Modulation of GABA(A) receptor function by neuroactive steroids: Evidence for heterogeneity of steroid sensitivity of recombinant GABA(A) receptor isoforms

Canadian Journal of Physiology and Pharmacology

Volumn 76, Issue 9, 1998, Pages 909-920

  Maitra, Rajatavo ^a   Reynolds, James N ^a  

^a QUEEN S UNIVERSITY   (Canada)

Author keywords

Allopregnanolone; Alphaxalone; GABA(A) receptor; Neurosteroid; Xenopus oocyte

Indexed keywords

3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3BETA HYDROXY 5BETA PREGNAN 20 ONE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALFAXALONE; NEUROSTEROID; RECEPTOR SUBTYPE; RECEPTOR SUBUNIT; RECOMBINANT RECEPTOR;

4 AMINOBUTYRIC ACID RELEASE; ALLOSTERISM; ANALGESIA; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; FEMALE; GABAERGIC SYSTEM; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN QUATERNARY STRUCTURE; RECEPTOR AFFINITY; RECEPTOR POTENTIAL; RECEPTOR SENSITIVITY; STEROID BINDING; TRANQUILIZING ACTIVITY; XENOPUS LAEVIS;

EID: 0032452644     PISSN: 00084212     EISSN: None     Source Type: Journal    
DOI: 10.1139/y98-091     Document Type: Article

References (45)

