Mechanisms of lipoapoptosis: Implications for human heart disease

Trends in Cardiovascular Medicine

Volumn 12, Issue 3, 2002, Pages 134-138

  Listenberger, Laura L ^a   Schaffer, Jean E ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CERAMIDE; LONG CHAIN FATTY ACID; PALMITIC ACID; REACTIVE OXYGEN METABOLITE; STEARIC ACID;

APOPTOSIS; CARDIOMYOPATHY; CELL DEATH; CYTOTOXICITY; DISEASE COURSE; HEART DISEASE; HEART FAILURE; HEART MUSCLE CELL; HUMAN; HYPERLIPIDEMIA; LIPID STORAGE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; REVIEW; SYNTHESIS;

ANIMALS; APOPTOSIS; CARDIOMYOPATHIES; CELL LINE; CERAMIDES; DISEASE MODELS, ANIMAL; FATTY ACIDS; HEART; HEART DISEASES; HUMANS; LIPID METABOLISM; MICE; MYOCARDIUM; PALMITATES; REACTIVE OXYGEN SPECIES;

EID: 0036233315     PISSN: 10501738     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1050-1738(02)00152-4     Document Type: Review

References (45)

1. Myocardial metabolism in insulin-deficient diabetic humans without coronary artery disease
2. Biochemical mechanisms of oxfenicine cardiotoxicity
3. Sodium palmitate induces partial mitochondrial uncoupling and reactive oxygen species in rat pancreatic islets in vitro
4. A novel mouse model of lipotoxic cardiomyopathy
5. Saturated but not mono-unsaturated fatty acids induce apoptotic cell death in neonatal rat ventricular myocytes
6. Glucose and palmitic acid induce degeneration of myofibrils and modulate apoptosis in rat adult cardiomyocytes
7. Abnormal myocardial lipid composition in an infant with type II glutaric aciduria
8. Protective effects of ranolazine on ventricular fibrillation induced by activation of the ATP-dependent potassium channel in the rabbit heart
9. NAD(P)H oxidase: Role in cardiovascular biology and disease
10. Mammalian cell mutants resistant to a sphingomyelin-directed cytolysin
11. Oleate activate phosphatidylinositol 3-kinase and promotes proliferation and reduces apoptosis of MDA-MB-231 breast cancer cells, whereas palmitate has opposite effects
12. Palmitate-mediated alterations in the fatty acid metabolism of rat neonatal cardiac myocytes
13. Systemic triglyceride storage disease with normal carnitine: A putative defect in long-chain fatty acid metabolism
14. Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death
15. High glucose level and free fatty acid stimulate reactive oxygen species production through protein kinase C-dependent activation of NAD(P)H oxidase in cultured vascular cells
16. Mechanisms of disease: Inherited cardiomyopathies
17. Lipolysis in isolated myocardial cells from diabetic rat hearts
18. Increases in serum unbound free fatty acid levels following coronary angioplasty
19. Palmitate-induced apoptosis in cardiomyocytes is mediated through alterations in mitochondria: Prevention by cyclosporin A
20. Targeted disruption of mouse long-chain acyl-CoA dehydrogenase gene reveals crucial roles for fatty acid oxidation
21. Characteristics of cardiac hypertrophy in the juvenile visceral steatosis mouse with systemic carnitine deficiency
22. Plasma triglyceride and fatty acid metabolism in diabetes mellitus
23. Increased cardiomyocyte apoptosis during the transition to heart failure in the spontaneously hypertensive rat
24. Palmitate-induced apoptosis can occur through a ceramide-independent pathway
25. Chronic inhibition of fatty acid oxidation: New model of diastolic dysfunction
26. Myocyte nuclear mitotric division and programmed myocyte cell death characterize the cardiac myopathy induced by rapid ventricular pacing in dogs
27. P53 and the hypoxia-induced apoptosis of cultured neonatal rat cardiac myocytes
28. Distinct effects of saturated and monounsaturated fatty acids on β-cell turnover and function
29. Relation between serum-free-fatty-acids and arrhythmias and death after acute myocardial infarction
30. Apoptosis in the failing human heart
31. 2+ in toxic cell killing
32. Decreased cardiolipin synthesis corresponds with cytochrome C release in palmitate-induced cardiomyocyte apoptosis
33. Inhibition of carnitine palmitoyltransferase I augments sphingolipid synthesis and palmitate-induced apoptosis
34. The role of sphingolipids in the process of signal transduction
35. A canine model of chronic heart failure produced by multiple sequential coronary microembolizations
36. Lipoapoptosis in beta-cells of obese prediabetic fa/fa rats
37. Fatty acid-induced B cell apoptosis: A link between obesity and diabetes
38. A metabolic role for mitochondria in palmitate-induced cardiac myocyte apoptosis
39. Apoptosis in pressure overload-induced heart hypertrophy in the rat
40. Idiopathic dilated cardiomyopathy - Evidence of abnormal lipid accumulation in myocardium
41. Diseases of liporegulation: New perspective on obesity and related disorders
42. Constitutive regulation of cardiac fatty acid metabolism through peroxisome proliferator-activated receptor α associated with age-dependent cardiac toxicity
43. Ranolazine, a partial fatty acid oxidation inhibitor, reduces myocardial infarct size and cardiac troponin T release in the rat
44. Lipotoxic heart disease in obese rats: Implications for human obesity
45. The metabolic response to the euglycemic insulin clamp in type I diabetes and normal humans