메뉴 건너뛰기




Volumn 5, Issue 5, 2003, Pages 307-313

Paraquat and iron exposure as possible synergistic environmental risk factors in Parkinson's disease

Author keywords

[No Author keywords available]

Indexed keywords

DOPAMINE; HERBICIDE; IRON; NERVE PROTEIN; PARAQUAT; SYNUCLEIN;

EID: 1242264027     PISSN: 10298428     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF03033150     Document Type: Article
Times cited : (33)

References (87)
  • 4
    • 0026584524 scopus 로고
    • Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses?
    • Beal MF (1992) Does impairment of energy metabolism result in excitotoxic neuronal death in neurodegenerative illnesses? Ann. Neurol. 31, 119-130.
    • (1992) Ann. Neurol. , vol.31 , pp. 119-130
    • Beal, M.F.1
  • 7
    • 65549118912 scopus 로고    scopus 로고
    • bin/cas/tree/store/bres/cas_sub/browese/browse.cgi?year=1999&volume= 1823&issue=1991-1992&aid=15178.
  • 8
    • 0027446382 scopus 로고
    • Electron spin resonance spin-trapping investigation into the effects of paraquat and desferrioxamine on hydroxyl radical generation during acute iron poisoning
    • Burkitt MJ, MB Kadiiska, PM Hanna, SJ Jordan and RP Mason (1993) Electron spin resonance spin-trapping investigation into the effects of paraquat and desferrioxamine on hydroxyl radical generation during acute iron poisoning. Mol. Pharmacol. 43, 257-263.
    • (1993) Mol. Pharmacol. , vol.43 , pp. 257-263
    • Burkitt, M.J.1    Kadiiska, M.B.2    Hanna, P.M.3    Jordan, S.J.4    Mason, R.P.5
  • 9
    • 0021288059 scopus 로고
    • Paraquat: Model for oxidant-initiated toxicity
    • Bus JS and JE Gibson (1984) Paraquat: Model for oxidant-initiated toxicity. Environ. Health Perspect. 55, 37-46.
    • (1984) Environ. Health Perspect. , vol.55 , pp. 37-46
    • Bus, J.S.1    Gibson, J.E.2
  • 11
    • 0035116226 scopus 로고    scopus 로고
    • Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism
    • Chun HS, GE Gibson, LA DeGiorgio, H Zhang, VJ Kidd and JH Son (2001) Dopaminergic cell death induced by MPP(+), oxidant and specific neurotoxicants shares the common molecular mechanism. J. Neurochem. 76, 1010-1021.
    • (2001) J. Neurochem. , vol.76 , pp. 1010-1021
    • Chun, H.S.1    Gibson, G.E.2    DeGiorgio, L.A.3    Zhang, H.4    Kidd, V.J.5    Son, J.H.6
  • 12
    • 0024392071 scopus 로고
    • Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals
    • Clejan L and AI Cederbaum (1989) Synergistic interactions between NADPH-cytochrome P-450 reductase, paraquat, and iron in the generation of active oxygen radicals. Biochem. Pharmacol. 38, 1779-1786.
    • (1989) Biochem. Pharmacol. , vol.38 , pp. 1779-1786
    • Clejan, L.1    Cederbaum, A.I.2
  • 18
    • 0026484388 scopus 로고
    • The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it
    • Fahn S and G Cohen (1992) The oxidant stress hypothesis in Parkinson's disease: Evidence supporting it. Ann. Neurol. 32, 804-812.
    • (1992) Ann. Neurol. , vol.32 , pp. 804-812
    • Fahn, S.1    Cohen, G.2
  • 19
    • 0034704752 scopus 로고    scopus 로고
    • A Drosophila model of Parkinson's disease
    • Feany MB and WW Bender (2000) A Drosophila model of Parkinson's disease. Nature 404, 394-398.
    • (2000) Nature , vol.404 , pp. 394-398
    • Feany, M.B.1    Bender, W.W.2
  • 20
    • 0027360342 scopus 로고
    • Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice
    • Fredriksson A, M Fredriksson and P Eriksson (1993) Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice. Toxicol. Appl. Pharmacol. 122, 258-264.
