메뉴 건너뛰기




Volumn 88, Issue 1, 2004, Pages 23-31

Puromycin selectively increases mdr1a expression in immortalized rat brain endothelial cell lines

Author keywords

Blood brain barrier; GPNT cell line; In vitro model; P glycoprotein; Puromycin

Indexed keywords

GLYCOPROTEIN P; MESSENGER RNA; MULTIDRUG RESISTANCE PROTEIN 1; MULTIDRUG RESISTANCE PROTEIN 1A; PUROMYCIN; UNCLASSIFIED DRUG;

EID: 0347363616     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02071.x     Document Type: Article
Times cited : (25)

References (39)
  • 1
    • 0030099527 scopus 로고    scopus 로고
    • Transporting therapeutics across the blood-brain barrier
    • Abbott N. J. and Romero I. A. (1996) Transporting therapeutics across the blood-brain barrier. Mol. Med. Today 2, 106-113.
    • (1996) Mol. Med. Today , vol.2 , pp. 106-113
    • Abbott, N.J.1    Romero, I.A.2
  • 2
    • 0033199027 scopus 로고    scopus 로고
    • The mouse Bcrp1/Mxr/Abcp gene: Amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxombicin
    • Allen J. D., Brinkhuis R. F., Wijnholds J. and Schinkel A. H. (1999) The mouse Bcrp1/Mxr/Abcp gene: amplification and overexpression in cell lines selected for resistance to topotecan, mitoxantrone, or doxombicin. Cancer Res. 59, 42374-241.
    • (1999) Cancer Res. , vol.59 , pp. 42374-42241
    • Allen, J.D.1    Brinkhuis, R.F.2    Wijnholds, J.3    Schinkel, A.H.4
  • 3
    • 0028892249 scopus 로고
    • Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta
    • Barrand M. A., Robertson K. J. and von Weikersthal S. F. (1995) Comparisons of P-glycoprotein expression in isolated rat brain microvessels and in primary cultures of endothelial cells derived from microvasculature of rat brain, epididymal fat pad and from aorta. FEBS Lett. 374, 179-183.
    • (1995) FEBS Lett. , vol.374 , pp. 179-183
    • Barrand, M.A.1    Robertson, K.J.2    Von Weikersthal, S.F.3
  • 6
    • 0027214172 scopus 로고
    • Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis
    • Bourgeois S., Gruol D. J., Newby R. F. and Rajah F. M. (1993) Expression of an mdr gene is associated with a new form of resistance to dexamethasone-induced apoptosis. Mol. Endocrinol. 7, 840-851.
    • (1993) Mol. Endocrinol. , vol.7 , pp. 840-851
    • Bourgeois, S.1    Gruol, D.J.2    Newby, R.F.3    Rajah, F.M.4
  • 7
    • 0028322713 scopus 로고
    • SV40-induced immortalization of human cells
    • Bryan T. M. and Reddel R. R. (1994) SV40-induced immortalization of human cells. Crit. Rev. Oncog. 5, 331-335.
    • (1994) Crit. Rev. Oncog. , vol.5 , pp. 331-335
    • Bryan, T.M.1    Reddel, R.R.2
  • 8
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P. and Sacchi N. (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 162, 156-159.
    • (1987) Anal. Biochem. , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 9
    • 0036086485 scopus 로고    scopus 로고
    • A new multidrug resistance protein at the blood-brain barrier
    • Eisenblätter T. and Galla H.-J. (2002) A new multidrug resistance protein at the blood-brain barrier. Biochem. Biophys. Res. Commun. 293, 1273-1278.
    • (2002) Biochem. Biophys. Res. Commun. , vol.293 , pp. 1273-1278
    • Eisenblätter, T.1    Galla, H.-J.2
  • 10
    • 0030738230 scopus 로고    scopus 로고
    • Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line
    • El Hafny B., Cano N., Piciotti M., Regina A., Scherrmann J.-M. and Roux F. (1997) Role of P-glycoprotein in colchicine and vinblastine cellular kinetics in an immortalized rat brain microvessel endothelial cell line. Biochem. Pharmacol. 53, 1735-1742.
