메뉴 건너뛰기




Volumn 52, Issue 6, 2004, Pages 401-409

RNA interference: A potential novel therapeutic combating HIV-1 in the central nervous system

Author keywords

HIV 1; RNA interference; siRNA; Therapeutics

Indexed keywords

LENTIVIRUS VECTOR; SMALL INTERFERING RNA;

EID: 12244311916     PISSN: 0004069X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (136)
  • 2
    • 0029778294 scopus 로고    scopus 로고
    • Neurovirulent simian immunodeficiency virus infection induce neuronal, endothelial, and glial apoptosis
    • Adamson D. C., Dawson T. M., Zink M. C., Clements J. E. and Dawson V. L. (1996): Neurovirulent simian immunodeficiency virus infection induce neuronal, endothelial, and glial apoptosis. Mol. Med., 2, 417-428.
    • (1996) Mol. Med. , vol.2 , pp. 417-428
    • Adamson, D.C.1    Dawson, T.M.2    Zink, M.C.3    Clements, J.E.4    Dawson, V.L.5
  • 6
    • 0037440005 scopus 로고    scopus 로고
    • Tolerance for mutations and chemical modifications in a siRNA
    • Amarzguioui M., Holen T., Babaie E. and Prydz H. (2003): Tolerance for mutations and chemical modifications in a siRNA. Nucleic Acids Res., 31, 589-595.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 589-595
    • Amarzguioui, M.1    Holen, T.2    Babaie, E.3    Prydz, H.4
  • 8
    • 0030011404 scopus 로고    scopus 로고
    • Cellular reservoirs of HIV-1 in the central nervous system of infected-individuals: Identification by the combination of in situ PCR and immunohistochemistry
    • Bagasra O., Lavi E., Bobroski L., Khalili K., Pestaner J. P. and Pomerantz R. J. (1996): Cellular reservoirs of HIV-1 in the central nervous system of infected-individuals: identification by the combination of in situ PCR and immunohistochemistry. AIDS, 10, 573-586.
    • (1996) AIDS , vol.10 , pp. 573-586
    • Bagasra, O.1    Lavi, E.2    Bobroski, L.3    Khalili, K.4    Pestaner, J.P.5    Pomerantz, R.J.6
  • 9
    • 0030052843 scopus 로고    scopus 로고
    • Intracerebral infection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat
    • Bagetta G., Corasaniti M. T., Aloe L., Berliocchi L., Costa N., Finazzai-Agro A. and Nistico G. (1996): Intracerebral infection of human immunodeficiency virus type 1 coat protein gp120 differentially affects the expression of nerve growth factor and nitric oxide synthase in the hippocampus of rat. Proc. Natl. Acad. Sci. USA, 93, 928-933.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 928-933
    • Bagetta, G.1    Corasaniti, M.T.2    Aloe, L.3    Berliocchi, L.4    Costa, N.5    Finazzai-Agro, A.6    Nistico, G.7
  • 10
    • 0029757620 scopus 로고    scopus 로고
    • The human immunodeficiency virus type 1 regulatory protein Tat inhibits interferon-induced iNOS activity in a murine acrophage cell-line
    • Barton C. H., Biggs T. E., Mee T. R. and Mann D. A. (1996): The human immunodeficiency virus type 1 regulatory protein Tat inhibits interferon-induced iNOS activity in a murine acrophage cell-line. J. Gen. Virol., 77, 1643-1647.
    • (1996) J. Gen. Virol. , vol.77 , pp. 1643-1647
    • Barton, C.H.1    Biggs, T.E.2    Mee, T.R.3    Mann, D.A.4
  • 11
    • 0037069417 scopus 로고    scopus 로고
    • Retroviral delivery of small interfering RNA into primary cells
    • Barton G. M. and Medzhitov R. (2002): Retroviral delivery of small interfering RNA into primary cells. Proc. Natl. Acad. Sci. USA, 99, 14943-14945.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14943-14945
    • Barton, G.M.1    Medzhitov, R.2
  • 12
    • 0027186544 scopus 로고
    • Human immunodeficiency virus and the brain: Investigation of virus load and neuropathologic changes in pre-AIDS subjects
    • Bell J. E., Busutti A., Ironside J. W., Rebus S., Donaldson Y. K., Simmonds P., Peutherer J. F. (1993): Human immunodeficiency virus and the brain: investigation of virus load and neuropathologic changes in pre-AIDS subjects. J. Infect. Dis., 168, 818-824.
    • (1993) J. Infect. Dis. , vol.168 , pp. 818-824
    • Bell, J.E.1    Busutti, A.2    Ironside, J.W.3    Rebus, S.4    Donaldson, Y.K.5    Simmonds, P.6    Peutherer, J.F.7
  • 13
    • 0028044732 scopus 로고
    • Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: Implications for AIDS dementia complex
    • Benos D. J., Han B. H., Bubien J. K., Ghosh S. K., Mashburn N. A., Chaikin M. A., Shaw G. M. and Benveniste E. N. (1994): Envelope glycoprotein gp120 of human immunodeficiency virus type 1 alters ion transport in astrocytes: implications for AIDS dementia complex. Proc. Natl. Acad. Sci. USA, 91, 494-498.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 494-498
    • Benos, D.J.1    Han, B.H.2    Bubien, J.K.3    Ghosh, S.K.4    Mashburn, N.A.5    Chaikin, M.A.6    Shaw, G.M.7    Benveniste, E.N.8
  • 14
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E., Caudy A. A., Hammond S. M. and Hannon G. J. (2001): Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature, 409, 363-366.
    • (2001) Nature , vol.409 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 17
    • 0035856381 scopus 로고    scopus 로고
    • Short 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila
    • Boutla A., Delidakis C., Livadaras I., Tsagris M. and Tabler M. (2001): Short 5′-phosphorylated double-stranded RNAs induce RNA interference in Drosophila. Curr. Biol., 11, 1776-1780.
