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Volumn 5, Issue 2, 2004, Pages 99-109

Peroxisome proliferator-activated receptor-γ and its role in the development and treatment of diabetes

Author keywords

Adipocyte; Diabetes; Gene expression; Nuclear receptors; Thiazolidinediones

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; DRUG RECEPTOR; GLUCOSE; INSULIN; LAMININ; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESISTIN; ROSIGLITAZONE;

EID: 16544393025     PISSN: 15438600     EISSN: None     Source Type: Journal    
DOI: 10.1080/15438600490451668     Document Type: Review
Times cited : (18)

References (82)
  • 1
    • 0035786906 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: From genes to physiology
    • Kliewer, S. A., Xu, H. E., Lambert, M. H., and Willson, T. M. (2001) Peroxisome proliferator-activated receptors: From genes to physiology. Recent Prog. Horm. Res., 56, 239-263.
    • (2001) Recent Prog. Horm. Res. , vol.56 , pp. 239-263
    • Kliewer, S.A.1    Xu, H.E.2    Lambert, M.H.3    Willson, T.M.4
  • 2
    • 0032710343 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions
    • Michalik, L., and Wahli, W. (1999) Peroxisome proliferator-activated receptors: Three isotypes for a multitude of functions. Curr. Opin. Biotechnol., 10, 564-570.
    • (1999) Curr. Opin. Biotechnol. , vol.10 , pp. 564-570
    • Michalik, L.1    Wahli, W.2
  • 3
    • 0027278522 scopus 로고
    • Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR)
    • Dreyer, C., Keller, H., Mahfoudi, A., Laudet, V., Krey, G., and Wahli, W. (1993) Positive regulation of the peroxisomal beta-oxidation pathway by fatty acids through activation of peroxisome proliferator-activated receptors (PPAR). Biol. Cell, 77, 67-76.
    • (1993) Biol. Cell , vol.77 , pp. 67-76
    • Dreyer, C.1    Keller, H.2    Mahfoudi, A.3    Laudet, V.4    Krey, G.5    Wahli, W.6
  • 4
    • 0030952937 scopus 로고    scopus 로고
    • Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta
    • Forman, B. M., Chen, J., and, Evans, R. M. (1997) Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta. Proc. Natl. Acad. Sci. U.S.A., 94, 4312-4317.
    • (1997) Proc. Natl. Acad. Sci. U.S.A. , vol.94 , pp. 4312-4317
    • Forman, B.M.1    Chen, J.2    Evans, R.M.3
  • 5
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay
    • Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., and Wahli, W. (1997) Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxisome proliferator-activated receptors by coactivator-dependent receptor ligand assay. Mol. Endocrinol., 11, 779-791.
    • (1997) Mol. Endocrinol. , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3    Kalkhoven, E.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 6
    • 0033625677 scopus 로고    scopus 로고
    • Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta)
    • Peters, J. M., Lee, S. S., Li, W., Ward, J. M., Gavrilova, O., Everett, C., Reitman, M. L., Hudson, L. D., and Gonzalez, F. J. (2000) Growth, adipose, brain, and skin alterations resulting from targeted disruption of the mouse peroxisome proliferator-activated receptor beta(delta). Mol. Cell. Biol., 20, 5119-5128.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5119-5128
    • Peters, J.M.1    Lee, S.S.2    Li, W.3    Ward, J.M.4    Gavrilova, O.5    Everett, C.6    Reitman, M.L.7    Hudson, L.D.8    Gonzalez, F.J.9
  • 9
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)
    • Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma). J. Biol. Chem., 270, 12953-12956.
    • (1995) J. Biol. Chem. , vol.270 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 10
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
    • Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J., and Glass, C. K. (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature, 391, 79-82.
    • (1998) Nature , vol.391 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 11
    • 0031888958 scopus 로고    scopus 로고
    • PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
    • Jiang, C., Ting, A. T., and Seed, B. (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature, 391, 82-86.