    • (1997) Biochem. Pharmacol. , vol.53 , pp. 1735-1742
    • El Hafny, B.1    Cano, N.2    Piciotti, M.3    Regina, A.4    Scherrmann, J.-M.5    Roux, F.6
  • 12
    • 0031819596 scopus 로고    scopus 로고
    • Inhibition of P-glycoprotein: Rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier
    • Fenart L., Buee-Scherrer V., Descamps L., Duhem C., Poullain M. G., Cechelli R. and Dehouck M. P. (1998) Inhibition of P-glycoprotein: rapid assessment of its implication in blood-brain barrier integrity and drug transport to the brain by an in vitro model of the blood-brain barrier. Pharm. Res. 15, 993-1000.
    • (1998) Pharm. Res. , vol.15 , pp. 993-1000
    • Fenart, L.1    Buee-Scherrer, V.2    Descamps, L.3    Duhem, C.4    Poullain, M.G.5    Cechelli, R.6    Dehouck, M.P.7
  • 13
    • 0026729075 scopus 로고
    • Characterisation of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium in vitro
    • Greenwood J. (1992) Characterisation of a rat retinal endothelial cell culture and the expression of P-glycoprotein in brain and retinal endothelium in vitro. J. Neuroimmunol. 39, 123-132.
    • (1992) J. Neuroimmunol. , vol.39 , pp. 123-132
    • Greenwood, J.1
  • 14
    • 0030560709 scopus 로고    scopus 로고
    • SV40 large-T immortalised cell lines of the rat blood-brain barriers retain their phenotypic and immunological characteristics
    • Greenwood J., Pryce G., Devine L., Male D. K., dos Santos W. L. C., Calder V. L. and Adamson P. (1996) SV40 large-T immortalised cell lines of the rat blood-brain barriers retain their phenotypic and immunological characteristics. J. Neuroimmunol. 71, 51-63.
    • (1996) J. Neuroimmunol. , vol.71 , pp. 51-63
    • Greenwood, J.1    Pryce, G.2    Devine, L.3    Male, D.K.4    Dos Santos, W.L.C.5    Calder, V.L.6    Adamson, P.7
  • 15
    • 0029786352 scopus 로고    scopus 로고
    • Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium
    • Huwyler J., Drewe J., Klusemann C. and Fricker G. (1996) Evidence for P-glycoprotein-modulated penetration of morphine-6-glucuronide into brain capillary endothelium. Br. J. Pharmacol. 118, 1879-1885.
    • (1996) Br. J. Pharmacol. , vol.118 , pp. 1879-1885
    • Huwyler, J.1    Drewe, J.2    Klusemann, C.3    Fricker, G.4
  • 16
    • 0024344261 scopus 로고
    • Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells
    • Hsu S. I., Lothstein L. and Horwitz S. B. (1989) Differential overexpression of three mdr gene family members in multidrug-resistant J774.2 mouse cells. J. Biol. Chem. 264, 12 053-12 062.
    • (1989) J. Biol. Chem. , vol.264 , pp. 12053-12062
    • Hsu, S.I.1    Lothstein, L.2    Horwitz, S.B.3
  • 17
    • 0030973162 scopus 로고    scopus 로고
    • Ribotoxic stress response: Activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA
    • Iordanov M. S., Pribnow D., Magun J. L., Dinh T.-H., Pearson J. A., Chen S. L.-Y. and Magun B. E. (1997) Ribotoxic stress response: activation of the stress-activated protein kinase JNK1 by inhibitors of the peptidyl transferase reaction and by sequence-specific RNA damage to the α-sarcin/ricin loop in the 28S rRNA. Molec. Cell. Biol. 17, 3373-3381.
