Effects of paraquat on the substantia nigra of the Wistar rats: Neurochemical, histological, and behavioral studies

Toxicology and Applied Pharmacology

Volumn 137, Issue 1, 1996, Pages 34-41

  Liou, Horng Huei ^a   Chen, Rong Chi ^a   Tsai, Yuan Feen ^a   Chen, Wen Pin ^a   Chang, Yang Chyuan ^a   Tsai, Ming Cheng ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

APOMORPHINE; DOPAMINE; PARAQUAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR; CONTROLLED STUDY; DOPAMINERGIC SYSTEM; DOSE RESPONSE; HISTOLOGY; MALE; NEUROCHEMISTRY; NONHUMAN; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; SUBSTANTIA NIGRA;

EID: 0029918777     PISSN: 0041008X     EISSN: None     Source Type: Journal    
DOI: 10.1006/taap.1996.0054     Document Type: Article

References (57)

1. Ballard, P. A., Tetrude, J. W., and Langston, J. W. (1985). Permanent human parkinsonism due to MPTP. Neurology 35, 969-976.
2. Barbeau, A., Roy, M., Cloutier, T., Plasse, L., and Paris, S. (1986). Environmental and genetic factors in the etiology of Parkinson's disease. In Advances in Neurology (M. D. Yahr and K. J. Bergmann, Eds.), Vol. 45, pp. 299-306. Raven, New York.
3. Barbeau, A., Roy, M., Bernier, G., Campanella, G., and Paris, S. (1987). Ecogenetics of Parkinson's disease: Prevalence and environmental aspects in rural areas. Can. J. Neurol. Sci. 14, 36-413.
4. Bocchetta, A., and Corsini, G. U. (1986). Parkinson's disease and pesticides. Lancet 2, 1163.
5. Bradbury, A. J., Costall, B., Domeney, A. M., Jenner, P., Kelly, M. E., Marsden, C. D., and Naylor, R. J. (1986). 1-Methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway. Nature 319, 56-57.
6. Burns, R. S., Chiueh, C. C., Markey, S. P., Ebert, M. H., Jacobowitz, D. M., and Kopin, I. J. (1983). A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Proc. Natl. Acad. Sci. USA 80, 4546-4550.
7. Burns, R. S., LeWitt, P. A., Ebert, M. H., Pakkenberg, H., and Kopin, I. J. (1985). The clinical syndrome of striatal dopamine deficiency; parkinsonism induced by MPTP. N. Engl. J. Med. 312, 1418-1421.
8. Bus, J. S., Cagen, S. Z., Olgaard, M., and Gibson, J. E. (1976). A mechanism of paraquat toxicity in mice and rats. Toxicol. Appl. Pharmacol. 35, 501-513.
9. Calne, D. B., and Langston, J. W. (1983). On the etiology of Parkinson's disease. Lancet 2, 1457-1459.
10. Calo, M., Iannone, M., Passafaro, M., and Nistico, G. (1990). Selective vulnerability of hippocampal CA3 neurones after microinfusion of paraquat into the rat substantia nigra or into the ventral tegmental area. J. Comp. Pathol. 103, 73-78.
11. Chui, Y. C., Poon, G., and Law, F. (1988). Toxicokinetics and bioavailability of paraquat in rats following different routes of administration. Toxicol. Indust. Health 4, 203-219.
12. Corasaniti, M. T., and Nistico, G. (1993). Determination of paraquat in rat brain by high-performance liquid chromatography. J. Chromatogr. 643, 419-425.
13. Costantini, P., Petronilli, V., Colonna, R., and Bernardi, P. (1995). On the effects of paraquat on isolated mitochondria. Evidence that paraquat causes opening of the cyclosporine A-sensitive permeability transition pore synergistically with nitric oxide. Toxicology 99, 77-88.
14. Creese, I., Burt, D. R., and Snyder, S. H. (1977). Dopamine receptor binding enhancement accompanies lesion-induced behavioural supersensitivity. Science 197, 596-598.
15. Endo, T., Hara, S., Kuriiwa, F., and Kano, S. (1988). Effects of a paraquat-containing herbicide, Gramoxon, on the central monoamines and acetylcholine in mice. Res. Commun. Psychol. Psych. Behav. 13, 261-270.