1. A receptors. J. Neuroendocrinol. 7: 171-177.
2. Britton, K.T., Page, M., Baldwin, H., and Koob, G.F. 1991. Anxiolytic activity of steroid anesthetic alphaxalone. J. Pharmacol. Exp. Ther. 258: 124-129.
3. A receptors comprised of α1β3 and β3 subunits expressed in human embryonic kidney 293 cells. Br. J. Pharmacol. 120: 899-909.
4. Garrett, K.M., Saito, N., Duman, R.S., Abel, M.S., Ashton, R.A., Fujimori, S., Beer, B., Tallman, J.F., Vitek, M.P., and Blume, A.J. 1990. Differential expression of gamma-aminobutyric acidA receptor subunits. Mol. Pharmacol. 37: 652-657.
5. A receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation. Mol. Pharmacol 40: 995-999.
6. Gee, K.W., Bolger, M.B., Brinton, R.E., Coirini, H., and McEwen, B.S. 1988. Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence, and mechanism of action. J. Pharmacol. Exp. Ther. 246: 803-812.
7. Gilron, I., and Coderre, T.J. 1996. Preemptive analgesic effects of steroid anesthesia with alphaxalone in the rat formalin test. Anesthesiology, 84: 572-579.
8. Harris, B.D., Wong, G., Moody, E.J., and Skolnick, P. 1995. Diferent subunit requirements for volatile and nonvolatile anesthetics at γ-aminobutyric acid type A receptors. Mol. Pharmacol. 47: 363-367.
9. A receptor. Eur. J. Pharmacol. 269: 157-163.
10. A receptor activation. Br. J. Pharmacol. 108: 711-716.
11. Hu, Z.Y., Bourreau, E., Jung-Testas, I., Robel, P., and Baulieu, E.-E. 1987. Neurosteroids: oligodendrocyte mitochondria convert cholesterol to pregnenolone. Proc. Natl. Acad. Sci. U.S.A. 84: 8215-8219.
12. A receptors comprising of the α3, β1 and γ2 subunits. Eur. J. Neurosci. 4: 1-9.
13. Kokate, T.G., Svensson, B.E., and Rogawski, M.A. 1994. Anti-convulsant activity of neurosteroids: correlation with γ-aminobutyric acid-evoked chloride current potentiation. J. Pharmacol. Exp. Ther. 270: 1223-1229.
14. A receptor α-subunit. Mol. Pharmacol 44: 87-92.
15. A receptors expressed in Xenopus oocytes: influence of α-and γ2-subunits. Brain Res. 784: 179-187.
16. A receptor function. Trends Pharmacol. Sci. 16: 295-303.
17. A receptors to neurosteroids. J. Neurochem. 57: 1818-1821.
18. A/benzo-diazepine receptor heterogeneity: neurophysiological implications. Neuropharmacology, 34: 245-254.
19. A receptor channels. Annu. Rev. Neurosci. 17: 569-602.
20. A receptor. Neuroscience, 43:369-380.
21. A receptor function by alphaxalone and allopregnanolone is differentially influenced by the subunit composition of the receptor. Society for Neuroscience 27th Annual Meeting. October 25-30, 1997, New Orleans, LA. Society for Neuroscience, Washington, D.C. p. 960.
22. A receptor. Mechanism of action and physiological significance. Prog. Neurobiol. 38: 379-395.
23. McAuley, J.W., Reynolds, I.J., Kroboth, F.J., Smith, R.B., and Kroboth, P.D. 1995. Orally administered progesterone enhances sensitivity to triazolam in postmenopausal women. J. Clin. Psychopharmacol. 15: 3-11.
24. McEwen, B.S., Biegon, A., Fischette, C., Luine, V., Parsons, B, and Rainbow, T. 1984. Toward a neurochemical basis of steroid action. In Frontiers in neuroendocrinology. Vol. 8. Edited by L. Martini and W.F. Ganong. Raven Press, New York. pp. 153-176.
25. A-receptor subtypes really occur in the brain? Trends Neurosci. 19: 139-143.
26. Morrow, A.L., Pace, J.R., Purdy, R.H., and Paul, S.M. 1990. Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: Evidence for multiple steroid recognition sites. Mol. Pharmacol. 37: 263-270.
27. A receptor determined by electron microscopic image analysis. J. Neurochem. 62: 815-818.
28. Paul, S.M., and Purdy, R.H. 1992. Neuroactive steroids. FASEB J. 6: 2311-2322.
29. A receptor subunit mRNAs in neurons of the rat spinal cord and dorsal root ganglia. Neuroscience, 42: 497-507.
30. A receptor complex in avian CNS. Neurochem. Res. 22: 221-225.
31. A receptor-mediated IPSCs by neuroactive steroids in a rat hypothalamo-hypophyseal coculture model. J. Physiol. 500: 475-485.
32. A receptor complex. Neurosci. Lett. 135: 273-275.
33. A receptors. Neuropharmacology, 32: 59-63.
34. A receptors. Neuron, 4: 759-765.
35. A receptor. Biochem. Pharmacol. 49: 1-16.
36. Sanna, E., Murgia, A., Casula, A., and Biggio, G. 1997. Differential subunit dependence of the actions of the general anesthetics alphaxalone and etomidate at γ-aminobutyric acid type A receptors expressed in Xenopus laevis oocytes. Mol. Pharmacol. 51: 484-490.
37. A receptors in rat brain. J. Pharmacol. Exp. Ther. 262: 801-808.
38. Selye, H. 1942. Correlations between the chemical structure and the pharmacological actions of the steroids. Endocrinology, 30: 437-453.
39. A receptor on the response to a neurosteroid. Eur. J. Pharmacol. 206: 77-80.
40. A receptors. Eur. J. Pharmacol. 291: 99-105.
41. Turner, D.M., Ransom, R.W., Yang, J.S.-J., and Olsen, E.W. 1989. Steroid anesthetics and naturally occuring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates. J. Pharmacol. Exp. Ther. 248: 960-966.
42. Viapiano, M.S., and Fiszer de Plazas, S. 1997. 3 Beta-OH-5 beta-pregnan-20-one enhances [3H]GABA binding in developing chick optic lobe. J. Recept. Signal Transduct. Res. 17: 585-597.
43. A receptor subtypes. Int. Rev. Neurobiol. 38: 95-139.
44. Wilson, M.A., and Biscardi, R. 1997. Influence of gender and brain region on neurosteroid modulation of GABA responses in rats. Life Sci. 60: 1679-1691.
45. A receptor in the rat brain. Neurosci. Lett. 127: 125-128.