    • (2001) Curr. Biol. , vol.11 , pp. 1776-1780
    • Boutla, A.1    Delidakis, C.2    Livadaras, I.3    Tsagris, M.4    Tabler, M.5
  • 18
    • 0028828644 scopus 로고
    • Functional redundancy of promoter elements ensures efficient transcription of the human 7SK gene in vivo
    • Boyd D. C., Turner P. C., Watkins N. J., Gerster T. and Murphy S. (1995): Functional redundancy of promoter elements ensures efficient transcription of the human 7SK gene in vivo. J. Mol. Biol., 253, 677-690.
    • (1995) J. Mol. Biol. , vol.253 , pp. 677-690
    • Boyd, D.C.1    Turner, P.C.2    Watkins, N.J.3    Gerster, T.4    Murphy, S.5
  • 19
    • 0023786731 scopus 로고
    • Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide
    • Brenneman D. E., Westbrook G. L., Fitzgerald S. P., Ennist D. L., Elkins K. L., Ruff M. R. and Pert C. B. (1988): Neuronal cell killing by the envelope protein of HIV and its prevention by vasoactive intestinal peptide. Nature, 335, 639-642.
    • (1988) Nature , vol.335 , pp. 639-642
    • Brenneman, D.E.1    Westbrook, G.L.2    Fitzgerald, S.P.3    Ennist, D.L.4    Elkins, K.L.5    Ruff, M.R.6    Pert, C.B.7
  • 20
    • 1642404325 scopus 로고    scopus 로고
    • Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex
    • Brew B. J. (2004): Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex. AIDS, 18, S75-78.
    • (2004) AIDS , vol.18
    • Brew, B.J.1
  • 21
    • 0037134020 scopus 로고    scopus 로고
    • A system for stable expression of short interfering RNAs in mammalian cells
    • Brummelkamp T. R., Bernards R. and Agami R. (2002): A system for stable expression of short interfering RNAs in mammalian cells. Science, 296, 550-553.
    • (2002) Science , vol.296 , pp. 550-553
    • Brummelkamp, T.R.1    Bernards, R.2    Agami, R.3
  • 22
    • 0037195064 scopus 로고    scopus 로고
    • Tissue-specific RNA interference in post implantation mouse embryos with endoribonuclease-prepared short interfering RNA
    • Calegari F., Haubensak W., Yang D., Huttner W. B. and Buchholz F. (2002): Tissue-specific RNA interference in post implantation mouse embryos with endoribonuclease-prepared short interfering RNA. Proc. Natl. Acad. Sci. USA, 99, 14236-14240.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 14236-14240
    • Calegari, F.1    Haubensak, W.2    Yang, D.3    Huttner, W.B.4    Buchholz, F.5
  • 23
    • 0005205454 scopus 로고    scopus 로고
    • HIV-1-infected cortical neurons in brain autopsy from children with HIV-1 related encephalopathy
    • Buenos Aires, Argentina, July 2001
    • Canto-Nogues C., Sanchez-Ramon S. and Munoz-Fernandez M. (2001): HIV-1-infected cortical neurons in brain autopsy from children with HIV-1 related encephalopathy. 1st IAS Conference on HIV Pathogenesis and Treatment, Buenos Aires, Argentina, July 2001, p. 263.
    • (2001) 1st IAS Conference on HIV Pathogenesis and Treatment , pp. 263
    • Canto-Nogues, C.1    Sanchez-Ramon, S.2    Munoz-Fernandez, M.3
  • 24
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
    • Caplen N. J., Parrish S. and Imani F., Fire A. and Morgan R. A. (2001): Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc. Natl. Acad. Sci. USA, 98, 9742-9747.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9742-9747
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3    Fire, A.4    Morgan, R.A.5
  • 25
    • 0036839458 scopus 로고    scopus 로고
    • Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference
    • Capodici J., Kariko K. and Weissman D. (2002): Inhibition of HIV-1 infection by small interfering RNA-mediated RNA interference. J. Immunol., 169, 5196-5201.
    • (2002) J. Immunol. , vol.169 , pp. 5196-5201
    • Capodici, J.1    Kariko, K.2    Weissman, D.3
  • 26
    • 0036847965 scopus 로고    scopus 로고
    • Functional siRNA expression from transfected PCR products
    • Castanotto D., Li H. and Rossi J. J. (2002): Functional siRNA expression from transfected PCR products. RNA, 8, 1454-1460.
    • (2002) RNA , vol.8 , pp. 1454-1460
    • Castanotto, D.1    Li, H.2    Rossi, J.J.3
  • 30
    • 0036721314 scopus 로고    scopus 로고
    • Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference
    • Coburn G. A. and Cullen B. R. (2002): Potent and specific inhibition of human immunodeficiency virus type 1 replication by RNA interference. J. Virol., 76, 9225-9231.
    • (2002) J. Virol. , vol.76 , pp. 9225-9231
    • Coburn, G.A.1    Cullen, B.R.2
  • 31
    • 0032716844 scopus 로고    scopus 로고
    • Homology-dependent gene silencing in plants and fungi: A number of variations on the same theme
    • Cogoni C. and Macino G. (1999): Homology-dependent gene silencing in plants and fungi: a number of variations on the same theme. Curr. Opin. Microbiol., 2, 657-662.
    • (1999) Curr. Opin. Microbiol. , vol.2 , pp. 657-662
    • Cogoni, C.1    Macino, G.2
  • 32
    • 0032493294 scopus 로고    scopus 로고
    • The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA
    • Connelly J. C., Kirkham L. A. and Leach D. R. (1998): The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA. Proc. Natl. Acad. Sci. USA, 95, 7969-7974.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7969-7974
    • Connelly, J.C.1    Kirkham, L.A.2    Leach, D.R.3
  • 33
    • 0027075975 scopus 로고
    • Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice
    • Corboy J. R., Buzy J. M., Zink M. C. and Clements J. E. (3992): Expression directed from HIV long terminal repeats in the central nervous system of transgenic mice. Science, 258, 1804-1808.
    • (1992) Science , vol.258 , pp. 1804-1808
    • Corboy, J.R.1    Buzy, J.M.2    Zink, M.C.3    Clements, J.E.4
  • 34
    • 12244311386 scopus 로고    scopus 로고
    • Antiviral effects of HIV-1-specific siRNAs against targets conserved in select neurotropic viral strains
    • in press
    • Dave R. S. and Pomerantz R. J. (2004): Antiviral effects of HIV-1-specific siRNAs against targets conserved in select neurotropic viral strains. J. Virol. (in press).
