ACRP30, a new hormone controlling fat and glucose metabolism

European Journal of Pharmacology

Volumn 440, Issue 2-3, 2002, Pages 213-221

  Tsao, Tsu Shuen ^a,b   Lodish, Harvey F ^a   Fruebis, Joachim ^c  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c Genset Corporation   (United States)

Author keywords

ACRP30 (adipocyte complement related protein of 30 kDa); Adiponectin; AdipoQ; Diabetes; Glucose metabolism; Insulin resistance; Lipid metabolism; Obesity

Indexed keywords

FAT; GLUCOSE; PROTEIN ACRP30; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG;

ADIPOCYTE; ARTICLE; BIOCHEMISTRY; BLOOD LEVEL; DIABETES MELLITUS; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; HUMAN; INSULIN RESISTANCE; LIPID METABOLISM; MEDICAL LITERATURE; MEDICAL RESEARCH; NONHUMAN; OBESITY; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN SECRETION; REDUCTION;

ADIPONECTIN; ADIPOSE TISSUE; AMINO ACID SEQUENCE; ANIMALS; DIABETES MELLITUS, TYPE 2; GENETIC PREDISPOSITION TO DISEASE; GLUCOSE; HUMANS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; MOLECULAR SEQUENCE DATA; OBESITY; PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0037066603     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)01430-9     Document Type: Article

References (53)

1. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
2. Leptin
3. Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity
4. Cloning of a Rab3 isotype predominantly expressed in adipocytes
5. Glycosylation/hydroxylation-induced stabilization of the collagen triple helix. 4-trans-hydroxyproline in the Xaa position can stabilize the triple helix
6. Sweet is stable: Glycosylation stabilizes collagen
7. The adipocyte-secreted protein ACRP30 enhances hepatic insulin action
8. Chromosomal localization, expression pattern, and promoter analysis of the mouse gene encoding adipocyte-specific secretory protein ACRP30
9. Stabilization of short collagen-like triple helices by protein engineering
10. Proteolytic cleavage product of 30-kDa adipocyte complement-related protein increases fatty acid oxidation in muscle and causes weight loss in mice
11. Heterogeneity of insulin responses: Phases leading to type 2 (non-insulin-dependent) diabetes mellitus in the rhesus monkey
12. Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
13. Increased adipose tissue expression of tumor necrosis factor-α in human obesity and insulin resistance
14. Plasma concentrations of a novel, adipose-specific protein, adiponectin, in type 2 diabetic patients
15. Circulating concentrations of the adipocyte protein adiponectin are decreased in parallel with reduced insulin sensitivity during the progression to type 2 diabetes in rhesus monkeys
16. AdipoQ is a novel adipose-specific gene dysregulated in obesity
17. Influences of ionomycin, dibutyryl-cycloAMP and tumour necrosis factor-α on intracellular amount and secretion of apM1 in differentiating primary human preadipocytes
18. The metabolic consequences of altered glucose transporter expression in transgenic mice
19. Modular organization of proteins containing C1q-like globular domain
20. C1q: Structure, function, and receptors
21. Quantitative trait loci on chromosomes 3 and 17 influence phenotypes of the metabolic syndrome
22. HNF-4 plays a pivotal role in the liver-specific transcription of the chipmunk HP-25 gene
23. Identification of novel blood proteins specific for mammalian hibernation
24. CDNA cloning and expression of a novel adipose specific collagen-like factor, apM1 (AdiPose most abundant gene transcript 1)
25. PPARgamma ligands increase expression and plasma concentrations of adiponectin, an adipose-derived protein
26. Molecular cloning and characterization of a novel gene, CORS26, encoding a putative secretory protein and its possible involvement in skeletal development
27. Life without white fat: A transgenic mouse
28. Isolation and characterization of GBP28, a novel gelatin-binding protein purified from human plasma
29. An adipocyte-derived plasma protein, adiponectin, adheres to injured vascular walls
30. Novel modulator for endothelial adhesion molecules: Adipocyte-derived plasma protein adiponectin
31. Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway
32. Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages
33. Transgenic mice lacking white fat: Models for understanding human lipoatrophic diabetes
34. Organization of the gene for gelatin-binding protein (GBP28)
35. Regulation of gelatin-binding protein 28 (GBP28) gene expression by C/EBP
36. Synthesis of (Pro-Hyp-Gly)n of defined molecular weights. Evidence for the stabilization of collagen triple helix by hydroxypyroline
37. Identification and adipocyte differentiation-dependent expression of the unique disialic acid residue in an adipose tissue specific glycoprotein, AdipoQ
38. Identification and characterization of the human adipocyte apM-1 promoter
39. The human apM-1, an adipocyte-specific gene linked to the family of TNF's and to genes expressed in activated T cells, is mapped to chromosome 1q21.3-q23, a susceptibility locus identified for familial combined hyperlipidaemia (FCH)
40. A novel serum protein similar to C1q, produced exclusively in adipocytes
41. The crystal structure of a complement-1q family protein suggests an evolutionary link to tumor necrosis factor
42. Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
43. Hydroxylysine-linked glycosides of human complement subcomponent C1q and various collagens
44. Genomic structure and mutations in adipose-specific gene, adiponectin
45. Hibernation-associated gene regulation of plasma proteins with a collagen-like domain in mammalian hibernators
46. Muscle-specific transgenic complementation of GLUT4-deficient mice. Effects on glucose but not lipid metabolism
47. Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
48. Hypoadiponectinemia in obesity and type 2 diabetes: Close association with insulin resistance and hyperinsulinemia
49. The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
50. Weight reduction increases plasma levels of an adipose-derived anti-inflammatory protein, adiponectin
51. Characterization of mouse GBP28 and its induction by exposure to cold
52. Adiponectin, a new member of the family of soluble defense collagens, negatively regulates the growth of myelomonocytic progenitors and the functions of macrophages
53. Comparable content of hydroxylysine-linked glycosides in subcomponents C1q of the first component of human, bovine and mouse complement