    • (1998) Nature , vol.391 , pp. 82-86
    • Jiang, C.1    Ting, A.T.2    Seed, B.3
  • 12
    • 0034769830 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors in endothelial cell biology
    • Plutzky, J. (2001) Peroxisome proliferator-activated receptors in endothelial cell biology. Curr. Opin. Lipidol., 12, 511-518.
    • (2001) Curr. Opin. Lipidol. , vol.12 , pp. 511-518
    • Plutzky, J.1
  • 13
    • 0001297403 scopus 로고    scopus 로고
    • Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT
    • Yang, X. Y., Wang, L. H., Chen, T., Hodge, D. R., Resau, J. H., DaSilva, L., and Farrar, W. L. (2000) Activation of human T lymphocytes is inhibited by peroxisome proliferator-activated receptor gamma (PPARgamma) agonists. PPARgamma co-association with transcription factor NFAT. J. Biol. Chem., 275, 4541-4544.
    • (2000) J. Biol. Chem. , vol.275 , pp. 4541-4544
    • Yang, X.Y.1    Wang, L.H.2    Chen, T.3    Hodge, D.R.4    Resau, J.H.5    DaSilva, L.6    Farrar, W.L.7
  • 14
    • 0033119162 scopus 로고    scopus 로고
    • Coactivator and corepressor complexes in nuclear receptor function
    • Xu, L., Glass, C. K., and Rosenfeld, M. G. (1999) Coactivator and corepressor complexes in nuclear receptor function. Curr. Opin. Genet. Dev., 9, 140-147.
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 140-147
    • Xu, L.1    Glass, C.K.2    Rosenfeld, M.G.3
  • 15
    • 0028180070 scopus 로고
    • mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer
    • Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) mPPAR gamma 2: Tissue-specific regulator of an adipocyte enhancer. Genes Dev., 8, 1224-1234.
    • (1994) Genes Dev. , vol.8 , pp. 1224-1234
    • Tontonoz, P.1    Hu, E.2    Graves, R.A.3    Budavari, A.I.4    Spiegelman, B.M.5
  • 16
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor
    • Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Stimulation of adipogenesis in fibroblasts by PPAR gamma 2, a lipid-activated transcription factor. Cell, 79, 1147-1156.
    • (1994) Cell , vol.79 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 19
    • 0032515065 scopus 로고    scopus 로고
    • The role of C/EBP genes in adipocyte differentiation
    • Darlington, G. J., Ross, S. E., and MacDougald, O. A. (1998) The role of C/EBP genes in adipocyte differentiation. J. Biol. Chem., 273, 30057-30060.
    • (1998) J. Biol. Chem. , vol.273 , pp. 30057-30060
    • Darlington, G.J.1    Ross, S.E.2    MacDougald, O.A.3
  • 20
    • 0031435337 scopus 로고    scopus 로고
    • Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene
    • Tanaka, T., Yoshida, N., Kishimoto, T., and Akira, S. (1997) Defective adipocyte differentiation in mice lacking the C/EBPbeta and/or C/EBPdelta gene. EMBO J., 16, 7432-7443.
    • (1997) EMBO J. , vol.16 , pp. 7432-7443
    • Tanaka, T.1    Yoshida, N.2    Kishimoto, T.3    Akira, S.4
  • 21
    • 0036007025 scopus 로고    scopus 로고
    • PPARgamma knockdown by engineered transcription factors: Exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis
    • Ren, D., Collingwood, T. N., Rebar, E. J., Wolffe, A. P., and Camp, H. S. (2002) PPARgamma knockdown by engineered transcription factors: Exogenous PPARgamma2 but not PPARgamma1 reactivates adipogenesis. Genes Dev., 16, 27-32.
    • (2002) Genes Dev. , vol.16 , pp. 27-32
    • Ren, D.1    Collingwood, T.N.2    Rebar, E.J.3    Wolffe, A.P.4    Camp, H.S.5
  • 22
    • 0033083803 scopus 로고    scopus 로고
    • Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity
    • Wu, Z., Rosen, E. D., Brun, R., Hauser, S., Adelmant, G., Troy, A. E., McKeon, C., Darlington, G. J., and Spiegelman, B. M. (1999) Cross-regulation of C/EBP alpha and PPAR gamma controls the transcriptional pathway of adipogenesis and insulin sensitivity. Mol. Cell, 3, 151-158.