    • (2004) J. Virol.
    • Dave, R.S.1    Pomerantz, R.J.2
  • 35
    • 0027480439 scopus 로고
    • Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures
    • Dawson V. L., Dawson T. M., Uhl G. R. and Snyder S. H. (1993): Human immunodeficiency virus type 1 coat protein neurotoxicity mediated by nitric oxide in primary cortical cultures. Proc. Natl. Acad. Sci. USA, 90, 3256-3259.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3256-3259
    • Dawson, V.L.1    Dawson, T.M.2    Uhl, G.R.3    Snyder, S.H.4
  • 36
  • 38
    • 0025278342 scopus 로고
    • HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists
    • Dreyer E. V., Kaiser P. K., Offermann J. T. and Lipton S. A. (1990): HIV-1 coat protein neurotoxicity prevented by calcium channel antagonists. Science, 248, 364-367.
    • (1990) Science , vol.248 , pp. 364-367
    • Dreyer, E.V.1    Kaiser, P.K.2    Offermann, J.T.3    Lipton, S.A.4
  • 40
    • 0036351317 scopus 로고    scopus 로고
    • Analysis of gene function in somatic mammalian cells using small interfering RNAs
    • Elbashir S. M., Harborth J., Weber K. and Tuschl T. (2002): Analysis of gene function in somatic mammalian cells using small interfering RNAs. Methods, 26, 199-213.
    • (2002) Methods , vol.26 , pp. 199-213
    • Elbashir, S.M.1    Harborth, J.2    Weber, K.3    Tuschl, T.4
  • 42
    • 0025728281 scopus 로고
    • Neuronal loss in the frontal cortex in HIV infection
    • Everall I. P., Luthert P. J. and Lantos P. L. (1991): Neuronal loss in the frontal cortex in HIV infection. Lancet, 337, 1119-1121.
    • (1991) Lancet , vol.337 , pp. 1119-1121
    • Everall, I.P.1    Luthert, P.J.2    Lantos, P.L.3
  • 44
    • 0022552689 scopus 로고
    • Immunohistochemical identification ot HTLV-III antigen in brains of patients with AIDS
    • Gabuzda D. H., Ho D. D., de la Monte S. M., Hirsch M. S., Rota T. R. and Sobel R. A. (1986): Immunohistochemical identification ot HTLV-III antigen in brains of patients with AIDS. Ann. Neurol., 20, 289-295.
    • (1986) Ann. Neurol. , vol.20 , pp. 289-295
    • Gabuzda, D.H.1    Ho, D.D.2    De La Monte, S.M.3    Hirsch, M.S.4    Rota, T.R.5    Sobel, R.A.6
  • 45
    • 0037418322 scopus 로고    scopus 로고
    • RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription
    • Ge Q., McManus M. T., Nguyen T., Shen C. H., Sharp P. A., Eisen H. N. and Chen J. (2003): RNA interference of influenza virus production by directly targeting mRNA for degradation and indirectly inhibiting all viral RNA transcription. Proc. Natl. Acad. Sci. USA, 100, 2718-2723.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 2718-2723
    • Ge, Q.1    McManus, M.T.2    Nguyen, T.3    Shen, C.H.4    Sharp, P.A.5    Eisen, H.N.6    Chen, J.7
  • 48
    • 0026440742 scopus 로고
    • Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophageastroglia interactions: Implications for the neuropathogenesis of HIV disease
    • Genis P., Jett M., Bernton E. W., Boyle T., Gelbard H. A., Dzenko K., Keane R. W., Resnick L., Mizrachi Y. and Volsky D. J. (1992): Cytokines and arachidonic metabolites produced during human immunodeficiency virus (HIV)-infected macrophageastroglia interactions: implications for the neuropathogenesis of HIV disease. J. Exp. Med., 176, 1703-1718.
    • (1992) J. Exp. Med. , vol.176 , pp. 1703-1718
    • Genis, P.1    Jett, M.2    Bernton, E.W.3    Boyle, T.4    Gelbard, H.A.5    Dzenko, K.6    Keane, R.W.7    Resnick, L.8    Mizrachi, Y.9    Volsky, D.J.10
  • 49
    • 0037173613 scopus 로고    scopus 로고
    • Short interfering RNA confers intracellular antiviral immunity in human cells
    • Gitlin L., Karelsky S. and Andino R. (2002): Short interfering RNA confers intracellular antiviral immunity in human cells. Nature. 418, 430-434.
    • (2002) Nature , vol.418 , pp. 430-434
    • Gitlin, L.1    Karelsky, S.2    Andino, R.3
  • 50
    • 0025609978 scopus 로고
    • Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1
    • Giulian D., Vaca K. and. Noonan C. A. (1990): Secretion of neurotoxins by mononuclear phagocytes infected with HIV-1. Science, 250, 1593-1596.
    • (1990) Science , vol.250 , pp. 1593-1596
    • Giulian, D.1    Vaca, K.2    Noonan, C.A.3
  • 51
    • 0027407936 scopus 로고
    • The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes
    • Giulian D., Wendt E., Vaca K. and Noonan C. A. (1993): The envelope glycoprotein of human immunodeficiency virus type 1 stimulates release of neurotoxins from monocytes. Proc. Natl. Acad. Sci. USA, 90, 2769-2773.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 2769-2773
    • Giulian, D.1    Wendt, E.2    Vaca, K.3    Noonan, C.A.4
  • 52
    • 0027932886 scopus 로고
    • Human immunodeficiency virus (HIV) distribution in HIV encephalitis: Study of 19 cases with combined use of in situ hybridization and immunocytochemistry
    • Gosztonyi G., Artigas J., Lamperth L. and Webster H. (1994): Human immunodeficiency virus (HIV) distribution in HIV encephalitis: study of 19 cases with combined use of in situ hybridization and immunocytochemistry. J. Neuropathol. Exp. Neurol., 53, 521-534.
