Expression of peroxisome proliferator-activated receptor-γ1 and peroxisome proliferator-activated receptor-γ2 in visceral and subcutaneous adipose tissue of obese women

Diabetes

Volumn 52, Issue 7, 2003, Pages 1673-1676

  Giusti, Vittorio ^a   Verdumo, Chantal ^a   Suter, Michel ^a   Gaillard, Rolf Christian ^a   Burckhardt, Peter ^a   Pralong, Francois ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA1; UNCLASSIFIED DRUG;

ADIPOSE TISSUE; ADULT; ARTICLE; BODY MASS; CARBOHYDRATE METABOLISM; CLINICAL ARTICLE; ENERGY METABOLISM; FEMALE; GASTRECTOMY; HOMEOSTASIS; HUMAN; OBESITY; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SUBCUTANEOUS TISSUE;

EID: 0038692185     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.52.7.1673     Document Type: Article

References (35)

1. Norgan NG: The beneficial effects of body fat and adipose tissue in humans. Int J Obes Relat Metab Disord 21:738-746, 1997
2. Desprès JP: Obesity and lipid metabolism: relevance of body fat distribution. Curr Opin Lipidol 2:5-15, 1991
3. Abate N, Garg A: Heterogeneity in adipose tissue metabolism: causes, implications and management of regional adiposity. Prog Lipid Res 34:53-70, 1995
4. Marin P, Andersson B, Ottosson M, Olbe L, Chowdhury B, Kvist H, Holm G, Sjostrom L, Bjorntorp P: The morphology and metabolism of intraabdominal adipose tissue in men. Metabolism 41:1242-1248, 1992
5. Arner P: Differences in lipolysis between human subcutaneous and omental adipose tissues. Ann Med 27:435-438, 1995
6. Rebuffe-Scrive M, Andersson B, Olbe L, Bjomtorp P: Metabolism of adipose tissue in intraabdominal depots of nonobese men and women. Metabolism 38:453-458, 1989
7. Wajchenberg BL: Subcutaneous and visceral adipose tissue: their relation to the metabolic syndrome. Endocr Rev 21:697-738, 2000
8. Hellmer J, Marcus C, Sonnenfeld T, Arner P: Mechanisms for differences in lipolysis between human subcutaneous and omental fat cells. J Clin Endocrinol Metab 75:15-20, 1992
9. Rosenbaum M, Leibel RL, Hirsch J: Obesity. N Engl J Med 337:396-407, 1997
10. Rebuffe-Scrive M: Neuroregulation of adipose tissue: molecular and hormonal mechanisms. Int J Obes 15 (Suppl. 2):83-86, 1991
11. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS: Role of leptin in fat regulation (Letter). Nature 380:677, 1996
12. Yanovski JA, Yanovski SZ: Recent advances in basic obesity research. JAMA 282:1504-1506, 1999
13. Flier JS, Maratos-Flier E: Obesity and the hypothalamus: novel peptides for new pathways. Cell 92:437-440, 1998
14. Fajas L, Auboeuf D, Raspe E, Schoonjans K, Lefebvre AM, Saladin R, Najib J, Laville M, Fruchart JC, Deeb S, Vidal-Puig A, Flier J, Briggs MR, Staels B, Vidal H, Auwerx J: The organization, promoter analysis, and expression of the human PPARgamma gene. J Biol Chem 272:18779-18789, 1997
15. Zhu Y, Qi C, Korenberg JR, Chen XN, Noya D, Rao MS, Reddy JK: Structural organization of mouse peroxisome proliferator-activated receptor gamma (mPPAR gamma) gene: alternative promoter use and different splicing yield two mPPAR gamma isoforms. Proc Natl Acad Sci U S A 92:7921-7925, 1995
16. Kersten S, Desvergne B, Wahli W: Roles of PPARs in health and disease. Nature 405:421-424, 2000
