qian, Y.2
Vogt, A.3
Sebti, S.M.4
Hamilton, A.D.5
Carthew, R.W.6
-
22
-
-
0027248872
-
Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor
-
KOHL, N.E., MOSSER, S D., DESSOLMS, S.J., GIULIANI, E A., POMPLIANO, D.L., GRAHAM, S.L , SMITH, R.L., SCOLNICK, E.M., OLIFF, A, & GIBBS, J.B. (1993). Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor. Science, 260, 1934.
-
(1993)
Science
, vol.260
, pp. 1934
-
-
Kohl, N.E.1
Mosser, S.D.2
Dessolms, S.J.3
Giuliani, E.A.4
Pompliano, D.L.5
Graham, S.L.6
Smith, R.L.7
Scolnick, E.M.8
Oliff, A.9
Gibbs, J.B.10
-
23
-
-
0028603395
-
Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice
-
KOHL, N.E., WILSON, F.R., MOSSER, S.D., GIULIANI, E., DESOLMS, S.J., CONNER, M.W., ANTHONY, N.J., HOLTZ, W.J., GOMEZ, R.P., LEE, T.J., SMITH, R.L., GRAHAM, S.L., HARTMAN, G., GIBBS, J.B. & OLIFF, A. (1994). Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice. Proceedings of the National Academy of Sciences, USA, 91, 9141.
-
(1994)
Proceedings of the National Academy of Sciences, USA
, vol.91
, pp. 9141
-
-
Kohl, N.E.1
Wilson, F.R.2
Mosser, S.D.3
Giuliani, E.4
Desolms, S.J.5
Conner, M.W.6
Anthony, N.J.7
Holtz, W.J.8
Gomez, R.P.9
Lee, T.J.10
Smith, R.L.11
Graham, S.L.12
Hartman, G.13
Gibbs, J.B.14
Oliff, A.15
-
24
-
-
0029074787
-
Development of inhibitors of protein farnesylation as potential chemotherapeutic agents
-
KOHL, N.E., CONNER, M.W , GRIBBS, J.B., GRAHAM, S.L., HARTMAN, G.D. & OLIFF, A. (1995a). Development of inhibitors of protein farnesylation as potential chemotherapeutic agents. Journal of Cellular Biochemistry, 22, 145.
-
(1995)
Journal of Cellular Biochemistry
, vol.22
, pp. 145
-
-
Kohl, N.E.1
Conner, M.W.2
Gribbs, J.B.3
Graham, S.L.4
Hartman, G.D.5
Oliff, A.6
-
25
-
-
0029150669
-
Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice
-
KOHL, N.E., OMER, C.A., CONNER, M.W., ANTHONY, N.J., DAVIDE, J.P., DESOLMS, S.J., GUILIANI, E.A , GOMEZ, R P., GRAHAM, S.L., HAMILTON, K., HANDT, L K., HARTMAN, G.-D , KOBLAN, K.S., KRAL, A.M., MILLER, P.J., MOSSER, S.O., O'NEILL, T.J., RANDS, E., SCHABER, M.D., GIBES, J B & OLIFF, A. (1995b). Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice. Nature Medicine, 1, 792.
-
(1995)
Nature Medicine
, vol.1
, pp. 792
-
-
Kohl, N.E.1
Omer, C.A.2
Conner, M.W.3
Anthony, N.J.4
Davide, J.P.5
Desolms, S.J.6
Guiliani, E.A.7
Gomez, R.P.8
Graham, S.L.9
Hamilton, K.10
Handt, L.K.11
Hartman, G.-D.12
Koblan, K.S.13
Kral, A.M.14
Miller, P.J.15
Mosser, S.O.16
O'Neill, T.J.17
Rands, E.18
Schaber, M.D.19
Gibes, J.B.20
Oliff, A.21
more..
-
26
-
-
0028810275
-
Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor
-
LERNER, E.C., QIAN, Y., HAMILTON, A.D. & SEBTI, S.M. (1995a). Disruption of oncogenic K-Ras4B processing and signaling by a potent geranylgeranyltransferase I inhibitor. Journal of Biological Chemistry, 270, 26770.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 26770
-
-
Lerner, E.C.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
27
-
-
0028973293
-
Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes
-
LERNER, E C., QIAN, Y, BLASKOVICH, M A , FOSSUM, R.D , VOGT, A , SUN, J., COX, A.D., DER, C.J., HAMILTON, A.D. & SEBTI, S.M. (1995b). Ras CAAX peptidomimetic FTI-277 selectively blocks oncogenic Ras signaling by inducing cytoplasmic accumulation of inactive Ras-Raf complexes. Journal of Biological Chemistry, 270, 26802.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 26802
-
-
Lerner, E.C.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Vogt, A.5
Sun, J.6
Cox, A.D.7
Der, C.J.8
Hamilton, A.D.9
Sebti, S.M.10
-
28
-
-
0030952552
-
Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines
-
in press
-
LERNER, E.C., ZHANG, T.T., KNOWLES, D , QIAN, Y, HAMILTON, A.D. & SEBTI, S.M. (1997). Inhibition of the prenylation of K-Ras, but not H- or N-Ras, is highly resistant to CAAX peptidomimetics and requires both a farnesyltransferase and a geranylgeranyltransferase I inhibitor in human tumor cell lines. Oncogene, in press.