    • (1993) Toxicol. Appl. Pharmacol. , vol.122 , pp. 258-264
    • Fredriksson, A.1    Fredriksson, M.2    Eriksson, P.3
  • 21
    • 0030300159 scopus 로고    scopus 로고
    • New horizons in molecular mechanisms underlying Parkinson's disease and in our understanding of the neuroprotective effects of selegiline
    • Gerlach M, H Desser, MB Youdim and P Riederer (1996) New horizons in molecular mechanisms underlying Parkinson's disease and in our understanding of the neuroprotective effects of selegiline. J. Neural Transm. Suppl. 48, 7-21.
    • (1996) J. Neural Transm. Suppl. , vol.48 , pp. 7-21
    • Gerlach, M.1    Desser, H.2    Youdim, M.B.3    Riederer, P.4
  • 22
    • 0034651575 scopus 로고    scopus 로고
    • A panel of epitope-specific antibodies detects protein domains distributed throughout human α-synuclein in Lewy bodies of Parkinson's disease
    • Giasson BL, R Jakes, M Goedert, JE Duda, S Leight, JQ Trojanowski and VM Lee (2000) A panel of epitope-specific antibodies detects protein domains distributed throughout human α-synuclein in Lewy bodies of Parkinson's disease. J. Neurosci. Res. 59, 528-533.
    • (2000) J. Neurosci. Res. , vol.59 , pp. 528-533
    • Giasson, B.L.1    Jakes, R.2    Goedert, M.3    Duda, J.E.4    Leight, S.5    Trojanowski, J.Q.6    Lee, V.M.7
  • 24
    • 0031843721 scopus 로고    scopus 로고
    • The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living
    • Gorell IM, CC Johnson, BA Rybicki, EL Peterson and RJ Richardson (1998) The risk of Parkinson's disease with exposure to pesticides, farming, well water, and rural living. Neurology 50, 1346-1350.
    • (1998) Neurology , vol.50 , pp. 1346-1350
    • Gorell, I.M.1    Johnson, C.C.2    Rybicki, B.A.3    Peterson, E.L.4    Richardson, R.J.5
  • 25
    • 0026635456 scopus 로고
    • Iron and oxygen radicals in brain
    • Gutteridge JM (1992) Iron and oxygen radicals in brain. Ann. Neurol. 32(Suppl.), S16-S21.
    • (1992) Ann. Neurol. , vol.32 , Issue.SUPPL.
    • Gutteridge, J.M.1
  • 26
    • 0032879452 scopus 로고    scopus 로고
    • Role of cytochrome c as a stimulator of α-synuclein aggregation in Lewy body disease
    • Hashimoto M, A Takeda, LJ Hsu, T Takenouchi and E Masliah (1999) Role of cytochrome c as a stimulator of α-synuclein aggregation in Lewy body disease. J. Biol. Chem. 274, 28849-28852.
    • (1999) J. Biol. Chem. , vol.274 , pp. 28849-28852
    • Hashimoto, M.1    Takeda, A.2    Hsu, L.J.3    Takenouchi, T.4    Masliah, E.5
  • 27
    • 0037893927 scopus 로고    scopus 로고
    • α-Synuclein protects against oxidative stress via inactivation of the c-jun N-terminal kinase stress signaling pathway in neuronal cells
    • Hashimoto M, LJ Hsu, E Rockestein, T Takenouchi, M Mallory and E Masliah (2002) α-Synuclein protects against oxidative stress via inactivation of the c-jun N-terminal kinase stress signaling pathway in neuronal cells. J. Biol. Chem. 14, 14.
    • (2002) J. Biol. Chem. , vol.14 , pp. 14
    • Hashimoto, M.1    Hsu, L.J.2    Rockestein, E.3    Takenouchi, T.4    Mallory, M.5    Masliah, E.6
  • 28
    • 0025230379 scopus 로고
    • Parkinson's disease: A case-control study of occupational and environmental risk factors
    • Hertzman C, M Wiens, D Bowering, B Snow and D Calne (1990) Parkinson's disease: A case-control study of occupational and environmental risk factors. Am. J. Ind. Med. 17 349-355.
    • (1990) Am. J. Ind. Med. , vol.17 , pp. 349-355
    • Hertzman, C.1    Wiens, M.2    Bowering, D.3    Snow, B.4    Calne, D.5
  • 29
    • 0026637866 scopus 로고
    • Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease?
