Therapeutic benefit of polyamine-modified catalase as a scavenger of hydrogen peroxide and nitric oxide in familial amyotrophic lateral sclerosis transgenics

Annals of Neurology

Volumn 48, Issue 6, 2000, Pages 943-947

  Poduslo, Joseph F ^a   Whelan, Shelly L ^a   Curran, Geoffry L ^a   Wengenack, Thomas M ^a  

^a MAYO CLINIC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; COPPER ZINC SUPEROXIDE DISMUTASE; FREE RADICAL; HYDROGEN PEROXIDE; NITRIC OXIDE; POLYAMINE; SCAVENGER;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD BRAIN BARRIER; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG FORMULATION; DRUG PENETRATION; FAMILIAL DISEASE; INFUSION PUMP; MOTOR NEURON DISEASE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PATHOGENESIS; PRIORITY JOURNAL; SURVIVAL; TRANSGENIC MOUSE; TREATMENT OUTCOME;

AMYOTROPHIC LATERAL SCLEROSIS; ANIMALS; BLOOD-BRAIN BARRIER; CATALASE; HYDROGEN PEROXIDE; MICE; MICE, TRANSGENIC; NITRIC OXIDE; PUTRESCINE; SURVIVAL ANALYSIS;

EID: 0033673060     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/1531-8249(200012)48:6<943::AID-ANA18>3.0.CO;2-1     Document Type: Article

References (20)

1. Macromolecular permeability across the blood-nerve and blood-brain barriers
2. Polyamine modification increases the permeability of proteins at the blood-nerve and blood-brain barriers
3. Increased permeability of superoxide dismutase at the blood-nerve and blood-brain barriers with retained enzymatic activity after covalent modification with the naturally occurring polyamine, putrescine
4. Postischemic, systemic administration of polyamine-modified superoxide dismutase reduces hippocampal CA1 neurodegeneration in rat global cerebral ischemia
5. Putrescine-modified catalase with preserved enzymatic activity exhibits increased permeability at the blood-nerve and blood-brain barriers
6. Plasma pharmacokinetics, nervous system biodistribution and biostability, and spinal cord permeability at the blood-brain barrier of putrescine-modified catalase in the adult rat
7. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis
8. Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation
9. Transgenic mice expressing an altered murine superoxide dismutase gene provide an animal model of amyotrophic lateral sclerosis
10. An adverse property of a familial ALS-linked SOD1 mutation causes motor neuron disease characterized by vacuolar degeneration of mitochondria
11. Studies on ascorbic acid. II. Physical changes in catalase following incubation with ascorbate or ascorbate and copper (II)
12. Increased 3-nitrotyrosine in both sporadic and familial amyotrophic lateral sclerosis
13. Elevated free nitrotyrosine levels, but not protein-bound nitrotyrosine or hydroxyl radicals, throughout amyotrophic lateral sclerosis (ALS)-like disease implicate tyrosine nitration as an aberrant in vivo property of one familial ALS-linked superoxide dismutase 1 mutant
14. ALS, SOD and peroxynitrite
15. Oxidative chemistry of NO: The roles of superoxide, peroxynitrite, and carbon dioxide
16. Reversible binding and inhibition of catalase by NO
17. Therapeutic benefits of putrescine-modified catalase in a transgenic mouse model of familial amyotrophic lateral sclerosis
18. Transgenic animal models of familial amyotrophic lateral sclerosis
19. Induction of NO-dependent apoptosis in motor neurons by zinc-deficient superoxide dismutase
20. Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death