Mutational analysis of a human immunodeficiency virus type 1 Tat protein transduction domain which is required for delivery of an exogenous protein into mammalian cells

Journal of General Virology

Volumn 83, Issue 5, 2002, Pages 1173-1181

  Park, Jinseu ^a   Ryu, Jiyoon ^a   Kim, Kyeong Ae ^a   Lee, Hak Joo ^a   Bahn, Jae Hoon ^a   Han, Kyuhyung ^a   Choi, Eui Yul ^a   Lee, Kil Soo ^a   Kwon, Hyeok Yil ^a   Choi, Soo Young ^a  

^a Hallym University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ARGININE; GREEN FLUORESCENT PROTEIN; HYBRID PROTEIN; LYSINE; RECOMBINANT PROTEIN; TRANSACTIVATOR PROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL MEMBRANE; CELL NUCLEUS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CYTOSOL; FLUORESCENCE MICROSCOPY; GENE DELETION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMAL CELL; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN MOTIF; PROTEIN TRANSPORT; WESTERN BLOTTING;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; MAMMALIA; RNA VIRUSES;

EID: 0036246659     PISSN: 00221317     EISSN: None     Source Type: Journal    
DOI: 10.1099/0022-1317-83-5-1173     Document Type: Article

References (35)

1. Nuclear translocation of an exogenous fusion protein containing HIV Tat requires unfolding
2. A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding
3. The third helix of the Antennapedia homeodomain translocates through biological membranes
4. Cell internalization of the third helix of the antennapedia homeodomain is receptor-independent
5. Trojan peptides: The penetration system for intracellular delivery
6. The HIV-1 Tat nuclear localization sequence confers novel nuclear import properties
7. Bioavailability and transport of peptides and peptide drugs into the brain
8. Intercellular trafficking and protein delivery by a herpesvirus structural protein
9. Release, uptake, and effects of extracellular human immunodeficiency virus type 1 Tat protein on cell growth and viral transactivation
10. Tat-mediated delivery of heterologous proteins into cells
11. Cellular uptake of the Tat protein from human immunodeficiency virus
12. Autonomous functional domains of chemically synthesized human immunodeficiency virus Tat trans-activator protein
13. Efficient intracellular delivery of GFP by homeodomains of Drosophila Fushitarazu and Engrailed proteins
14. Transduction of human catalase mediated by an HIV-1 TAT protein basic domain and arginine-rich peptides into mammalian cells
15. Antennapedia homeobox peptide regulates neural morphogenesis
16. Transduction of Cu,Zn-superoxide dismutase mediated by a HIV-1 Tat protein basic domain into mammalian cells
17. Reorganization of myosin and focal adhesion protein in Swiss 3T3 fibroblasts induced by transforming growth factor beta
18. Cell-penetrating peptides
19. Endocytosis and targeting of exogenous HIV-1 Tat protein
20. Transduction of full-length TAT fusion proteins into mammalian cells: TAT-p27Kip1 induces cell migration
21. Development of a scintillation proximity assay for histone deacetylase using a biotinylated peptide derived from histone-H4
22. 9-Polylysine protein transduction domain; enhanced transduction efficiencies of superoxide dismutase into mammalian cells and skin
23. 13C nuclear magnetic resonance assignment and structural characterization of HIV-1 Tat protein
24. Structural and functional characterization of human immunodeficiency virus Tat protein
25. The basic domain in HIV-1 Tat protein as a target for polysulfonated heparin-mimicking extracellular Tat antagonist
26. In vivo protein transduction: Intracellular delivery of biologically active proteins, compounds and DNA
27. In vivo protein transduction: Delivery of a biologically active protein into the mouse
28. Protein transduction: Unrestricted delivery into all cells?
29. The green fluorescent protein
30. Internalization of HIV-1 TAT requires cell surface heparan sulfate proteoglycans
31. A truncated HIV-1 Tat protein basic domain rapidly translocates through the plasma membrane and accumulates in the cell nucleus
32. Killing HIV-infected cells by transduction with an HIV protease-activated caspase-3 protein
33. HIV-1-trans-activating (Tat) protein: Both a target and a tool in therapeutic approaches
34. The design, synthesis, and evaluation of molecules that enable or enhance cellular uptake: Peptoid molecular transporters