Combination of rapamycin and protein tyrosine kinase (PTK) inhibitors for the treatment of leukemias caused by oncogenic PTKs

Proceedings of the National Academy of Sciences of the United States of America

Volumn 101, Issue 9, 2004, Pages 3130-3135

  Mohi, M Golam ^a   Boulton, Christina ^b   Gu, Ting Lei ^b   Sternberg, David W ^b   Neuberg, Donna ^c   Griffin, James D ^c   Gilliland, D Gary ^b   Neel, Benjamin G ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

^c DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BCR ABL PROTEIN; FLT3 LIGAND; IMATINIB; MIDOSTAURIN; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RAPAMYCIN; UO 126;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BONE MARROW CELL; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CHEMICAL ANALYSIS; CHRONIC MYELOID LEUKEMIA; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG EFFICACY; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; GENE MUTATION; HUMAN; HUMAN CELL; LEUKEMOGENESIS; LYMPHOID CELL; MOUSE; NONHUMAN; ONCOGENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SOLID TUMOR;

ANTIBIOTICS, ANTINEOPLASTIC; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL DIVISION; CELL LINE, TUMOR; ENZYME INHIBITORS; FUSION PROTEINS, BCR-ABL; HUMANS; K562 CELLS; LEUKEMIA; PIPERAZINES; PROTEIN-TYROSINE KINASES; PYRIMIDINES; SIROLIMUS; STAUROSPORINE;

ANIMALIA; MURINAE;

EID: 1542327671     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0400063101     Document Type: Article

References (52)

