A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling

Genes and Development

Volumn 14, Issue 13, 2000, Pages 1651-1663

  Wasserman, Jonathan D ^a,b   Urban, Sinisa ^a   Freeman, Matthew ^a  

^a MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^b BOSTON CHILDREN S HOSPITAL   (United States)

Author keywords

Apoptosis; Drosophila; EGF receptor; Rhomboid; Roughoid; Signaling

Indexed keywords

EPIDERMAL GROWTH FACTOR RECEPTOR;

ARTICLE; CELL GROWTH; CELL MATURATION; DROSOPHILA; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; TRANSLATION INITIATION;

AMINO ACID SEQUENCE; ANIMALS; ANIMALS, GENETICALLY MODIFIED; DROSOPHILA; DROSOPHILA PROTEINS; EVOLUTION, MOLECULAR; EYE; HUMANS; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SEQUENCE HOMOLOGY, AMINO ACID; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 0034234250     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (48)

1. Baker, N.E. and Rubin, G.M. 1989. Effect on eye development of dominant mutations in Drosophila homologue of the EGF receptor. Nature 340: 150-153.
2. Baker, N.E., Yu, S., and Han, D. 1996. Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye. Curr. Biol. 6: 1290-1301.
3. Bang, A.G. and Kintner, C. 2000. Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz. Genes & Dev. 14: 177-186.
4. Bier, E. 1998. Localized activation of RTK/MAPK pathways during Drosophila development. Bioessays 20: 189-194.
5. Bier, E., Ackerman, L., Barbel, S., Jan, L., and Jan, Y.N. 1988. Identification and characterization of a neuron-specific nuclear antigen in Drosophila. Science 240: 913-916.
6. Bier, E., Jan, L. Y., and Jan, Y.N. 1990. rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster. Genes & Dev. 4: 190-203.
7. Black, R.A. and White, J.M. 1998. ADAMs: focus on the protease domain. Curr. Opin. Cell Biol. 10: 654-659.
8. Brand, A.H. and Perrimon, N. 1993. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development 118: 401-415.
9. Capdevila, J. and Guerrero, I. 1994. Targeted expression of the signaling molecule decapemaplegic induces pattern duplications and growth alterations in Drosophila wings. EMBO J. 13: 4459-4468.
10. Casci, T. and Freeman, M. 1999. Control of EGF receptor signaling: Lessons from fruitflies. Cancer and Metastasis Rev. 18: 181-201.
11. Davis, I., Girdham, C.H., and O'Farrell, P.H. 1995. A nuclear GFP that marks nuclei in living Drosophila embryos; maternal supply overcomes a delay in the appearance of zygotic fluorescence. Dev. Biol. 170: 726-729.
12. de Celis, J.F., Bray, S., and Garcia-Bellido, A. 1997. Notch signaling regulates veinlet expression and establishes boundaries between veins and interveins in the Drosophila wing. Development 124: 1919-1928.
13. Dokucu, M.E., Zipursky, S.L., and Cagan, R.L. 1996. Atonal, Rough and the resolution of proneural clusters in the developing Drosophila retina. Development 122: 4139-4147.
14. Domínguez, M., Wasserman, J.D., and Freeman, M. 1998. Multiple functions of the EGF receptor in Drosophila eye development. Curr. Biol. 8: 1039-1048.
15. Freeman, M. 1994. The spitz gene is required for photoreceptor determination in the Drosophila eye where it interacts with the EGF receptor. Mech. Dev. 48:25-33.
16. _. 1996. Reiterative use of the EGF receptor triggers differentiation of all cell types in the Drosophila eye. Cell 87: 651-660.
17. _. 1997. Cell determination strategies in the Drosophila eye. Development 124: 261-270.
18. Freeman, M., Kimmel, B.E., and Rubin, G.M. 1992. Identifying targets of the rough homeobox gene of Drosophila: Evidence that rhomboid functions in eye development. Development 116: 335-346.
19. Gabay, L., Seger, R., and Shilo, B.-Z. 1997. In situ activation pattern of Drosophila EGF receptor pathway during development. Science 277: 1103-1106.
20. Golembo, M., Raz, E., and Shilo, B.-Z. 1996. The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm. Development 122: 3363-3370.
21. Guichard, A., Biehs, B., Sturtevant, M.A., Wickline, L., Chacko, J., Howard, K., and Bier, E. 1999. rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development. Development 126: 2663-2676.
22. Hay, B.A., Wolff, T., and Rubin, G.M. 1994. Expression of baculovirus P35 prevents cell death in Drosophila. Development 120: 2121-2129.
