Quantitative monitoring of BCR/ABL transcript during STI-571 therapy

Leukemia and Lymphoma

Volumn 43, Issue 12, 2002, Pages 2281-2289

  Wu, Catherine J ^a   Neuberg, Donna ^a   Chillemi, Antoinette ^a   Mclaughlin, Stephen ^a   Hochberg, Ephraim P ^a   Galinsky, Ilene ^a   DeAngelo, Daniel ^a   Soiffer, Robert J ^a   Alyea, Edwin P ^a   Capdeville, Renaud ^a   Stone, Richard M ^a   Ritz, Jerome ^a  

^a DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

Chronic myelocytic leukemia; PCR; Quantitative; STI 571

Indexed keywords

ALPHA INTERFERON; BCR ABL PROTEIN; BUSULFAN; CHLORAMBUCIL; CYTARABINE; HOMOHARRINGTONINE; HYDROXYUREA; IMATINIB; INTERLEUKIN 2; MESSENGER RNA; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; ST 571; TOPOTECAN; PIPERAZINE DERIVATIVE; PYRIMIDINE DERIVATIVE;

ADULT; AGED; ALLOGENIC BONE MARROW TRANSPLANTATION; ARTICLE; BONE MARROW CELL; CANCER STAGING; CHROMOSOME ANALYSIS; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORRELATION ANALYSIS; CYTOPENIA; DRUG RESPONSE; FEMALE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; MALE; MINIMAL RESIDUAL DISEASE; MULTICENTER STUDY; PHASE 2 CLINICAL TRIAL; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; QUANTITATIVE ASSAY; SENSITIVITY AND SPECIFICITY; STATISTICAL SIGNIFICANCE; BONE MARROW EXAMINATION; COMPARATIVE STUDY; DRUG MONITORING; GENETICS; METHODOLOGY; MIDDLE AGED; MONONUCLEAR CELL; PATHOLOGY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STANDARD;

ADULT; AGED; BONE MARROW EXAMINATION; CYTOGENETIC ANALYSIS; DRUG MONITORING; FEMALE; FUSION PROTEINS, BCR-ABL; HUMANS; LEUKEMIA, MYELOID, CHRONIC; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; PIPERAZINES; PYRIMIDINES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SENSITIVITY AND SPECIFICITY;

EID: 0036891873     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.1080/1042819021000039992     Document Type: Article

References (40)