    • (1999) Mol. Cell , vol.3 , pp. 151-158
    • Wu, Z.1    Rosen, E.D.2    Brun, R.3    Hauser, S.4    Adelmant, G.5    Troy, A.E.6    McKeon, C.7    Darlington, G.J.8    Spiegelman, B.M.9
  • 24
    • 0028129499 scopus 로고
    • Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells
    • Freytag, S. O., Paielli, D. L., and Gilbert, J. D. (1994) Ectopic expression of the CCAAT/enhancer-binding protein alpha promotes the adipogenic program in a variety of mouse fibroblastic cells. Genes. Dev., 8, 1654-1663.
    • (1994) Genes Dev. , vol.8 , pp. 1654-1663
    • Freytag, S.O.1    Paielli, D.L.2    Gilbert, J.D.3
  • 26
    • 0032189782 scopus 로고    scopus 로고
    • Obesity associated with a mutation in a genetic regulator of adipocyte differentiation
    • Ristow, M., Muller-Wieland, D., Pfeiffer, A., Krone, W., and Kahn, C. R. (1998) Obesity associated with a mutation in a genetic regulator of adipocyte differentiation. N. Engl. J. Med., 339, 953-959.
    • (1998) N. Engl. J. Med. , vol.339 , pp. 953-959
    • Ristow, M.1    Muller-Wieland, D.2    Pfeiffer, A.3    Krone, W.4    Kahn, C.R.5
  • 28
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • Hegele, R. A., Cao, H., Frankowski, C., Mathews, S. T., and Leff, T. (2002) PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy. Diabetes, 51, 3586-3590.
    • (2002) Diabetes , vol.51 , pp. 3586-3590
    • Hegele, R.A.1    Cao, H.2    Frankowski, C.3    Mathews, S.T.4    Leff, T.5
  • 29
    • 0036146384 scopus 로고    scopus 로고
    • A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy
    • Agarwal, A. K. and Garg, A. (2002) A novel heterozygous mutation in peroxisome proliferator-activated receptor-gamma gene in a patient with familial partial lipodystrophy. J. Clin. Endocrinol. Metab., 87, 408-411.
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 408-411
    • Agarwal, A.K.1    Garg, A.2
  • 31
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR gamma 2 missense mutation
    • Yen, C. J., Beamer, B. A., Negri, C., Silver, K., Brown, K. A., Yarnall, D. P., Burns, D. K., Roth, J., and Shuldiner, A. R. (1997) Molecular scanning of the human peroxisome proliferator activated receptor gamma (hPPAR gamma) gene in diabetic Caucasians: Identification of a Pro12Ala PPAR gamma 2 missense mutation. Biochem. Biophys. Res. Commun., 241, 270-274.
    • (1997) Biochem. Biophys. Res. Commun. , vol.241 , pp. 270-274
    • Yen, C.J.1    Beamer, B.A.2    Negri, C.3    Silver, K.4    Brown, K.A.5    Yarnall, D.P.6    Burns, D.K.7    Roth, J.8    Shuldiner, A.R.9
  • 32
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb, S. S., Fajas, L., Nemoto, M., Pihlajamaki, J., Mykkanen, L., Kuusisto, J., Laakso, M., Fujimoto, W., and Auwerx, J. (1998) A Pro12Ala substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet., 20, 284-287.
    • (1998) Nat. Genet. , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5    Kuusisto, J.6    Laakso, M.7    Fujimoto, W.8    Auwerx, J.9
  • 35
    • 0031667127 scopus 로고    scopus 로고
    • Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations
    • Beamer, B. A., Yen, C. J., Andersen, R. E., Muller, D., Elahi, D., Cheskin, L. J., Andres, R., Roth, J., and Shuldiner, A. R. (1998) Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-gamma2 gene with obesity in two Caucasian populations. Diabetes, 47, 1806-1808.