    • (1994) J. Neuropathol. Exp. Neurol. , vol.53 , pp. 521-534
    • Gosztonyi, G.1    Artigas, J.2    Lamperth, L.3    Webster, H.4
  • 55
    • 0032492918 scopus 로고    scopus 로고
    • Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4
    • Hesselgesser J., Taub D., Baskar P., Greenberg M., Hoxie J., Kolson D. L. and Horuk R. (1998): Neuronal apoptosis induced by HIV-1 gp120 and the chemokine SDF-1α is mediated by the chemokine receptor CXCR4. Curr. Biol., 8, 595-598.
    • (1998) Curr. Biol. , vol.8 , pp. 595-598
    • Hesselgesser, J.1    Taub, D.2    Baskar, P.3    Greenberg, M.4    Hoxie, J.5    Kolson, D.L.6    Horuk, R.7
  • 56
    • 0037031148 scopus 로고    scopus 로고
    • Inhibition of retroviral pathogenesis by RNA interference
    • Hu W. Y., Myers C. P., Kilzer J. M., Pfaff S. L. and Bushman F. D. (2002): Inhibition of retroviral pathogenesis by RNA interference. Curr. Biol., 12, 1301-1311.
    • (2002) Curr. Biol. , vol.12 , pp. 1301-1311
    • Hu, W.Y.1    Myers, C.P.2    Kilzer, J.M.3    Pfaff, S.L.4    Bushman, F.D.5
  • 57
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G. and Zamore P. D. (2002): A microRNA in a multiple-turnover RNAi enzyme complex. Science, 297, 2056-2060.
    • (2002) Science , vol.297 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 58
    • 0037173610 scopus 로고    scopus 로고
    • Modulation of HIV-1 replication by RNA interference
    • Jacque J. M., Triques K. and Stevenson M. (2002): Modulation of HIV-1 replication by RNA interference. Nature, 418, 435-438.
    • (2002) Nature , vol.418 , pp. 435-438
    • Jacque, J.M.1    Triques, K.2    Stevenson, M.3
  • 59
    • 0037372313 scopus 로고    scopus 로고
    • Inhibition of gammaherpesvirus replication by RNA interference
    • Ji Q. and Sun R. (2003): Inhibition of gammaherpesvirus replication by RNA interference. J. Virol., 77, 3301-3306.
    • (2003) J. Virol. , vol.77 , pp. 3301-3306
    • Ji, Q.1    Sun, R.2
  • 60
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M. and Milner J. (2002): Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene, 21, 6041-6048.
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 62
    • 0025272486 scopus 로고
    • Loss of neurons in the frontal cortex in AIDS brains
    • Ketzler S., Weis S., Haug H. and Budka H. (1990): Loss of neurons in the frontal cortex in AIDS brains. Acta Neuropathol., 80, 92-94.
    • (1990) Acta Neuropathol. , vol.80 , pp. 92-94
    • Ketzler, S.1    Weis, S.2    Haug, H.3    Budka, H.4
  • 63
    • 0030483487 scopus 로고    scopus 로고
    • AIDS dementia and HIV-1-induced neurotoxicity: Pathogenic associations and mechanisms
    • Kolson D. L. and Pomerantz R. J. (1997): AIDS dementia and HIV-1-induced neurotoxicity: Pathogenic associations and mechanisms. J. Biomed. Sci., 3, 389-414.
    • (1997) J. Biomed. Sci. , vol.3 , pp. 389-414
    • Kolson, D.L.1    Pomerantz, R.J.2
  • 64
    • 0030601322 scopus 로고    scopus 로고
    • The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and pro-inflammatory cytokines in mixed glial cell cultures
    • Kong L.-Y., Wilson B. C., McMillian M. K., Bing G., Hudson P. M. and Hong J.-S. (1996): The effects of the HIV-1 envelope protein gp120 on the production of nitric oxide and pro-inflammatory cytokines in mixed glial cell cultures. Cell. Immunol., 172, 77-83.
    • (1996) Cell. Immunol. , vol.172 , pp. 77-83
    • Kong, L.-Y.1    Wilson, B.C.2    McMillian, M.K.3    Bing, G.4    Hudson, P.M.5    Hong, J.-S.6
  • 65
    • 0025283788 scopus 로고
    • Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method
    • Kure K., Lyman W. D., Weidenheim K. M. and Dickson D. W. (1990): Cellular localization of an HIV-1 antigen in subacute AIDS encephalitis using an improved double-labeling immunohistochemical method. Am. J. Pathol., 136, 1085-1092.
    • (1990) Am. J. Pathol. , vol.136 , pp. 1085-1092
    • Kure, K.1    Lyman, W.D.2    Weidenheim, K.M.3    Dickson, D.W.4
  • 66
    • 0029669179 scopus 로고    scopus 로고
    • Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: Applications to HIV-induced central nervous system disease
    • Lane T. E., Buchmeier M. J., Watry D. D. and Fox H. S. (1996): Expression of inflammatory cytokines and inducible nitric oxide synthase in brains of SIV-infected rhesus monkeys: applications to HIV-induced central nervous system disease. Mol. Med., 96, 27-37.
    • (1996) Mol. Med. , vol.96 , pp. 27-37
    • Lane, T.E.1    Buchmeier, M.J.2    Watry, D.D.3    Fox, H.S.4
  • 67
    • 0029842390 scopus 로고    scopus 로고
    • Localization simian immunodeficiency virus nucleic acid and antigen in brains of fetal macaques inoculated in utero
    • Lane J. H., Tarantal A. F., Pauley D., Marthas M., Miller C. J. and Lackner A. A. (1996): Localization simian immunodeficiency virus nucleic acid and antigen in brains of fetal macaques inoculated in utero. Am. J. Pathol., 149, 1097-1104.
