Cytokine regulation of P-glycoprotein

Drug Metabolism Reviews

Volumn 35, Issue 1, 2003, Pages 19-33

  McRae, Mary Peace ^a   Brouwer, Kim L R ^a   Kashuba, Angela D M ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; ANTIARRHYTHMIC AGENT; ANTINEOPLASTIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CYTOKINE; GAMMA INTERFERON; GLYCOPROTEIN P; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN 1; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 6; MULTIDRUG RESISTANCE PROTEIN 1; PROTEINASE INHIBITOR; STEROID; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CARCINOMA CELL; CYTOKINE PRODUCTION; DRUG DISPOSITION; EVALUATION; HUMAN; HUMAN CELL; INFECTION; INFLAMMATION; LIVER CELL; MEDICAL LITERATURE; MEMBRANE BINDING; NONHUMAN; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; RAT; STATISTICAL SIGNIFICANCE; STIMULUS RESPONSE; STRUCTURE ACTIVITY RELATION; XENOBIOTIC METABOLISM;

ANIMALS; CYTOKINES; GENE EXPRESSION REGULATION; HUMANS; INFLAMMATION; P-GLYCOPROTEIN; RNA, MESSENGER;

EID: 0037281616     PISSN: 03602532     EISSN: None     Source Type: Journal    
DOI: 10.1081/DMR-120018247     Document Type: Article

References (28)

