Characterization of a human peptide deformylase: Implications for antibacterial drug design

Biochemistry

Volumn 42, Issue 33, 2003, Pages 9952-9958

  Nguyen, Kiet T ^a   Hu, Xubo ^a   Colton, Craig ^a   Chakrabarti, Ratna ^b   Zhu, Michael X ^a   Pei, Dehua ^a  

^a OHIO STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CENTRAL FLORIDA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTICS; CATALYSIS; CATALYST ACTIVITY; CELLS; DNA; ENZYME INHIBITION; ESCHERICHIA COLI; FLUORESCENCE; PROTEINS; SUBSTITUTION REACTIONS; SYNTHESIS (CHEMICAL);

HOMO SAPIENS;

POLYPEPTIDES;

ANTIINFECTIVE AGENT; COBALT; COMPLEMENTARY DNA; GREEN FLUORESCENT PROTEIN; HOMO SAPIENS PEPTIDE DEFORMYLASE; N (1 TERT BUTYL 2 DIMETHYLAMINO 2 OXOETHYL) 2 (N FORMYL N HYDROXYAMINOMETHYL)HEXANAMIDE; N FORMYLMETHIONYL TRANSFER RNA; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR; POLYPEPTIDE; TRANSFER RNA; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANTIBACTERIAL ACTIVITY; ARTICLE; CELL ORGANELLE; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; ENZYME STRUCTURE; ESCHERICHIA COLI; EUBACTERIUM; EUKARYOTE; GENE FUSION; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC CODE; HUMAN; HUMAN CELL; KIDNEY CELL; MITOCHONDRION; MOLECULAR CLONING; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROKARYOTE; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN SYNTHESIS; PROTEIN TARGETING; SEQUENCE ANALYSIS;

AMIDOHYDROLASES; AMINO ACID SEQUENCE; AMINOPEPTIDASES; ANTI-BACTERIAL AGENTS; CELL DIVISION; CELLS, CULTURED; CLONING, MOLECULAR; DNA, COMPLEMENTARY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DESIGN; ENZYME INHIBITORS; ESCHERICHIA COLI; GREEN FLUORESCENT PROTEINS; HUMANS; KIDNEY; KINETICS; LEUCINE; LUMINESCENT PROTEINS; MITOCHONDRIA; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDES; PROTEIN BINDING; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; EUKARYOTA; HOMO; HOMO SAPIENS; MAMMALIA; PROKARYOTA;

EID: 0042473206     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0346446     Document Type: Article

References (31)

1. Meinnel, T., Mechulam, Y., and Blanquet, S. (1993) Biochimie 75, 1061-1075.
2. Giglione, C., Pierre, M., and Meinnel, T. (2000) Mol. Microbiol. 36, 1197-1205.
3. Pei, D. (2001) Emerging Ther. Targets 5, 23-40.
4. Giglione, C., and Meinnel, T. (2001) Emerging Ther. Targets 5, 41-57.
5. Rajagopalan, P. T. R., Yu, X. C., and Pei, D. (1997) J. Am. Chem. Soc. 119, 12418-12419.
6. Groche, D., Becker, A., Schlichting, I., Kabasch, W., Schultz, S., and Wagner, A. F. V. (1998) Biochem. Biophys. Res. Commun. 246, 342-346.
7. Mazel, D., Pochet, S., and Marliere, P. (1994) EMBO J. 13, 914-923.
8. Meinnel, T., and Blanquet, S. (1994) J. Bacteriol. 176, 7387-7390.
9. Margolis, P. S., Hackbarth, C. J., Young, D. C., Wang, W., Chen, D., Yuan, Z., White, R., and Trias, J. (2001) Antimicrob. Agents Chemother. 44, 1825-1831.
10. Huntington, K. M., Yi, T., Wei, Y., and Pei, D. (2000) Biochemistry 39, 4543-4551.
11. Chen, D. Z., Patel, D. V., Hackbarth, C. J., Wang, W., Dreyer, G., Young, D., Margolis, P. S., Wu, C., Ni, Z.-J., Trias, J., White, R., and Yuan, Z, (2000) Biochemistry 39, 1256-1262.
12. Apfel, C., Banner, D. W., Bur, D., Dietz, M., Hirata, T., Hubschwerlen, C., Locher, H., Page, M. G. P., Pirson, W., Rosse, G., and Specklin, J.-L. (2000) J. Med. Chem. 43, 2324-2331.
13. Clements, J. M., Beckett, R. P., Brown, A., Catlin, G., Lobell, M., Palan, S., Thomas, W., Whittaker, M., Wood, S., Salama, S., Baker, P. J., Rodgers, H. F., Barynin, V., Rice, D. W., and Hunter, M. G. (2001) Antimicrob. Agents Chemother. 45, 563-570.
14. Giglione, C., Serero, A., Pierre, M., Boisson, B., and Meinnel, T. (2000) EMBO J. 19, 5916-5929.
15. Bracchi-Ricard, V., Nguyen, K. T., Zhou, Y., Rajagopalan, P. T. R., Chakrabarti, D., and Pei, D. (2001) Arch. Biochem. Biophys. 396, 162-170.
16. Prescott, J. M., and Wilkes, S. H. (1976) Methods Enzylmol. 45, 530.
17. Chenchik, A., Diachenko, L., Moqadam, F., Tarabykin, V., Lukyanov, S., and Siebert, P. D. (1996) BioTechniques 21, 526-534.
18. Rajagopalan, P. T. R., Datta, A., and Pei, D. (1997) Biochemistry 36, 13910-13918.
19. Rajagopalan, P. T. R. R., Grimme, S., and Pei, D. (2000) Biochemistry 39, 779-790.
20. Wei, Y., and Pei, D. (1997) Anal. Biochem. 250, 29-35.
21. Lazennec, C., and Meinnel, T. (1997) Anal. Biochem. 244, 180-182.
22. Rajagopalan, P. T. R., and Pei, D. (1998) J. Biol. Chem. 273, 22305-22310.
23. Ragusa, S., Blanquet, S., and Meinnel, T. (1998) J. Mol. Biol. 280, 515-523.
24. Anderson, S., Bankier, A. T., Barrell, B. G., de Bruijn, M. H., Coulson, A. R., Drouin, J., Eperon, I. C., Nierlich. D. P., Roe, B. A., Sanger, F., Schreier, P. H., Smith, A. J., Staden, R., and Young, I. G. (1981) Nature 290, 457-465.
25. Hao, B., Gong, W., Rajagopalan, P. T. R., Zhou, Y., Pei, D., and Chan, M. K. (1999) Biochemistry 38, 4712-4719.
26. Becker, A., Schlichting, I., Kabsch, W., Groche, D., Schultz, S., and Wagner, A. F. (1998) Nat. Struct. Biol. 5, 1053-1058.
27. Guilloteau, J.-P., Mathieu, M., Giglione, C., Blanc, V., Dupuy, A., Chevrier, M., Gil, P., Famechon, A., Meinnel, T., and Mikol, V. (2002) J. Mol. Biol. 320, 951-962.
28. Nielson, H., Brunak, S., and von Heijne, G. (1999) Protein Eng. 12, 3-9.
29. Hauschild-Rogat, P. (1968) Mol. Gen. Genet. 102, 95-101.
30. Marasco, W. A., Phan, S. H., Krutzsch, H., Showell, H. J., Feltner, D. E., Naim, R., Becker, E. L., and Ward, P. A. (1984) J. Biol. Chem. 259, 5430-5439.
31. Milligan, D. L., and Koshland, D. E., Jr. (1990) J. Biol. Chem. 265, 4455-4460.