Structure-activity relationships of the peptide deformylase inhibitor BB-3497: Modification of the metal binding group

Bioorganic and Medicinal Chemistry Letters

Volumn 12, Issue 24, 2002, Pages 3595-3599

  Smith, Helen K ^a   Beckett, R Paul ^a   Clements, John M ^a   Doel, Sheila ^a   East, Stephen P ^a   Launchbury, Steven B ^a   Pratt, Lisa M ^a   Spavold, Zoë M ^a   Thomas, Wayne ^a   Todd, Richard S ^a   Whittaker, Mark ^a  

^a British Biotech Pharmaceuticals Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHELATING AGENT; HYDROXAMIC ACID DERIVATIVE; HYDROXYLAMINE; N (1 TERT BUTYL 2 DIMETHYLAMINO 2 OXOETHYL) 2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANAMIDE; PEPTIDE DEFORMYLASE INHIBITOR; UNCLASSIFIED DRUG; AMIDASE; AMINOPEPTIDASE; ENZYME INHIBITOR; ESCHERICHIA COLI PROTEIN; HYDROXAMIC ACID; METAL; PEPTIDE DEFORMYLASE;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; METAL BINDING; STRUCTURE ACTIVITY RELATION; BACTERIUM; BINDING SITE; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; IC 50; MICROBIOLOGICAL EXAMINATION; SYNTHESIS;

AMIDOHYDROLASES; AMINOPEPTIDASES; BACTERIA; BINDING SITES; ENZYME INHIBITORS; ESCHERICHIA COLI PROTEINS; HYDROXAMIC ACIDS; INHIBITORY CONCENTRATION 50; METALS; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 17744420893     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(02)00790-4     Document Type: Article

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