Evidence for a change in AIDS dementia complex in the era of highly active antiretroviral therapy and the possibility of new forms of AIDS dementia complex

AIDS

Volumn 18, Issue SUPPL. 1, 2004, Pages

  Brew, Bruce J ^a,b  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

AIDS dementia; Alzheimer's disease; Antiretroviral therapy; HIV

Indexed keywords

ABACAVIR; ANTIRETROVIRUS AGENT; BETA 2 MICROGLOBULIN; CD4 ANTIGEN; CHOLESTEROL; LIPID; MARKER; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NEOPTERIN; NEUROTOXIN; PROTEINASE INHIBITOR; STAVUDINE; TESTOSTERONE; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; AGING; ALZHEIMER DISEASE; AXONAL INJURY; BRAIN INFECTION; CELL COUNT; CEREBROSPINAL FLUID; CHRONIC DISEASE; COGNITIVE DEFECT; COMORBIDITY; CONFERENCE PAPER; DATA ANALYSIS; DISEASE CLASSIFICATION; EPIDEMIOLOGICAL DATA; EVIDENCE BASED MEDICINE; HEAD INJURY; HEPATITIS C; HIGHLY ACTIVE ANTIRETROVIRAL THERAPY; HORMONE DEFICIENCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LIPID PEROXIDATION; MITOCHONDRIAL TOXICITY; NEUROPSYCHOLOGICAL TEST; PERIPHERAL NEUROPATHY; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RISK; VIRUS LOAD;

AGE FACTORS; AIDS DEMENTIA COMPLEX; ALZHEIMER DISEASE; ANTI-HIV AGENTS; ANTIRETROVIRAL THERAPY, HIGHLY ACTIVE; CD4 LYMPHOCYTE COUNT; CHRONIC DISEASE; COGNITION DISORDERS; DIDEOXYNUCLEOSIDES; HUMANS; RNA, VIRAL; SEVERITY OF ILLNESS INDEX;

EID: 1642404325     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper

References (25)