    • Hirsch EC (1992) Why are nigral catecholaminergic neurons more vulnerable than other cells in Parkinson's disease? Ann. Neurol. 32, S88-S93.
    • (1992) Ann. Neurol. , vol.32
    • Hirsch, E.C.1
  • 30
    • 84996080984 scopus 로고
    • Selective vulnerability of pigmented dopaminergic neurons in Parkinson's disease
    • Hirsch EC, AM Graybiel and Y Agid (1989) Selective vulnerability of pigmented dopaminergic neurons in Parkinson's disease. Acta Neurol. Scand. Suppl. 126, 19-22.
    • (1989) Acta Neurol. Scand. Suppl. , vol.126 , pp. 19-22
    • Hirsch, E.C.1    Graybiel, A.M.2    Agid, Y.3
  • 33
    • 0028968082 scopus 로고
    • Geographical variations in mortality from Parkinson's disease in Japan, 1977-1985
    • Imaizumi Y (1995) Geographical variations in mortality from Parkinson's disease in Japan, 1977-1985. Acta Neurol. Scand. 91, 311-316.
    • (1995) Acta Neurol. Scand. , vol.91 , pp. 311-316
    • Imaizumi, Y.1
  • 35
    • 0027185713 scopus 로고
    • Altered mitochondrial function, iron metabolism and glutathone levels in Parkinson's disease
    • Jenner P (1993) Altered mitochondrial function, iron metabolism and glutathone levels in Parkinson's disease. Acta Neurol. Scand. Suppl. 146, 6-13.
    • (1993) Acta Neurol. Scand. Suppl. , vol.146 , pp. 6-13
    • Jenner, P.1
  • 36
    • 0031687793 scopus 로고    scopus 로고
    • Understanding cell death in Parkinson's disease
    • Jenner P and CW Olanow (1998) Understanding cell death in Parkinson's disease. Ann. Neurol. 44, S72-S84.
    • (1998) Ann. Neurol. , vol.44
    • Jenner, P.1    Olanow, C.W.2
  • 37
    • 0036329641 scopus 로고    scopus 로고
    • Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: Relevance for Parkinson's disease?
    • Jha N, MJ Kumar, R Boonplueang and JK Andersen (2002) Glutathione decreases in dopaminergic PC12 cells interfere with the ubiquitin protein degradation pathway: Relevance for Parkinson's disease? J. Neurochem. 80, 555-561.
    • (2002) J. Neurochem. , vol.80 , pp. 555-561
    • Jha, N.1    Kumar, M.J.2    Boonplueang, R.3    Andersen, J.K.4
  • 38
    • 0026524695 scopus 로고
    • Exposure to well water and pesticides in Parkinson's disease: A case-control study in the Madrid area
    • Jimenez-Jimenez FJ, D Mateo and S Gimenez-Roldan (1992) Exposure to well water and pesticides in Parkinson's disease: A case-control study in the Madrid area. Mov. Disord. 7, 149-152.
    • (1992) Mov. Disord. , vol.7 , pp. 149-152
    • Jimenez-Jimenez, F.J.1    Mateo, D.2    Gimenez-Roldan, S.3
  • 39
    • 0037040491 scopus 로고    scopus 로고
    • Human α-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine
    • Junn E and MM Mouradian (2002) Human α-synuclein over-expression increases intracellular reactive oxygen species levels and susceptibility to dopamine. Neurosci. Lett. 320, 146-150.
    • (2002) Neurosci. Lett. , vol.320 , pp. 146-150
    • Junn, E.1    Mouradian, M.M.2
  • 40
    • 0027526988 scopus 로고
    • In vivo ESR spin trapping evidence for hydroxyl radical-mediated toxicity of paraquat and copper in rats
    • Kadiiska MB, PM Hanna and RP Mason (1993) In vivo ESR spin trapping evidence for hydroxyl radical-mediated toxicity of paraquat and copper in rats. Toxicol. Appl. Pharmacol. 123, 187-192.
    • (1993) Toxicol. Appl. Pharmacol. , vol.123 , pp. 187-192
    • Kadiiska, M.B.1    Hanna, P.M.2    Mason, R.P.3
  • 42
    • 0022762974 scopus 로고
    • Paraquat and Parkinson's disease
    • Koller WC (1986) Paraquat and Parkinson's disease. Neurology 36, 1147.