    • (1997) Molec. Cell. Biol. , vol.17 , pp. 3373-3381
    • Iordanov, M.S.1    Pribnow, D.2    Magun, J.L.3    Dinh, T.-H.4    Pearson, J.A.5    Chen, S.L.-Y.6    Magun, B.E.7
  • 18
    • 0028788284 scopus 로고
    • Interaction of drugs with P-glycoprotein in brain capillaries
    • Jette L., Murphy G. F., Leclerc J. and Beliveau R. (1995) Interaction of drugs with P-glycoprotein in brain capillaries. Biochem. Pharmacol. 50, 1701-1709.
    • (1995) Biochem. Pharmacol. , vol.50 , pp. 1701-1709
    • Jette, L.1    Murphy, G.F.2    Leclerc, J.3    Beliveau, R.4
  • 19
    • 0034947674 scopus 로고    scopus 로고
    • From MDR to MXR: New understanding of multidrug resistance systems, their properties and clinical significance
    • Litman T., Druley T. E., Stein W. D. and Bates S. E. (2001) From MDR to MXR: new understanding of multidrug resistance systems, their properties and clinical significance. Cell Mol. Life Sci. 58, 931-959.
    • (2001) Cell Mol. Life Sci. , vol.58 , pp. 931-959
    • Litman, T.1    Druley, T.E.2    Stein, W.D.3    Bates, S.E.4
  • 20
    • 0024978569 scopus 로고
    • Alternate overexpression of two phosphoglycoprotein genes is associated with changes in multidrug resistance in a J774.2 cell line
    • Lothstein L., Hsu S. I., Horwitz S. B. and Greenberger L. M. (1989) Alternate overexpression of two phosphoglycoprotein genes is associated with changes in multidrug resistance in a J774.2 cell line. J. Biol. Chem. 264, 16 054-16 058.
    • (1989) J. Biol. Chem. , vol.264 , pp. 16054-16058
    • Lothstein, L.1    Hsu, S.I.2    Horwitz, S.B.3    Greenberger, L.M.4
  • 22
    • 0027253523 scopus 로고
    • Characterization of the P-glycoprotein over-expressing drug resistance phenotype exhibited by Chinese hamster ovary cells following their in-vitro exposure to fractionated X-irradiation
    • McClean S., Whelan R. D., Hosking L. K., Hodges G. M., Thompson F. H., Meyers M. B., Schuurhuis G. J. and Hill B. T. (1993) Characterization of the P-glycoprotein over-expressing drug resistance phenotype exhibited by Chinese hamster ovary cells following their in-vitro exposure to fractionated X-irradiation. Biochim. Biophys. Acta 1177, 117-126.
    • (1993) Biochim. Biophys. Acta , vol.1177 , pp. 117-126
    • McClean, S.1    Whelan, R.D.2    Hosking, L.K.3    Hodges, G.M.4    Thompson, F.H.5    Meyers, M.B.6    Schuurhuis, G.J.7    Hill, B.T.8
  • 23
    • 0033664346 scopus 로고    scopus 로고
    • Xenobiotic transport across isolated brain microvessels studied by confocal microscopy
    • Miller D. S., Nobmann S. N., Gutmann H., Toeroek M., Drewe J. and Fricker G. (2000) Xenobiotic transport across isolated brain microvessels studied by confocal microscopy. Mol. Pharmacol. 58, 1357-1367.
    • (2000) Mol. Pharmacol. , vol.58 , pp. 1357-1367
    • Miller, D.S.1    Nobmann, S.N.2    Gutmann, H.3    Toeroek, M.4    Drewe, J.5    Fricker, G.6
  • 25
    • 0029851730 scopus 로고    scopus 로고
    • 2-terminal protein kinase pathway in the cellular response to adriamycine and other chemotherapeutic drugs
    • 2-terminal protein kinase pathway in the cellular response to adriamycine and other chemotherapeutic drugs. J. Biol. Chem. 271, 30950-30955.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30950-30955
    • Osborn, M.T.1    Chambers, T.C.2
  • 26
    • 0031724003 scopus 로고    scopus 로고
    • Mrp1 multi-drug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells
    • Regina A., Koman A., Piciotti M., El Hafny B., Center M. S., Bergmann R., Couraud P. O. and Roux F. (1998) Mrp1 multi-drug resistance-associated protein and P-glycoprotein expression in rat brain microvessel endothelial cells. J. Neurochem. 71, 705-715.