1. Melo, J.V. (1996) "The diversity of BCR/ABL fusion proteins and their relationship to leukemia phenotype", Blood 88, 2375-2384.
2. Deininger, M.W., Goldman, J.M. and Melo, J.V. (2000) "The molecular biology of chronic myeloid leukemia", Blood 96, 3343-3356.
3. Daley, G.Q., Van Etten, R.A. and Baltimore, D. (1990) "Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome", Science 247, 824-830.
4. Laurent, E., Talpaz, M., Kantarjian, H. and Kurzrock, R. (2001) "The BCR gene and Philadelphia chromosome-positive leukemogenesis", Cancer Res. 61, 2343-2355.
5. Buchdunger, E., Zimmermann, J., Mett, H., Meyer, T., Muller, M., Druker, B.J. and Lydon, N.B. (1996) "Inhibition of the Abl protein-tyrosine kinase in vitro and in vivo by a 2-phenylaminopyrimidine derivative", Cancer Res. 56, 100-104.
6. Druker, B.J., Tamura, S., Buchdunger, E., Ohno, S., Segal, G.M., Fanning, S., Zimmermann, J. and Lydon, N.B. (1996) "Effects of a selective inhibitor of the Abl tyrosine kinase on the growth of Bcr-Abl positive cells", Nat. Med. 2, 561-566.
7. Deininger, M.W., Goldman, J.M., Lydon, N. and Melo, J.V. (1997) "The tyrosine kinase inhibitor CGP57148B selectively inhibits the growth of BCR-ABL-positive cells", Blood 90, 3691-3698.
8. Druker, B.J., Sawyers, C.L., Kantarjian, H., Resta, D.J., Reese, S.F., Ford, J.M., Capdeville, R. and Talpaz, M. (2001) "Activity of a specific inhibitor of the BCR-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome", N. Engl. J. Med. 344, 1038-1042.
9. Druker, B.J., Talpaz, M., Resta, D.J., Peng, B., Buchdunger, E., Ford, J.M., Lydon, N.B., Kantarjian, H., Capdeville, R., Ohno-Jones, S. and Sawyers, C.L. (2001) "Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia", N. Engl. J. Med. 344, 1031-1037.
10. Amarante-Mendes, G.P., Naekyung Kim, C., Liu, L., Huang, Y., Perkins, C.L., Green, D.R. and Bhalla, K. (1998) "Bcr-Abl exerts its antiapoptotic effect against diverse apoptotic stimuli through blockage of mitochondrial release of cytochrome C and activation of caspase-3", Blood 91, 1700-1705.
11. Fang, G., Kim, C.N., Perkins, C.L., Ramadevi, N., Winton, E., Wittmann, S. and Bhalla, K.N. (2000) "CGP57148B (STI-571) induces differentiation and apoptosis and sensitizes Bcr-Abl-positive human leukemia cells to apoptosis due to antileukemic drugs", Blood 96, 2246-2253.
12. Vigneri, P. and Wang, J.Y. (2001) "Induction of apoptosis in chronic myelogenous leukemia cells through nuclear entrapment of BCR-ABL tyrosine kinase", Nat. Med. 7, 228-234.
13. Delage, R., Soiffer, R.J., Dear, K. and Ritz, J. (1991) "Clinical significance of bcr-abl gene rearrangement detected by polymerase chain reaction after allogeneic bone marrow transplantation in chronic myelogenous leukemia", Blood 78, 2759-2767.
14. Roth, M.S., Antin, J.H., Ash, R., Terry, V.H., Gotlieb, M., Silver, S.M. and Ginsburg, D. (1992) "Prognostic significance of Philadelphia chromosome-positive cells detected by the polymerase chain reaction after allogeneic bone marrow transplant for chronic myelogenous leukemia", Blood 79, 276-282.
15. Pichert, G., Alyea, E.P., Soiffer, R.J., Roy, D.C. and Ritz, J. (1994) "Persistence of myeloid progenitor cells expressing BCR-ABL mRNA after allogeneic bone marrow transplantation for chronic myelogenous leukemia", Blood 84, 2109-2114.
16. Pichert, G., Roy, D.C., Gonin, R., Alyea, E.P., Belanger, R., Gyger, M., Perreault, C., Bonny, Y., Lerra, I., Murray, C., Soiffer, R.J. and Ritz, J. (1995) "Distinct patterns of minimal residual disease associated with graft-versus-host disease after allogeneic bone marrow transplantation for chronic myelogenous leukemia", J. Clin. Oncol. 13, 1704-1713.
17. Alyea, E.P., Soiffer, R.J., Canning, C., Neuberg, D., Schlossman, R., Pickett, C., Collins, H., Wang, Y., Anderson, K.C. and Ritz, J. (1998) "Toxicity and efficacy of defined doses of CD4(+) donor lymphocytes for treatment of relapse after allogeneic bone marrow transplant", Blood 91, 3671-3680.
18. Preudhomme, C., Revillion, F., Merlat, A., Hornez, L., Roumier, C., Duflos-Grardel, N., Jouet, J.P., Cosson, A., Peyrat, J.P. and Fenaux, P. (1999) "Detection of BCR-ABL transcripts in chronic myeloid leukemia (CML) using a real time quantitative RT-PCR assay", Leukemia 13, 957-964.
19. Branford, S., Hughes, T.P. and Rudzki, Z. (1999) "Monitoring chronic myeloid leukaemia therapy by real-time quantitative PCR in blood is a reliable alternative to bone marrow cytogenetics", Br. J. Haematol. 107, 587-599.
20. Kreuzer, K.A., Lass, U., Nagel, S., Ellerbrok, H., Pauli, G., Pawlaczyk-Peter, B., Siegert, W., Huhn, D. and Schmidt, C.A. (2000) "Applicability of an absolute quantitative procedure to monitor intra- individual bcr/abl transcript kinetics in clinical samples from chronic myelogenous leukemia patients", Int. J. Cancer 86, 741-746.
21. Emig, M., Saussele, S., Wittor, H., Weisser, A., Reiter, A., Willer, A., Berger, U., Hehlmann, R., Cross, N.C. and Hochhaus, A. (1999) "Accurate and rapid analysis of residual disease in patients with CML using specific fluorescent hybridization probes for real time quantitative RT-PCR", Leukemia 13, 1825-1832.
22. Eder, M., Battmer, K., Kafert, S., Stucki, A., Ganser, A. and Hertenstein, B. (1999) "Monitoring of BCR-ABL expression using real-time RT-PCR in CML after bone marrow or peripheral blood stem cell transplantation", Leukemia 13, 1383-1389.