1. Brew BJ. AIDS dementia complex. In: HIV Neurology. Oxford: Oxford University Press; 2001. pp. 53-90.
2. Dore G, Correll P, Kaldor J, Brew BJ. Changes to the natural history of AIDS dementia complex in the era of HAART. AIDS 1999, 13:1249-1253.
3. Maschke M, Kastrup O, Esser S, Ross B, Hengge U, Hufnagel A. Incidence and prevalence of neurological disorders associated with HIV since the introduction of highly active antiretroviral therapy (HAART). J Neurol Neurosurg Psychiatry 2000, 69:376-380.
4. Berger JR, Nath A, Greenberg RN, Anderson AH, Greene RA, Bognar A, Avison MJ. Cerebrovascular changes in the basal ganglia with HIV dementia. Neurology 2000, 54:921-926.
5. Sacktor N, Lyles RH, Skolasky R, Kleeberger C, Seines OA, Miller EN, et al., for the Multicenter AIDS Cohort Study. HIV-associated neurologic disease incidence changes: Multicenter AIDS Cohort Study, 1990-1998. Neurology 2001, 56:257-260.
6. Childs EA, Lyler RH, Seines OA, Chen B, Miller EN, Cohen BA, et al. Plasma viral load and CD4 lymphocytes predict HIV-associated dementia and sensory neuropathy. Neurology 1999, 52:607-613.
7. Navia B, Jordan BD, Price RW. The AIDS dementia complex: I. Clinical features. Ann Neurol 1986, 19:517-524.
8. Dore GJ, McDonald A, Li Y, Kaldor J, Brew BJ. Marked improvement in survival following AIDS dementia complex in the era of highly active antiretroviral therapy. AIDS 2003, 17:1539-1545.
9. Cysique L, Brew BJ, Maruff P. High rate of neuropsychologiocal impairment in patients with HIV infection despite long term HAART. In: XIVth International AIDS Conference. Barcelona, Spain, 9-14 July 2002.
10. Brew BJ, Fulham M, Garsia R. Factors associated with AIDS dementia complex. In: 9th Conference on Retroviruses and Opportunistic Infections. Seattle, 24-28 February 2002.
11. van Gorp W, Mandelkern MA, Gee M, Hinkin CH, Stern CE, Paz DK, et al. Cerebral metabolic dysfunction in AIDS: findings in a sample with and without dementia. J Neuropsychiatry Clin Neurosci 1992, 43:280-287.
12. Fujimura RK, Goodkin K, Petito CK, Douyon R, Feaster DJ, Concha M, Shapshak P. HIV-1 proviral DNA load across neuroanatomic regions of individuals with evidence for HIV-associated dementia. J Acquired Immune Defic Syndr Hum Retrovirol 1997, 16:146-152.
13. Brew BJ, Brown SJ, Catalan J, Sacktor N, Price RW, Brown S, et al. Safety and efficacy of abacavir (ABC, 1592) in AIDS dementia complex (Study CNAB 3001). In: 12th World AIDS Conference. Geneva, 28 June-3 July 1998.
14. Brew BJ, Pemberton L, Cunningham P, Law M. Levels of HIV-1 RNA correlate with AIDS dementia. J Infect Dis 1997, 175:963-966.
15. Chang L, Ernst T, Leonido-Yee M, Witt M, Speck O, Walot I, Miller EN. Highly active antiretroviral therapy reverses brain metabolite abnormalities in mild dementia. Neurology 1999, 53:782-789.
16. Abdulle S, Hagberg L, Svennerholm B, Fuchs D, Gisslen M. Continuing intrathecal immunoactivation despite two years of effective antiretroviral therapy against HIV-1 infection. AIDS 2002, 16:2145-2149.
17. Gunthard HF, Havlir DV, Fiscus S, Zhang ZQ, Eron J, Mellors J, et al. Residual human immunodeficiency virus (HIV) type 1 RNA and DNA in lymph nodes and HIV RNA in genital secretions and in cerebrospinal fluid after suppression of viremia for 2 years. J Infect Dis 2001, 183:1318-1327.
18. Bashin S, Bremmer W. Emerging issues in androgen replacement therapy. J Clin Endocrinol Metab 1997, 82:3-8.
19. Gouchie C, Kimura D. The relation between T levels and cognitive ability patterns. Psychoneuroendocrinology 1991, 16:323-324.
20. Letendre S, Cherner M, Ellis R, Marcotte T, Heaton R, McCutchan JA, Grant I. Individuals coinfected with hepatitis C (HCV) and HIV are more cognitively impaired than those with either virus alone. J Neurovirol 2002, 8 (Suppl. 1):14.
21. Valcour VG, Shikuma CM, Watters MR, Sacktor NC. Cognitive impairment in older HIV-1 seropositive individuals: prevalence and potential mechanisms. AIDS 2004, 18 (Suppl. 1):S79-S86.
22. Kivipelto M, Helkala EL, Laakso MP, Hänninen T, Hallikainen M, Alhainen K, et al. Apolipoprotein E epsilon4 allele, elevated midlife total cholesterol level, and high midlife systolic blood pressure are independent risk factors for late-life Alzheimer disease. Ann Intern Med 2002, 137:149-155.
23. Nebuloni M, Pellegrinelli A, Ferri A, Bonetto S, Boldorini R, Vago L, et al. Beta amyloid precursor protein and patterns of HIV p24 immunohistochemistry in different brain areas of AIDS patients. AIDS 2001, 15:571-575.
24. Rempel H, Buffum D, Pulliam L. HIV-1 tat inhibits the amyloid beta degrading enzyme, neprilysin. J Neurovirol 2002, 8(Suppl. 1):12.
25. Guiliemin GJ, Smith DG, Williams KR, Smythe GA, Dorment D, Brew BJ. Quinolinic acid in the pathogenesis of Alzheimer's disease. Adv Exp Med Biol 2003, in press.