-
1
-
-
0035786906
-
Peroxisome proliferator-activated receptors: From genes to physiology
-
Kliewer, S. A., Xu, H. E., Lambert, M. H., and Willson, T. M. (2001) Peroxisome proliferator-activated receptors: From genes to physiology. Recent Prog. Horm. Res., 56, 239-263.
-
(2001)
Recent Prog. Horm. Res.
, vol.56
, pp. 239-263
-
-
Kliewer, S.A.1
Xu, H.E.2
Lambert, M.H.3
Willson, T.M.4
-
2
-
-
0032710343
-
Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions
-
Michalik, L., and Wahli, W. (1999) Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions. Curr. Opin. Biotechnol., 10, 564-570.
-
(1999)
Curr. Opin. Biotechnol.
, vol.10
, pp. 564-570
-
-
Michalik, L.1
Wahli, W.2
-
3
-
-
0027278522
-
Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)
-
Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G., and Wahli, W. (1993) Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol. Cell, 77, 67-76.
-
(1993)
Biol. Cell
, vol.77
, pp. 67-76
-
-
Dreyer, C.1
Keller, H.2
Mahfoudi, A.3
Laudet, V.4
Krey, G.5
Wahli, W.6
-
4
-
-
0030952937
-
Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
-
Forman, B. M., Chen, J., and, Evans, R. M. (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. U.S.A., 94, 4312-4317.
-
(1997)
Proc. Natl. Acad. Sci. U.S.A.
, vol.94
, pp. 4312-4317
-
-
Forman, B.M.1
Chen, J.2
Evans, R.M.3
-
5
-
-
0030985318
-
Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
-
Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., and Wahli, W. (1997) Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol., 11, 779-791.
-
(1997)
Mol. Endocrinol.
, vol.11
, pp. 779-791
-
-
Krey, G.1
Braissant, O.2
L'Horset, F.3
Kalkhoven, E.4
Perroud, M.5
Parker, M.G.6
Wahli, W.7
-
6
-
-
0033625677
-
Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
-
Peters, J. M., Lee, S. S., Li, W., Ward, J. M., Gavrilova, O., Everett, C., Reitman, M. L., Hudson, L. D., and Gonzalez, F. J. (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol. Cell. Biol., 20, 5119-5128.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5119-5128
-
-
Peters, J.M.1
Lee, S.S.2
Li, W.3
Ward, J.M.4
Gavrilova, O.5
Everett, C.6
Reitman, M.L.7
Hudson, L.D.8
Gonzalez, F.J.9
-
7
-
-
0035921419
-
Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice
-
Michalik, L., Desvergne, B., Tan, N. S., Basu-Modak, S., Escher, P., Rieusset, J., Peters, J. M., Kaya, G., Gonzalez, F. J., Zakany, J., Metzger, D., Chambon, P., Duboule, D., and Wahli, W. (2001) Impaired skin wound healing in peroxisome proliferator-activated receptor (PPAR)alpha and PPARbeta mutant mice. J. Cell. Biol., 154, 799-814.
-
(2001)
J. Cell. Biol.
, vol.154
, pp. 799-814
-
-
Michalik, L.1
Desvergne, B.2
Tan, N.S.3
Basu-Modak, S.4
Escher, P.5
Rieusset, J.6
Peters, J.M.7
Kaya, G.8
Gonzalez, F.J.9
Zakany, J.10
Metzger, D.11
Chambon, P.12
Duboule, D.13
Wahli, W.14
-
8
-
-
0035942162
-
A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport
-
Oliver, W. R., Jr., Shenk, J. L., Snaith, M. R., Russell, C. S., Plunket, K. D., Bodkin, N. L., Lewis, M. C., Winegar, D. A., Sznaidman, M. L., Lambert, M. H., Xu, H. E., Sternbach, D. D., Kliewer, S. A., Hansen, B. C., and Wilson, T. M. (2001) A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport. Proc. Natl. Acad. Sci. U.S.A., 98, 5306-5311.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 5306-5311
-
-
Oliver Jr., W.R.1
Shenk, J.L.2
Snaith, M.R.3
Russell, C.S.4
Plunket, K.D.5
Bodkin, N.L.6
Lewis, M.C.7
Winegar, D.A.8
Sznaidman, M.L.9
Lambert, M.H.10
Xu, H.E.11
Sternbach, D.D.12
Kliewer, S.A.13
Hansen, B.C.14
Wilson, T.M.15
-
9
-
-
0029016829
-
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
-
Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem., 270, 12953-12956.
-
(1995)
J. Biol. Chem.
, vol.270
, pp. 12953-12956
-
-
Lehmann, J.M.1
Moore, L.B.2
Smith-Oliver, T.A.3
Wilkison, W.O.4
Willson, T.M.5
Kliewer, S.A.6
-
10
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature, 391, 79-82.
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
11
-
-
0031888958
-
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
-
Jiang, C., Ting, A. T., and Seed, B. (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 391, 82-86.
-
(1998)
Nature
, vol.391
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
12
-
-
0034769830
-
Peroxisome proliferator-activated receptors in endothelial cell biology
-
Plutzky, J. (2001) Peroxisome proliferator-activated receptors in endothelial cell biology. Curr. Opin. Lipidol., 12, 511-518.
-
(2001)
Curr. Opin. Lipidol.
, vol.12
, pp. 511-518
-
-
Plutzky, J.1
-
13
-
-
0001297403
-
Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT
-
Yang, X. Y., Wang, L. H., Chen, T., Hodge, D. R., Resau, J. H., DaSilva, L., and Farrar, W. L. (2000) Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT. J. Biol. Chem., 275, 4541-4544.