    • (1986) Neurology , vol.36 , pp. 1147
    • Koller, W.C.1
  • 44
    • 0030864433 scopus 로고    scopus 로고
    • Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice
    • Lan J and DH Jiang (1997a) Desferrioxamine and vitamin E protect against iron and MPTP-induced neurodegeneration in mice. J. Neural Transm. 104, 469-481.
    • (1997) J. Neural Transm. , vol.104 , pp. 469-481
    • Lan, J.1    Jiang, D.H.2
  • 45
    • 0030666415 scopus 로고    scopus 로고
    • Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease
    • Lan J and DH Jiang (1997b) Excessive iron accumulation in the brain: A possible potential risk of neurodegeneration in Parkinson's disease. J. Neural Transm. 104, 649-660.
    • (1997) J. Neural Transm. , vol.104 , pp. 649-660
    • Lan, J.1    Jiang, D.H.2
  • 46
    • 0020680904 scopus 로고
    • Chronic Parkinsonism in humans due to a product of meperidine analog synthesis
    • Langston JW, P Ballard, JW Tetrud and I Irwin (1983) Chronic Parkinsonism in humans due to a product of meperidine analog synthesis. Science 219, 979-980.
    • (1983) Science , vol.219 , pp. 979-980
    • Langston, J.W.1    Ballard, P.2    Tetrud, J.W.3    Irwin, I.4
  • 47
    • 0030795781 scopus 로고    scopus 로고
    • The geographic distribution of Parkinson's disease mortality in the United States
    • Lanska DJ (1997) The geographic distribution of Parkinson's disease mortality in the United States. J. Neurol. Sci. 150, 63-70.
    • (1997) J. Neurol. Sci. , vol.150 , pp. 63-70
    • Lanska, D.J.1
  • 48
    • 0035109909 scopus 로고    scopus 로고
    • Effect of the overexpression of wild-type or mutant α-synuclein or cell susceptibility to insult
    • Lee M, D Hyun, B Halliwell and P Jenner (2001) Effect of the overexpression of wild-type or mutant α-synuclein or cell susceptibility to insult. J. Neurochem. 76, 998-1009.
    • (2001) J. Neurochem. , vol.76 , pp. 998-1009
    • Lee, M.1    Hyun, D.2    Halliwell, B.3    Jenner, P.4
  • 49
    • 0029918777 scopus 로고    scopus 로고
    • Effects of paraquat on the substantia nigra of the wistar rats: Neurochemical, histological, and behavioral studies
    • Liou HH, RC Chen, YF Tsai, WP Chen, YC Chang and MC Tsai (1996) Effects of paraquat on the substantia nigra of the wistar rats: Neurochemical, histological, and behavioral studies. Toxicol. Appl. Pharmacol. 137, 34-41.
    • (1996) Toxicol. Appl. Pharmacol. , vol.137 , pp. 34-41
    • Liou, H.H.1    Chen, R.C.2    Tsai, Y.F.3    Chen, W.P.4    Chang, Y.C.5    Tsai, M.C.6
  • 51
    • 0035312466 scopus 로고    scopus 로고
    • Attenuation of paraquat-induced dopaminergic toxicity on the substantia migra by (-)-deprenyl in vivo
    • Liou HH, RC Chen, TH Chen, YF Tsai and MC Tsai (2001) Attenuation of paraquat-induced dopaminergic toxicity on the substantia migra by (-)-deprenyl in vivo. Toxicol. Appl. Pharmacol. 172, 37-43.
    • (2001) Toxicol. Appl. Pharmacol. , vol.172 , pp. 37-43
    • Liou, H.H.1    Chen, R.C.2    Chen, T.H.3    Tsai, Y.F.4    Tsai, M.C.5
  • 53
    • 0037127197 scopus 로고    scopus 로고
    • The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice: Paraquat and α-synuclein
    • Manning-Bog AB, AL McCormack, J Li, VN Uversky, AL Fink and D Di Monte (2002) The herbicide paraquat causes up-regulation and aggregation of α-synuclein in mice: Paraquat and α-synuclein. J. Biol. Chem. 277, 1641-1644.