    • (1996) Am. J. Pathol. , vol.149 , pp. 1097-1104
    • Lane, J.H.1    Tarantal, A.F.2    Pauley, D.3    Marthas, M.4    Miller, C.J.5    Lackner, A.A.6
  • 68
    • 0027409048 scopus 로고
    • Human immunodeficiency virus coat protein gp120 inhibits the a-adrenergic regulation of astroglial and microglial functions
    • Levi G., Patrizio M., Bernardo A., Petrucci T. C. and Agresti C. (1993): Human immunodeficiency virus coat protein gp120 inhibits the a-adrenergic regulation of astroglial and microglial functions. Proc. Natl. Acad. Sci. USA, 90, 1541-1545.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 1541-1545
    • Levi, G.1    Patrizio, M.2    Bernardo, A.3    Petrucci, T.C.4    Agresti, C.5
  • 69
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis D. L., Hagstrom J. E., Loomis A. G., Wolff J. A. and Herweijer H. (2002): Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat. Genet., 32, 107-108.
    • (2002) Nat. Genet. , vol.32 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herweijer, H.5
  • 70
    • 0029062573 scopus 로고
    • Induction of apoptosis in uninfected T-lymphocytes by HIV-1 Tat protein
    • Li C. J., Friedman D. J., Wang C., Metelev V. and Pardee A. B. (1995): Induction of apoptosis in uninfected T-lymphocytes by HIV-1 Tat protein. Science, 268, 429-431.
    • (1995) Science , vol.268 , pp. 429-431
    • Li, C.J.1    Friedman, D.J.2    Wang, C.3    Metelev, V.4    Pardee, A.B.5
  • 71
    • 0037123630 scopus 로고    scopus 로고
    • Induction and suppression of RNA silencing by an animal virus
    • Li H., Li W. X. and Ding S. W. (2002): Induction and suppression of RNA silencing by an animal virus. Science, 296, 1319-1321.
    • (2002) Science , vol.296 , pp. 1319-1321
    • Li, H.1    Li, W.X.2    Ding, S.W.3
  • 72
    • 0028909868 scopus 로고
    • Dementia associated with the acquired immunodeficiency syndrome
    • Lipton S. A. and Gendelman H. E. (1995): Dementia associated with the acquired immunodeficiency syndrome. N. Engl. J. Med., 14, 934-940.
    • (1995) N. Engl. J. Med. , vol.14 , pp. 934-940
    • Lipton, S.A.1    Gendelman, H.E.2
  • 73
    • 0037032933 scopus 로고    scopus 로고
    • Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication
    • Martinez M. A., Gutierrez A., Armand-Ugon M., Blanco J., Parera M., Gomez J., Clotet B. and Este J. A. (2002): Suppression of chemokine receptor expression by RNA interference allows for inhibition of HIV-1 replication. AIDS, 16, 2385-2390.
    • (2002) AIDS , vol.16 , pp. 2385-2390
    • Martinez, M.A.1    Gutierrez, A.2    Armand-Ugon, M.3    Blanco, J.4    Parera, M.5    Gomez, J.6    Clotet, B.7    Este, J.A.8
  • 74
    • 0030993833 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 protease inhibitors
    • McDonald C. K. and Kuritzkes D. R. (1997): Human immunodeficiency virus type 1 protease inhibitors. Arch. Intern. Med., 157, 951-959.
    • (1997) Arch. Intern. Med. , vol.157 , pp. 951-959
    • McDonald, C.K.1    Kuritzkes, D.R.2
  • 75
    • 0026554880 scopus 로고
    • Induction of interleukin-1 and tumor necrosis factor α in brain cultures by human immunodeficiency virus type 1
    • Merrill J. E., Koyanagi Y., Zack J., Thomas L., Martin F. and Chen I. S. Y. (1992): Induction of interleukin-1 and tumor necrosis factor α in brain cultures by human immunodeficiency virus type 1. J. Virol., 66, 2217-2225.
    • (1992) J. Virol. , vol.66 , pp. 2217-2225
    • Merrill, J.E.1    Koyanagi, Y.2    Zack, J.3    Thomas, L.4    Martin, F.5    Chen, I.S.Y.6
  • 76
    • 0028139228 scopus 로고
    • Clinical comparison of adult and pediatric NeuroAIDS
    • Mintz M. (1994): Clinical comparison of adult and pediatric NeuroAIDS. Adv. Neuroimmunol., 4, 207-221.
    • (1994) Adv. Neuroimmunol. , vol.4 , pp. 207-221
    • Mintz, M.1
  • 77
    • 0027436826 scopus 로고
    • Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism
    • Moses A. V., Bloom F. E., Pauza C. D. and Nelson J. A. (1993): Human immunodeficiency virus infection of human brain capillary endothelial cells occurs via a CD4/galactosylceramide-independent mechanism. Proc. Natl. Acad. Sci. USA, 90, 10474-10478.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 10474-10478
    • Moses, A.V.1    Bloom, F.E.2    Pauza, C.D.3    Nelson, J.A.4
  • 78
    • 0028073842 scopus 로고
    • HIV infection of human brain capillary endothelial cells-implications for AIDS dementia
    • Moses A. V. and Nelson J. A. (1994): HIV infection of human brain capillary endothelial cells-implications for AIDS dementia. Adv. Neuroimmunol., 4, 239-247.
    • (1994) Adv. Neuroimmunol. , vol.4 , pp. 239-247
    • Moses, A.V.1    Nelson, J.A.2
  • 79
    • 0029887106 scopus 로고    scopus 로고
    • Sequences regulating tropism of human immunodeficiency virus type I for brain capillary endothelial cells map to a unique region on the viral genome
    • Moses A. V., Stenglein S. G., Strussenberg J. G., Wehrly K., Chesebro B. and Nelson J. A. (1996): Sequences regulating tropism of human immunodeficiency virus type I for brain capillary endothelial cells map to a unique region on the viral genome. J. Virol., 70, 3401-3406.
    • (1996) J. Virol. , vol.70 , pp. 3401-3406
    • Moses, A.V.1    Stenglein, S.G.2    Strussenberg, J.G.3    Wehrly, K.4    Chesebro, B.5    Nelson, J.A.6
  • 81
    • 0033777861 scopus 로고    scopus 로고
    • Development of an in vitro blood:brain barrier model to study molecular neuropathogenesis and neurovirological disorders induced by HIV-1 infection
    • Mukhtar M. and Pomerantz R. J. (2000): Development of an in vitro blood:brain barrier model to study molecular neuropathogenesis and neurovirological disorders induced by HIV-1 infection. J. Hum. Virol., 3, 324-335.