    • (1998) J. Neurochem. , vol.71 , pp. 705-715
    • Regina, A.1    Koman, A.2    Piciotti, M.3    El Hafny, B.4    Center, M.S.5    Bergmann, R.6    Couraud, P.O.7    Roux, F.8
  • 27
    • 0344980089 scopus 로고    scopus 로고
    • Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT
    • Regina A., Romero I. A., Greenwood J., Adamson P., Bourre J. M., Couraud P. O. and Roux F. (1999) Dexamethasone regulation of P-glycoprotein activity in an immortalized rat brain endothelial cell line, GPNT. J. Neurochem. 73, 1954-1963.
    • (1999) J. Neurochem. , vol.73 , pp. 1954-1963
    • Regina, A.1    Romero, I.A.2    Greenwood, J.3    Adamson, P.4    Bourre, J.M.5    Couraud, P.O.6    Roux, F.7
  • 28
    • 0033526176 scopus 로고    scopus 로고
    • P-glycoprotein, a gatekeeper in the blood-brain barrier
    • Schinkel A. H. (1999) P-glycoprotein, a gatekeeper in the blood-brain barrier. Adv. Drug Deliv. Rev. 36, 179-194.
    • (1999) Adv. Drug Deliv. Rev. , vol.36 , pp. 179-194
    • Schinkel, A.H.1
  • 29
    • 0028229150 scopus 로고
    • Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs
    • Schinkel A. H., Smit J. J. M., van Tellingen O. et al. (1994) Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs. Cell 77, 491-502.
    • (1994) Cell , vol.77 , pp. 491-502
    • Schinkel, A.H.1    Smit, J.J.M.2    Van Tellingen, O.3
  • 30
    • 0027205348 scopus 로고
    • Differential over-expression of mdrl genes in multidrug-resistant rat glioblastoma cell lines selected with doxorubicin or vincristine
    • Schott B., Bennis S., Pourquier P., Ries C., Londos-Gagliardi D. and Robert J. (1993) Differential over-expression of mdrl genes in multidrug-resistant rat glioblastoma cell lines selected with doxorubicin or vincristine. Int. J. Cancer. 55, 115-121.
    • (1993) Int. J. Cancer , vol.55 , pp. 115-121
    • Schott, B.1    Bennis, S.2    Pourquier, P.3    Ries, C.4    Londos-Gagliardi, D.5    Robert, J.6
  • 31
    • 0029061103 scopus 로고
    • Reconstitution of drug transport by purified P-glycoprotein
    • Shapiro A. B. and Ling V. (1995) Reconstitution of drug transport by purified P-glycoprotein. J. Biol. Chem. 270, 16 167-16 175.
    • (1995) J. Biol. Chem. , vol.270 , pp. 16167-16175
    • Shapiro, A.B.1    Ling, V.2
  • 32
    • 0032548862 scopus 로고    scopus 로고
    • Protein synthesis inhibitors exhibit a nonspecific effect on phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocytes
    • Sidhu J. S. and Omiecinski J. O. (1998) Protein synthesis inhibitors exhibit a nonspecific effect on phenobarbital-inducible cytochrome P450 gene expression in primary rat hepatocytes. J. Biol. Chem. 273, 47694-775.
    • (1998) J. Biol. Chem. , vol.273 , pp. 47694-47775
    • Sidhu, J.S.1    Omiecinski, J.O.2
  • 33
    • 0034185251 scopus 로고    scopus 로고
    • Regulation of the multidrug resistance genes by stress signals
    • Sukhai M. and Piquette-Miller M. (2000) Regulation of the multidrug resistance genes by stress signals. J. Pharm. Pharmaceut. Sci. 3, 262-280.