    • (2002) J. Biol. Chem. , vol.277 , pp. 1641-1644
    • Manning-Bog, A.B.1    McCormack, A.L.2    Li, J.3    Uversky, V.N.4    Fink, A.L.5    Di Monte, D.6
  • 55
    • 0037380982 scopus 로고    scopus 로고
    • Effects of l-dopa and other amino acids against paraquat-induced nigrostriatal degeneration
    • McCormack AL and D Di Monte (2003) Effects of l-dopa and other amino acids against paraquat-induced nigrostriatal degeneration. J. Neurochem. 85, 82-86.
    • (2003) J. Neurochem. , vol.85 , pp. 82-86
    • McCormack, A.L.1    Di Monte, D.2
  • 57
    • 0034468706 scopus 로고    scopus 로고
    • Crosslinking of α-synuclein by advanced glycation endproducts - An early pathophysiological step in Lewy body formation?
    • Munch G, HJ Luth, A Wong, T Arendt, E Hirsch, R Ravid and P Riederer (2000) Crosslinking of α-synuclein by advanced glycation endproducts - an early pathophysiological step in Lewy body formation? J. Chem. Neuroanat. 20, 253-257.
    • (2000) J. Chem. Neuroanat. , vol.20 , pp. 253-257
    • Munch, G.1    Luth, H.J.2    Wong, A.3    Arendt, T.4    Hirsch, E.5    Ravid, R.6    Riederer, P.7
  • 59
    • 0033564726 scopus 로고    scopus 로고
    • Copper(II)-induced self-oligomerization of α-synuclein
    • Paik SR, HJ Shin, JH Lee, CS Chang and J Kim (1999) Copper(II)-induced self-oligomerization of α-synuclein. Biochem. J. 340, 821-828.
    • (1999) Biochem. J. , vol.340 , pp. 821-828
    • Paik, S.R.1    Shin, H.J.2    Lee, J.H.3    Chang, C.S.4    Kim, J.5
  • 60
    • 0022553605 scopus 로고
    • Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients
    • Perry TL and VW Yong (1986) Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients. Neurosci. Lett. 67, 269-274.
    • (1986) Neurosci. Lett. , vol.67 , pp. 269-274
    • Perry, T.L.1    Yong, V.W.2
  • 61
    • 0020308323 scopus 로고
    • Parkinson's disease: A disorder due to nigral glutathione deficiency?
    • Perry TL, DV Godin and S Hansen (1982) Parkinson's disease: A disorder due to nigral glutathione deficiency? Neurosci. Lett. 33, 305-310.
    • (1982) Neurosci. Lett. , vol.33 , pp. 305-310
    • Perry, T.L.1    Godin, D.V.2    Hansen, S.3
  • 62
    • 0022445973 scopus 로고
    • Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to not damage dopaminergic nigrostriatal neurons in the mouse
    • Perry TL, VW Yong, RA Wall and K Jones (1986) Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine to not damage dopaminergic nigrostriatal neurons in the mouse. Neurosci. Lett. 69, 285-289.
    • (1986) Neurosci. Lett. , vol.69 , pp. 285-289
    • Perry, T.L.1    Yong, V.W.2    Wall, R.A.3    Jones, K.4
  • 63
    • 0022353536 scopus 로고
    • The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals
    • Poirier J, J Donaldson and A Barbeau (1985) The specific vulnerability of the substantia nigra to MPTP is related to the presence of transition metals. Biochem. Biophys. Res. Commun. 128, 25-33.
    • (1985) Biochem. Biophys. Res. Commun. , vol.128 , pp. 25-33
    • Poirier, J.1    Donaldson, J.2    Barbeau, A.3
  • 65
    • 0035091767 scopus 로고    scopus 로고
    • The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): A technical review of its utility and safety
    • Przedborski S, V Jackson-Lewis, AB Naini, M Jakowec, G Petzinger, R Miller and M Akram (2001) The parkinsonian toxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP): A technical review of its utility and safety. J. Neurochem. 76, 1265-1274.
    • (2001) J. Neurochem. , vol.76 , pp. 1265-1274
    • Przedborski, S.1    Jackson-Lewis, V.2    Naini, A.B.3    Jakowec, M.4    Petzinger, G.5    Miller, R.6    Akram, M.7
  • 67
    • 0023897535 scopus 로고
    • Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain
    • Schneider JS and FJ Denaro (1988) Astrocytic responses to the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in cat and mouse brain. J. Neuropathol. Exp. Neurol. 47, 452-458.
