-
1
-
-
0033565561
-
The biology of chronic myeloid leukemia
-
Faderl S, Talpaz M, Estrov Z, O'Brien S, Kurzrock R, Kantarjian HM. The biology of chronic myeloid leukemia. N Engl J Med. 1999;341:164-172.
-
(1999)
N Engl J Med
, vol.341
, pp. 164-172
-
-
Faderl, S.1
Talpaz, M.2
Estrov, Z.3
O'Brien, S.4
Kurzrock, R.5
Kantarjian, H.M.6
-
2
-
-
0033762280
-
Consequences of BCR-ABL expression within the hematopoietic stem cell in chronic myeloid leukemia
-
Kabarowski JH, Witte ON. Consequences of BCR-ABL expression within the hematopoietic stem cell in chronic myeloid leukemia. Stem Cells. 2000;18:399-408.
-
(2000)
Stem Cells
, vol.18
, pp. 399-408
-
-
Kabarowski, J.H.1
Witte, O.N.2
-
3
-
-
0025117392
-
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome
-
Daley GQ, Van Etten RA, Baltimore D. Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science. 1990;247:824-830.
-
(1990)
Science
, vol.247
, pp. 824-830
-
-
Daley, G.Q.1
Van Etten, R.A.2
Baltimore, D.3
-
4
-
-
0025271543
-
bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haematopoietic neoplasms in mice
-
Elefanty AG, Hariharan IK, Cory S. bcr-abl, the hallmark of chronic myeloid leukaemia in man, induces multiple haematopoietic neoplasms in mice. EMBO J. 1990;9:1069-1078.
-
(1990)
EMBO J
, vol.9
, pp. 1069-1078
-
-
Elefanty, A.G.1
Hariharan, I.K.2
Cory, S.3
-
5
-
-
0025187837
-
Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and bcr/abl
-
Kelliher MA, McLaughlin J, Witte ON, Rosenberg N. Induction of a chronic myelogenous leukemia-like syndrome in mice with v-abl and bcr/abl. Proc Natl Acad Sci U S A. 1990;87:6649-6653.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 6649-6653
-
-
Kelliher, M.A.1
McLaughlin, J.2
Witte, O.N.3
Rosenberg, N.4
-
6
-
-
0027506288
-
Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice
-
Gishizky MI, Johnson-White J, Witte ON. Efficient transplantation of BCR-ABL-induced chronic myelogenous leukemia-like syndrome in mice. Proc Natl Acad Sci U S A. 1993;90:3755-3759.
-
(1993)
Proc Natl Acad Sci U S A
, vol.90
, pp. 3755-3759
-
-
Gishizky, M.I.1
Johnson-White, J.2
Witte, O.N.3
-
7
-
-
0032533257
-
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow
-
Pear WS, Miller JP, Xu L, et al. Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood. 1998;92:3780-3792.
-
(1998)
Blood
, vol.92
, pp. 3780-3792
-
-
Pear, W.S.1
Miller, J.P.2
Xu, L.3
-
8
-
-
0034661522
-
The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase
-
Million RP, Van Etten RA. The Grb2 binding site is required for the induction of chronic myeloid leukemia-like disease in mice by the Bcr/Abl tyrosine kinase. Blood. 2000;96:664-670.
-
(2000)
Blood
, vol.96
, pp. 664-670
-
-
Million, R.P.1
Van Etten, R.A.2
-
9
-
-
0035166003
-
The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase
-
Roumiantsev S, de Aos IE, Varticovski L, Ilaria RL, Van Etten RA. The src homology 2 domain of Bcr/Abl is required for efficient induction of chronic myeloid leukemia-like disease in mice but not for lymphoid leukemogenesis or activation of phosphatidylinositol 3-kinase. Blood. 2001;97:4-13.
-
(2001)
Blood
, vol.97
, pp. 4-13
-
-
Roumiantsev, S.1
De Aos, I.E.2
Varticovski, L.3
Ilaria, R.L.4
Van Etten, R.A.5
-
10
-
-
0035136290
-
The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl
-
Zhang X, Subrahmanyam R, Wong R, Gross AW, Ren R. The NH(2)-terminal coiled-coil domain and tyrosine 177 play important roles in induction of a myeloproliferative disease in mice by Bcr-Abl. Mol Cell Biol. 2001;21:840-853.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 840-853
-
-
Zhang, X.1
Subrahmanyam, R.2
Wong, R.3
Gross, A.W.4
Ren, R.5
-
11
-
-
0035174344
-
The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype
-
Zhang X, Wong R, Hao SX, Pear WS, Ren R. The SH2 domain of bcr-Abl is not required to induce a murine myeloproliferative disease; however, SH2 signaling influences disease latency and phenotype. Blood. 2001;97:277-287.