    • (1998) Diabetes , vol.47 , pp. 1806-1808
    • Beamer, B.A.1    Yen, C.J.2    Andersen, R.E.3    Muller, D.4    Elahi, D.5    Cheskin, L.J.6    Andres, R.7    Roth, J.8    Shuldiner, A.R.9
  • 38
    • 0036320603 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism
    • Stumvoll, M., and Haring, H. (2002) The peroxisome proliferator-activated receptor-gamma2 Pro12Ala polymorphism. Diabetes, 51, 2341-2347.
    • (2002) Diabetes , vol.51 , pp. 2341-2347
    • Stumvoll, M.1    Haring, H.2
  • 40
    • 0034519552 scopus 로고    scopus 로고
    • Familial partial lipodystrophy: A monogenic form of the insulin resistance syndrome
    • Hegele, R. A. (2000) Familial partial lipodystrophy: A monogenic form of the insulin resistance syndrome. Mol. Genet. Metab., 71, 539-544.
    • (2000) Mol. Genet. Metab. , vol.71 , pp. 539-544
    • Hegele, R.A.1
  • 41
    • 0034059075 scopus 로고    scopus 로고
    • Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy
    • Cao, H., and Hegele, R. A. (2000) Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet., 9, 109-112.
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 109-112
    • Cao, H.1    Hegele, R.A.2
  • 43
    • 0033912260 scopus 로고    scopus 로고
    • Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C
    • Speckman, R. A., Garg, A., Du, F., Bennett, L., Veile, R., Arioglu, E., Taylor, S. I., Lovett, M., and Bowcock, A. M. (2000) Mutational and haplotype analyses of families with familial partial lipodystrophy (Dunnigan variety) reveal recurrent missense mutations in the globular C-terminal domain of lamin A/C. Am. J. Hum. Genet., 66, 1192-1198.
    • (2000) Am. J. Hum. Genet. , vol.66 , pp. 1192-1198
    • Speckman, R.A.1    Garg, A.2    Du, F.3    Bennett, L.4    Veile, R.5    Arioglu, E.6    Taylor, S.I.7    Lovett, M.8    Bowcock, A.M.9
  • 47
    • 0033973843 scopus 로고    scopus 로고
    • Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency
    • Miles, P. D., Barak, Y., He, W., Evans, R. M., and Olefsky, J. M. (2000) Improved insulin-sensitivity in mice heterozygous for PPAR-gamma deficiency. J. Clin. Invest., 105, 287-292.
    • (2000) J. Clin. Invest. , vol.105 , pp. 287-292
    • Miles, P.D.1    Barak, Y.2    He, W.3    Evans, R.M.4    Olefsky, J.M.5
  • 49
    • 0038776380 scopus 로고    scopus 로고
    • Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma
    • Hu, E., Kim, J. B., Sarraf, P., and Spiegelman, B. M. (1996) Inhibition of adipogenesis through MAP kinase-mediated phosphorylation of PPARgamma. Science, 274, 2100-2103.
    • (1996) Science , vol.274 , pp. 2100-2103
    • Hu, E.1    Kim, B.2    Sarraf, P.3    Spiegelman, B.M.4
  • 50
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
    • Camp, H. S., and Tafuri, S. R. (1997) Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J. Biol. Chem., 272, 10811-10816.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 53
    • 0034974186 scopus 로고    scopus 로고
    • Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort
    • Schaffler, A., Barth, N., Schmitz, G., Zietz, B., Palitzsch, K. D., and Scholmerich, J. (2001) Frequency and significance of Pro12Ala and Pro115Gln polymorphism in gene for peroxisome proliferation-activated receptor-gamma regarding metabolic parameters in a Caucasian cohort. Endocrine, 14, 369-373.
    • (2001) Endocrine , vol.14 , pp. 369-373
    • Schaffler, A.1    Barth, N.2    Schmitz, G.3    Zietz, B.4    Palitzsch, K.D.5    Scholmerich, J.6
  • 55
    • 0037396071 scopus 로고    scopus 로고
    • Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance
    • Bluher, M., and Paschke, R. (2003) Analysis of the relationship between PPAR-gamma 2 gene variants and severe insulin resistance in obese patients with impaired glucose tolerance. Exp. Clin. Endocrinol. Diabetes, 111, 85-90.