17. Debril MB, Renaud JP, Fajas L, Auwerx J: The pleiotropic functions of peroxisome proliferator-activated receptor gamma. J Mol Med 79:30-47, 2001
18. Lowell BB: PPARgamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell 99:239-242, 1999
19. Lopez-Liuchi JV, Meier CA: PPARgamma: from adipose tissue to the atherosclerotic plaque. Eur J Endocrinol 139:363-364, 1998
20. Zeghari N, Vidal H, Perche S, Meyer L, Ziegler O, Guerci B, Donner M, Drouin P: Adipose peroxisome proliferator-activated receptor gamma mRNA expression in insulin-resistant obese patients: relationship with adipocyte membrane phospholipids. Lipids 34 (Suppl.):S161, 1999
21. Rosen ED, Spiegelman BM: Molecular regulation of adipogenesis. Annu Rev Cell Dev Biol 16:145-171, 2000
22. Auwerx J, Martin G, Guerre-Millo M, Staels B: Transcription, adipocyte differentiation, and obesity. J Mol Med 74:347-352, 1996
23. Loftus TM, Lane MD: Modulating the transcriptional control of adipogenesis. Curr Opin Genet Dev 7:603-608, 1997
24. Chawla A, Schwarz EJ, Dimaculangan DD, Lazar MA: Peroxisome proliferator-activated receptor (PPAR) gamma: adipose-predominant expression and induction early in adipocyte differentiation. Endocrinology 135:798-800, 1994
25. Brun RP, Tontonoz P, Forman BM, Ellis R, Chen J, Evans RM, Spiegelman BM: Differential activation of adipogenesis by multiple PPAR isoforms. Genes Dev 10:974-984, 1996
26. Braissant O, Foufelle F, Scotto C, Dauca M, Wahli W: Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-alpha, -beta, and -gamma in the adult rat. Endocrinology 137:354-366, 1996
27. Zhu Y, Alvares K, Huang Q, Rao MS, Reddy JK: Cloning of a new member of the peroxisome proliferator-activated receptor gene family from mouse liver. J Biol Chem 268:26817-26820, 1993
28. Forman BM, Tontonoz P, Chen J, Brun RP, Spiegelman BM, Evans RM: 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell 83:803-812, 1995
29. Auwerx J: Regulation of gene expression by fatty acids and fibric acid derivates: an interactive role for peroxisome proliferator activated receptors. Horm Res 38:269-277, 1993
30. Auboeuf D, Rieusset J, Fajas L, Vallier P, Frering V, Riou JP, Staels B, Auwerx J, Laville M, Vidal H: Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patients. Diabetes 46:1319-1327, 1997
31. Sewter CP, Blows F, Vidal-Puig A, O'Rahilly S: Regional differences in the response of human pre-adipocytes to PPARγ and RXRα agonists. Diabetes 51:718-723, 2002
32. Rieusset J, Andreelli F, Auboeuf D, Roques M, Vallier P, Riou JP, Auwerx J, Laville M, Vidal H: Insulin acutely regulates the expression of the peroxisome proliferator-activated receptor-gamma in human adipocytes. Diabetes 48:699-705, 1999
33. Vidal-Puig AJ, Considine RV, Jimenez-Linan M, Werman A, Pories WJ, Caro JF, Flier JS: Peroxisome proliferator-activated receptor gene expression in human tissues: effects of obesity, weight loss, and regulation by insulin and glucocorticoids. J Clin Invest 99:2416-2422, 1997
34. Jakicic JM, Donnelly JE, Jawad AF, Jacobsen DJ, Gunderson SC, Pascale R: Association between blood lipids and different measures of body fat distribution: effects of BMI and age. Int J Obes Relat Metab Disord 17:131-137, 1993
35. Janke J, Engeli S, Gorzelniak K, Sharma AM: Extraction of total RNA from adipocytes. Horm Metab Res 33:213-215, 2001