1. Akazawa, Y., Kawaguchi, H., Funahashi, M., Watanabe, Y., Yamaoka, K., Hashida, M., Takakura, Y. (2002). Effect of interferons on P-glycoprotein-mediated rhodamine123 efflux in cultured rat hepatocytes. J. Pharm. Sci. 91(10):2110-2115.
2. Bertilsson, P. M., Olsson, P., Magnusson, K. E. (2001). Cytokines influence MRNA expression of cytochrome P450 3A4 and MDRI in intestinal cells. J. Pharm. Sci. 90(5):638-646.
3. Fantuzzi, G., Dinarello, C. A. (1996). The inflammatory response in interleukin-1 betadeficient mice: comparison with other cytokine-related knock-out mice. J. Leukoc. Biol. 59(4):489-493.
4. Fellay, J., Marzolini, C., Meaden, E. R., Back, D. J., Buclin, T., Chave, J. P., Decosterd, L. A., Furrer, H., Opravil, M., Pantaleo, G., Retelska, D., Ruiz, L., Schinkel, A. H., Vernazza, P., Eap, C. B., Telenti, A. (2002). Response to antiretroviral treatment in HIV-1-infected individuals with allelic variants of the multidrug resistance transporter 1: a pharmacogenetics study. Lancet 359(9300):30-36.
5. Hartmann, G., Kim, H., Piquette-Miller, M. (2001). Regulation of the hepatic multidrug resistance gene expression by endotoxin and inflammatory cytokines in mice. Int. Immunopharmacol. 1(2):189-199.
6. Heinrich, P. C., Castell, J. V., Andus, T. (1990). Interleukin-6 and the acute phase response. Biochem. J. 265(3):621-636.
7. Hirsch-Ernst, K. I., Ziemann, C., Foth, H., Kozian, D., Schmitz-Salue, C., Kahl, G. F. (1998). Induction of Mdr1b MRNA and P-glycoprotein expression by tumor necrosis factor alpha in primary rat hepatocyte cultures. J. Cell. Physiol. 176(3):506-515.
8. Hochman, J. H., Chiba, M., Yamazaki, M., Tang, C., Lin, J. H. (2001). P-glycoproteinmediated efflux of indinavir metabolites in Caco-2 cells expressing cytochrome P450 3A4. J. Pharmacol. Exp. Ther. 298(1):323-330.
9. Hoffmeyer, S., Burk, O., von Richter, O., Arnold, H. P., Brockmoller, J., Johne, A., Cascorbi, I., Gerloff, T., Roots, I., Eichelbaum, M., Brinkmann, U. (2000). Functional polymorphisms of the human multidrug-resistance gene: multiple sequence variations and correlation of one allele with P-glycoprotein expression and activity in vivo. Proc. Natl Acad. Sci. USA 97(7):3473-3478.
10. Huang, L., Wring, S. A., Woolley, J. L., Brouwer, K. R., Serabjit-Singh, C., Polli, J. W. (2001). Induction of P-glycoprotein and cytochrome P450 3A by HIV protease inhibitors. Drug Metab. Dispos. 29(5):754-760.
11. Ito, S., Ieiri, I., Tanabe, M., Suzuki, A., Higuchi, S., Otsubo, K. (2001). Polymorphism of the ABC transporter genes, MDR1, MRP1 and MRP2/CMOAT, in healthy Japanese subjects. Pharmacogenetics 11(2):175-184.
12. Kang, Y., Perry, R. R. (1994). Effect of alpha-interferon on P-glycoprotein expression and function and on verapamil modulation of doxorubicin resistance. Cancer Res. 54(11):2952-2958.
13. Kim, R. B., Leake, B. F., Choo, E. F., Dresser, G. K., Kubba, S. V., Schwarz, U. I., Taylor, A., Xie, H. G., McKinsey, J., Zhou, S., Lan, L. B., Schuetz, J. D., Schuetz, E. G., Wilkinson, G. R. (2001). Identification of functionally variant MDR1 alleles among European Americans and African Americans. Clin. Pharmacol. Ther. 70(2):189-199.
14. Matheny, C. J., Lamb, M. W., Brouwer, K. R., Pollack, G. M. (2001). Pharmacokinetic and pharmacodynamic implications of P-glycoprotein modulation. Pharmacotherapy 21(7):778-796.
15. Morgan, E. T. (1997). Regulation of cytochromes P450 during inflammation and infection. Drug Metab. Rev. 29(4):1129-1188.
16. Morgan, E. T. (2001). Regulation of cytochrome P450 by inflammatory mediators: why and how? Drug Metab. Dispos. 29(3):207-212.
17. Piquette-Miller, M., Pak, A., Kim, H., Anari, R., Shahzamani, A. (1998). Decreased expression and activity of P-glycoprotein in rat liver during acute inflammation. Pharm. Res. 15(5):706-711.
18. Salphati, L., Benet, L. Z. (1998). Modulation of P-glycoprotein expression by cytochrome P450 3A inducers in male and female rat livers. Biochem. Pharmacol. 55(4):387-395.
19. Smith, A. J., Timmermans-Hereijgers, J. L., Roelofsen, B., Wirtz, K. W., van Blitterswijk, W. J., Smit, J. J., Schinkel, A. H., Borst, P. (1994). The human MDR3 P-glycoprotein promotes translocation of phosphatidylcholine through the plasma membrane of fibroblasts from transgenic mice. FEBS Lett. 354(3):263-266.
20. Stein, U., Walther, W., Shoemaker, R. H. (1996a). Modulation of Mdr1 expression by cytokines in human colon carcinoma cells: an approach for reversal of multidrug resistance. Br. J. Cancer 74(9):1384-1391.
21. Stein, U., Walther, W., Shoemaker, R. H. (1996b). Reversal of multidrug resistance by transduction of cytokine genes into human colon carcinoma cells. J. Natl Cancer Inst. 88(19):1383-1392.
22. Sukhai, M., Yong, A., Kalitsky, J., Piquette-Miller, M. (2000). Inflammation and interleukin-6 mediate reductions in the hepatic expression and transcription of the Mdr1a and Mdr1b genes. Mol. Cell Biol. Res. Commun. 4(4):248-256.
23. Sukhai, M., Yong, A., Pak, A., Piquette-Miller, M. (2001). Decreased expression of P-glycoprotein in interleukin-1 beta and interleukin-6 treated rat hepatocytes. Inflamm. Res. 50(7):362-370.
24. Talamini, M. A., Kappus, B., Hubbard, A. (1997). Repolarization of hepatocytes in culture. Hepatology 25(1):167-172.
25. Trauner, M., Arrese, M., Soroka, C. J., Ananthanarayanan, M., Koeppel, T. A., Schlosser, S. F., Suchy, F. J., Keppler, D., Boyer, J. L. (1997). The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis. Gastroenterology 113(1):255-264.
26. Vos, T. A., Hooiveld, G. J., Koning, H., Childs, S., Meijer, D. K., Moshage, H., Jansen, P. L., Muller, M. (1998). Up-regulation of the multidrug resistance genes, Mrpl and Mdr1b, and down-regulation of the organic anion transporter, Mrp2, and the bile salt transporter, Spgp, in endotoxemic rat liver. Hepatology 28(6):1637-1644.
27. Walther, W., Stein, U. (1994). Influence of cytokines on Mdr1 expression in human colon carcinoma cell lines: increased cytotoxicity of MDR relevant drugs. J. Cancer Res. Clin. Oncol. 120(8):471-478.
28. Walther, W., Stein, U., Pfeil, D. (1995). Gene transfer of human TNF alpha into glioblastoma cells permits modulation of Mdr1 expression and potentiation of chemosensitivity. Int. J. Cancer 61(6):832-839.