    • (2000) J. Pharm. Pharmaceut. Sci. , vol.3 , pp. 262-280
    • Sukhai, M.1    Piquette-Miller, M.2
  • 34
    • 0028961304 scopus 로고
    • Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators
    • Tang-Wai D. F., Kajiji S., DiCapua F., de Graaf D., Roninson I. B. and Gros P. (1995) Human (MDR1) and mouse (mdr1, mdr3) P-glycoproteins can be distinguished by their respective drug resistance profiles and sensitivity to modulators. Biochemistry 34, 32-39.
    • (1995) Biochemistry , vol.34 , pp. 32-39
    • Tang-Wai, D.F.1    Kajiji, S.2    DiCapua, F.3    De Graaf, D.4    Roninson, I.B.5    Gros, P.6
  • 35
    • 0026669192 scopus 로고
    • Functional involvement of P-glycoprotein in blood-brain barrier
    • Tatsuta T., Naito M., Oh-hara T., Sugarawa I. and Tsuruo T. (1992) Functional involvement of P-glycoprotein in blood-brain barrier. J. Biol. Chem. 267, 20 383-20 391.
    • (1992) J. Biol. Chem. , vol.267 , pp. 20383-20391
    • Tatsuta, T.1    Naito, M.2    Oh-Hara, T.3    Sugarawa, I.4    Tsuruo, T.5
  • 36
    • 0027377964 scopus 로고    scopus 로고
    • Activation of distinct multidrug resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis
    • Teeter L. D., Estes M., Chan J. Y., Atassi H., Sell S., Becker F. F. and Kuo M. T. (1996) Activation of distinct multidrug resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol. Carcinogen 8, 67-73.
    • (1996) Mol. Carcinogen , vol.8 , pp. 67-73
    • Teeter, L.D.1    Estes, M.2    Chan, J.Y.3    Atassi, H.4    Sell, S.5    Becker, F.F.6    Kuo, M.T.7
  • 37
    • 0030984112 scopus 로고    scopus 로고
    • p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents
    • Thottassery J. V., Zambetti G. P., Arimori K., Schuetz E. G. and Schuetz J. D. (1997) p53-dependent regulation of MDR1 gene expression causes selective resistance to chemotherapeutic agents. Proc. Natl. Acad. Sci. USA 94, 11 037-11 042.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 11037-11042
    • Thottassery, J.V.1    Zambetti, G.P.2    Arimori, K.3    Schuetz, E.G.4    Schuetz, J.D.5
  • 38
    • 0022336717 scopus 로고
    • Biosynthesis of puromycin by Streptomyces alboniger: Characterization of puromycin N-acetyltransferase
    • Vara J., Perez-Gonzalez J. A. and Jimenez A. (1985) Biosynthesis of puromycin by Streptomyces alboniger: characterization of puromycin N-acetyltransferase. Biochemistry 24, 8074-8081.
    • (1985) Biochemistry , vol.24 , pp. 8074-8081
    • Vara, J.1    Perez-Gonzalez, J.A.2    Jimenez, A.3
  • 39
    • 0035119989 scopus 로고    scopus 로고
    • In vitro substrate identification studies for P-glycoprotein-mediated transport: Species difference and predictability of in vivo results
    • Yamazaki M., Neway W. E., Ohe T., Chen I.-W., Rowe J. F., Hochman J. H., Chiba M. and Lin J. H. (2001) In vitro substrate identification studies for P-glycoprotein-mediated transport: species difference and predictability of in vivo results. J. Pharmacol. Exp. Ther. 296, 723-735.
    • (2001) J. Pharmacol. Exp. Ther. , vol.296 , pp. 723-735
    • Yamazaki, M.1    Neway, W.E.2    Ohe, T.3    Chen, I.-W.4    Rowe, J.F.5    Hochman, J.H.6    Chiba, M.7    Lin, J.H.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.