23. Hariharan, I.K. and Adams, J.M. (1987) "cDNA sequence for human bcr, the gene that translocates to the abl oncogene in chronic myeloid leukaemia", Embo J. 6, 115-119.
24. Meissner, R.V., Dias, P.M., Covas, D.T., Job, F., Leite, M. and Nardi, N.B. (1998) "A polymorphism in exon b2 of the major breakpoint cluster region (M-bcr) identified in chronic myeloid leukaemia patients", Br. J. Haematol. 103, 224-226.
25. Cox, M.C., Maffei, L., Buffolino, S., Del Poeta, G., Venditti, A., Cantonetti, M., Aronica, G., Aquilina, P., Masi, M. and Amadori, S. (1998) "A comparative analysis of FISH, RT-PCR, and cytogenetics for the diagnosis of bcr-abl-positive leukemias", Am. J. Clin. Pathol. 109, 24-31.
26. Duba, H.C., Hilbe, W., Mehringer, A., Erdel, M., Thaler, J. and Utermann, G. (2000) "Hypermetaphase and interphase fluorescence in situ hybridisation for monitoring of remission status in Philadelphia chromosome positive chronic myeloid leukaemia", Int. J. Oncol. 17, 1245-1249.
27. Radich, J.P., Gehly, G., Gooley, T., Bryant, E., Clift, R.A., Collins, S., Edmands, S., Kirk, J., Lee, A., Kessler, P., et al., (1995) "Polymerase chain reaction detection of the BCR-ABL fusion transcript after allogeneic marrow transplantation for chronic myeloid leukemia: results and implications in 346 patients", Blood 85, 2632-2638.
28. Olavarria, E., Kanfer, E., Szydlo, R., Kaeda, J., Rezvani, K., Cwynarski, K., Pocock, C., Dazzi, F., Craddock, C., Apperley, J.F., Cross, N.C. and Goldman, J.M. (2001) "Early detection of BCR-ABL transcripts by quantitative reverse transcriptase-polymerase chain reaction predicts outcome after allogeneic stem cell transplantation for chronic myeloid leukemia", Blood 97, 1560-1565.
29. Cross, N.P., Lin, F., Chase, A., Bungey, J., Hughes, T.P. and Goldman, J.M. (1993) "Competitive polymerase chain reaction to estimate the number of BCR-ABL transcripts in chronic myeloid leukemia patients after bone marrow transplantation", Blood 82, 1929-1936.
30. Lion, T., Izraeli, S., Henn, T., Gaiger, A., Mor, W. and Gadner, H. (1992) "Monitoring of residual disease in chronic myelogenous leukemia by quantitative polymerase chain reaction", Leukemia 6, 495-499.
31. Malinge, M.C., Mahon, F.X., Delfau, M.H., Daheron, L., Kitzis, A., Guilhot, F., Tanzer, J. and Grandchamp, B. (1992) "Quantitative determination of the hybrid Bcr-Abl RNA in patients with chronic myelogenous leukaemia under interferon therapy", Br. J. Haematol. 82, 701-707.
32. Martinelli, G., Testoni, N., Amabile, M., Bonifazi, F., De Vivo, A., Farabegoli, P., Terragna, C., Montefusco, V., Ottaviani, E., Russo, D., Baccarani, M. and Tura, S. (2000) "Quantification of BCR-ABL transcripts in CML patients in cytogenetic remission after interferon-α based therapy", Bone Marrow Transplant. 25, 729-736.
33. Messink, E., van de Locht, A., Schattenberg, A., Linders, E., Schaap, N., Geurts van Kessel, A. and De Witte, T. (1998) "Quantitation of minimal residual disease in Philadelphia chromosome positive chronic myeloid leukaemia patients using real-time quantitative RT-PCR", Br. J. Haematol. 102, 768-774.
34. Livak, K.J., Flood, S.J.A., Marmaro, J., Gusti, W. and Deetz, K. (1995) "Oligonucleotides with fluorescent dyes at opposite ends provide a quenched probe system useful for detecting PCR product and nucleic acid hybridization", PCR Meth. Appl. 4, 357-362.
35. Heid, C.A., Stevens, J., Livak, K.J. and Williams, P.M. (1996) "Real-time quantitative PCR", Genome Res. 6, 986-994.
36. Preudhomme, C., Wattel, E., Lai, J.L., Henic, N., Meyer, L., Noel, M.P., Cosson, A., Jouet, J.P. and Fenaux, P. (1995) "Good predictive value of combined cytogenetic and molecular follow up in chronic myelogeneous leukemia after non T-cell depleted allogeneic bone marrow transplantation: a report on 38 consecutive cases", Leuk. Lymphoma 18, 265-271.
37. Hochhaus, A., Reiter, A., Saubele, S., Reichert, A., Emig, M., Kaeda, J., Schutheis, B., Berger, U., Shepard, P.C.A., Allan, N.C., Hehlman, R., Goldman, J.M. and Cross, N.P. (2000) "Molecular heterogeneity in complete cytogenetic responders after interferon-a therapy for chronic myelogenous leukemia: low levels of minimal residual disease are associated with continuing remission", Blood 95, 62-66.
38. Seeger, K., Kreuzer, K.A., Lass, U., Taube, T., Buchwald, D., Eckert, C., Korner, G., Schmidt, C.A. and Henze, G. (2001) "Molecular quantification of response to therapy and remission status in TEL-AML1-positive childhood ALL by real-time reverse transcription polymerase chain reaction", Cancer Res. 61, 2517-2522.
39. Perego, R.A., Costantini, M., Cornacchini, G., Gargantini, L., Bianchi, C., Pungolino, E., Rovida, E. and Morra, E. (2000) "The possible influences of B2A2 and B3A2 BCR/ABL protein structure on thrombopoiesis in chronic myeloid leukaemia", Eur. J. Cancer 36, 1395-1401.
40. Stentoft, J., Pallisgaard, N., Kjeldsen, E., Holm, M.S., Nielsen, J.L. and Hokland, P. (2001) "Kinetics of BCR-ABL fusion transcript levels in chronic myeloid leukemia patients treated with STI571 measured by quantitative real-time polymerase chain reaction", Eur. J. Haematol. 67, 302-308.