Substrate specificity of human 3(20)α-hydroxysteroid dehydrogenase for neurosteroids and its inhibition by benzodiazepines

Biological and Pharmaceutical Bulletin

Volumn 25, Issue 4, 2002, Pages 441-445

  Usami, Noriyuki ^a   Yamamoto, Tomohiro ^a   Shintani, Syunichi ^a   Higaki, Yu ^a   Ishikura, Shuhei ^a   Katagiri, Yoshihiro ^b   Hara, Akira ^a  

^a GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^b GIFU UNIVERSITY HOSPITAL   (Japan)

Author keywords

20 hydroxysteroid dehydrogenase; 3 hydroxysteroid dehydrogenase; Benzodiazepine; Neurosteroid

Indexed keywords

20ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA HYDROXY 5ALPHA PREGNAN 20 ONE; 3ALPHA HYDROXYSTEROID DEHYDROGENASE; 3ALPHA,5ALPHA TETRAHYDRODEOXYCORTICOSTERONE; 5ALPHA DIHYDRODEOXYCORTICOSTERONE; 5ALPHA PREGNANE 3,20 DIONE; BENZODIAZEPINE; BENZODIAZEPINE DERIVATIVE; CLOXAZOLAM; DIAZEPAM; ENZYME AKR1C1; ENZYME AKR1C2; ENZYME AKR1C3; ESTAZOLAM; ISOENZYME; MEDAZEPAM; NEUROSTEROID; NITRAZEPAM; PROGESTERONE; UNCLASSIFIED DRUG; 3 ALPHA HYDROXYSTEROID DEHYDROGENASE (B SPECIFIC); 3(OR 17)BETA HYDROXYSTEROID DEHYDROGENASE; 5 DIHYDRODEOXYCORTICOSTERONE; 5-DIHYDRODEOXYCORTICOSTERONE; CORTICOSTERONE; DRUG DERIVATIVE; ELTANOLONE; ENZYME INHIBITOR; PREGNANEDIONE;

ARTICLE; BRAIN LEVEL; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME KINETICS; ENZYME MECHANISM; ENZYME MODIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; HUMAN; PHARMACODYNAMICS; PROTEIN SYNTHESIS; STEROID METABOLISM; STEROIDOGENESIS; CHEMISTRY; COMPARATIVE STUDY; DRUG ANTAGONISM; METABOLISM;

3-ALPHA-HYDROXYSTEROID DEHYDROGENASE (B-SPECIFIC); 3-HYDROXYSTEROID DEHYDROGENASES; 5-ALPHA-DIHYDROPROGESTERONE; BENZODIAZEPINES; CORTICOSTERONE; ENZYME INHIBITORS; HUMANS; ISOENZYMES; PREGNANEDIONES; PREGNANOLONE; SUBSTRATE SPECIFICITY;

EID: 0036547847     PISSN: 09186158     EISSN: None     Source Type: Journal    
DOI: 10.1248/bpb.25.441     Document Type: Article

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