1. Chopra, R., Pu, Q. Q. & Elefanty, A. G. (1999) Blood Rev. 13, 211-229.
2. Golub, T. R., Barker, G. F., Lovett, M. & Gilliland, D. G. (1994) Cell 77, 307-316.
3. Gilliland, D. G. (2001) Curr. Opin. Hematol. 8, 189-191.
4. Gilliland, D. G. & Griffin, J. D. (2002) Curr. Opin. Hematol. 9, 274-281.
5. Van Etten, R. A. (2002) Oncogene 21, 8643-8651.
6. Druker, B. J. & Lydon, N. B. (2000) J. Clin. Invest. 105, 3-7.
7. Kantarjian, H., Sawyers, C., Hochhaus, A., Guilhot, F., Schiffer, C., Gambaccorti-Passerini, C., Niederwieser, D., Resta, D., Capdeville, R. & Zoellner, U. E. (2002) N. Engl. J. Med. 346, 645-652.
8. Druker, B. J. (2002) Oncogene 21, 8541-8546.
9. Joensuu, H., Roberts, P. J., Sarlomo-Rikala, M., Anderson, L. C., Tervahartiala, P., Tuveson, D., Silberman, S., Capdeville, R., Dimitrijevic, S., Druker, B. & Demetri, G. D. (2001) N. Engl. J. Med. 344, 1052-1056.
10. Demetri, G. D., von Mehren, M., Blanke, C. D., Van den Abbeele, A. D., Eisenberg, B., Roberts, P. J., Heinrich, M. C., Tuveson, D. A., Singer, S., Janicek, M., et al. (2002) N. Engl. J. Med. 347, 462-463.
11. Apperley, J. F., Gardembas, M., Melo, J. V., Russell-Jones, R., Bain, B. J., Baxter, E. J., Chase, A., Chessells, J. M., Colombat, M., Dearden, C. E., et al. (2002) N. Engl. J. Med. 347, 481-487.
12. Cools, J., DeAngelo, D. J., Gotlib, J., Stover, E. H., Legare, R. D., Cortes, J., Kutok, J., Clark, J., Galinsky, I., Griffin, J. D., et al. (2003) N. Engl. J. Med. 348, 1199-1200.
13. Weisberg, E., Boulton, C., Kelly, L. M., Manley, P., Fabbro, D., Meyer, T., Gilliland, D. G. & Griffin, J. D. (2002) Cancer Cell 1, 433-443.
14. Kelly, L. M., Yu, J. C., Boulton, C., Apatira, M., Li, J., Sullivan. C. M., Williums, I., Amaral, S. M., Curley, D. P., Duclos, N., et al. (2002) Cancer Cell 1, 421-432.
15. Levis, M., Allebach, J., Tse, K. F., Zheng, R., Baldwin, B. R., Smith, B. D., Jones-Bolin, S., Ruggeri, B., Dionne, C. & Small, D. (2002) Blood 99, 3885-3891.
16. O'Farrell, A. M., Abrams, T. J., Yuen, H. A., Ngai, T. J., Louie, S. G., Yee, K. W., Wong, L. M., Hong, W., Lee, L. B., Town, A., et al. (2003) Blood 101, 3597-3605.
17. Druker, B. J., Sawyers, C. L., Kantarjian, H., Resta, D. J., Reese, S. F., Ford, J. M., Capdeville, R. & Talpaz, M. (2001) N. Engl. J. Med. 344, 1038-1042.
18. O'Brien, S. G., Guilhot, F., Larson, R. A., Gathmann, I., Baccarani, M., Cervantes, F., Cornelissen, J. J., Fischer, T., Hochhaus, A., Hughes, T., et al. (2003) N. Engl. J. Med. 348, 994-1004.
19. Wu, C. J., Neuberg, D., Chillemi, A., McLaughlin, S., Hochberg, E. P., Galinsky, I., DeAngelo, D., Soiffer, R. J., Alyea, E. P., Capdeville, R., et al. (2002) Leuk. Lymphoma 43, 2281-2289.
20. Azam, M., Latek, R. R. & Daley, G. Q. (2003) Cell 112, 831-843.
21. Sattler, M., Mohi, M. G., Pride, Y. B., Quinnan, L. R., Malouf, N. A., Podar, K., Gesbert, F., Iwaski, H., Li, S., Van Etten, R. A., et al. (2002) Cancer Cell 1, 479-492.
22. Skorski, T., Kanakaraj, P., Nieborowskaskorska, M., Ratajczak, M. Z., Wen, S. C., Zon, G., Gewirtz, A. M., Perussia, B. & Calabretta, B. (1995) Blood 86, 726-736.
23. Cortez, D., Reuther, G. & Pendergast, A. M. (1997) Oncogene 15, 2333-2342.
24. Sebolt-Leopold, J. (2000) Oncogene 19, 6594-6599.
25. Sekulic, A., Hudson, C. C., Homme, J. L., Yin, P., Otterness, D. M., Karnitz, L. M. & Abraham, R. T. (2000) Cancer Res. 60, 3504-3513.
26. Manning, B. D., Tee, A. R., Logsdon, M. N., Blenis, J. & Cantley, L. C. (2002) Mol. Cell 10, 151-162.
27. Hidalgo, M. & Rowinsky, E. K. (2000) Oncogene 19, 6680-6686.
28. Gingras, A.-C., Raught, B. & Sonenberg, N. (2001) Genes Dev. 15, 807-826.
29. Sawyers, C. L. (2003) Cancer Cell 4, 343-348.
30. Chou, T.-C. & Talalay, P. (1983) Trends Pharmacol. Sci. 4, 450-454.
31. Gu, H., Maeda, H., Moon, J. J., Lord, J. D., Yoakim, M., Nelson, B. H. & Neel, B. G. (2000) Mol. Cell. Biol. 20, 7109-7120.
32. MacDonald, A., Scarola, J., Burke, J. T. & Zimmerman, J. J. (2000) Clin. Ther. 22, Suppl. B, B101-B121.
33. Gishizky, M. L. & Witte, O. N. (1992) Science 256, 836-839.
34. Lozzio, C. B. & Lozzio, B. B. (1975) Blood 45, 321-334.
35. Shah, N. P., Nicoll, J. M., Nagar, B., Gorre, M. E., Paquette, R. L., Kuriyan, J. & Sawyers, C. L. (2002) Cancer Cell 2, 117-125.
36. Nichols, G. L., Raines, M. A., Vera, J. C., Lacomis, L., Tempst, P. & Golde, D. W. (1994) Blood 84, 2912-2918.
37. Oda, T., Heaney, C., Hagopian, J. R., Okuda, K., Griffin, J. D. & Druker, B. J. (1994) J. Biol. Chem. 269, 22925-22928.
38. Yu, C., Krystal, G., Varticovksi, L., McKinstry, R., Rahmani, M., Dent, P. & Grant, S. (2002) Cancer Res. 62, 188-199.
39. Wolff, N. C. & Ilaria, R. L., Jr. (2001) Blood 98, 2808-2816.
40. Skorski, T., Bellacosa, A., Nieborowska-Skorska, M., Majewski, M., Martinez, R., Choi, J. K., Trotta, R., Wlodarski, P., Perrotti, D., Chan, T. O., et al. (1997) EMBO J. 16, 6151-6161.
41. Tee, A. R., Fingar, D. C., Manning, B. D., Kwiatkowski, D. J., Cantley, L. C. & Blenis, J. (2002) Proc. Natl. Acad. Sci. USA 99, 13571-13576.
42. Ly, C., Arechiga, A. F., Melo, J. V., Walsh, C. M. & Ong, S. T. (2003) Cancer Res. 63, 5716-5722.
43. Thiesing, J. T., Ohno-Jones, S., Kolibaba, K. S. & Druker, B. J. (2000) Blood 96, 3195-3199.
44. Topaly, J., Zeller, W. J. & Fruehauf, S. (2001) Leukemia 15, 342-347.
45. Marley, S. B., Davidson, R. J., Goldman, J. M. & Gordon, M. Y. (2002) Br. J. Haematol. 116, 162-165.
46. Porosnicu, M., Nimmanapalli, R., Nguyen, D., Worthington, E., Perkins, C. & Bhalla, K. N. (2001) Leukemia 15, 772-778.
47. Hoover, R. R., Mahon, F.-X., Melo, J. V. & Daley, G. Q. (2002) Blood 100, 1068-1071.
48. Gorre, M. E., Ellwood-Yen, K., Chiosis, G., Rosen, N. & Sawyers, C. L. (2002) Blood 100, 3041-3044.
49. McMahon, L. P., Choi, K. M., Lin, T.-A., Abraham, R. T. & Lawrence, J. C., Jr. (2002) Mol. Cell. Biol. 22, 7428-7438.
50. Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J. L., Bonenfant, D., Oppliger, W., Jenoe, P. & Hall, M. N. (2002) Mol. Cell 10, 457-468.
51. Hara, K., Maruki, Y., Long, X., Yoshino, K., Oshiro, N., Hidayat, S., Tokunaga, C., Avruch, J. & Yonezawa, K. (2002) Cell 110, 177-189.
52. Peterson, R. T., Desai, B. N., Hardwick, J. S. & Schreiber, S. L. (1999) Proc. Natl. Acad. Sci. USA 96, 4438-4442.