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 4541-4544
-
-
Yang, X.Y.1
Wang, L.H.2
Chen, T.3
Hodge, D.R.4
Resau, J.H.5
DaSilva, L.6
Farrar, W.L.7
-
14
-
-
0033119162
-
Coactivator and corepressor complexes in nuclear receptor function
-
Xu, L., Glass, C. K., and Rosenfeld, M. G. (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev., 9, 140-147.
-
(1999)
Curr. Opin. Genet. Dev.
, vol.9
, pp. 140-147
-
-
Xu, L.1
Glass, C.K.2
Rosenfeld, M.G.3
-
15
-
-
0028180070
-
mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer
-
Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer. Genes Dev., 8, 1224-1234.
-
(1994)
Genes Dev.
, vol.8
, pp. 1224-1234
-
-
Tontonoz, P.1
Hu, E.2
Graves, R.A.3
Budavari, A.I.4
Spiegelman, B.M.5
-
16
-
-
0028641559
-
Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
-
Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell, 79, 1147-1156.
-
(1994)
Cell
, vol.79
, pp. 1147-1156
-
-
Tontonoz, P.1
Hu, E.2
Spiegelman, B.M.3
-
17
-
-
0033213637
-
PPAR gamma is required for placental, cardiac, and adipose tissue development
-
Barak, Y., Nelson, M. C., Ong, E. S., Jones, Y. Z., Ruiz-Lozano, P., Chien, K. R., Koder, A., and Evans, R. M. (1999) PPAR gamma is required for placental, cardiac, and adipose tissue development. Mol. Cell., 4, 585-595.
-
(1999)
Mol. Cell.
, vol.4
, pp. 585-595
-
-
Barak, Y.1
Nelson, M.C.2
Ong, E.S.3
Jones, Y.Z.4
Ruiz-Lozano, P.5
Chien, K.R.6
Koder, A.7
Evans, R.M.8
-
19
-
-
0032515065
-
The role of C/EBP genes in adipocyte differentiation
-
Darlington, G. J., Ross, S. E., and MacDougald, O. A. (1998) The role of C/EBP genes in adipocyte differentiation. J. Biol. Chem., 273, 30057-30060.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 30057-30060
-
-
Darlington, G.J.1
Ross, S.E.2
MacDougald, O.A.3
-
20
-
-
0031435337
-
Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene
-
Tanaka, T., Yoshida, N., Kishimoto, T., and Akira, S. (1997) Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J., 16, 7432-7443.
-
(1997)
EMBO J.
, vol.16
, pp. 7432-7443
-
-
Tanaka, T.1
Yoshida, N.2
Kishimoto, T.3
Akira, S.4
-
21
-
-
0036007025
-
PPARgamma knockdown by engineered transcription factors: Exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis
-
Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P., and Camp, H. S. (2002) PPARgamma knockdown by engineered transcription factors: Exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev., 16, 27-32.
-
(2002)
Genes Dev.
, vol.16
, pp. 27-32
-
-
Ren, D.1
Collingwood, T.N.2
Rebar, E.J.3
Wolffe, A.P.4
Camp, H.S.5
-
22
-
-
0033083803
-
Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
-
Wu, Z., Rosen, E. D., Brun, R., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G. J., and Spiegelman, B. M. (1999) Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell, 3, 151-158.
-
(1999)
Mol. Cell
, vol.3
, pp. 151-158
-
-
Wu, Z.1
Rosen, E.D.2
Brun, R.3
Hauser, S.4
Adelmant, G.5
Troy, A.E.6
McKeon, C.7
Darlington, G.J.8
Spiegelman, B.M.9
-
23
-
-
0029160028
-
Impaired energy homeostasis in C/EBP alpha knockout mice
-
Wang, N. D., Finegold, M. J., Bradley, A., Ou, C. N., Abdelsayed, S. V., Wilde, M. D., Taylor, L. R., Wilson, D. R., and Darlington, G. J. (1995) Impaired energy homeostasis in C/EBP alpha knockout mice. Science, 269, 1108-1112.
-
(1995)
Science
, vol.269
, pp. 1108-1112
-
-
Wang, N.D.1
Finegold, M.J.2
Bradley, A.3
Ou, C.N.4
Abdelsayed, S.V.5
Wilde, M.D.6
Taylor, L.R.7
Wilson, D.R.8
Darlington, G.J.9
-
24
-
-
0028129499
-
Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells
-
Freytag, S. O., Paielli, D. L., and Gilbert, J. D. (1994) Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes. Dev., 8, 1654-1663.
-
(1994)
Genes Dev.
, vol.8
, pp. 1654-1663
-
-
Freytag, S.O.1
Paielli, D.L.2
Gilbert, J.D.3
-
25
-
-
0036007024
-
C/EBPalpha induces adipogenesis through PPARgamma: A unified pathway
-
Rosen, E. D., Hsu, C. H., Wang, X., Sakai, S., Freeman, M. W., Gonzalez, F. J., and Spiegelman, B. M. (2002) C/EBPalpha induces adipogenesis through PPARgamma: A unified pathway. Genes Dev., 16, 22-26.
-
(2002)
Genes Dev.
, vol.16
, pp. 22-26
-
-
Rosen, E.D.1
Hsu, C.H.2
Wang, X.3
Sakai, S.4
Freeman, M.W.5
Gonzalez, F.J.6
Spiegelman, B.M.7
-
26
-
-
0032189782
-
Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
-
Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W., and Kahn, C. R. (1998) Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl. J. Med., 339, 953-959.
-
(1998)
N. Engl. J. Med.
, vol.339
, pp. 953-959
-
-
Ristow, M.1
Muller-Wieland, D.2
Pfeiffer, A.3
Krone, W.4
Kahn, C.R.5
-
27
-
-
0033599038
-
Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension
-
Barroso, I., Gurnell, M., Crowley, V. E., Agostini, M., Schwabe, J. W., Soos, M. A., Maslen, G. L., Williams, T. D., Lewis, H., Schafer, A. J., Chatterjee, V. K., and O'Rahilly, S. (1999) Dominant negative mutations in human PPARgamma associated with severe insulin resistance, diabetes mellitus and hypertension. Nature, 402, 880-883.