    • (2000) J. Hum. Virol. , vol.3 , pp. 324-335
    • Mukhtar, M.1    Pomerantz, R.J.2
  • 82
    • 0026598118 scopus 로고
    • Cognitive and motor impairments associated with SIV infection in rhesus monkeys
    • Murray E., Rausch D., Lendvay J., Sharer L. and Eiden L. (1992): Cognitive and motor impairments associated with SIV infection in rhesus monkeys. Science, 255, 1246-1249.
    • (1992) Science , vol.255 , pp. 1246-1249
    • Murray, E.1    Rausch, D.2    Lendvay, J.3    Sharer, L.4    Eiden, L.5
  • 83
    • 0035875333 scopus 로고    scopus 로고
    • An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene
    • Myslinski E., Ame J. C., Krol A. and Carbon P. (2001): An unusually compact external promoter for RNA polymerase III transcription of the human H1RNA gene. Nucleic Acids Res., 29, 2502-2509.
    • (2001) Nucleic Acids Res. , vol.29 , pp. 2502-2509
    • Myslinski, E.1    Ame, J.C.2    Krol, A.3    Carbon, P.4
  • 84
    • 0035891288 scopus 로고    scopus 로고
    • 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes
    • Nguyen V. T., Kiss T., Michels A. A. and Bensaude O. (2001): 7SK small nuclear RNA binds to and inhibits the activity of CDK9/cyclin T complexes. Nature, 414, 322-325.
    • (2001) Nature , vol.414 , pp. 322-325
    • Nguyen, V.T.1    Kiss, T.2    Michels, A.A.3    Bensaude, O.4
  • 85
    • 17544379695 scopus 로고    scopus 로고
    • Evidence of post-transcriptional regulation of U6 small nuclear RNA
    • Noonberg S. B., Scott G. K. and Benz C. C. (1996): Evidence of post-transcriptional regulation of U6 small nuclear RNA. J. Biol. Chem., 271, 10477-10481.
    • (1996) J. Biol. Chem. , vol.271 , pp. 10477-10481
    • Noonberg, S.B.1    Scott, G.K.2    Benz, C.C.3
  • 88
    • 0037016479 scopus 로고    scopus 로고
    • Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: Latency without on-going cellular infections
    • Nunnari G., Otero M., Dornadula G., Vanella M., Zhang H., Frank I. and Pomerantz R. J. (2002): Residual HIV-1 disease in seminal cells of HIV-1-infected men on suppressive HAART: latency without on-going cellular infections. AIDS, 16, 39-45.
    • (2002) AIDS , vol.16 , pp. 39-45
    • Nunnari, G.1    Otero, M.2    Dornadula, G.3    Vanella, M.4    Zhang, H.5    Frank, I.6    Pomerantz, R.J.7
  • 89
    • 0028356005 scopus 로고
    • In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-α RNA in the central nervous system
    • Nuovo G. J., Gallary F., MacConnell P. and Braun A. (1994): In situ detection of polymerase chain reaction-amplified HIV-1 nucleic acids and tumor necrosis factor-α RNA in the central nervous system. Am. J. Pathol., 144, 659-666.
    • (1994) Am. J. Pathol. , vol.144 , pp. 659-666
    • Nuovo, G.J.1    Gallary, F.2    MacConnell, P.3    Braun, A.4
  • 91
    • 0028785967 scopus 로고
    • Role of apoptosis in HIV disease pathogenesis
    • Oyaizu N. and Pahwa S. (1995): Role of apoptosis in HIV disease pathogenesis. J. Clin. Immunol., 15, 217-231.
    • (1995) J. Clin. Immunol. , vol.15 , pp. 217-231
    • Oyaizu, N.1    Pahwa, S.2
  • 94
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span and viral generation time
    • Perelson A. S., Neumann A. U., Markowitz M., Leonard J. M. and Ho D. D. (1996): HIV-1 dynamics in vivo: virion clearance rate, infected cell life-span and viral generation time. Science, 271, 1582-1586.
    • (1996) Science , vol.271 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 95
    • 0029065185 scopus 로고
    • Evidence of apoptotic cell death in HIV encephalitis
    • Petito C. K. and Roberts B. (1995): Evidence of apoptotic cell death in HIV encephalitis. Am. J. Pathol., 146, 1121-1130.
    • (1995) Am. J. Pathol. , vol.146 , pp. 1121-1130
    • Petito, C.K.1    Roberts, B.2
  • 96
    • 0030791962 scopus 로고    scopus 로고
    • Central nervous system as a sanctuary for HIV-1 infection despite treatment and zidovudine, amivudine and indinavir
    • Pialouz G., Fournier S., Moulignier A., Poveda J.-D., Clavel F. and Dupont B. (1997): Central nervous system as a sanctuary for HIV-1 infection despite treatment and zidovudine, amivudine and indinavir. AIDS, 11, 1302-1303.
    • (1997) AIDS , vol.11 , pp. 1302-1303
    • Pialouz, G.1    Fournier, S.2    Moulignier, A.3    Poveda, J.-D.4    Clavel, F.5    Dupont, B.6
  • 97
    • 0033609318 scopus 로고    scopus 로고
    • Residual HIV-1 disease in the era of highly active antiretroviral therapy
    • Pomerantz R. J. (1999): Residual HIV-1 disease in the era of highly active antiretroviral therapy. N. Engl. J. Med., 340, 1672-1674.
    • (1999) N. Engl. J. Med. , vol.340 , pp. 1672-1674
    • Pomerantz, R.J.1
  • 98
    • 0036133364 scopus 로고    scopus 로고
    • HIV-1 reservoirs: The major obstacle to viral eradication
    • Pomerantz R. J. (2002): HIV-1 reservoirs: the major obstacle to viral eradication. Clin. Infect. Dis., 34, 91-97.
    • (2002) Clin. Infect. Dis. , vol.34 , pp. 91-97
    • Pomerantz, R.J.1
  • 99
    • 0023832296 scopus 로고
    • The brain in AIDS: Central nervous system HIV-1 infection and AIDS dementia complex
    • Price R. W., Brew B., Sidtis J., Rosenblum M., Scheck A. C. and Cleary P. (1988): The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science, 239, 586-592.