-
(2001)
Blood
, vol.97
, pp. 277-287
-
-
Zhang, X.1
Wong, R.2
Hao, S.X.3
Pear, W.S.4
Ren, R.5
-
12
-
-
0034665676
-
Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5
-
Sexl V, Piekorz R, Moriggl R, et al. Stat5a/b contribute to interleukin 7-induced B-cell precursor expansion, but abl- and bcr/abl-induced transformation are independent of stat5. Blood. 2000;96:2277-2283.
-
(2000)
Blood
, vol.96
, pp. 2277-2283
-
-
Sexl, V.1
Piekorz, R.2
Moriggl, R.3
-
13
-
-
0033519238
-
The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity
-
Li S, Ilaria RL Jr, Million RP, Daley GQ, Van Etten RA. The P190, P210, and P230 forms of the BCR/ABL oncogene induce a similar chronic myeloid leukemia-like syndrome in mice but have different lymphoid leukemogenic activity. J Exp Med. 1999;189:1399-1412.
-
(1999)
J Exp Med
, vol.189
, pp. 1399-1412
-
-
Li, S.1
Ilaria R.L., Jr.2
Million, R.P.3
Daley, G.Q.4
Van Etten, R.A.5
-
14
-
-
0344603587
-
Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation
-
Ilaria RL, Hawley RG, Van Etten RA. Dominant negative mutants implicate STAT5 in myeloid cell proliferation and neutrophil differentiation. Blood. 1999;93:4154-4166.
-
(1999)
Blood
, vol.93
, pp. 4154-4166
-
-
Ilaria, R.L.1
Hawley, R.G.2
Van Etten, R.A.3
-
15
-
-
0029892399
-
Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: Role of Stat5 in proliferation
-
Mui AL, Wakao H, Kinoshita T, Kitamura T, Miyajima A. Suppression of interleukin-3-induced gene expression by a C-terminal truncated Stat5: role of Stat5 in proliferation. EMBO J. 1996;15:2425-2433.
-
(1996)
EMBO J
, vol.15
, pp. 2425-2433
-
-
Mui, A.L.1
Wakao, H.2
Kinoshita, T.3
Kitamura, T.4
Miyajima, A.5
-
16
-
-
0029947186
-
Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells
-
Druker BJ, Tamura S, Buchdunger E, et al. Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells. Nat Med. 1996;2:561-566.
-
(1996)
Nat Med
, vol.2
, pp. 561-566
-
-
Druker, B.J.1
Tamura, S.2
Buchdunger, E.3
-
17
-
-
0033585504
-
In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor
-
le Coutre P, Mologni L, Cleris L, et al. In vivo eradication of human BCR/ABL-positive leukemia cells with an ABL kinase inhibitor. J Natl Cancer Inst. 1999;91:163-168.
-
(1999)
J Natl Cancer Inst
, vol.91
, pp. 163-168
-
-
Le Coutre, P.1
Mologni, L.2
Cleris, L.3
-
18
-
-
0026576755
-
Hematologic disease induced in BALB/c mice by a bcr/abl retrovirus is influenced by infection conditions
-
Elefanty AG, Cory S. Hematologic disease induced in BALB/c mice by a bcr/abl retrovirus is influenced by infection conditions. Mol Cell Biol. 1992;12:1755-1763.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 1755-1763
-
-
Elefanty, A.G.1
Cory, S.2
-
19
-
-
0030031766
-
Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative
-
Buchdunger E, Zimmermann J, Mett H, et al. Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative. Cancer Res. 1996;56:100-104.
-
(1996)
Cancer Res
, vol.56
, pp. 100-104
-
-
Buchdunger, E.1
Zimmermann, J.2
Mett, H.3
-
20
-
-
0031454003
-
CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
-
Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood. 1997;90: 4947-4952.
-
(1997)
Blood
, vol.90
, pp. 4947-4952
-
-
Carroll, M.1
Ohno-Jones, S.2
Tamura, S.3
-
21
-
-
0034210577
-
Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines
-
Weisberg E, Griffin JD. Mechanism of resistance to the ABL tyrosine kinase inhibitor STI571 in BCR/ABL-transformed hematopoietic cell lines. Blood. 2000;95:3498-3505.
-
(2000)
Blood
, vol.95
, pp. 3498-3505
-
-
Weisberg, E.1
Griffin, J.D.2
-
22
-
-
0028084554
-
Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway
-
Tauchi T, Boswell HS, Leibowitz D, Broxmeyer HE. Coupling between p210bcr-abl and Shc and Grb2 adaptor proteins in hematopoietic cells permits growth factor receptor-independent link to ras activation pathway. J Exp Med. 1994;179:167-175.