-
(1999)
Nature
, vol.402
, pp. 880-883
-
-
Barroso, I.1
Gurnell, M.2
Crowley, V.E.3
Agostini, M.4
Schwabe, J.W.5
Soos, M.A.6
Maslen, G.L.7
Williams, T.D.8
Lewis, H.9
Schafer, A.J.10
Chatterjee, V.K.11
O'Rahilly, S.12
-
28
-
-
0036894397
-
PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
-
Hegele, R. A., Cao, H., Frankowski, C., Mathews, S. T., and Leff, T. (2002) PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes, 51, 3586-3590.
-
(2002)
Diabetes
, vol.51
, pp. 3586-3590
-
-
Hegele, R.A.1
Cao, H.2
Frankowski, C.3
Mathews, S.T.4
Leff, T.5
-
29
-
-
0036146384
-
A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
-
Agarwal, A. K. and Garg, A. (2002) A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy. J. Clin. Endocrinol. Metab., 87, 408-411.
-
(2002)
J. Clin. Endocrinol. Metab.
, vol.87
, pp. 408-411
-
-
Agarwal, A.K.1
Garg, A.2
-
30
-
-
18644382993
-
Digenic inheritance of severe insulin resistance in a human pedigree
-
Savage, D. B., Agostini, M., Barroso, I., Gurnell, M., Luan, J., Meirhaeghe, A., Harding, A. H., Ihrke, G., Rajanayagam, O., Soos, M. A., George, S., Berger, D., Thomas, E. L., Bell, J. D., Meeran, K., Ross, R. J., Vidal-Puig, A., Wareham, N. J., O'Rahilly, S., Chatterjee, V. K., and Schafer, A. J. (2002) Digenic inheritance of severe insulin resistance in a human pedigree. Nat. Genet., 31, 379-384.
-
(2002)
Nat. Genet.
, vol.31
, pp. 379-384
-
-
Savage, D.B.1
Agostini, M.2
Barroso, I.3
Gurnell, M.4
Luan, J.5
Meirhaeghe, A.6
Harding, A.H.7
Ihrke, G.8
Rajanayagam, O.9
Soos, M.A.10
George, S.11
Berger, D.12
Thomas, E.L.13
Bell, J.D.14
Meeran, K.15
Ross, R.J.16
Vidal-Puig, A.17
Wareham, N.J.18
O'Rahilly, S.19
Chatterjee, V.K.20
Schafer, A.J.21
more..
-
31
-
-
0345164399
-
Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR gamma 2 missense mutation
-
Yen, C. J., Beamer, B. A., Negri, C., Silver, K., Brown, K. A., Yarnall, D. P., Burns, D. K., Roth, J., and Shuldiner, A. R. (1997) Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR gamma 2 missense mutation. Biochem. Biophys. Res. Commun., 241, 270-274.
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.241
, pp. 270-274
-
-
Yen, C.J.1
Beamer, B.A.2
Negri, C.3
Silver, K.4
Brown, K.A.5
Yarnall, D.P.6
Burns, D.K.7
Roth, J.8
Shuldiner, A.R.9
-
32
-
-
0031595923
-
A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
-
Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamaki, J., Mykkanen, L., Kuusisto, J., Laakso, M., Fujimoto, W., and Auwerx, J. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet., 20, 284-287.
-
(1998)
Nat. Genet.
, vol.20
, pp. 284-287
-
-
Deeb, S.S.1
Fajas, L.2
Nemoto, M.3
Pihlajamaki, J.4
Mykkanen, L.5
Kuusisto, J.6
Laakso, M.7
Fujimoto, W.8
Auwerx, J.9
-
33
-
-
0345363159
-
Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects
-
Hamann, A., Munzberg, H., Buttron, P., Busing, B., Hinney, A., Mayer, H., Siegfried, W., Hebebrand, J., and Greten, H. (1999) Missense variants in the human peroxisome proliferator-activated receptor-gamma2 gene in lean and obese subjects. Eur. J. Endocrinol., 141, 90-92.
-
(1999)
Eur. J. Endocrinol.
, vol.141
, pp. 90-92
-
-
Hamann, A.1
Munzberg, H.2
Buttron, P.3
Busing, B.4
Hinney, A.5
Mayer, H.6
Siegfried, W.7
Hebebrand, J.8
Greten, H.9
-
34
-
-
0004509649
-
The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes
-
Clement, K., Hercberg, S., Passinge, B., Galan, P., Varroud-Vial, M., Shuldiner, A. R., Beamer, B. A., Charpentier, G., Guy-Grand, B., Froguel, P., and Vaisse, C. (2000) The Pro115Gln and Pro12Ala PPAR gamma gene mutations in obesity and type 2 diabetes. Int. J. Obes. Relat. Metab. Disord., 24, 391-393.
-
(2000)
Int. J. Obes. Relat. Metab. Disord.
, vol.24
, pp. 391-393
-
-
Clement, K.1
Hercberg, S.2
Passinge, B.3
Galan, P.4
Varroud-Vial, M.5
Shuldiner, A.R.6
Beamer, B.A.7
Charpentier, G.8
Guy-Grand, B.9
Froguel, P.10
Vaisse, C.11
-
35
-
-
0031667127
-
Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations
-
Beamer, B. A., Yen, C. J., Andersen, R. E., Muller, D., Elahi, D., Cheskin, L. J., Andres, R., Roth, J., and Shuldiner, A. R. (1998) Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes, 47, 1806-1808.
