PDF inhibitors: An emerging class of antibacterial drugs

Current Drug Targets - Infectious Disorders

Volumn 5, Issue 1, 2005, Pages 39-52

  Johnson, K W ^a   Lofland, D ^a   Moser, Heinz E ^a  

^a NONE   (United States)

Author keywords

Antibiotics; Enzyme inhibitor; Peptide analogs; Peptide deformylase; Pharmacokinetics; Pharmacology; Review

Indexed keywords

ACTINONIN; ANTIINFECTIVE AGENT; BB 84887; BB 85318; HYDROXAMIC ACID; HYDROXYLAMINE; MATRIX METALLOPROTEINASE; N (1 TERT BUTYL 2 DIMETHYLAMINO 2 OXOETHYL) 2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANAMIDE; N [1 TERT BUTYL 2 OXO 2 [4 (2 THIAZOLYLMETHYL) 1 PIPERAZINYL]ETHYL] 3 CYCLOPENTYL 2 (N FORMYL N HYDROXYAMINOMETHYL)PROPIONAMIDE; NVP PDF 386; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR; PEPTIDE DERIVATIVE; PROLINE DERIVATIVE; SCH 382583; UNCLASSIFIED DRUG; VRC 3324; VRC 3375; VRC 4307;

ANTIBACTERIAL ACTIVITY; BACTERIAL INFECTION; CLINICAL TRIAL; CROSS RESISTANCE; DRUG DESIGN; DRUG METABOLISM; DRUG POTENCY; DRUG TARGETING; DRUG TOLERABILITY; HUMAN; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PEPTIDE SYNTHESIS; REVIEW; STRUCTURE ACTIVITY RELATION;

AMIDOHYDROLASES; ANIMALS; ANTI-BACTERIAL AGENTS; HUMANS; MICROBIAL SENSITIVITY TESTS; PROTEASE INHIBITORS;

EID: 16344362653     PISSN: 15680053     EISSN: None     Source Type: Journal    
DOI: 10.2174/1568005053174618     Document Type: Review

References (56)

