메뉴 건너뛰기




Volumn 87, Issue 1 SPEC. ISS., 2005, Pages 57-64

Longevity, lipotoxicity and leptin: The adipocyte defense against feasting and famine

Author keywords

Apoptosis; Ceramide; Leptin; Lipodystrophy; Lipotoxicity; Longevity; Metabolic syndrome; Obesity

Indexed keywords

LEPTIN;

EID: 14544279805     PISSN: 03009084     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biochi.2004.11.014     Document Type: Conference Paper
Times cited : (136)

References (59)
  • 1
    • 0141719702 scopus 로고    scopus 로고
    • Small molecule activators of sirtuins extend saccharomyces cerevisiae lifespan
    • K.T. Howitz, K.J. Bitterman, H.Y. Cohen, D.W. Lamming, S. Lavu, and J.G. Wood Small molecule activators of sirtuins extend saccharomyces cerevisiae lifespan Nature 425 2003 191 196
    • (2003) Nature , vol.425 , pp. 191-196
    • Howitz, K.T.1    Bitterman, K.J.2    Cohen, H.Y.3    Lamming, D.W.4    Lavu, S.5    Wood, J.G.6
  • 2
    • 2942716674 scopus 로고    scopus 로고
    • The Roy Walford legacy: Diet restriction from molecules to mice to monkeys to man and onto mimetics
    • M.A. Lane, R. de Cabo, J. Mattison, R.M. Anson, G.S. Roth, and D.K. Ingram The Roy Walford legacy: diet restriction from molecules to mice to monkeys to man and onto mimetics Exp. Gerontol. 39 2004 897 902
    • (2004) Exp. Gerontol. , vol.39 , pp. 897-902
    • Lane, M.A.1    De Cabo, R.2    Mattison, J.3    Anson, R.M.4    Roth, G.S.5    Ingram, D.K.6
  • 3
    • 0037160097 scopus 로고    scopus 로고
    • Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1
    • K.J. Bitterman, R.M. Anderson, H.Y. Cohen, M. Latorre-Esteves, and D.A. Sinclair Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1 J. Biol. Chem. 277 2002 45099 45107
    • (2002) J. Biol. Chem. , vol.277 , pp. 45099-45107
    • Bitterman, K.J.1    Anderson, R.M.2    Cohen, H.Y.3    Latorre-Esteves, M.4    Sinclair, D.A.5
  • 6
    • 0032478314 scopus 로고    scopus 로고
    • Fatty acid-induced beta cell apoptosis: A link between obesity and diabetes
    • M. Shimabukuro, Y.T. Zhou, M. Levi, and R.H. Unger Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes Proc. Natl. Acad. Sci. USA 95 1998 2498 2502
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 2498-2502
    • Shimabukuro, M.1    Zhou, Y.T.2    Levi, M.3    Unger, R.H.4
  • 7
    • 0032484132 scopus 로고    scopus 로고
    • Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression
    • M. Shimabukuro, M. Higa, Y.T. Zhou, M.Y. Wang, C.B. Newgard, and R.H. Unger Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats. Role of serine palmitoyltransferase overexpression J. Biol. Chem. 273 1998 32487 32490
    • (1998) J. Biol. Chem. , vol.273 , pp. 32487-32490
    • Shimabukuro, M.1    Higa, M.2    Zhou, Y.T.3    Wang, M.Y.4    Newgard, C.B.5    Unger, R.H.6
  • 8
    • 0036233315 scopus 로고    scopus 로고
    • Mechanisms of lipoapoptosis: Implications for human heart disease
    • L.L. Listenberger, and J.E. Schaffer Mechanisms of lipoapoptosis: implications for human heart disease Trends Cardiovasc. Med. 12 2002 134 138
    • (2002) Trends Cardiovasc. Med. , vol.12 , pp. 134-138
    • Listenberger, L.L.1    Schaffer, J.E.2
  • 10
    • 0029151863 scopus 로고
    • Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications
    • R.H. Unger Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications Diabetes 44 1995 863 870
    • (1995) Diabetes , vol.44 , pp. 863-870
    • Unger, R.H.1
  • 11
    • 0033694535 scopus 로고    scopus 로고
    • Lipotoxic diseases of nonadipose tissues in obesity
    • R.H. Unger, and L. Orci Lipotoxic diseases of nonadipose tissues in obesity Int. J. Obes. Relat. Metab. Disord. 24 Suppl. 4 2000 S28 S32
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , Issue.SUPPL. 4
    • Unger, R.H.1    Orci, L.2
  • 12
    • 0035125917 scopus 로고    scopus 로고
    • Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover
    • R.H. Unger, and Y.T. Zhou Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover Diabetes 50 Suppl. 1 2001 S118 S121
    • (2001) Diabetes , vol.50 , Issue.SUPPL. 1
    • Unger, R.H.1    Zhou, Y.T.2
  • 13
    • 0036182137 scopus 로고    scopus 로고
    • Lipotoxic diseases
    • R.H. Unger Lipotoxic diseases Annu. Rev. Med. 53 2002 319 336
    • (2002) Annu. Rev. Med. , vol.53 , pp. 319-336
    • Unger, R.H.1
  • 14
    • 0030885230 scopus 로고    scopus 로고
    • Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity
    • M. Shimabukuro, K. Koyama, Y. Lee, and R.H. Unger Leptin- or troglitazone-induced lipopenia protects islets from interleukin 1beta cytotoxicity J. Clin. Invest. 100 1997 1750 1754
    • (1997) J. Clin. Invest. , vol.100 , pp. 1750-1754
    • Shimabukuro, M.1    Koyama, K.2    Lee, Y.3    Unger, R.H.4
  • 16
    • 0037059013 scopus 로고    scopus 로고
    • Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: Acetyl-CoA carboxyl's inhibition and AMP-activated protein kinase activation
    • E. Tomas, T.S. Tsao, A.K. Saha, H.E. Murrey, C.C. Zhang, and S.I. Itani Enhanced muscle fat oxidation and glucose transport by ACRP30 globular domain: acetyl-CoA carboxyl's inhibition and AMP-activated protein kinase activation Proc. Natl. Acad. Sci. USA 99 2002 16309 16313
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 16309-16313
    • Tomas, E.1    Tsao, T.S.2    Saha, A.K.3    Murrey, H.E.4    Zhang, C.C.5    Itani, S.I.6
  • 19
    • 0031048115 scopus 로고    scopus 로고
    • Increased lipogenic capacity of the islets of obese rats: A role in the pathogenesis of NIDDM
    • Y. Lee, H. Hirose, Y.T. Zhou, V. Esser, J.D. McGarry, and R.H. Unger Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM Diabetes 46 1997 408 413
    • (1997) Diabetes , vol.46 , pp. 408-413
    • Lee, Y.1    Hirose, H.2    Zhou, Y.T.3    Esser, V.4    McGarry, J.D.5    Unger, R.H.6
  • 22
    • 0035937174 scopus 로고    scopus 로고
    • Liporegulation in diet-induced obesity. the antisteatotic role of hyperleptinemia
    • Y. Lee, M.Y. Wang, T. Kakuma, Z.W. Wang, E. Babcock, and K. McCorkle Liporegulation in diet-induced obesity. The antisteatotic role of hyperleptinemia J. Biol. Chem. 276 2001 5629 5635
    • (2001) J. Biol. Chem. , vol.276 , pp. 5629-5635
    • Lee, Y.1    Wang, M.Y.2    Kakuma, T.3    Wang, Z.W.4    Babcock, E.5    McCorkle, K.6
  • 23
    • 14544282620 scopus 로고    scopus 로고
    • How adipocytes integrate surplus caloric intake with caloric storage: Lessons from Morgan Spurlock and some French geese
    • R. Unger How adipocytes integrate surplus caloric intake with caloric storage: lessons from Morgan Spurlock and some French geese Curr. Opin. Endocrinol. Diabetes 11 2004 251 257
    • (2004) Curr. Opin. Endocrinol. Diabetes , vol.11 , pp. 251-257
    • Unger, R.1
  • 24
    • 0037636366 scopus 로고    scopus 로고
    • The physiology of cellular liporegulation
    • R.H. Unger The physiology of cellular liporegulation Ann. Rev. Physiol. 65 2003 333 337
    • (2003) Ann. Rev. Physiol. , vol.65 , pp. 333-337
    • Unger, R.H.1
  • 25
    • 0027512732 scopus 로고
    • Role of insulin resistance in human disease (syndrome X): An expanded definition
    • G.M. Reaven Role of insulin resistance in human disease (syndrome X): an expanded definition Annu. Rev. Med. 44 1993 121 131
    • (1993) Annu. Rev. Med. , vol.44 , pp. 121-131
    • Reaven, G.M.1
  • 26
    • 11144356189 scopus 로고    scopus 로고
    • Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease
    • K. Ohashi, N. Ouchi, S. Kihara, T. Funahashi, T. Nakamura, and S. Sumitsuji Adiponectin I164T mutation is associated with the metabolic syndrome and coronary artery disease J. Am. Coll. Cardiol. 43 2004 1195 1200
    • (2004) J. Am. Coll. Cardiol. , vol.43 , pp. 1195-1200
    • Ohashi, K.1    Ouchi, N.2    Kihara, S.3    Funahashi, T.4    Nakamura, T.5    Sumitsuji, S.6
  • 27
    • 0014369193 scopus 로고
    • Endocrine and metabolic adaptation to obesity and starvation