    • (1988) Science , vol.239 , pp. 586-592
    • Price, R.W.1    Brew, B.2    Sidtis, J.3    Rosenblum, M.4    Scheck, A.C.5    Cleary, P.6
  • 102
    • 0037422583 scopus 로고    scopus 로고
    • Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5
    • Qin X.-F., An D. S., Chen I. S. Y. and Baltimore D. (2003): Inhibiting HIV-1 infection in human T cells by lentiviral-mediated delivery of small interfering RNA against CCR5. Proc. Natl. Acad. Sci. USA, 100, 183-188.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 183-188
    • Qin, X.-F.1    An, D.S.2    Chen, I.S.Y.3    Baltimore, D.4
  • 103
    • 0037422607 scopus 로고    scopus 로고
    • Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs
    • Randall G., Grakoui A. and Rice C. M. (2003): Clearance of replicating hepatitis C virus replicon RNAs in cell culture by small interfering RNAs. Proc. Natl. Acad. Sci. USA, 100, 235-240.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 235-240
    • Randall, G.1    Grakoui, A.2    Rice, C.M.3
  • 104
    • 0029115618 scopus 로고
    • Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia
    • Ranki A., Nyberg M., Ovod V., Haltia M., Elovaara I., Raininko R., Haapasalo H. and Krohn K. (1995): Abundant expression of HIV Nef and Rev proteins in brain astrocytes in vivo is associated with dementia. AIDS, 9, 1001-1008.
    • (1995) AIDS , vol.9 , pp. 1001-1008
    • Ranki, A.1    Nyberg, M.2    Ovod, V.3    Haltia, M.4    Elovaara, I.5    Raininko, R.6    Haapasalo, H.7    Krohn, K.8
  • 106
    • 0029035116 scopus 로고
    • Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus
    • Rausch D. M., Heyes M. P., Murray A. and Eiden L. E. (1995): Zidovudine treatment prolongs survival and decreases virus load in the central nervous system of rhesus macaques infected perinatally with simian immunodeficiency virus. J. Infect. Dis., 172, 59-69.
    • (1995) J. Infect. Dis. , vol.172 , pp. 59-69
    • Rausch, D.M.1    Heyes, M.P.2    Murray, A.3    Eiden, L.E.4
  • 108
    • 0034062389 scopus 로고    scopus 로고
    • Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors
    • Sacktor N. C., Skolasky R. L., Lyles R. H., Esposito D., Seines O. A. and McArthur J. C. (2000): Improvement in HIV-associated motor slowing after antiretroviral therapy including protease inhibitors. J. Neurovirol., 6, 84-88.
    • (2000) J. Neurovirol. , vol.6 , pp. 84-88
    • Sacktor, N.C.1    Skolasky, R.L.2    Lyles, R.H.3    Esposito, D.4    Seines, O.A.5    McArthur, J.C.6
  • 109
    • 0028230433 scopus 로고
    • Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in post-mortem pediatric central nervous tissues
    • Saito Y., Sharer L. R., Epstein L. G., Michaels J., Mintz M., Louder M., Golding K., Cvetkovich T. A. and Blumberg B. M. (1994): Overexpression of nef as a marker for restricted HIV-1 infection of astrocytes in post-mortem pediatric central nervous tissues. Neurology, 44, 474-481.
    • (1994) Neurology , vol.44 , pp. 474-481
    • Saito, Y.1    Sharer, L.R.2    Epstein, L.G.3    Michaels, J.4    Mintz, M.5    Louder, M.6    Golding, K.7    Cvetkovich, T.A.8    Blumberg, B.M.9
  • 110
  • 112
    • 0031863689 scopus 로고    scopus 로고
    • Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia
    • Shi B., Raina J., Lorenzo A., Busciglio J. and Gabuzda D. (1998): Neuronal apoptosis induced by HIV-1 Tat protein and TNF-α potentiation of neurotoxicity mediated by oxidative stress and implications for HIV-1 dementia. J. Neurovirol., 4, 281-290.
    • (1998) J. Neurovirol. , vol.4 , pp. 281-290
    • Shi, B.1    Raina, J.2    Lorenzo, A.3    Busciglio, J.4    Gabuzda, D.5
  • 113
    • 0034082199 scopus 로고    scopus 로고
    • Post-transcriptiorial gene-silencing: RNAs on the attack or on the defense?
    • Sijen T. and Kooter J. M. (2000): Post-transcriptiorial gene-silencing: RNAs on the attack or on the defense? Bioessays, 22, 520-531.
    • (2000) Bioessays , vol.22 , pp. 520-531
    • Sijen, T.1    Kooter, J.M.2
  • 115
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic siRNAs in adult mice
    • Sorensen D. R., Leirdal M. and Sioud M. (2003): Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J. Mol. Biol., 327, 761-766.
    • (2003) J. Mol. Biol. , vol.327 , pp. 761-766
    • Sorensen, D.R.1    Leirdal, M.2    Sioud, M.3
  • 119
    • 0027737784 scopus 로고
    • The seemingly identical 7SK and U6 core promoters depend on different transcription factor complexes
    • Surig D., Bredow S. and Benecke B. J. (1993): The seemingly identical 7SK and U6 core promoters depend on different transcription factor complexes. Gene Exp., 3, 175-185.
    • (1993) Gene Exp. , vol.3 , pp. 175-185
    • Surig, D.1    Bredow, S.2    Benecke, B.J.3
  • 120
    • 0032875534 scopus 로고    scopus 로고
    • Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy
    • Tashima K. T., Caliendo A. M., Ahmad M., Gormley J. M., Fiske W. D., Brennan J. M. and Flanigan T. P. (1999): Cerebrospinal fluid human immunodeficiency virus type 1 (HIV-1) suppression and efavirenz drug concentrations in HIV-1-infected patients receiving combination therapy. J. Infect. Dis., 180, 862-864.