-
(1998)
Diabetes
, vol.47
, pp. 1806-1808
-
-
Beamer, B.A.1
Yen, C.J.2
Andersen, R.E.3
Muller, D.4
Elahi, D.5
Cheskin, L.J.6
Andres, R.7
Roth, J.8
Shuldiner, A.R.9
-
36
-
-
0034076458
-
The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans
-
Cole, S. A., Mitchell, B. D., Hsueh, W. C., Pineda, P., Beamer, B. A., Shuldiner, A. R., Comuzzie, A. G., Blangero, J., and Hixson, J. E. (2000) The Pro12Ala variant of peroxisome proliferator-activated receptor-gamma2 (PPAR-gamma2) is associated with measures of obesity in Mexican Americans. Int. J. Obes. Relat. Metab. Disord., 24, 522-524.
-
(2000)
Int. J. Obes. Relat. Metab. Disord.
, vol.24
, pp. 522-524
-
-
Cole, S.A.1
Mitchell, B.D.2
Hsueh, W.C.3
Pineda, P.4
Beamer, B.A.5
Shuldiner, A.R.6
Comuzzie, A.G.7
Blangero, J.8
Hixson, J.E.9
-
37
-
-
0033304551
-
Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women
-
Valve, R., Sivenius, K., Miettinen, R., Pihlajamaki, J., Rissanen, A., Deeb, S. S., Auwerx, J., Uusitupa, M., and Laakso, M. (1999) Two polymorphisms in the peroxisome proliferator-activated receptor-gamma gene are associated with severe overweight among obese women. J. Clin. Endocrinol. Metab., 84, 3708-3712.
-
(1999)
J. Clin. Endocrinol. Metab.
, vol.84
, pp. 3708-3712
-
-
Valve, R.1
Sivenius, K.2
Miettinen, R.3
Pihlajamaki, J.4
Rissanen, A.5
Deeb, S.S.6
Auwerx, J.7
Uusitupa, M.8
Laakso, M.9
-
38
-
-
0036320603
-
The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism
-
Stumvoll, M., and Haring, H. (2002) The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism. Diabetes, 51, 2341-2347.
-
(2002)
Diabetes
, vol.51
, pp. 2341-2347
-
-
Stumvoll, M.1
Haring, H.2
-
39
-
-
0033624575
-
The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
-
Altshuler, D., Hirschhorn, J. N., Klannemark, M., Lindgren, C. M., Vohl, M. C., Nemesh, J., Lane, C. R., Schaffner, S. F., Bolk, S., Brewer, C., Tuomi, T., Gaudet, D., Hudson, T. J., Daly, M., Groop, L., and Lander, E. S. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet., 26, 76-80.
-
(2000)
Nat. Genet.
, vol.26
, pp. 76-80
-
-
Altshuler, D.1
Hirschhorn, J.N.2
Klannemark, M.3
Lindgren, C.M.4
Vohl, M.C.5
Nemesh, J.6
Lane, C.R.7
Schaffner, S.F.8
Bolk, S.9
Brewer, C.10
Tuomi, T.11
Gaudet, D.12
Hudson, T.J.13
Daly, M.14
Groop, L.15
Lander, E.S.16
-
40
-
-
0034519552
-
Familial partial lipodystrophy: A monogenic form of the insulin resistance syndrome
-
Hegele, R. A. (2000) Familial partial lipodystrophy: A monogenic form of the insulin resistance syndrome. Mol. Genet. Metab., 71, 539-544.
-
(2000)
Mol. Genet. Metab.
, vol.71
, pp. 539-544
-
-
Hegele, R.A.1
-
41
-
-
0034059075
-
Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy
-
Cao, H., and Hegele, R. A. (2000) Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet., 9, 109-112.
-
(2000)
Hum. Mol. Genet.
, vol.9
, pp. 109-112
-
-
Cao, H.1
Hegele, R.A.2
-
42
-
-
0033951216
-
LMNA, encoding lamin A/C, is mutated in partial lipodystrophy
-
Shackleton, S., Lloyd, D. J., Jackson, S. N., Evans, R., Niermeijer, M. F., Singh, B. M., Schmidt, H., Brabant, G., Kumar, S., Durrington, P. N., Gregory, S., O'Rahilly, S., and Trembath, R. C. (2000) LMNA, encoding lamin A/C, is mutated in partial lipodystrophy. Nat. Genet., 24, 153-156.
-
(2000)
Nat. Genet.
, vol.24
, pp. 153-156
-
-
Shackleton, S.1
Lloyd, D.J.2
Jackson, S.N.3
Evans, R.4
Niermeijer, M.F.5
Singh, B.M.6
Schmidt, H.7
Brabant, G.8
Kumar, S.9
Durrington, P.N.10
Gregory, S.11
O'Rahilly, S.12
Trembath, R.C.13
-
43
-
-
0033912260
-
Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C
-
Speckman, R. A., Garg, A., Du, F., Bennett, L., Veile, R., Arioglu, E., Taylor, S. I., Lovett, M., and Bowcock, A. M. (2000) Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. Am. J. Hum. Genet., 66, 1192-1198.
-
(2000)
Am. J. Hum. Genet.
, vol.66
, pp. 1192-1198
-
-
Speckman, R.A.1
Garg, A.2
Du, F.3
Bennett, L.4
Veile, R.5
Arioglu, E.6
Taylor, S.I.7
Lovett, M.8
Bowcock, A.M.9
-
44
-
-
12144291700
-
Tyrosine agonists reverse the molecular defects associated with dominant negative mutations in human PPAR gamma
-
Agostini, M., Gurnell, M., Savage, D. B., Wood, E. M., Smith, A. G., Rajanayagam, O., Garnes, K. T., Levinson, S. H., Xu, H. E., Schwabe, J. W., Willson, T. M., O'Rahilly, S., and Chatterjee, V. K. (2003) Tyrosine agonists reverse the molecular defects associated with dominant negative mutations in human PPAR gamma. Endocrinology, 145, 1527-1538.