    • E.A. Sims, and E.S. Horton Endocrine and metabolic adaptation to obesity and starvation Am. J. Clin. Nutr. 21 1968 1455 1470
    • (1968) Am. J. Clin. Nutr. , vol.21 , pp. 1455-1470
    • Sims, E.A.1    Horton, E.S.2
  • 29
    • 0037491475 scopus 로고    scopus 로고
    • Nonalcoholic steatohepatitis in children
    • E.A. Roberts Nonalcoholic steatohepatitis in children Curr. Gastroenterol. Rep. 5 2003 253 259
    • (2003) Curr. Gastroenterol. Rep. , vol.5 , pp. 253-259
    • Roberts, E.A.1
  • 33
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • I. Shimomura, R.E. Hammer, S. Ikemoto, M.S. Brown, and J.L. Goldstein Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy Nature 401 1999 73 76
    • (1999) Nature , vol.401 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 36
    • 0035162054 scopus 로고    scopus 로고
    • The role of leptin resistance in the lipid abnormalities of aging
    • Z.W. Wang, W.T. Pan, Y. Lee, T. Kakuma, Y.T. Zhou, and R.H. Unger The role of leptin resistance in the lipid abnormalities of aging FASEB J. 15 2000 108 114
    • (2000) FASEB J. , vol.15 , pp. 108-114
    • Wang, Z.W.1    Pan, W.T.2    Lee, Y.3    Kakuma, T.4    Zhou, Y.T.5    Unger, R.H.6
  • 37
    • 0032041972 scopus 로고    scopus 로고
    • The insulin resistance-dyslipidemic syndrome of visceral obesity: Effect on patients' risk
    • J.P. Despres The insulin resistance-dyslipidemic syndrome of visceral obesity: effect on patients' risk Obes. Res. 6 Suppl. 1 1998 8S 17S
    • (1998) Obes. Res. , vol.6 , Issue.SUPPL. 1
    • Despres, J.P.1
  • 38
    • 0042521201 scopus 로고    scopus 로고
    • Surgical removal of visceral adipose tissue: Effects on insulin action
    • I. Gabriely, and N. Barzilai Surgical removal of visceral adipose tissue: effects on insulin action Curr. Diab. Rep. 3 2003 201 206
    • (2003) Curr. Diab. Rep. , vol.3 , pp. 201-206
    • Gabriely, I.1    Barzilai, N.2
  • 42
    • 0027947379 scopus 로고
    • Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: Impairment in adipocyte-beta-cell relationships
    • Y. Lee, H. Hirose, M. Ohneda, J.H. Johnson, J.D. McGarry, and R.H. Unger Beta-cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-beta-cell relationships Proc. Natl. Acad. Sci. USA 91 1994 10878 10882
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10878-10882
    • Lee, Y.1    Hirose, H.2    Ohneda, M.3    Johnson, J.H.4    McGarry, J.D.5    Unger, R.H.6
  • 43
    • 0033613181 scopus 로고    scopus 로고
    • Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats
    • M. Higa, Y.T. Zhou, M. Ravazzola, D. Baetens, L. Orci, and R.H. Unger Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats Proc. Natl. Acad. Sci. USA 96 1999 11513 11518
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 11513-11518
    • Higa, M.1    Zhou, Y.T.2    Ravazzola, M.3    Baetens, D.4    Orci, L.5    Unger, R.H.6
  • 45
    • 0036828824 scopus 로고    scopus 로고
    • Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy
    • S.K. Gan, K. Samaras, C.H. Thompson, E.W. Kraegen, A. Carr, and D.A. Cooper Altered myocellular and abdominal fat partitioning predict disturbance in insulin action in HIV protease inhibitor-related lipodystrophy Diabetes 51 2002 3163 3169
    • (2002) Diabetes , vol.51 , pp. 3163-3169
    • Gan, S.K.1    Samaras, K.2    Thompson, C.H.3    Kraegen, E.W.4    Carr, A.5    Cooper, D.A.6
  • 46
    • 0141763847 scopus 로고    scopus 로고
    • Prediabetes in obese youth: A syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning
    • R. Weiss, S. Dufour, S.E. Taksali, W.V. Tamborlane, K.F. Petersen, and R.C. Bonadonna Prediabetes in obese youth: a syndrome of impaired glucose tolerance, severe insulin resistance, and altered myocellular and abdominal fat partitioning Lancet 362 2003 951 957
    • (2003) Lancet , vol.362 , pp. 951-957
    • Weiss, R.1    Dufour, S.2    Taksali, S.E.3    Tamborlane, W.V.4    Petersen, K.F.5    Bonadonna, R.C.6
  • 47
    • 0037371754 scopus 로고    scopus 로고
