Peptide deformylase as an antibacterial drug target: Target validation and resistance development

Antimicrobial Agents and Chemotherapy

Volumn 45, Issue 4, 2001, Pages 1058-1064

  Apfel, C M ^a   Locher, H ^a   Evers, S ^a   Takacs B ^a   Hubschwerlen, C ^a   Pirson, W ^a   Page, M G P ^a   Keck, W ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFECTIVE AGENT; BACTERIAL DNA; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR; PROTEOME; RO 061467; RO 660376; RO 666976; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GENE; BACTERIAL GROWTH; BACTERIOSTASIS; BACTERIUM MUTANT; CONTROLLED STUDY; DNA SEQUENCE; DRUG INHIBITION; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ESCHERICHIA COLI; GENE MUTATION; GROWTH INHIBITION; GROWTH RATE; HAEMOPHILUS INFLUENZAE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIAE;

AMIDOHYDROLASES; AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; ANTI-INFECTIVE AGENTS, URINARY; BACTERIAL PROTEINS; DRUG ANTAGONISM; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; GENES, BACTERIAL; HAEMOPHILUS INFLUENZAE; MICROBIAL SENSITIVITY TESTS; MUTAGENESIS, INSERTIONAL; MUTATION; STREPTOCOCCUS PNEUMONIAE; TRANSFORMATION, BACTERIAL; TRIMETHOPRIM;

EID: 0035080531     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.45.4.1058-1064.2001     Document Type: Article

References (30)

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