16. Ferraz, H. B., Hertolucci, P. H. F., Pereira, J. S., Lima, J. G. C., and Andrade, L. A. F. (1988). Chronic exposure to the fungicide Maneb may produce symptoms and signs of CNS manganese intoxication. Neurology 38, 550-553.
17. Fleming, L., Mann, J. B., Bean, J., Briggle, T., and Sanchez-Ramos, J. R. (1994). Parkinson's disease and brain level of organochlorine pesticides. Ann. Neurol. 36, 100-103.
18. Fredriksson, A., Fredriksson, M., and Eriksson, P. (1993). Neonatal exposure to paraquat or MPTP induces permanent changes in striatum dopamine and behavior in adult mice. Toxicol. Appl. Pharmacol. 122, 258-264.
19. Fukushima, T., Yamada, K., Hojo, N., Isobe, A., and Shiwaku, K. (1994). Mechanism of cytotoxicity of paraquat. III. The effects of acute paraquat exposure on the electron transport system in rat mitochondria. Exp. Toxicol. Pathol. 46, 437-441.
20. + (1-methyl-4-phenylpyridium) in rat and mouse. Brain Res. 461, 361-366.
21. Harik, S. I., Schmidley, J. W., Iacofano, L. A., Blue, P., Arora, P. K., and Sayre, L. M. (1987). On the mechanisms underlying 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity: The effect of peringral infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, its metabolite, and their analogs in the rat. J. Pharmacol. Exp. Ther. 241, 669-676.
22. Hefti, F., Enz, A., and Melamed, E. (1985). Partial lesions of the nigrostriatal pathway in the rats. Neuropharmacology 24, 19-23.
23. 3H]spiroperidol binding and rotational behavior in unilateral 6-hydroxydopamine-lesioned rats. Brain Res. 211, 285-292.
24. +) to rats. Neurosci. Lett. 59, 135-140.
25. Hertzman, C., Wiens, M., Bowering, D., Snow, B., and Calne, D. (1990). Parkinson's disease: A case-control study of occupational and environmental risk factors. Am. J. Ind. Med. 17, 349-355.
26. Hirai, K. I., Witschi, H., and Cote, M. G. (1985). Mitochondrial injury of pulmonary alveolar epithelial cells in acute paraquat intoxication. Exp. Mol. Pathol. 43, 242-252.
27. Ho, S. C., Woo, J., and Lee, C. M. (1989). Epidemiologic study of Parkinson's disease in Hong Kong. Neurology 39, 1314-1318.
28. Hudson, J. L., Levin, D. R., and Hoffer, B. J. (1993). A sixteen-channel automated rotometer system for reliable measurement of turning behavior in 6-hydroxydopamine lesioned and transplanted rats. Cell Transpl. 2, 507-514.
29. Javitch, J. A., D'Amato, R. J., Strittmatter, S. M., and Snyder, S. H. (1985). Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc. Natl. Acad. Sci. USA 82, 2173-2177.
30. Jimenez-Jimenez, F. J., Mateo, D., and Gimenez-Roldan, S. (1992). Exposure to well water and pesticides in Parkinson's disease: A case-control study in the Madrid area. Movement Disord. 7, 149-152.
31. Kadiiska, M. B., Hanna, P. M., and Mason, R. P. (1993). In vivo ESR spin trapping evidence for hydroxyl radical-mediated toxicity of paraquat and copper in rats. Toxicol. Appl. Pharmacol. 123, 187-192.
32. + administration. Eur. J. Pharmacol. 175, 57-61.
33. Langsten, J. W., Ballard, P., Tetrud, J. W., and Irwin, I. (1983). Chronic parkinsonism in humans due to a product of meperidine analog synthesis. Science 219, 979-980.
34. Lewin, R. (1985). Parkinson's disease: An environmental cause? Science 229, 257-258.
35. 3H-MTPT. Acta Pharmacol. Toxicol. 59, 161-164.
36. 14C]diquat in frogs and mice: accumulation in neuromelanin. Neurosci. Lett. 93, 1-6.
37. Lowry, O. H., Rosebrough, N. J., Farr, A. L., and Randall, R. J. (1951). Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275.