23. Ikura, M. 1996. Calcium binding and conformational response in EF-hand proteins. Trends Biochem. Sci. 21: 14-17.
24. Jarman, A.P., Grell, E.H., Ackerman, L., Jan, L.Y., and Jan, Y.N. 1994. atonal is the proneural gene for Drosophila photoreceptors. Nature 369:398-400.
25. Jarman, A.P., Sun, Y., Jan, L.Y., and Jan, Y.N. 1995. Role of the proneural gene, atonal, in formation of Drosophila chordotonal organs and photoreceptors. Development 121: 2019-2030.
26. Kimmel, B.E., Heberlein, U., and Rubin, G.M. 1990. The homeo domain protein rough is expressed in a subset of cells in the developing Drosophila eye where it can specify photoreceptor cell subtype. Genes & Dev. 4: 712-727.
27. Kumar, J.P., Tio, M., Hsiung, F., Akopyan, S., Gabay, L., Seger, R., Shilo, B.Z., and Moses, K. 1998. Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation. Development 125: 3875-3885.
28. Mayer, U. and Nüsslein-Volhard, C. 1988. A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo. Genes & Dev. 2: 1496-1511.
29. McLaughlin, S. and Dixon, J.E. 1993. Alternative splicing gives rise to a nuclear protein tyrosine phosphatase in Drosophila. J. Biol. Chem. 268: 6839-6842.
30. Nagaraj, R., Pickup, A.T., Howes, R., Moses, K., Freeman, M., and Banerjee, U. 1999. Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial. Development 126: 975-985.
31. Pascall, J.C. and Brown, K.D. 1998. Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid. FEBS Lett. 429: 337-340.
32. Preston, C.R. and Engels, W.R. 1996. P-element-induced male recombination and gene conversion in Drosophila. Genetics 144: 1611-1622.
33. Preston, C.R., Sved, J.A., and Engels, W.R. 1996. Flanking duplications and deletions associated with P-induced male recombination in Drosophila. Genetics 144: 1623-1638.
34. Queenan, A.M., Ghabrial, A., and Schüpbach, T. 1997. Ectopic activation of torpedo/Egfr, a Drosophila receptor tyrosine kinase, dorsalizes both the eggshell and the embryo. Development 124: 3871-3880.
35. Robertson, H.M., Preston, C.R., Phillis, R.W., Johnson-Schlitz, D.M., Benz, W.K., and Engels, W.R. 1988. A stable genomic source of P element transposase in Drosophila melanogaster. Genetics 118: 461-470.
36. Ruohola-Baker, H., Grell, E., Chou, T.B., Baker, D., Jan, L.Y., and Jan, Y.N. 1993. Spatially localized rhomboid is required for establishment of the dorsal-ventral axis in Drosophila oogenesis. Cell 73: 953-965.
37. Rutledge, B.J., Zhang, K., Bier, E., Jan, Y.N., and Perrimon, N. 1992. The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis. Genes & Dev. 6: 1503-1517.
38. Sambrook, J., Fritsch, E.F., and Maniatis, T. 1989. Molecular cloning: A laboratory manual, 2nd Ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
39. Schweitzer, R., Shaharabany, M., Seger, R., and Shilo, B.-Z. 1995. Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination. Genes & Dev. 9: 1518-1529.
40. Spencer, S.A., Powell, P.A., Miller, D.T., and Cagan, R.L. 1998. Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina. Development 125: 4777-4790.
41. Strong, L.C. 1920. roughoid, a mutant located to the left of sepia in the third chromosome of Drosophila melanogaster. Biol. Bull. Woods Hole 38: 33-37.
42. Sturtevant, M.A., Roark, M., and Bier, E. 1993. The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway. Genes & Dev. 7: 961-973.
43. Tio, M., Ma, C., and Moses, K. 1994. Spitz, a Drosophila homolog of transforming growth factor-alpha, is required in the founding photoreceptor cells of the compound eye facets. Mech. Dev. 48: 13-23.
44. Wasserman, J.D. and Freeman, M. 1997. Control of EGF receptor activation in Drosophila. Trends Cell Biol. 7: 431-436.
45. _. 1998. An autoregulatory cascade of EGF receptor signaling patterns the Drosophila egg. Cell 95: 355-364.
46. Wolff, T. and Ready, D.F. 1991. Cell death in normal and rough eye mutants of Drosophila. Development 113: 825-839.
47. Xu, T. and Rubin, G.M. 1993. Analysis of genetic mosaics in developing and adult Drosophila tissues. Development 117: 1223-1237.
48. zür Lage, P., Jan, Y.N., and Jarman, A.P. 1997. Requirement for EGF receptor signaling in neural recruitment during formation of Drosophila chordotonal sense organ clusters. Curr. Biol. 7: 166-175.