1. Projan, S. J. Current Opinion in Pharmacology 2002, 2, 513.
2. Rogers, B. L. Curr. Opin. Drug Discovery & Dev. 2004 7, 211.
3. Clements, J. M.; Ayscough, A. P.; Keavey, K.; East, S. P. Current Medicinal Chemistry: Anti-Infective Agents 2002, 1 239.
4. Waller, A. S.; Clements, J. M. Curr. Opin. Drug Discovery & Dev. 2002, 5, 785.
5. Giglione, C.; Meinnel, T. Emerging Ther. Targets 2001, 5, 41.
6. Pei, D. Emerging Ther. Targets 2001, 5, 23.
7. Giglione, C.; Pierre, M.; Meinnel, T. Mol. Microbiol. 2000, 36, 1197.
8. Marcker, K.; Sanger, F. J. Mol. Biol. 1964, 8 835.
9. Adams, J. M.; Capecchi, M. R. Proc. Natl. Acad. Sci. USA 1966, 55, 147.
10. Adams, J. M. J. Mol. Biol. 1968, 33, 571.
11. Meinnel, T.; Mechulam, Y.; Blanquet, S. Biochimie 1993, 75, 1061.
12. Meinnel, T.; Blanquet, S. Journal of Bacteriology 1993, 175, 7737.
13. Meinnel, T.; Blanquet, S. Journal of Bacteriology 1994, 176, 7387.
14. Apfel, C. M.; Locher, H.; Evers, S.; Takacs, B.; Hubschwerlen, C.; Pirson, W.; Page, M. G. P.; Keck, W. Antimicrobial Agents and Chemotherapy 2001, 45, 1058.
15. Margolis, P. S.; Hackbarth, C. J.; Young, D. C.; Wang, W.; Chen, D.; Yuan, Z.; White, R.; Trias, J. Antimicrob. Agents Chemother. 2000, 44, 1825.
16. Mazel, D.; Pochet, S.; Marliere, P. EMBO Journal 1994 13, 914.
17. Giglione, C.; Serero, A.; Pierre, M.; Boisson, B.; Meinnel, T. EMBO Journal 2000, 19, 5916.
18. Meinnel, T. Parasitology Today 2000, 16, 165.
19. Bracchi-Ricard, V.; Nguyen, K. T.; Zhou, Y.; Rajagopalan, P. T. R.; Chakrabarti, D.; Pei, D. Arch. Biochem. Biophys. 2001, 396, 162.
20. Lee, M. D.; Antczak, C.; Li, Y.; Sirotnak, F. M.; Bornmann, W. G.; Scheinberg, D. A. Biochem. Biophys. Res. Commun. 2003, 312, 309.
21. Nguyen, K. T.; Hu, X.; Colton, C.; Chakrabarti, R.; Zhu, M. X.; Pei, D. Biochemistry 2003, 42, 9952.
22. Hu, Y. J.; Wei, Y.; Zhou, Y.; Ravi Rajagopalan, P. T.; Pei, D. Biochemistry 1999, 38, 643.
23. Wei, Y.; Pei, D. Anal. Biochem. 1997, 250, 29.
24. Huntington, K. M.; Yi, T.; Wei, Y.; Pei, D. Biochemistry 2000, 39, 4543.
25. Meinnel, T.; Patiny, L.; Ragusa, S.; Blanquet, S. Biochemistry 1999, 38, 4287.
26. Chen, D. Z.; Patel, D. V.; Hackbarth, C. J.; Wang, W.; Dreyer, G.; Young, D. C.; Margolis, P. S.; Wu, C.; Ni, Z. J.; Trias, J.; White, R. J.; Yuan, Z. Biochemistry 2000, 39, 1256.
27. Guilloteau, J. P.; Mathieu, M.; Giglione, C.; Blanc, V.; Dupuy, A.; Chevrier, M.; Gil, P.; Famechon, A.; Meinnel, T.; Mikol, V. J. Mol. Biol. 2002, 320, 951.
28. Clements, J. M.; Beckett, R. P.; Brown, A.; Catlin, G.; Lobell, M.; Palan, S.; Thomas, W.; Whittaker, M.; Wood, S.; Salama, S.; Baker, P. J.; Rodgers, H. F.; Barynin, V.; Rice, D. W.; Hunter, M. G. Antimicrob. Agents Chemother. 2001, 45, 563.
29. Durand, D. J.; Gordon Green, B.; O'Connell, J. F.; Grant, S. K. Arch. Biochem. Biophys. 1999, 367, 297.
30. Madison, V.; Duca, J.; Bennett, F.; Bohanon, S.; Cooper, A.; Chu, M.; Desai, J.; Girijavallabhan, V.; Hare, R.; Hruza, A.; Hendrata, S.; Huang, Y.; Kravec, C.; Malcolm, B.; McCormick, J.; Miesel, L.; Ramanathan, L.; Reichert, P.; Saksena, A.; Wang, J.; Weber, P. C.; Zhu, H.; Fischmann, T. Biophys. Chem. 2002, 101-102 239.
31. Smith, H. K.; Beckett, R. P.; Clements, J. M.; Doel, S.; East, S. P.; Launchbury, S. B.; Pratt, L. M.; Spavold, Z. M.; Thomas, W.; Todd, R. S.; Whittaker, M. Bioorg. Med. Chem. Lett. 2002, 12, 3595.
32. Chen, D.; Hackbarth, C.; Ni, Z. J.; Wu, C.; Wang, W.; Jain, R.; He, Y.; Bracken, K.; Weidmann, B.; Patel, D. V.; Trias, J.; White, R. J.; Yuan, Z. Antimicrob. Agents Chemother. 2004, 48, 250.