-
(2003)
Endocrinology
, vol.145
, pp. 1527-1538
-
-
Agostini, M.1
Gurnell, M.2
Savage, D.B.3
Wood, E.M.4
Smith, A.G.5
Rajanayagam, O.6
Garnes, K.T.7
Levinson, S.H.8
Xu, H.E.9
Schwabe, J.W.10
Willson, T.M.11
O'Rahilly, S.12
Chatterjee, V.K.13
-
45
-
-
0344375097
-
Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma
-
Savage, D. B., Tan, G. D., Acerini, C. L., Jebb, S. A., Agostini, M., Gurnell, M., Williams, R. L., Umpleby, A. M., Thomas, E. L., Bell, J. D., Dixon, A. K., Dunne, F., Boiani, R., Cinti, S., Vidal-Puig, A., Karpe, F., Chatterjee, V. K., and O'Rahilly, S. (2003) Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-gamma. Diabetes, 52, 910-917.
-
(2003)
Diabetes
, vol.52
, pp. 910-917
-
-
Savage, D.B.1
Tan, G.D.2
Acerini, C.L.3
Jebb, S.A.4
Agostini, M.5
Gurnell, M.6
Williams, R.L.7
Umpleby, A.M.8
Thomas, E.L.9
Bell, J.D.10
Dixon, A.K.11
Dunne, F.12
Boiani, R.13
Cinti, S.14
Vidal-Puig, A.15
Karpe, F.16
Chatterjee, V.K.17
O'Rahilly, S.18
-
46
-
-
0032505096
-
Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma
-
Nolte, R. T., Wisely, G. B., Westin, S., Cobb, J. E., Lambert, M. H., Kurokawa, R., Rosenfeld, M. G., Willson, T. M., Glass, C. K., and Milburn, M. V. (1998) Ligand binding and co-activator assembly of the peroxisome proliferator-activated receptor-gamma. Nature, 395, 137-143.
-
(1998)
Nature
, vol.395
, pp. 137-143
-
-
Nolte, R.T.1
Wisely, G.B.2
Westin, S.3
Cobb, J.E.4
Lambert, M.H.5
Kurokawa, R.6
Rosenfeld, M.G.7
Willson, T.M.8
Glass, C.K.9
Milburn, M.V.10
-
47
-
-
0033973843
-
Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency
-
Miles, P. D., Barak, Y., He, W., Evans, R. M., and Olefsky, J. M. (2000) Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J. Clin. Invest., 105, 287-292.
-
(2000)
J. Clin. Invest.
, vol.105
, pp. 287-292
-
-
Miles, P.D.1
Barak, Y.2
He, W.3
Evans, R.M.4
Olefsky, J.M.5
-
48
-
-
0033212964
-
PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
-
Kubota, N., Terauchi, Y., Miki, H., Tamemoto, H., Yamauchi, T., Komeda, K., Satoh, S., Nakano, R., Ishii, C., Sugiyama, T., Eto, K., Tsubamoto, Y., Okuno, A., Murakami, K., Sekihara, H., Hasegawa, G., Naito, M., Toyoshima, Y., Tanaka, S., Shiota, K., Kitamura, T., Fujita, T., Ezaki, O., Aizawa, S., Kadowaki, T., et al. (1999) PPAR gamma mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance. Mol. Cell, 4, 597-609.
-
(1999)
Mol. Cell
, vol.4
, pp. 597-609
-
-
Kubota, N.1
Terauchi, Y.2
Miki, H.3
Tamemoto, H.4
Yamauchi, T.5
Komeda, K.6
Satoh, S.7
Nakano, R.8
Ishii, C.9
Sugiyama, T.10
Eto, K.11
Tsubamoto, Y.12
Okuno, A.13
Murakami, K.14
Sekihara, H.15
Hasegawa, G.16
Naito, M.17
Toyoshima, Y.18
Tanaka, S.19
Shiota, K.20
Kitamura, T.21
Fujita, T.22
Ezaki, O.23
Aizawa, S.24
Kadowaki, T.25
more..
-
49
-
-
0038776380
-
Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
-
Hu, E., Kim, J. B., Sarraf, P., and Spiegelman, B. M. (1996) Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science, 274, 2100-2103.
-
(1996)
Science
, vol.274
, pp. 2100-2103
-
-
Hu, E.1
Kim, B.2
Sarraf, P.3
Spiegelman, B.M.4
-
50
-
-
0030964085
-
Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
-
Camp, H. S., and Tafuri, S. R. (1997) Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J. Biol. Chem., 272, 10811-10816.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 10811-10816
-
-
Camp, H.S.1
Tafuri, S.R.2
-
51
-
-
0141920726
-
Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity
-
Rangwala, S. M., Rhoades, B., Shapiro, J. S., Rich, A. S., Kim, J. K., Shulman, G. I., Kaestner, K. H., and Lazar, M. A. (2003) Genetic modulation of PPARgamma phosphorylation regulates insulin sensitivity. Dev. Cell, 5, 657-663.
-
(2003)
Dev. Cell.
, vol.5
, pp. 657-663
-
-
Rangwala, S.M.1
Rhoades, B.2
Shapiro, J.S.3
Rich, A.S.4
Kim, J.K.5
Shulman, G.I.6
Kaestner, K.H.7
Lazar, M.A.8
-
52
-
-
0033970582
-
Pro115Gln peroxisome proliferator-activated receptor-gamma and obesity
-
Shuldiner, A. R., Nguyen, W., Kao, W. H., Beamer, B. A., Andersen, R. E., Pratley, R., and Brancati, F. L. (2000) Pro115Gln peroxisome proliferator-activated receptor-gamma and obesity. Diabetes Care, 23, 126-127.