-
(1997)
Oncogene
-
-
Lerner, E.C.1
Zhang, T.T.2
Knowles, D.3
Qian, Y.4
Hamilton, A.D.5
Sebti, S.M.6
-
29
-
-
0029000897
-
Bisubstrate inhibitors of farnesyltransferase: A novel class of specific inhibitors of ras transformed cells
-
MANNE, V , YAN, N , CARBONI, J.M., TUOMARI, A.V , RICCA, C.S., BROWN, J.G., ANDAHAZY, M.L., SCHMIDT, R.J., PATEL, D & ZAHLER, R. (1995). Bisubstrate inhibitors of farnesyltransferase: a novel class of specific inhibitors of ras transformed cells. Oncogene, 10, 1763.
-
(1995)
Oncogene
, vol.10
, pp. 1763
-
-
Manne, V.1
Yan, N.2
Carboni, J.M.3
Tuomari, A.V.4
Ricca, C.S.5
Brown, J.G.6
Andahazy, M.L.7
Schmidt, R.J.8
Patel, D.9
Zahler, R.10
-
30
-
-
0027212082
-
How receptors turn Ras on
-
MCCORMICK, F. (1993). How receptors turn Ras on. Nature, 363, 15.
-
(1993)
Nature
, vol.363
, pp. 15
-
-
Mccormick, F.1
-
31
-
-
0029119373
-
CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase
-
MCGUIRE, T.F., QIAN, Y., BLASKOVICH, M A , FOSSUM, R.D., SUN, J., MARLOWE, T. COREY, S.J., WATHEN, S.P., VOGT, A., HAMILTON, A.D. & SEBTI, S M (1995). CAAX peptidomimetic FTI-244 decreases platelet-derived growth factor receptor tyrosine phosphorylation levels and inhibits stimulation of phosphatidylinositol 3-kinase but not mitogen-activated protein kinase. Biochemical and Biophysical Research Communications, 214, 295.
-
(1995)
Biochemical and Biophysical Research Communications
, vol.214
, pp. 295
-
-
Mcguire, T.F.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Sun, J.5
Marlowe, T.6
Corey, S.J.7
Wathen, S.P.8
Vogt, A.9
Hamilton, A.D.10
Sebti, S.M.11
-
32
-
-
0029926493
-
Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation
-
MCGUIRE, TF, QIAN, Y, VOGT, A., HAMILTON, A.D. & SEBTI, S M (1996). Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation. Journal of Biological Chemistry, 271, 27402.
-
(1996)
Journal of Biological Chemistry
, vol.271
, pp. 27402
-
-
Mcguire, T.F.1
Qian, Y.2
Vogt, A.3
Hamilton, A.D.4
Sebti, S.M.5
-
33
-
-
0031004491
-
GGTI-298 induces 60/61 block and apoptosis whereas FTI-277 causes 62/M enrichment in A549 cells
-
in press
-
MIQUEL, K , PRADINES, A., SUN, J., QIAN, Y., HAMILTON, A.D. SEBTI, S M & FAURE, G. (1997). GGTI-298 induces 60/61 block and apoptosis whereas FTI-277 causes 62/M enrichment in A549 cells. Cancer Research, in press.
-
(1997)
Cancer Research
-
-
Miquel, K.1
Pradines, A.2
Sun, J.3
Qian, Y.4
Hamilton, A.D.5
Sebti, S.M.6
Faure, G.7
-
34
-
-
0026806554
-
Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements
-
MOOMAW, J F. & CASEY, P.J (1992). Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. Journal of Biological Chemistry, 267, 17438.