    • (2003) Exp. Clin. Endocrinol. Diabetes , vol.111 , pp. 85-90
    • Bluher, M.1    Paschke, R.2
  • 56
    • 0041333132 scopus 로고    scopus 로고
    • Multicenter retrospective assessment of thiazolidinedione monotherapy and combination therapy in patients with type 2 diabetes: Comparative subgroup analyses of glycemic control and blood lipid levels
    • Olansky, L., Marchetti, A., and Lau, H. (2003) Multicenter retrospective assessment of thiazolidinedione monotherapy and combination therapy in patients with type 2 diabetes: Comparative subgroup analyses of glycemic control and blood lipid levels. Clin. Ther., 25(Suppl B), B64-B80.
    • (2003) Clin. Ther. , vol.25 , Issue.SUPPL. B
    • Olansky, L.1    Marchetti, A.2    Lau, H.3
  • 57
    • 0026517080 scopus 로고
    • Enhancement of adipocyte differentiation by an insulin-sensitizing agent
    • Kletzien, R. F., Clarke, S. D., and Ulrich, R. G. (1992) Enhancement of adipocyte differentiation by an insulin-sensitizing agent. Mol. Pharmacol., 41, 393-398.
    • (1992) Mol. Pharmacol. , vol.41 , pp. 393-398
    • Kletzien, R.F.1    Clarke, S.D.2    Ulrich, R.G.3
  • 58
    • 0028015713 scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation
    • Chawla, A., Schwarz, E. J., Dimaculangan, D. D., and Lazar, M. A. (1994) Peroxisome proliferator-activated receptor (PPAR) gamma: Adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology, 135, 798-800.
    • (1994) Endocrinology , vol.135 , pp. 798-800
    • Chawla, A.1    Schwarz, E.J.2    Dimaculangan, D.D.3    Lazar, M.A.4
  • 59
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman, B. M. (1998) PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor. Diabetes, 47, 507-514.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 65
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • Unger, R. H. (2002) Lipotoxic diseases. Annu. Rev. Med., 53, 319-336.
    • (2002) Annu. Rev. Med. , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 68
    • 0035430576 scopus 로고    scopus 로고
    • Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance
    • de Souza, C. J., Eckhardt, M., Gagen, K., Dong, M., Chen, W., Laurent, D., and Burkey, B. F. (2001) Effects of pioglitazone on adipose tissue remodeling within the setting of obesity and insulin resistance. Diabetes, 50, 1863-1871.
    • (2001) Diabetes , vol.50 , pp. 1863-1871
    • de Souza, C.J.1    Eckhardt, M.2    Gagen, K.3    Dong, M.4    Chen, W.5    Laurent, D.6    Burkey, B.F.7
  • 69
    • 0033851886 scopus 로고    scopus 로고
    • Efficacy of troglitazone on body fat distribution in type 2 diabetes
    • Akazawa, S., Sun, F., Ito, M., Kawasaki, E., and Eguchi, K. (2000) Efficacy of troglitazone on body fat distribution in type 2 diabetes. Diabetes Care, 23, 1067-1071.
    • (2000) Diabetes Care , vol.23 , pp. 1067-1071
    • Akazawa, S.1    Sun, F.2    Ito, M.3    Kawasaki, E.4    Eguchi, K.5
  • 71
    • 0038692185 scopus 로고    scopus 로고
    • Expression of peroxisome proliferator-activated receptor-gamma1 and peroxisome proliferator-activated receptor-gamma2 in visceral and subcutaneous adipose tissue of obese women
    • Giusti, V., Verdumo, C., Suter, M., Gaillard, R. C., Burckhardt, P., and Pralong, F. (2003) Expression of peroxisome proliferator-activated receptor-gamma1 and peroxisome proliferator-activated receptor-gamma2 in visceral and subcutaneous adipose tissue of obese women. Diabetes, 52, 1673-1676.