38. +(1-methyl-4-phenylpyridine) is a neurotoxin to dopamine-, norephrine-and sertonin-containing neurons. Eur. J. Pharmacol. 136, 31-37.
39. +, a metabolite of the neurotoxin MPTP. Life Sci. 36, 2503-2508.
40. Palkovits, M. (1973). Isolated removal of hypothalamic or other brain nuclei of the brain of the rat. Brain Res. 59, 449-450.
41. Paxinos, G., and Waston, C. (1986). The Rat Brain in Stereotaxic Coordinates. Academic Press, London.
42. Perry, T. L., Yong, V. W., Wall, R. A., and Jones, K. (1986). Paraquat and two endogenous analogues of the neurotoxic substance N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine do not damage dopaminergic nigrostriatal neurons in the mouse. Neurosci. Lett. 69, 285-289.
43. Peters, H. A., Levine, R. L., Matthews, C. G., and Chapman, L. J. (1988). Extrapyramidal and other neurologic manifestations associated with carbon disulfide fumigant exposure. Arch. Neurol. 45, 537-540.
44. Scatton, B., Javoy-Agid, F., Rouquier, L., Dobis, B., and Agid, Y. (1983). Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease. Brain Res. 275, 321-328.
45. Schapira, A. H. V., Cooper, J. M., Dexter, D., Clark, J. B., Jenner, P., and Marsden, C. D. (1990). Mitochondrial complex I deficiency in Parkinson's disease. J. Neurochem. 54, 823-827.
46. Shoffner, J. M., Watts, R. L., Juncos, J. L., Torroni, A., and Wallace, D. C. (1991). Mitochondrial oxidative phosphorylation defects in Parkinson's disease. Ann. Neurol. 30, 332-339.
47. + into the nigrostriatal dopamine pathway-1. Behavioral, neurochemical and histological characterization of the lesion. Neuroscience 27, 117-128.
48. Sun, C. J., Johannessen, J. N., Gessner, W., Namura, I., Singhaniyom, W., Brossi, A., and Chiueh, C. C. (1988). Neurotoxic damage to the nigrostriatal system in rats following intranigral administration of MPDP+ and MPP+. J. Neural. Transm. 74, 75-86.
49. Tanner, C. M. (1989). The role of environmental toxins in the etiology of Parkinson's disease. Trends Neurosci. 12, 49-54.
50. Tanner, C. M., Chen, B., Wang, W., Peng, M., Liu, Z., Liang, X., Kao, L. C., Gilley, D. W., Goetz, C. G., and Schoenberg, B. G. (1989). Environmental factors and Parkinson's disease: a case-control study in China. Neurology 39, 660-664.
51. Trush, M. A., Mimnaugh, E. G., Ginsberg, E., 61nd Gram, T. E. (1981). In vivo stimulation by paraquat of reactive oxygen-mediated lipid peroxidation in rat lung microsomes. Toxicol. Appl. Pharmacol. 60, 279-286.
52. Tsai, Y. F., Wang, H. J., Tai, M. Y., and Lu, K. S. (1991). Norepinephrine levels in the vomeronasal system and their responses to male urine in young and old female rats. Proc. Natl. Sci. Counc. ROC B. 15, 75-79.
53. Tsai, Y. F., Tsai, H. W., and Tai, M. Y. (1994). Comparison of brain dopamine depletion induced by low-dose 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in young and aged rats. Neurosci. Res. 20, 27-33.
54. Udea, T., Hirai, K. I., and Ogawa, K. (1985). Effects of paraquat on the mitochondrial structure and Ca-ATPase activity in rat hepatocytes. J. Electron Microsc. 34, 85-91.
55. Ungerstedt, U. (1971). Striatal dopamine release after amphetamine or nerve degeneration revealed by rotational behavior. Acta. Phys. (Suppl.) 367, 49-66.
56. Ungerstedt, U., and Arbuthnott, F. W. (1970). Quantitative recording of rotational behavior in rats after 6-hydroxydopamine lesions of the nigrostriatal dopamine system. Brain Res. 24, 485-493.
57. Wang, G. Y., Hirai, K. I., and Shimada, H. (1992). Mitochondrial breakage induced by the herbicide paraquat in cultured human lung cells. J. Electron Microsc. 41, 181-184.