Human 20α-hydroxysteroid dehydrogenase: Crystallographic and site-directed mutagenesis studies lead to the identification of an alternative binding site for C21-steroids

Journal of Molecular Biology

Volumn 331, Issue 3, 2003, Pages 593-604

  Couture, Jean François ^a   Legrand, Pierre ^a   Cantin, Line ^a   Luu The, Van ^a   Labrie, Fernand ^a   Breton, Rock ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

20 hydroxy progesterone; Aldo keto reductase; Crystal structure; Human 20 hydroxysteroid dehydrogenase; Progesterone

Indexed keywords

20ALPHA DIHYDROPROGESTERONE; 20ALPHA HYDROXYSTEROID DEHYDROGENASE; HISTIDINE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING KINETICS; BINDING SITE; CATALYST; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; ENZYME STRUCTURE; HUMAN; HYDROGEN BOND; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; STEREOSPECIFICITY; STEROID ANALYSIS; STEROID BINDING;

EID: 0043095539     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-2836(03)00762-9     Document Type: Article

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