    • (1988) J. Neuropathol. Exp. Neurol. , vol.47 , pp. 452-458
    • Schneider, J.S.1    Denaro, F.J.2
  • 68
    • 0026711037 scopus 로고
    • Parkinson's disease and exposure to agricultural work and pesticide chemicals
    • Semchuk KM, EJ Love and RG Lee (1992) Parkinson's disease and exposure to agricultural work and pesticide chemicals. Neurology 42, 1328-1335.
    • (1992) Neurology , vol.42 , pp. 1328-1335
    • Semchuk, K.M.1    Love, E.J.2    Lee, R.G.3
  • 69
    • 0032030445 scopus 로고    scopus 로고
    • Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers
    • Shimada H, K Hirai, E Simamura and J Pan (1998) Mitochondrial NADH-quinone oxidoreductase of the outer membrane is responsible for paraquat cytotoxicity in rat livers. Arch. Biochem. Biophys. 351, 75-81.
    • (1998) Arch. Biochem. Biophys. , vol.351 , pp. 75-81
    • Shimada, H.1    Hirai, K.2    Simamura, E.3    Pan, J.4
  • 71
    • 0025963530 scopus 로고
    • Selective increase of iron in substantia nigra zona compacta of parkinsonian brains
    • Sofic E, W Paulus, K Jellinger, P Riederer and MB Youdim (1991) Selective increase of iron in substantia nigra zona compacta of parkinsonian brains. J. Neurochem. 56, 978-982.
    • (1991) J. Neurochem. , vol.56 , pp. 978-982
    • Sofic, E.1    Paulus, W.2    Jellinger, K.3    Riederer, P.4    Youdim, M.B.5
  • 73
    • 0032568534 scopus 로고    scopus 로고
    • α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies
    • Spillantini MG, RA Crowther, R Jakes, M Hasegawa and M Goedert (1998) α-Synuclein in filamentous inclusions of Lewy bodies from Parkinson's disease and dementia with Lewy bodies. Proc. Natl. Acad. Sci. USA 95, 6469-6473.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6469-6473
    • Spillantini, M.G.1    Crowther, R.A.2    Jakes, R.3    Hasegawa, M.4    Goedert, M.5
  • 74
    • 0034697823 scopus 로고    scopus 로고
    • Exposure to home pesticides linked to Parkinson disease
    • Stephenson J (2000) Exposure to home pesticides linked to Parkinson disease. JAMA 283, 3055-3056.
    • (2000) JAMA , vol.283 , pp. 3055-3056
    • Stephenson, J.1
  • 76
    • 0025354340 scopus 로고
    • Developmental changes in transferrin and iron uptake by the brain in the rat
    • Taylor EM and EH Morgan (1990) Developmental changes in transferrin and iron uptake by the brain in the rat. Brain Res. Dev. Brain Res. 55, 35-42.
    • (1990) Brain Res. Dev. Brain Res. , vol.55 , pp. 35-42
    • Taylor, E.M.1    Morgan, E.H.2
  • 77
    • 0025993856 scopus 로고
    • Transferrin and iron uptake by the brain: Effects of altered iron status
    • Taylor EM, A Crowe and EH Morgan (1991) Transferrin and iron uptake by the brain: Effects of altered iron status. J. Neurochem. 57, 1584-1592.
    • (1991) J. Neurochem. , vol.57 , pp. 1584-1592
    • Taylor, E.M.1    Crowe, A.2    Morgan, E.H.3
  • 78
    • 0034637267 scopus 로고    scopus 로고
    • Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: Environmental risk factors for Parkinson's disease?
    • Thiruchelvam M, BJ Brockel, EK Richfield, RB Baggs and DA Cory-Slechta (2000) Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: Environmental risk factors for Parkinson's disease? Brain Res. 873, 225-234.
