Peptide Deformylase Inhibitors as Antibacterial Agents: Identification of VRC3375, a Proline-3-Alkylsuccinyl Hydroxamate Derivative, by Using an Integrated Combinatorial and Medicinal Chemistry Approach

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 1, 2004, Pages 250-261

  Chen, D ^a   Hackbarth, C ^a   Ni, Z J ^a   Wu, C ^a   Wang, W ^a   Jain, R ^a   He, Y ^b   Bracken, K ^b   Weidmann, B ^b   Patel, D V ^a   Trias, J ^a   White, R J ^a   Yuan, Z ^a  

^a Vicuron Pharmaceuticals   (United States)

^b NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTINONIN; ANTIINFECTIVE AGENT; BACTERIAL ENZYME; HYDROXAMIC ACID DERIVATIVE; N HYDROXY 3 BUTYL 3 [2 (TERT BUTOXYCARBONYL)PYRROLIDIN 1 YLCARBONYL]PROPIONAMIDE; PEPTIDE DEFORMYLASE; PEPTIDE DEFORMYLASE INHIBITOR; PROLINE; PROPIONAMIDE DERIVATIVE; UNCLASSIFIED DRUG; VANCOMYCIN; VRC 3305; VRC 3324; VRC 3335; VRC 3375; VRC 3376; VRC 3416; VRC 3460; VRC 3557; VRC 3559;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBACTERIAL ACTIVITY; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; CELL STRAIN K 562; COMBINATORIAL CHEMISTRY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG CYTOTOXICITY; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG IDENTIFICATION; DRUG MECHANISM; DRUG POTENCY; DRUG SCREENING; ENZYME ACTIVITY; ENZYME INHIBITION; ESCHERICHIA COLI; FEMALE; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; MINIMUM INHIBITORY CONCENTRATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; SINGLE DRUG DOSE; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS INFECTION; STRUCTURE ACTIVITY RELATION; TISSUE DISTRIBUTION; TOXICITY TESTING;

ALGORITHMS; AMIDOHYDROLASES; ANIMALS; ANTI-INFECTIVE AGENTS; ANTINEOPLASTIC AGENTS; BINDING SITES; CELL LINE, TUMOR; CHELATING AGENTS; COMBINATORIAL CHEMISTRY TECHNIQUES; DRUG DESIGN; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; ESCHERICHIA COLI; FEMALE; HALF-LIFE; HUMANS; HYDROXAMIC ACIDS; LETHAL DOSE 50; MICE; MODELS, MOLECULAR; PEPTIDE LIBRARY; PROLINE; SEPSIS; STRUCTURE-ACTIVITY RELATIONSHIP; TISSUE DISTRIBUTION; X-RAY DIFFRACTION;

EID: 9144268506     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.1.250-261.2004     Document Type: Article

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