Hydroxamic acid derivatives as potent peptide deformylase inhibitors and antibacterial agents

Journal of Medicinal Chemistry

Volumn 43, Issue 12, 2000, Pages 2324-2331

  Apfel, Christian ^a   Banner, David W ^a   Bur, Daniel ^a   Dietz, Michel ^a   Hirata, Takahiro ^a   Hubschwerlen, Christian ^a   Locher, Hans ^a   Page, Malcolm G P ^a   Pirson, Wolfgang ^a   Rossé, Gérard ^a,b   Specklin, Jean Luc ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b Selectide Corporation   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (BENZENESULFINYL)HEPTANOIC ACID HYDROXYAMIDE; 3 (PHENYLSULFONYL)HEPTANOIC ACID HYDROXYAMIDE; ACTINONIN; ANTIINFECTIVE AGENT; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; ENZYME INHIBITOR; HYDROXAMIC ACID; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CRYSTAL STRUCTURE; DRUG POTENCY; ESCHERICHIA COLI; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STREPTOCOCCUS PNEUMONIAE;

AMIDOHYDROLASES; AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; CHLAMYDOPHILA PNEUMONIAE; CRYSTALLOGRAPHY, X-RAY; DRUG RESISTANCE, MICROBIAL; ENZYME INHIBITORS; ESCHERICHIA COLI; HAEMOPHILUS INFLUENZAE; HYDROXAMIC ACIDS; MODELS, MOLECULAR; MORAXELLA (BRANHAMELLA) CATARRHALIS; MYCOPLASMA PNEUMONIAE; PROTEASE INHIBITORS; RESPIRATORY TRACT INFECTIONS; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17644447403     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000018k     Document Type: Article

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