    • Myocardial triglycerides and systolic function in humans: In vivo evaluation by localized proton spectroscopy and cardiac imaging
    • L.S. Szczepaniak, R.L. Dobbins, G.J. Metzger, G. Sartoni-D'Ambrosia, D. Arbique, and W. Vongpatanasin Myocardial triglycerides and systolic function in humans: in vivo evaluation by localized proton spectroscopy and cardiac imaging Magn. Reson. Med. 49 2003 417 423
    • (2003) Magn. Reson. Med. , vol.49 , pp. 417-423
    • Szczepaniak, L.S.1    Dobbins, R.L.2    Metzger, G.J.3    Sartoni-D'Ambrosia, G.4    Arbique, D.5    Vongpatanasin, W.6
  • 50
    • 2942746378 scopus 로고    scopus 로고
    • Optimizing fat oxidation through exercise and diet
    • J. Achten, and A.E. Jeukendrup Optimizing fat oxidation through exercise and diet Nutrition 20 2004 716 727
    • (2004) Nutrition , vol.20 , pp. 716-727
    • Achten, J.1    Jeukendrup, A.E.2
  • 51
    • 0037122766 scopus 로고    scopus 로고
    • Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
    • Y. Minokoshi, Y.B. Kim, O.D. Peroni, L.G. Fryer, C. Muller, and D. Carling Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase Nature 415 2002 339 343
    • (2002) Nature , vol.415 , pp. 339-343
    • Minokoshi, Y.1    Kim, Y.B.2    Peroni, O.D.3    Fryer, L.G.4    Muller, C.5    Carling, D.6
  • 53
    • 0037067666 scopus 로고    scopus 로고
    • The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways
    • L.G. Fryer, A. Parbu-Patel, and D. Carling The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways J. Biol. Chem. 277 2002 25226 25232
    • (2002) J. Biol. Chem. , vol.277 , pp. 25226-25232
    • Fryer, L.G.1    Parbu-Patel, A.2    Carling, D.3
  • 54
    • 0036788292 scopus 로고    scopus 로고
    • AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats
    • M.A. Iglesias, J.M. Ye, G. Frangioudakis, A.K. Saha, E. Tomas, and N.B. Ruderman AICAR administration causes an apparent enhancement of muscle and liver insulin action in insulin-resistant high-fat-fed rats Diabetes 51 2002 2886 2894
    • (2002) Diabetes , vol.51 , pp. 2886-2894
    • Iglesias, M.A.1    Ye, J.M.2    Frangioudakis, G.3    Saha, A.K.4    Tomas, E.5    Ruderman, N.B.6
  • 55
    • 0030755002 scopus 로고    scopus 로고
    • Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis
    • B. Weiss, and W. Stoffel Human and murine serine-palmitoyl-CoA transferase--cloning, expression and characterization of the key enzyme in sphingolipid synthesis Eur. J. Biochem. 249 1997 239 247
    • (1997) Eur. J. Biochem. , vol.249 , pp. 239-247
    • Weiss, B.1    Stoffel, W.2
  • 56
    • 0030852877 scopus 로고    scopus 로고
    • Role of nitric oxide in obesity-induced beta cell disease
    • M. Shimabukura, M. Ohneda, Y. Lee, and R.H. Unger Role of nitric oxide in obesity-induced beta cell disease J. Clin. Invest. 100 1997 290 295
    • (1997) J. Clin. Invest. , vol.100 , pp. 290-295
    • Shimabukura, M.1    Ohneda, M.2    Lee, Y.3    Unger, R.H.4
  • 58
    • 0032482988 scopus 로고    scopus 로고
    • Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression
    • M. Shimabukura, M.Y. Wang, Y.T. Zhou, C.B. Newgard, and R.H. Unger Protection against lipoapoptosis of beta cells through leptin-dependent maintenance of Bcl-2 expression Proc. Natl. Acad. Sci. USA 95 1998 9558 9561
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 9558-9561
    • Shimabukura, M.1    Wang, M.Y.2    Zhou, Y.T.3    Newgard, C.B.4    Unger, R.H.5
  • 59
    • 0037116641 scopus 로고    scopus 로고
    • Prevalence of the metabolic syndrome among US adults: Findings from the third National Health and Nutrition Examination Survey
    • E.S. Ford, W.H. Giles, and W.H. Dietz Prevalence of the metabolic syndrome among US adults: findings from the third National Health and Nutrition Examination Survey JAMA 287 2002 356 359
    • (2002) JAMA , vol.287 , pp. 356-359
    • Ford, E.S.1    Giles, W.H.2    Dietz, W.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.