    • (2003) Diabetes , vol.52 , pp. 1673-1676
    • Giusti, V.1    Verdumo, C.2    Suter, M.3    Gaillard, R.C.4    Burckhardt, P.5    Pralong, F.6
  • 72
    • 0037066603 scopus 로고    scopus 로고
    • ACRP30, a new hormone controlling fat and glucose metabolism
    • Tsao, T. S., Lodish, H. F., and Fruebis, J. (2002) ACRP30, a new hormone controlling fat and glucose metabolism. Eur. J. Pharmacol., 440, 213-221.
    • (2002) Eur. J. Pharmacol. , vol.440 , pp. 213-221
    • Tsao, T.S.1    Lodish, H.F.2    Fruebis, J.3
  • 74
    • 0034881391 scopus 로고    scopus 로고
    • The adipocyte-secreted protein Acrp30 enhances hepatic insulin action
    • Berg, A. H., Combs, T. P., Du, X., Brownlee, M., and Scherer, P. E. (2001) The adipocyte-secreted protein Acrp30 enhances hepatic insulin action. Nat. Med., 7, 947-953.
    • (2001) Nat. Med. , vol.7 , pp. 947-953
    • Berg, A.H.1    Combs, T.P.2    Du, X.3    Brownlee, M.4    Scherer, P.E.5
  • 75
    • 0035852760 scopus 로고    scopus 로고
    • Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
    • Fruebis, J., Tsao, T. S., Javorschi, S., Ebbets-Reed, D., Erickson, M. R., Yen, F. T., Bihain, B. E., and Lodish, H. F. (2001) Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice. Proc. Natl. Acad. Sci. U.S.A., 98, 2005-2010.
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 2005-2010
    • Fruebis, J.1    Tsao, T.S.2    Javorschi, S.3    Ebbets-Reed, D.4    Erickson, M.R.5    Yen, F.T.6    Bihain, B.E.7    Lodish, H.F.8
  • 76
    • 0036134187 scopus 로고    scopus 로고
    • Resistin and obesity-associated insulin resistance
    • Steppan, C. M., and Lazar, M. A. (2002) Resistin and obesity-associated insulin resistance. Trends Endocrinol. Metab., 13, 18-23.
    • (2002) Trends Endocrinol. Metab. , vol.13 , pp. 18-23
    • Steppan, C.M.1    Lazar, M.A.2
  • 79
    • 0035487109 scopus 로고    scopus 로고
    • Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans
    • Savage, D. B., Sewter, C. P., Klenk, E. S., Segal, D. G., Vidal-Puig, A., Considine, R. V., and O'Rahilly, S. (2001) Resistin/Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans. Diabetes, 50, 2199-2202.
    • (2001) Diabetes , vol.50 , pp. 2199-2202
    • Savage, D.B.1    Sewter, C.P.2    Klenk, E.S.3    Segal, D.G.4    Vidal-Puig, A.5    Considine, R.V.6    O'Rahilly, S.7
  • 80
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance
    • Hotamisligil, G. S., Shargill, N. S., and Spiegelman, B. M. (1993) Adipose expression of tumor necrosis factor-alpha: Direct role in obesity-linked insulin resistance. Science, 259, 87-91.
    • (1993) Science , vol.259 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 81
    • 0033867178 scopus 로고    scopus 로고
    • Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes
    • Moller, D. E. (2000) Potential role of TNF-alpha in the pathogenesis of insulin resistance and type 2 diabetes. Trends Endocrinol. Metab., 11, 212-217.
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 212-217
    • Moller, D.E.1
  • 82
    • 0028931724 scopus 로고
    • Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance
    • Hotamisligil, G. S., Arner, P., Caro, J. F., Atkinson, R. L., and Spiegelman, B. M. (1995) Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance. J. Clin. Invest., 95, 2409-2415.
    • (1995) J. Clin. Invest. , vol.95 , pp. 2409-2415
    • Hotamisligil, G.S.1    Arner, P.2    Caro, J.F.3    Atkinson, R.L.4    Spiegelman, B.M.5


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