-
(2000)
Diabetes Care
, vol.23
, pp. 126-127
-
-
Shuldiner, A.R.1
Nguyen, W.2
Kao, W.H.3
Beamer, B.A.4
Andersen, R.E.5
Pratley, R.6
Brancati, F.L.7
-
53
-
-
0034974186
-
Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort
-
Schaffler, A., Barth, N., Schmitz, G., Zietz, B., Palitzsch, K. D., and Scholmerich, J. (2001) Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort. Endocrine, 14, 369-373.
-
(2001)
Endocrine
, vol.14
, pp. 369-373
-
-
Schaffler, A.1
Barth, N.2
Schmitz, G.3
Zietz, B.4
Palitzsch, K.D.5
Scholmerich, J.6
-
54
-
-
0036024171
-
The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity
-
Hamer, O. W., Forstner, D., Ottinger, I., Ristow, M., Bollheimer, L. C., Scholmerich, J., and Palitzsch, K. D. (2002) The Pro115Gln polymorphism within the PPAR gamma2 gene has no epidemiological impact on morbid obesity. Exp. Clin. Endocrinol. Diabetes, 110, 230-234.
-
(2002)
Exp. Clin. Endocrinol. Diabetes
, vol.110
, pp. 230-234
-
-
Hamer, O.W.1
Forstner, D.2
Ottinger, I.3
Ristow, M.4
Bollheimer, L.C.5
Scholmerich, J.6
Palitzsch, K.D.7
-
55
-
-
0037396071
-
Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance
-
Bluher, M., and Paschke, R. (2003) Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance. Exp. Clin. Endocrinol. Diabetes, 111, 85-90.
-
(2003)
Exp. Clin. Endocrinol. Diabetes
, vol.111
, pp. 85-90
-
-
Bluher, M.1
Paschke, R.2
-
56
-
-
0041333132
-
Multicenter retrospective assessment of thiazolidinedione monotherapy and combination therapy in patients with type 2 diabetes: Comparative subgroup analyses of glycemic control and blood lipid levels
-
Olansky, L., Marchetti, A., and Lau, H. (2003) Multicenter retrospective assessment of thiazolidinedione monotherapy and combination therapy in patients with type 2 diabetes: Comparative subgroup analyses of glycemic control and blood lipid levels. Clin. Ther., 25(Suppl B), B64-B80.
-
(2003)
Clin. Ther.
, vol.25
, Issue.SUPPL. B
-
-
Olansky, L.1
Marchetti, A.2
Lau, H.3
-
57
-
-
0026517080
-
Enhancement of adipocyte differentiation by an insulin-sensitizing agent
-
Kletzien, R. F., Clarke, S. D., and Ulrich, R. G. (1992) Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol. Pharmacol., 41, 393-398.
-
(1992)
Mol. Pharmacol.
, vol.41
, pp. 393-398
-
-
Kletzien, R.F.1
Clarke, S.D.2
Ulrich, R.G.3
-
58
-
-
0028015713
-
Peroxisome proliferator-activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation
-
Chawla, A., Schwarz, E. J., Dimaculangan, D. D., and Lazar, M. A. (1994) Peroxisome proliferator-activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology, 135, 798-800.
-
(1994)
Endocrinology
, vol.135
, pp. 798-800
-
-
Chawla, A.1
Schwarz, E.J.2
Dimaculangan, D.D.3
Lazar, M.A.4
-
59
-
-
0031898610
-
PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
-
Spiegelman, B. M. (1998) PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor. Diabetes, 47, 507-514.
-
(1998)
Diabetes
, vol.47
, pp. 507-514
-
-
Spiegelman, B.M.1
-
60
-
-
7844232968
-
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent
-
Cobb, J. E., Blanchard, S. G., Boswell, E. G., Brown, K. K., Charifson, P. S., Cooper, J. P., Collins, J. L., Dezube, M., Henke, B. R., Hull-Ryde, E. A., Lake, D. H., Lenhard, J. M., Oliver, W., Jr., Oplinger, J., Pentti, M., Parks, D. J., Plunket, K. D., and Tong, W. Q. (1998) N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent. J. Med. Chem., 41, 5055-5069.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 5055-5069
-
-
Cobb, J.E.1
Blanchard, S.G.2
Boswell, E.G.3
Brown, K.K.4
Charifson, P.S.5
Cooper, J.P.6
Collins, J.L.7
Dezube, M.8
Henke, B.R.9
Hull-Ryde, E.A.10
Lake, D.H.11
Lenhard, J.M.12
Oliver Jr., W.13
Oplinger, J.14
Pentti, M.15
Parks, D.J.16
Plunket, K.D.17
Tong, W.Q.18
-
61
-
-
0031441286
-
Troglitazone action is independent of adipose tissue
-
Burant, C. F., Sreenan, S., Hirano, K., Tai, T. A., Lohmiller, J., Lukens, J., Davidson, N. O., Ross, S., and Graves, R. A. (1997) Troglitazone action is independent of adipose tissue. J. Clin. Invest., 100, 2900-2908.
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 2900-2908
-
-
Burant, C.F.1
Sreenan, S.2
Hirano, K.3
Tai, T.A.4
Lohmiller, J.5
Lukens, J.6
Davidson, N.O.7
Ross, S.8
Graves, R.A.9
-
62
-
-
0033708410
-
Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones
-
Chao, L., Marcus-Samuels, B., Mason, M. M., Moitra, J., Vinson, C., Axioglu, E., Gavrilova, O., and Reitman, M. L. (2000) Adipose tissue is required for the antidiabetic, but not for the hypolipidemic, effect of thiazolidinediones. J. Clin. Invest., 106, 1221-1228.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1221-1228
-
-
Chao, L.1
Marcus-Samuels, B.2
Mason, M.M.3
Moitra, J.4
Vinson, C.5
Axioglu, E.6
Gavrilova, O.7
Reitman, M.L.8
-
63
-
-
0346027235
-
Muscle-specific Pparg deletion causes insulin resistance
-
Hevener, A. L., He, W., Barak, Y., Le, J., Bandyopadhyay, G., Olson, P., Wilkes, J., Evans, R. M., and Olefsky, J. (2003) Muscle-specific Pparg deletion causes insulin resistance. Nat. Med., 9, 1491-1497.
