Intramembrane cleavage of microneme proteins at the surface of the apicomplexan parasite Toxoplasma gondii

EMBO Journal

Volumn 21, Issue 7, 2002, Pages 1577-1585

  Opitz, Corinna ^a   Di Cristina, Manlio ^a   Reiss, Matthias ^a   Ruppert, Thomas ^a   Crisanti, Andrea ^a   Soldati, Dominique ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Apicomplexa; Microneme; MPPI protease; Regulated secretion; Toxoplasma gondii

Indexed keywords

CELL RECEPTOR; LIGAND; MEMBRANE ANTIGEN; MEMBRANE PROTEIN; MYOSIN ADENOSINE TRIPHOSPHATASE; PROTEINASE;

APICOMPLEXA; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL INVASION; CELL MEMBRANE PERMEABILITY; CONTROLLED STUDY; HOST CELL; LIGAND BINDING; NONHUMAN; PARASITE MIGRATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN SECRETION; RECEPTOR BINDING; SITE DIRECTED MUTAGENESIS; TOXOPLASMA GONDII;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; BIOLOGICAL TRANSPORT; CELL MEMBRANE; CONSERVED SEQUENCE; CYTOPLASM; ENDOPEPTIDASES; ENZYME ACTIVATION; MEMBRANE PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PEPTIDE MAPPING; POINT MUTATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTOZOAN PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TOXOPLASMA;

APICOMPLEXA; PROTOZOA; TOXOPLASMA GONDII;

EID: 0037007235     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.7.1577     Document Type: Article

References (34)

1. Toxoplasma gondii: Purification and characterization of an immunogenic metallopeptidase
2. Contributions of mass spectrometry to peptide and protein structure
3. The toxoplasma micronemal protein MIC4 is an adhesin composed of six conserved apple domains
4. Molecular characterization of TgMIC5, a proteolytically processed antigen secreted from the micronemes of Toxoplasma gondii
5. Mobilization of intracellular calcium stimulates microneme discharge in Toxoplasma gondii
6. Secretion of micronemal proteins is associated with toxoplasma invasion of host cells
7. +] and stimulate microneme discharge in Toxoplasma gondii
8. The Toxoplasma adhesive protein MIC2 is proteolytically processed at multiple sites by two parasite-derived proteases
9. Evidence that the 42- and 40-amino acid forms of amyloid β protein are generated from the β-amyloid precursor protein by different protease activities
10. CTRP is essential for mosquito infection by malaria ookinetes
11. Two conserved amino acid motifs mediate protein targeting to the micronemes of the apicomplexan parasite Toxoplasma gondii
12. The toxoplasma homolog of plasmodium apical membrane antigen-1 (AMA-1) is a microneme protein secreted in response to elevated intracellular calcium levels
13. Insertional tagging, cloning and expression of the Toxoplasma gondii hypoxanthine-xanthine-guanine phosphoribosyltransferase gene. Use as a selectable marker for stable transformation
14. Second-site cleavage in sterol regulatory element-binding protein occurs at transmembrane junctions as determined by cysteine panning
15. A portrait of Alzheimer secretases-new features and familiar faces
16. The microneme protein MIC3 of Toxoplasma gondii is a secretory adhesin that binds to both the surface of the host cells and the surface of the parasite
17. Toxoplasma gondii homologue of plasmodium apical membrane antigen 1 is involved in invasion of host cells
18. Targeting to rhoptry organelles of Toxoplasma gondii involves evolutionarily conserved mechanisms
19. Conservation of a gliding motility and cell invasion machinery in apicomplexan parasites
20. The protozoan parasite Toxoplasma gondii targets proteins to dense granules and the vacuolar space using both conserved and unusual mechanisms
21. Molecular characterization of a thrombospondin-related anonymous protein homologue in Neospora caninum
22. A family of transmembrane microneme proteins of Toxoplasma gondii contain EGF-like domains and function as escorters
23. A conserved subtilisin-like protein TgSUB1 in microneme organelles of Toxoplasma gondii
24. Mapping of phosphorylation sites of gel-isolated proteins by nanoelectrospray tandem mass spectrometry: Potentials and limitations
25. TgM2AP participates in Toxoplasma gondii invasion of host cells and is tightly associated with the adhesive protein TgMIC2
26. Complementation cloning of S2P, a gene encoding a putative metalloprotease required for intramembrane cleavage of SREBPs
27. Identification and characterisation of an escorter for two secretory adhesins in Toxoplasma gondii
28. In-gel digestion of proteins for internal sequence analysis after one- or two-dimensional gel electrophoresis
29. Mass spectrometric sequencing of proteins on silver-stained polyacrylamide gels
30. TRAP is necessary for gliding motility and infectivity of plasmodium sporozoites
31. Developmental arrest of the human malaria parasite Plasmodium falciparum within the mosquito midgut via CTRP gene disruption
32. Mix and match modules: Structure and function of microneme proteins in apicomplexan parasites
33. Release of signal peptide fragments into the cytosol requires cleavage in the transmembrane region by a protease activity that is specifically blocked by a novel cysteine protease inhibitor
34. Targeted disruption of the Plasmodium berghei CTRP gene reveals its essential role in malaria infection of the vector mosquito