-
(1994)
J Exp Med
, vol.179
, pp. 167-175
-
-
Tauchi, T.1
Boswell, H.S.2
Leibowitz, D.3
Broxmeyer, H.E.4
-
23
-
-
0028147448
-
Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway
-
Puil L, Liu J, Gish G, et al. Bcr-Abl oncoproteins bind directly to activators of the Ras signalling pathway. EMBO J. 1994;13:764-773.
-
(1994)
EMBO J
, vol.13
, pp. 764-773
-
-
Puil, L.1
Liu, J.2
Gish, G.3
-
24
-
-
0027939947
-
Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL
-
Matsuguchi T, Salgia R, Hallek M, et al. Shc phosphorylation in myeloid cells is regulated by granulocyte macrophage colony-stimulating factor, interleukin-3, and steel factor and is constitutively increased by p210BCR/ABL. J Biol Chem. 1994;269:5016-5021.
-
(1994)
J Biol Chem
, vol.269
, pp. 5016-5021
-
-
Matsuguchi, T.1
Salgia, R.2
Hallek, M.3
-
25
-
-
0028142490
-
Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia
-
Oda T, Heaney C, Hagopian JR, Okuda K, Griffin JD, Druker BJ. Crkl is the major tyrosine-phosphorylated protein in neutrophils from patients with chronic myelogenous leukemia. J Biol Chem. 1994;269:22925-22928.
-
(1994)
J Biol Chem
, vol.269
, pp. 22925-22928
-
-
Oda, T.1
Heaney, C.2
Hagopian, J.R.3
Okuda, K.4
Griffin, J.D.5
Druker, B.J.6
-
26
-
-
0028024938
-
Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia
-
ten Hoeve J, Arlinghaus RB, Guo JQ, Heisterkamp N, Groffen J. Tyrosine phosphorylation of CRKL in Philadelphia+ leukemia. Blood. 1994;84:1731-1736.
-
(1994)
Blood
, vol.84
, pp. 1731-1736
-
-
Ten Hoeve, J.1
Arlinghaus, R.B.2
Guo, J.Q.3
Heisterkamp, N.4
Groffen, J.5
-
27
-
-
0028116526
-
Identification of CRKL as the constitutively phosphorylated 39-κD tyrosine phosphoprotein in chronic myelogenous leukemia cells
-
Nichols GL, Raines MA, Vera JC, Lacomis L, Tempst P, Golde DW. Identification of CRKL as the constitutively phosphorylated 39-κD tyrosine phosphoprotein in chronic myelogenous leukemia cells. Blood. 1994;84:2912-2918.
-
(1994)
Blood
, vol.84
, pp. 2912-2918
-
-
Nichols, G.L.1
Raines, M.A.2
Vera, J.C.3
Lacomis, L.4
Tempst, P.5
Golde, D.W.6
-
28
-
-
0028006156
-
Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line
-
Carlesso N, Griffin JD, Druker BJ. Use of a temperature-sensitive mutant to define the biological effects of the p210BCR-ABL tyrosine kinase on proliferation of a factor-dependent murine myeloid cell line. Oncogene. 1994;9:149-156.
-
(1994)
Oncogene
, vol.9
, pp. 149-156
-
-
Carlesso, N.1
Griffin, J.D.2
Druker, B.J.3
-
29
-
-
0035810147
-
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
-
Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037.
-
(2001)
N Engl J Med
, vol.344
, pp. 1031-1037
-
-
Druker, B.J.1
Talpaz, M.2
Resta, D.J.3
-
30
-
-
0028972103
-
The SH2 domain of P210BCR/ABL is not required for the transformation of hematopoietic factor-dependent cells
-
Ilaria Jr RL, Van Etten RA. The SH2 domain of P210BCR/ABL is not required for the transformation of hematopoietic factor-dependent cells. Blood. 1995;86:3897-3904.
-
(1995)
Blood
, vol.86
, pp. 3897-3904
-
-
Ilaria R.L., Jr.1
Van Etten, R.A.2
-
31
-
-
0029863169
-
Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl
-
Carlesso N, Frank DA, Griffin JD. Tyrosyl phosphorylation and DNA binding activity of signal transducers and activators of transcription (STAT) proteins in hematopoietic cell lines transformed by Bcr/Abl. J Exp Med. 1996;183:811-820.
-
(1996)
J Exp Med
, vol.183
, pp. 811-820
-
-
Carlesso, N.1
Frank, D.A.2
Griffin, J.D.3
-
32
-
-
0000506439
-
P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members
-
Ilaria RL Jr, Van Etten RA. P210 and P190(BCR/ABL) induce the tyrosine phosphorylation and DNA binding activity of multiple specific STAT family members. J Biol Chem. 1996;271:31704-31710.
-
(1996)
J Biol Chem
, vol.271
, pp. 31704-31710
-
-
Ilaria R.L., Jr.1
Van Etten, R.A.2
-
33
-
-
0029796725
-
BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats
-
Frank DA, Varticovski L. BCR/abl leads to the constitutive activation of Stat proteins, and shares an epitope with tyrosine phosphorylated Stats. Leukemia. 1996;10:1724-1730.