33. Davies, S. J.; Ayscough, A. P.; Beckett, R. P.; Bragg, R. A.; Clements, J. M.; Doel, S.; Grew, C.; Launchbury, S. B.; Perkins, G. M.; Pratt, L. M.; Smith, H. K.; Spavold, Z. M.; Thomas, S. W.; Todd, R. S.; Whittaker, M. Bioorg. Med. Chem. Lett. 2003, 13, 2709.
34. Jain, R.; Sundram, A.; Lopez, S.; Neckermann, G.; Wu, C.; Hackbarth, C.; Chen, D.; Wang, W.; Ryder, N. S.; Weidmann, B.; Patel, D.; Trias, J.; White, R.; Yuan, Z. Bioorg. Med. Chem. Lett. 2003, 13, 4223.
35. Hackbarth, C. J.; Chen, D. Z.; Lewis, J. G.; Clark, K.; Mangold, J. B.; Cramer, J. A.; Margolis, P. S.; Wang, W.; Koehn, J.; Wu, C.; Lopez, S.; Withers, G.; III; Gu, H.; Dunn, E.; Kulathila, R.; Pan, S. H.; Porter, W. L.; Jacobs, J.; Trias, J.; Patel, D. V.; Weidmann, B.; White, R. J.; Yuan, Z. Antimicrob. Agents Chemother. 2002, 46, 2752.
36. Davies, S. J.; Ayscough, A. P.; Beckett, R. P.; Clements, J. M.; Doel, S.; Pratt, L. M.; Spavold, Z. M.; Thomas, S. W.; Whittaker, M. Bioorg. Med. Chem. Lett. 2003, 13, 2715.
37. Chu, M.; Mierzwa, R.; He, L.; Xu, L.; Gentile, F.; Terracciano, J.; Patel, M.; Miesel, L.; Bohanon, S.; Kravec, C.; Cramer, C.; Fischman, T. O.; Hruza, A.; Ramanathan, L.; Shipkova, P.; Chan, T. M. Tetrahedron Lett. 2001, 42, 3549.
38. Molteni, V.; He, X.; Nabakka, J.; Yang, K.; Kreusch, A.; Gordon, P.; Bursulaya, B.; Warner, I.; Shin, T.; Biorac, T.; Ryder, N. S.; Goldberg, R.; Doughty, J.; He, Y. Bioorg. Med. Chem. Lett. 2004, 14, 1477.
39. East, S. P.; Beckett, R. P.; Brookings, D. C.; Clements, J. M.; Doel, S.; Keavey, K.; Pain, G.; Smith, H. K.; Thomas, W.; Thompson, A. J.; Todd, R. S.; Whittaker, M. Bioorg. Med. Chem. Lett. 2004, 14, 59.
40. Bowker, K. E.; Noel, A. R.; MacGowan, A. P. Int. J. Antimicrob. Agents 2003, 22, 557.
41. Wise, R.; Andrews, J. M.; Ashby, J. Antimicrob. Agents Chemother. 2002, 46, 1117.
42. Apfel, C.; Banner, D. W.; Bur, D.; Dietz, M.; Hirata, T.; Hubschwerlen, C.; Locher, H.; Page, M. G. P.; Pirson, W.; Rosse, G.; Specklin, J. L. J. Med. Chem. 2000, 43, 2324.
43. Lofland, D.; Difuntorum, S.; Waller, A.; Clements, J. M.; Weaver, M. K.; Karlowsky, J. A.; Johnson, K. J.Antimicrob. Chemother. 2004, 53, 664.
44. Hackbarth, C.; Lopez, S.; Wang, W.; Jacobs, J.; Jain, R.; Ni, Z. J.; Trias, J.; Chen, D.; Withers, G.; Patel, D.; Yuan, Z., 40th ICAAC 2000, Abstract 2173.
45. Roblin, P. M.; Hammerschlag, M. R. Antimicrob. Agents Chemother. 2003, 47, 1447.
46. Morrissey, I.; Dencer, C.; Salman, H.; Leaky, A., 42nd ICAAC 2002, Abstract F-1678.
47. Jones, R. N.; Rhomberg, P. R. J. Antimicrob. Chemother. 2003, 51, 157.
48. Waller, A.; Johnson, I.; Clements, J., 42nd ICAAC 2002, Abstract 736.
49. Bozdogan, B.; Esel, D.; Whitener, C.; Browne, F. A.; Appelbaum, P. C. J. Antimicrob. Chemother. 2003, 52, 864.
50. Margolis, P.; Hackbarth, C.; Lopez, S.; Maniar, M.; Wang, W.; Yuan, Z.; White, R.; Trias, J. Antimicrob. Agents Chemother. 2001, 45, 2432.
51. Noel, A. R.; Bowker, K. E.; Howe, R. E.; MacGowan, A. P., 4nd ICAAC 2002, Abstract F-1680.
52. Gross, M.; Clements, J.; Beckett, R. P.; Thomas, W.; Taylor, S.; Lofland, D.; Ramanathan-Girish, S.; Garcia, M.; Difuntorum, S.; Hoch, U.; Chen, H.; Johnson, K. W. J. Antimicrob. Chemother. 2004, 53, 487.
53. Sanchez, L.; Pan, W.; Vinas, M.; Nikaido, H. J. Bacteriol. 1997, 179, 6855.
54. Azoulay-dupuis, E.; Mohler, J.; Bedos, J. P. Antimicrob. Agents Chemother. 2004, 48, 80.
55. Ramanathan-Girish, S.; McColm, J.; Clements, J.M.; Taupin, P.; Barrowcliffe, S.; Hevizi, J.; Safrin, S.; Moore, C.; Patou, G.; Moser, H.; Gadd, A.; Hoch, U.; Jiang, V.; Lofland, D.; Johnson, K.W. Antimicrob. Agents Chemother. 2004, 48, 4835.
56. Craig, W., Andes, D. 2001. 41st ICAAC 2001, Abstract F-355.