-
(2003)
Nat. Med.
, vol.9
, pp. 1491-1497
-
-
Hevener, A.L.1
He, W.2
Barak, Y.3
Le, J.4
Bandyopadhyay, G.5
Olson, P.6
Wilkes, J.7
Evans, R.M.8
Olefsky, J.9
-
64
-
-
85047693638
-
Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
-
Norris, A. W., Chen, L., Fisher, S. J., Szanto, I., Ristow, M., Jozsi, A. C., Hirshman, M. F., Rosen, E. D., Goodyear, L. J., Gonzalez, F. J., Spiegelman, B. M., and Kahn, C. R. (2003) Muscle-specific PPARgamma-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J. Clin. Invest., 112, 608-618.
-
(2003)
J. Clin. Invest.
, vol.112
, pp. 608-618
-
-
Norris, A.W.1
Chen, L.2
Fisher, S.J.3
Szanto, I.4
Ristow, M.5
Jozsi, A.C.6
Hirshman, M.F.7
Rosen, E.D.8
Goodyear, L.J.9
Gonzalez, F.J.10
Spiegelman, B.M.11
Kahn, C.R.12
-
65
-
-
0036182137
-
Lipotoxic diseases
-
Unger, R. H. (2002) Lipotoxic diseases. Annu. Rev. Med., 53, 319-336.
-
(2002)
Annu. Rev. Med.
, vol.53
, pp. 319-336
-
-
Unger, R.H.1
-
66
-
-
0035798713
-
The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance
-
Yamauchi, T., Kamon, J., Waki, H., Murakami, K., Motojima, K., Korneda, K., Ide, T., Kubota, N., Terauchi, Y., Tobe, K., Miki, H., Tsuchida, A., Akanuma, Y., Nagai, R., Kimura, S., and Kadowaki, T. (2001) The mechanisms by which both heterozygous peroxisome proliferator-activated receptor gamma (PPARgamma) deficiency and PPARgamma agonist improve insulin resistance. J. Biol. Chem., 276, 41245-41254.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 41245-41254
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Murakami, K.4
Motojima, K.5
Korneda, K.6
Ide, T.7
Kubota, N.8
Terauchi, Y.9
Tobe, K.10
Miki, H.11
Tsuchida, A.12
Akanuma, Y.13
Nagai, R.14
Kimura, S.15
Kadowaki, T.16
-
67
-
-
0032520921
-
Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats
-
Okuno, A., Tamemoto, H., Tobe, K., Ueki, K., Mori, Y., Iwamoto, K., Umesono, K., Akanuma, Y., Fujiwara, T., Horikoshi, H., Yazaki, Y., and Kadowaki, T. (1998) Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats. J. Clin. Invest. 101, 1354-1361.
-
(1998)
J. Clin. Invest.
, vol.101
, pp. 1354-1361
-
-
Okuno, A.1
Tamemoto, H.2
Tobe, K.3
Ueki, K.4
Mori, Y.5
Iwamoto, K.6
Umesono, K.7
Akanuma, Y.8
Fujiwara, T.9
Horikoshi, H.10
Yazaki, Y.11
Kadowaki, T.12
-
68
-
-
0035430576
-
Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance
-
de Souza, C. J., Eckhardt, M., Gagen, K., Dong, M., Chen, W., Laurent, D., and Burkey, B. F. (2001) Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes, 50, 1863-1871.
-
(2001)
Diabetes
, vol.50
, pp. 1863-1871
-
-
de Souza, C.J.1
Eckhardt, M.2
Gagen, K.3
Dong, M.4
Chen, W.5
Laurent, D.6
Burkey, B.F.7
-
69
-
-
0033851886
-
Efficacy of troglitazone on body fat distribution in type 2 diabetes
-
Akazawa, S., Sun, F., Ito, M., Kawasaki, E., and Eguchi, K. (2000) Efficacy of troglitazone on body fat distribution in type 2 diabetes. Diabetes Care, 23, 1067-1071.
-
(2000)
Diabetes Care
, vol.23
, pp. 1067-1071
-
-
Akazawa, S.1
Sun, F.2
Ito, M.3
Kawasaki, E.4
Eguchi, K.5
-
70
-
-
0032969421
-
Effect of troglitazone on body fat distribution in type 2 diabetic patients
-
Mori, Y., Murakawa, Y., Okada, K., Horikoshi, H., Yokoyama, J., Tajima, N., and Ikeda, Y. (1999) Effect of troglitazone on body fat distribution in type 2 diabetic patients. Diabetes Care, 22, 908-912.
-
(1999)
Diabetes Care
, vol.22
, pp. 908-912
-
-
Mori, Y.1
Murakawa, Y.2
Okada, K.3
Horikoshi, H.4
Yokoyama, J.5
Tajima, N.6
Ikeda, Y.7
-
71
-
-
0038692185
-
Expression of peroxisome proliferator-activated receptor-gamma1 and peroxisome proliferator-activated receptor-gamma2 in visceral and subcutaneous adipose tissue of obese women
-
Giusti, V., Verdumo, C., Suter, M., Gaillard, R. C., Burckhardt, P., and Pralong, F. (2003) Expression of peroxisome proliferator-activated receptor-gamma1 and peroxisome proliferator-activated receptor-gamma2 in visceral and subcutaneous adipose tissue of obese women. Diabetes, 52, 1673-1676.