-
(1996)
Leukemia
, vol.10
, pp. 1724-1730
-
-
Frank, D.A.1
Varticovski, L.2
-
34
-
-
0029810923
-
Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia
-
Shuai K, Halpern J, ten Hoeve J, Rao X, Sawyers CL. Constitutive activation of STAT5 by the BCR-ABL oncogene in chronic myelogenous leukemia. Oncogene. 1996;13:247-254.
-
(1996)
Oncogene
, vol.13
, pp. 247-254
-
-
Shuai, K.1
Halpern, J.2
Ten Hoeve, J.3
Rao, X.4
Sawyers, C.L.5
-
35
-
-
0031573141
-
Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
-
Chai SK, Nichols GL, Rothman P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J Immunol. 1997;159:4720-4728.
-
(1997)
J Immunol
, vol.159
, pp. 4720-4728
-
-
Chai, S.K.1
Nichols, G.L.2
Rothman, P.3
-
36
-
-
0033583530
-
Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis
-
Nieborowska-Skorska M, Wasik MA, Slupianek A, et al. Signal transducer and activator of transcription (STAT)5 activation by BCR/ABL is dependent on intact Src homology (SH)3 and SH2 domains of BCR/ABL and is required for leukemogenesis. J Exp Med. 1999;189:1229-1242.
-
(1999)
J Exp Med
, vol.189
, pp. 1229-1242
-
-
Nieborowska-Skorska, M.1
Wasik, M.A.2
Slupianek, A.3
-
37
-
-
0033178667
-
STAT5 activation by Bcr-Abl contributes to transformation of K562 leukemia cells
-
de Groot RP, Raaijmakers JA, Lammers JW, Jove R, Koenderman L. STAT5 activation by Bcr-Abl contributes to transformation of K562 leukemia cells. Blood. 1999;94:1108-1112.
-
(1999)
Blood
, vol.94
, pp. 1108-1112
-
-
De Groot, R.P.1
Raaijmakers, J.A.2
Lammers, J.W.3
Jove, R.4
Koenderman, L.5
-
38
-
-
0034653929
-
STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells
-
Sillaber C, Gesbert F, Frank DA, Sattler M, Griffin JD. STAT5 activation contributes to growth and viability in Bcr/Abl-transformed cells. Blood. 2000;95:2118-2125.
-
(2000)
Blood
, vol.95
, pp. 2118-2125
-
-
Sillaber, C.1
Gesbert, F.2
Frank, D.A.3
Sattler, M.4
Griffin, J.D.5
-
39
-
-
0034161460
-
Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification
-
le Coutre P, Tassi E, Varella-Garcia M, et al. Induction of resistance to the Abelson inhibitor STI571 in human leukemic cells through gene amplification. Blood. 2000;95:1758-1766.
-
(2000)
Blood
, vol.95
, pp. 1758-1766
-
-
Le Coutre, P.1
Tassi, E.2
Varella-Garcia, M.3
-
40
-
-
0034330931
-
Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells
-
Thiesing JT, Ohno-Jones S, Kolibaba KS, Druker BJ. Efficacy of STI571, an abl tyrosine kinase inhibitor, in conjunction with other antileukemic agents against bcr-abl-positive cells. Blood. 2000;96:3195-3199.
-
(2000)
Blood
, vol.96
, pp. 3195-3199
-
-
Thiesing, J.T.1
Ohno-Jones, S.2
Kolibaba, K.S.3
Druker, B.J.4
-
41
-
-
0035810142
-
Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
-
Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001;344:1038-1042.
-
(2001)
N Engl J Med
, vol.344
, pp. 1038-1042
-
-
Druker, B.J.1
Sawyers, C.L.2
Kantarjian, H.3
-
42
-
-
0034689031
-
Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL
-
Horita M, Andreu EJ, Benito A, et al. Blockade of the Bcr-Abl kinase activity induces apoptosis of chronic myelogenous leukemia cells by suppressing signal transducer and activator of transcription 5-dependent expression of Bcl-xL. J Exp Med. 2000;191:977-984.
-
(2000)
J Exp Med
, vol.191
, pp. 977-984
-
-
Horita, M.1
Andreu, E.J.2
Benito, A.3
-
44
-
-
0025176833
-
Clonal and systemic analysis of long-term hematopoiesis in the mouse
-
Jordan CT, Lemischka IR. Clonal and systemic analysis of long-term hematopoiesis in the mouse. Genes Dev. 1990;4:220-232.
-
(1990)
Genes Dev
, vol.4
, pp. 220-232
-
-
Jordan, C.T.1
Lemischka, I.R.2
|