-
(1992)
Journal of Biological Chemistry
, vol.267
, pp. 17438
-
-
Moomaw, J.F.1
Casey, P.J.2
-
35
-
-
0028869067
-
Inhibition of human tumor xenograft growth by treatment with farnesyltransferase inhibitor B956
-
NAGASU, T., YOSHIMATSU, K , ROWELL, C , LEWIS, M D. & GARCIA, A.M. (1995). Inhibition of human tumor xenograft growth by treatment with farnesyltransferase inhibitor B956. Cancer Research, 55, 5310.
-
(1995)
Cancer Research
, vol.55
, pp. 5310
-
-
Nagasu, T.1
Yoshimatsu, K.2
Rowell, C.3
Lewis, M.D.4
Garcia, A.M.5
-
36
-
-
0027522046
-
Potent inhibition of human tumor p21 ras farnesyltransferase by A1 A2-lacking p21 ras CA1A2X peptidomimetics
-
NIGAM, M., SEONG, C.M., QIAN, Y., HAMILTON, A.D. & SEBTI, S.M (1993). Potent inhibition of human tumor p21 ras farnesyltransferase by A1 A2-lacking p21 ras CA1A2X peptidomimetics. Journal of Biological Chemistry, 268, 20695.
-
(1993)
Journal of Biological Chemistry
, vol.268
, pp. 20695
-
-
Nigam, M.1
Seong, C.M.2
Qian, Y.3
Hamilton, A.D.4
Sebti, S.M.5
-
37
-
-
0029025272
-
Phosphinyl acid-based bisubstrate analog inhibitors of farnesyl protein transferase
-
PATEL, D V , GORDON, E.M., SCHMIDT, R.J., WELLER, H.N., YOUNG, M.G., ZAHLER, R , BARBACID, M , CARBONI, J M., GULLO-BROWN, J.L , HUNIHAN, L., RICCA, C., ROBINSON, S., SWIZINGER, B.R , TUOMARI. A V. & MANNE, V. (1995). Phosphinyl acid-based bisubstrate analog inhibitors of farnesyl protein transferase. Journal of Medicinal Chemistry, 38, 435.
-
(1995)
Journal of Medicinal Chemistry
, vol.38
, pp. 435
-
-
Patel, D.V.1
Gordon, E.M.2
Schmidt, R.J.3
Weller, H.N.4
Young, M.G.5
Zahler, R.6
Barbacid, M.7
Carboni, J.M.8
Gullo-Brown, J.L.9
Hunihan, L.10
Ricca, C.11
Robinson, S.12
Swizinger, B.R.13
Tuomari, A.V.14
Manne, V.15
-
38
-
-
0028352281
-
Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase
-
QIAN, Y., BLASKOVICH, M A., SALEEM, M., SEONG, C.M., WATHEN, S.P. HAMILTON, A.D & SEBTI, S.M. (1994a). Design and structural requirements of potent peptidomimetic inhibitors of p21ras farnesyltransferase. Journal of Biological Chemistry, 269, 12410.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 12410
-
-
Qian, Y.1
Blaskovich, M.A.2
Saleem, M.3
Seong, C.M.4
Wathen, S.P.5
Hamilton, A.D.6
Sebti, S.M.7
-
39
-
-
0028132044
-
Peptidomimetic inhibitors of p21ras farnesyltransferase: Hydrophobia functionalization leads to disruption of p21 ras membrane association in whole cells
-
QIAN, Y., BLASKOVICH, M.A., SEONG, C.-M., VOGT, A., HAMILTON, A.D. & SEBTI, S.M (1994b). Peptidomimetic inhibitors of p21ras farnesyltransferase: hydrophobia functionalization leads to disruption of p21 ras membrane association in whole cells. Bioorganic and Medicinal Chemistry Letters, 4, 2579.
-
(1994)
Bioorganic and Medicinal Chemistry Letters
, vol.4
, pp. 2579
-
-
Qian, Y.1
Blaskovich, M.A.2
Seong, C.-M.3
Vogt, A.4
Hamilton, A.D.5
Sebti, S.M.6
-
40
-
-
0030046735
-
Design and synthesis of non-peptide ras CAAX mimetics as potent farnesyltransferase inhibitors
-
QIAN, Y., VOGT, A., SEBTI, S.M. & HAMILTON, A D. (1996). Design and synthesis of non-peptide ras CAAX mimetics as potent farnesyltransferase inhibitors. Journal of Medicinal Chemistry, 39, 217.
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, pp. 217
-
-
Qian, Y.1
Vogt, A.2
Sebti, S.M.3
Hamilton, A.D.4
-
41
-
-
0025194466
-
Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides
-
REISS, Y, GOLDSTEIN, J.L , SEABRA, M C, CASEY, P.J. & BROWN, M.S. (1990). Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides. Cell 62, 81.