    • (2000) Brain Res. , vol.873 , pp. 225-234
    • Thiruchelvam, M.1    Brockel, B.J.2    Richfield, E.K.3    Baggs, R.B.4    Cory-Slechta, D.A.5
  • 79
    • 0031910093 scopus 로고    scopus 로고
    • Aggregation of neurofilament and α-synuclein proteins in Lewy bodies: Implications for the pathogenesis of Parkinson disease and Lewy body Dementia
    • Trojanowski JQ and VM Lee (1998) Aggregation of neurofilament and α-synuclein proteins in Lewy bodies: Implications for the pathogenesis of Parkinson disease and Lewy body dementia. Arch. Neurol. 55, 151-152.
    • (1998) Arch. Neurol. , vol.55 , pp. 151-152
    • Trojanowski, J.Q.1    Lee, V.M.2
  • 80
    • 0031762949 scopus 로고    scopus 로고
    • Fatal attractions: Abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia
    • Trojanowski JQ, M Goedert, T Iwatsubo and VM Lee (1998) Fatal attractions: Abnormal protein aggregation and neuron death in Parkinson's disease and Lewy body dementia. Cell Death Differ. 5, 832-837.
    • (1998) Cell Death Differ. , vol.5 , pp. 832-837
    • Trojanowski, J.Q.1    Goedert, M.2    Iwatsubo, T.3    Lee, V.M.4
  • 81
    • 0035941201 scopus 로고    scopus 로고
    • Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure
    • Uversky VN, J Li and AL Fink (2001a) Metal-triggered structural transformations, aggregation, and fibrillation of human α-synuclein. A possible molecular NK between Parkinson's disease and heavy metal exposure. J. Biol. Chem. 276, 44284-44296.
    • (2001) J. Biol. Chem. , vol.276 , pp. 44284-44296
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 82
    • 0035816404 scopus 로고    scopus 로고
    • Pesticides directly accelerate the rate of α-synuclein fibril formation: A possible factor in Parkinson's disease
    • Uversky VN, J Li and AL Fink (2001b) Pesticides directly accelerate the rate of α-synuclein fibril formation: A possible factor in Parkinson's disease. FEBS Lett. 500, 105-108.
    • (2001) FEBS Lett. , vol.500 , pp. 105-108
    • Uversky, V.N.1    Li, J.2    Fink, A.L.3
  • 83
    • 0029866523 scopus 로고    scopus 로고
    • Influence of age on the passage of paraquat through the blood-brain barrier in rats: A distribution and pathological examination
    • Widdowson PS, MJ Farnworth, MG Simpson and EA Lock (1996a) Influence of age on the passage of paraquat through the blood-brain barrier in rats: a distribution and pathological examination. Hum. Exp. Toxicol. 15, 231-236.
    • (1996) Hum. Exp. Toxicol. , vol.15 , pp. 231-236
    • Widdowson, P.S.1    Farnworth, M.J.2    Simpson, M.G.3    Lock, E.A.4
  • 84
    • 0029739461 scopus 로고    scopus 로고
    • No changes in behaviour, nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats
    • Widdowson PS, MJ Farnworth, R Upton and MG Simpson (1996b) No changes in behaviour, nigro-striatal system neurochemistry or neuronal cell death following toxic multiple oral paraquat administration to rats. Hum. Exp. Toxicol. 15, 583-591.
    • (1996) Hum. Exp. Toxicol. , vol.15 , pp. 583-591
    • Widdowson, P.S.1    Farnworth, M.J.2    Upton, R.3    Simpson, M.G.4
  • 86
    • 0031943867 scopus 로고    scopus 로고
    • Paraquat-induced free radical reaction in mouse brain microsomes
    • Yang W and AY Sun (1998) Paraquat-induced free radical reaction in mouse brain microsomes. Neurochem. Res. 23, 47-53.
    • (1998) Neurochem. Res. , vol.23 , pp. 47-53
    • Yang, W.1    Sun, A.Y.2
  • 87
    • 0027497409 scopus 로고
    • The possible role of iron in the etiopathology of Parkinson's disease
    • [published erratum appears in Mov. Disord. 1993 Apr; 8 (2):255]
    • Youdim MB, D Ben-Schachar and P Riederer (1993) The possible role of iron in the etiopathology of Parkinson's disease [published erratum appears in Mov. Disord. 1993 Apr; 8 (2):255]. Mov. Disord. 8, 1-12.
    • (1993) Mov. Disord. , vol.8 , pp. 1-12
    • Youdim, M.B.1    Ben-Schachar, D.2    Riederer, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.