    • (1999) J. Infect. Dis. , vol.180 , pp. 862-864
    • Tashima, K.T.1    Caliendo, A.M.2    Ahmad, M.3    Gormley, J.M.4    Fiske, W.D.5    Brennan, J.M.6    Flanigan, T.P.7
  • 121
    • 0035130607 scopus 로고    scopus 로고
    • Antiretroviral drug concentrations in semen of HIV-1-infected men
    • Taylor S. and Pereria A. S. (2001): Antiretroviral drug concentrations in semen of HIV-1-infected men. Sex Transm. Infect., 77, 4-11.
    • (2001) Sex Transm. Infect. , vol.77 , pp. 4-11
    • Taylor, S.1    Pereria, A.S.2
  • 122
    • 0028009187 scopus 로고
    • Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice
    • Toggas S. M., Masliah E., Rockenstein E. M., Rali G. F., Abraham C. R. and Mucke L. (1994): Central nervous system damage produced by expression of the HIV-1 coat protein gp120 in transgenic mice. Nature. 367, 188-194.
    • (1994) Nature , vol.367 , pp. 188-194
    • Toggas, S.M.1    Masliah, E.2    Rockenstein, E.M.3    Rali, G.F.4    Abraham, C.R.5    Mucke, L.6
  • 123
    • 0028226662 scopus 로고
    • HIV-1 infection of subcortical astrocytes in the pediatric central nervous system
    • Tornatore C., Changra R., Berger J. R. and Major E. O. (1994): HIV-1 infection of subcortical astrocytes in the pediatric central nervous system. Neurology, 44, 481-487.
    • (1994) Neurology , vol.44 , pp. 481-487
    • Tornatore, C.1    Changra, R.2    Berger, J.R.3    Major, E.O.4
  • 126
    • 0025254631 scopus 로고
    • Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector
    • Venkatesh L. K., Arens M. Q., Subramanian T. and Chinnadurai G. (1990): Selective induction of toxicity to human cells expressing human immunodeficiency virus type 1 Tat by a conditionally cytotoxic adenovirus vector. Proc. Natl. Acad. Sci. USA, 87, 8746-8750.
    • (1990) Proc. Natl. Acad. Sci. USA , vol.87 , pp. 8746-8750
    • Venkatesh, L.K.1    Arens, M.Q.2    Subramanian, T.3    Chinnadurai, G.4
  • 128
    • 0036535172 scopus 로고    scopus 로고
    • Therapeutic effects of non-nucleoside reverse transcriptase inhibitors on the central nervous system in HIV-1-infected patients
    • von Giesen H.-J., Koller H., Theise A. and Arendt G. (2002): Therapeutic effects of non-nucleoside reverse transcriptase inhibitors on the central nervous system in HIV-1-infected patients. J. Acquir. Immune Defic. Syndr., 29, 363-367.
    • (2002) J. Acquir. Immune Defic. Syndr. , vol.29 , pp. 363-367
    • Von Giesen, H.-J.1    Koller, H.2    Theise, A.3    Arendt, G.4
  • 131
    • 0030019995 scopus 로고    scopus 로고
    • Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis
    • Wyss-Coray T., Masliah E., Toggas S. M., Rockenstein E. M, Brooker M. J., Lee H. S. and Mucke L. (1996): Dysregulation of signal transduction pathways as a potential mechanism of nervous system alterations in HIV-1 gp120 transgenic mice and humans with HIV-1 encephalitis. J. Clin. Invest., 97, 789-798.
    • (1996) J. Clin. Invest. , vol.97 , pp. 789-798
    • Wyss-Coray, T.1    Masliah, E.2    Toggas, S.M.3    Rockenstein, E.M.4    Brooker, M.J.5    Lee, H.S.6    Mucke, L.7
  • 132
    • 0037197914 scopus 로고    scopus 로고
    • RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells
    • Yu J. Y., DeRuiter S. L. and Turner D. L. (2002): RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. USA, 99, 6047-6052.
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 6047-6052
    • Yu, J.Y.1    DeRuiter, S.L.2    Turner, D.L.3
  • 133
    • 0037303455 scopus 로고    scopus 로고
    • Simultaneous inhibition of GSK3α and GSK3β using hairpin siRNA expression vectors
    • Yu J. Y., Taylor J., DeRuiter S. L., Vojtek A. B. and Turner D. L. (2003): Simultaneous inhibition of GSK3α and GSK3β using hairpin siRNA expression vectors. Mol. Ther., 7, 228-236.
    • (2003) Mol. Ther. , vol.7 , pp. 228-236
    • Yu, J.Y.1    Taylor, J.2    DeRuiter, S.L.3    Vojtek, A.B.4    Turner, D.L.5
  • 135
    • 0032851787 scopus 로고    scopus 로고
    • Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: Implications for human immunodeficiency virus type 1-associated dementia
    • Zheng J., Ghorpade A., Niemann D., Cotter R. L., Thylin M. R., Epstein L., Swartz J. M., Shepard R. B., Liu X., Nukuna A. and Gendelman H. E. (1999): Lymphotropic virions affect chemokine receptor-mediated neural signaling and apoptosis: implications for human immunodeficiency virus type 1-associated dementia. J. Virol., 73, 8256-8267.
    • (1999) J. Virol. , vol.73 , pp. 8256-8267
    • Zheng, J.1    Ghorpade, A.2    Niemann, D.3    Cotter, R.L.4    Thylin, M.R.5    Epstein, L.6    Swartz, J.M.7    Shepard, R.B.8    Liu, X.9    Nukuna, A.10    Gendelman, H.E.11
  • 136
    • 9944222768 scopus 로고    scopus 로고
    • Inhibition of HIV-1 fusion with small interfering RNAs (siRNAs) targeting the chemokine co-receptor, CXCR4
    • in press
    • Zhou N., Fang J., Mukhtar M., Acheampong E. and Pomerantz R. J. (2004): Inhibition of HIV-1 fusion with small interfering RNAs (siRNAs) targeting the chemokine co-receptor, CXCR4. Gene Ther. (in press).
    • (2004) Gene Ther.
    • Zhou, N.1    Fang, J.2    Mukhtar, M.3    Acheampong, E.4    Pomerantz, R.J.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.