-
(1990)
Cell
, vol.62
, pp. 81
-
-
Reiss, Y.1
Goldstein, J.L.2
Seabra, M.C.3
Casey, P.J.4
Brown, M.S.5
-
42
-
-
0025923649
-
Nonidentical subunits of p21H-Ras farnesyltransferase
-
REISS, Y., SEABRA, M.C., ARMSTRONG, S.A., SLAUGHTER, C.A., GOLDSTEIN, J.L. & BROWN, M.S (1991). Nonidentical subunits of p21H-Ras farnesyltransferase. Journal of Biological Chemistry, 266, 10672.
-
(1991)
Journal of Biological Chemistry
, vol.266
, pp. 10672
-
-
Reiss, Y.1
Seabra, M.C.2
Armstrong, S.A.3
Slaughter, C.A.4
Goldstein, J.L.5
Brown, M.S.6
-
43
-
-
0002857679
-
Prenylation of ras and inhibitors of prenyltransferases
-
Maruta, H. & Burgess, A.W. (eds), R.G. Landers: Austin, TX
-
SATTLER, I & TAMANOI, F. (1996). Prenylation of ras and inhibitors of prenyltransferases. In Regulation of the Ras Signaling Network, Molecular Biological Intelligence Unit Series. Maruta, H. & Burgess, A.W. (eds), p. 95. R.G. Landers: Austin, TX.
-
(1996)
Regulation of the Ras Signaling Network, Molecular Biological Intelligence Unit Series
, pp. 95
-
-
Sattler, I.1
Tamanoi, F.2
-
44
-
-
0025819073
-
Protein farnesyltransferase and geranylgeranyltransferase share a common α-subunit
-
SEABRA, M C , REISS, Y., CASEY, P.J., BROWN, M.S. & GOLDSTEIN, J.L (1991). Protein farnesyltransferase and geranylgeranyltransferase share a common α-subunit. Cell, 65, 429.
-
(1991)
Cell
, vol.65
, pp. 429
-
-
Seabra, M.C.1
Reiss, Y.2
Casey, P.J.3
Brown, M.S.4
Goldstein, J.L.5
-
45
-
-
8244265056
-
Synthesis and evaluation of novel tri- and dipeptide inhibitors of ras farnesyl protein transferase
-
Abstract no. 2561
-
SEBOLT-LEOPOLD, J S., GOWAN, R.C , SCHOLTEN, J , CRESWELL, M & BOLTON, G.L (1995). Synthesis and evaluation of novel tri- and dipeptide inhibitors of ras farnesyl protein transferase. 86th Annual Meeting of American Association for Cancer Research, Toronto, Canada, Abstract no. 2561.
-
(1995)
86th Annual Meeting of American Association for Cancer Research, Toronto, Canada
-
-
Sebolt-Leopold, J.S.1
Gowan, R.C.2
Scholten, J.3
Creswell, M.4
Bolton, G.L.5
-
46
-
-
0030749464
-
Inhibition of Ras prenylation: A novel approach to cancer chemotherapy
-
in press
-
SEBTI, S M & HAMILTON, A.D. (1997). Inhibition of Ras prenylation: a novel approach to cancer chemotherapy. Pharmacology and Therapeutics, in press.
-
(1997)
Pharmacology and Therapeutics
-
-
Sebti, S.M.1
Hamilton, A.D.2
-
47
-
-
0028835253
-
A peptidomimetic inhibitor of farnesyltransferase blocks the anchorage-dependent and -independent growth of human tumor cell lines
-
SEPP-LORENZINO, L., MA, Z., RANDS, E , KHOL, N.E., GIBBS, J.B., OLIFF, A & ROSEN, N (1995). A peptidomimetic inhibitor of farnesyltransferase blocks the anchorage-dependent and -independent growth of human tumor cell lines. Cancer Research, 55, 5302.
-
(1995)
Cancer Research
, vol.55
, pp. 5302
-
-
Sepp-Lorenzino, L.1
Ma, Z.2
Rands, E.3
Khol, N.E.4
Gibbs, J.B.5
Oliff, A.6
Rosen, N.7
-
48
-
-
0029023145
-
Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-ras mutation and p53 deletion
-
SUN, J , QIAN, Y., HAMILTON, A.D & SEBTI, S.M (1995). Ras CAAX peptidomimetic FTI 276 selectively blocks tumor growth in nude mice of a human lung carcinoma with K-ras mutation and p53 deletion. Cancer Research, 55, 4243.