-
(2003)
Diabetes
, vol.52
, pp. 1673-1676
-
-
Giusti, V.1
Verdumo, C.2
Suter, M.3
Gaillard, R.C.4
Burckhardt, P.5
Pralong, F.6
-
72
-
-
0037066603
-
ACRP30, a new hormone controlling fat and glucose metabolism
-
Tsao, T. S., Lodish, H. F., and Fruebis, J. (2002) ACRP30, a new hormone controlling fat and glucose metabolism. Eur. J. Pharmacol., 440, 213-221.
-
(2002)
Eur. J. Pharmacol.
, vol.440
, pp. 213-221
-
-
Tsao, T.S.1
Lodish, H.F.2
Fruebis, J.3
-
73
-
-
17944365228
-
The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
-
Yamauchi, T., Kamon, J., Waki, H., Terauchi, Y., Kubota, N., Hara, K., Mori, Y., Ide, T., Murakami, K., Tsuboyama-Kasaoka, N., Ezaki, O., Akanuma, Y, Gavrilova, O., Vinson, C., Reitman, M. L., Kagechika, H., Shudo, K., Yoda, M., Nakano, Y., Tobe, K., Nagai, R., Kimura, S., Tomita, M., Froguel, P., and Kadowaki, T. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat. Med., 7, 941-946.
-
(2001)
Nat. Med.
, vol.7
, pp. 941-946
-
-
Yamauchi, T.1
Kamon, J.2
Waki, H.3
Terauchi, Y.4
Kubota, N.5
Hara, K.6
Mori, Y.7
Ide, T.8
Murakami, K.9
Tsuboyama-Kasaoka, N.10
Ezaki, O.11
Akanuma, Y.12
Gavrilova, O.13
Vinson, C.14
Reitman, M.L.15
Kagechika, H.16
Shudo, K.17
Yoda, M.18
Nakano, Y.19
Tobe, K.20
Nagai, R.21
Kimura, S.22
Tomita, M.23
Froguel, P.24
Kadowaki, T.25
more..
-
74
-
-
0034881391
-
The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
-
Berg, A. H., Combs, T. P., Du, X., Brownlee, M., and Scherer, P. E. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med., 7, 947-953.
-
(2001)
Nat. Med.
, vol.7
, pp. 947-953
-
-
Berg, A.H.1
Combs, T.P.2
Du, X.3
Brownlee, M.4
Scherer, P.E.5
-
75
-
-
0035852760
-
Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
-
Fruebis, J., Tsao, T. S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R., Yen, F. T., Bihain, B. E., and Lodish, H. F. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U.S.A., 98, 2005-2010.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, pp. 2005-2010
-
-
Fruebis, J.1
Tsao, T.S.2
Javorschi, S.3
Ebbets-Reed, D.4
Erickson, M.R.5
Yen, F.T.6
Bihain, B.E.7
Lodish, H.F.8
-
76
-
-
0036134187
-
Resistin and obesity-associated insulin resistance
-
Steppan, C. M., and Lazar, M. A. (2002) Resistin and obesity-associated insulin resistance. Trends Endocrinol. Metab., 13, 18-23.
-
(2002)
Trends Endocrinol. Metab.
, vol.13
, pp. 18-23
-
-
Steppan, C.M.1
Lazar, M.A.2
-
77
-
-
0035905758
-
The hormone resistin links obesity to diabetes
-
Steppan, C. M., Bailey, S. T., Bhat, S., Brown, E. J., Banerjee, R. R., Wright, C. M., Patel, H. R., Ahima, R. S., and Lazar, M. A. (2001) The hormone resistin links obesity to diabetes. Nature, 409, 307-312.
-
(2001)
Nature
, vol.409
, pp. 307-312
-
-
Steppan, C.M.1
Bailey, S.T.2
Bhat, S.3
Brown, E.J.4
Banerjee, R.R.5
Wright, C.M.6
Patel, H.R.7
Ahima, R.S.8
Lazar, M.A.9
-
78
-
-
0242641149
-
Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists
-
Way, J. M., Gorgun, C. Z., Tong, Q., Uysal, K. T., Brown, K. K., Harrington, W. W., Oliver, W. R., Jr., Willson, T. M., Kliewer, S. A., and Hotamisligil, G. S. (2001) Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. J. Biol. Chem., 276, 25651-25653.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 25651-25653
-
-
Way, J.M.1
Gorgun, C.Z.2
Tong, Q.3
Uysal, K.T.4
Brown, K.K.5
Harrington, W.W.6
Oliver Jr., W.R.7
Willson, T.M.8
Kliewer, S.A.9
Hotamisligil, G.S.10
-
79
-
-
0035487109
-
Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
-
Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., and O'Rahilly, S. (2001) Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes, 50, 2199-2202.
-
(2001)
Diabetes
, vol.50
, pp. 2199-2202
-
-
Savage, D.B.1
Sewter, C.P.2
Klenk, E.S.3
Segal, D.G.4
Vidal-Puig, A.5
Considine, R.V.6
O'Rahilly, S.7
-
80
-
-
0027459878
-
Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
-
Hotamisligil, G. S., Shargill, N. S., and Spiegelman, B. M. (1993) Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science, 259, 87-91.
-
(1993)
Science
, vol.259
, pp. 87-91
-
-
Hotamisligil, G.S.1
Shargill, N.S.2
Spiegelman, B.M.3
-
81
-
-
0033867178
-
Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
-
Moller, D. E. (2000) Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab., 11, 212-217.
-
(2000)
Trends Endocrinol. Metab.
, vol.11
, pp. 212-217
-
-
Moller, D.E.1
-
82
-
-
0028931724
-
Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
-
Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., and Spiegelman, B. M. (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest., 95, 2409-2415.
-
(1995)
J. Clin. Invest.
, vol.95
, pp. 2409-2415
-
-
Hotamisligil, G.S.1
Arner, P.2
Caro, J.F.3
Atkinson, R.L.4
Spiegelman, B.M.5
|