-
(1995)
Cancer Research
, vol.55
, pp. 4243
-
-
Sun, J.1
Qian, Y.2
Hamilton, A.D.3
Sebti, S.M.4
-
49
-
-
0027213688
-
Inhibitors of Ras farnesyltransferase
-
TAMANOI, F. (1993). Inhibitors of Ras farnesyltransferase. Trends in Biochemical Science, 18, 349.
-
(1993)
Trends in Biochemical Science
, vol.18
, pp. 349
-
-
Tamanoi, F.1
-
50
-
-
0027299926
-
Genetic evidence for in vivo cross-specificity of the CAAX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase I in Saccharomyces cerevisiae
-
TRUEBLOOD, C.E., OHYA, Y & RHINE, J. (1993). Genetic evidence for in vivo cross-specificity of the CAAX-box protein prenyltransferases farnesyltransferase and geranylgeranyltransferase I in Saccharomyces cerevisiae. Molecular and Cellular Biology, 13, 4260.
-
(1993)
Molecular and Cellular Biology
, vol.13
, pp. 4260
-
-
Trueblood, C.E.1
Ohya, Y.2
Rhine, J.3
-
51
-
-
0028912593
-
A non-peptide mimetic of Ras-CAAX: Selective inhibition of farnesyltransferase and Ras processing
-
VOGT, A., QIAN, Y., BLASKOVICH, M A , FOSSUM, R.D., HAMILTON, A D. & SEBTI, S.M. (1995). A non-peptide mimetic of Ras-CAAX: selective inhibition of farnesyltransferase and Ras processing. Journal of Biological Chemistry, 270, 660.
-
(1995)
Journal of Biological Chemistry
, vol.270
, pp. 660
-
-
Vogt, A.1
Qian, Y.2
Blaskovich, M.A.3
Fossum, R.D.4
Hamilton, A.D.5
Sebti, S.M.6
-
53
-
-
0029986149
-
2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase
-
WILLIAMS, T.M., CICCARONE, T M., MACTOUGH, S.C., BOCK, R.L , CONNER, M W, DAVIDE, J P, HAMILTON, K., KOBLAN, K S , KOHL, E.E , KRAL, A M., MOSSER, S.D , OMER, C. A., POMPLIANO, D L , RANDS, E., SCHABER, M.D., SHAH, D., WILSON, F.R., GIBBS, J.B., GRAHAM, S.L., HARTMAN, G.D., OLIFF, A I & SMITH, R.L. (1996). 2-Substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase. Journal of Medicinal Chemistry, 39, 1345.
-
(1996)
Journal of Medicinal Chemistry
, vol.39
, pp. 1345
-
-
Williams, T.M.1
Ciccarone, T.M.2
Mactough, S.C.3
Bock, R.L.4
Conner, M.W.5
Davide, J.P.6
Hamilton, K.7
Koblan, K.S.8
Kohl, E.E.9
Kral, A.M.10
Mosser, S.D.11
Omer, C.A.12
Pompliano, D.L.13
Rands, E.14
Schaber, M.D.15
Shah, D.16
Wilson, F.R.17
Gibbs, J.B.18
Graham, S.L.19
Hartman, G.D.20
Oliff, A.I.21
Smith, R.L.22
more..
-
54
-
-
0026001936
-
A protein geranylgeranyltransferase from bovine brain: Implications for protein prenylation specificity
-
YOKOYAMA, K., GOODWIN, G W., GHOMASHCHI, F., GLOMSET, J.A. & GELB, M.H (1991). A protein geranylgeranyltransferase from bovine brain: implications for protein prenylation specificity. Proceedings of the National Academy of Sciences, USA, 88, 5302.
-
(1991)
Proceedings of the National Academy of Sciences, USA
, vol.88
, pp. 5302
-
-
Yokoyama, K.1
Goodwin, G.W.2
Ghomashchi, F.3
Glomset, J.A.4
Gelb, M.H.5
-
55
-
-
0027981210
-
cDNA cloning and expression of rat and human protein geranylgeranyl transferase type-I
-
ZHANG, F L , DIEHL, R.E., KHOL, N.E., GIBBS, J.B , GIROS, B., CASEY, P.J. & OMER, C A. (1994). cDNA cloning and expression of rat and human protein geranylgeranyl transferase type-I. Journal of Biological Chemistry, 269, 3175.
-
(1994)
Journal of Biological Chemistry
, vol.269
, pp. 3175
-
-
Zhang, F.L.1
Diehl, R.E.2
Khol, N.E.3
Gibbs, J.B.4
Giros, B.5
Casey, P.J.6
Omer, C.A.7
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