Cloning of a novel prolyl 4-hydroxylase subunit expressed in the fibrous cap of human atherosclerotic plaque

Circulation

Volumn 108, Issue 5, 2003, Pages 508-511

  Van Den Diepstraten, Caroline ^b   Papay, Karen ^b   Bolender, Zuzana ^b   Brown, Arthur ^b   Pickering, J Geoffrey ^a  

^a LONDON HEALTH SCIENCES CENTRE   (Canada)

^b NONE

Author keywords

Atherosclerosis; Collagen; Genes; Muscle, smooth

Indexed keywords

2 OXOGLUTARIC ACID; COLLAGEN; FERROUS ION; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE;

ALPHA CHAIN; ARTICLE; ATHEROSCLEROTIC PLAQUE; BETA CHAIN; CAROTID ARTERY; CATALYSIS; CLONING; COLLAGEN SYNTHESIS; ENZYME ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; HYDROXYLATION; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROCESSING; SMOOTH MUSCLE FIBER; TISSUE DISTRIBUTION; VASCULAR SMOOTH MUSCLE;

ARTERIOSCLEROSIS; BLOTTING, NORTHERN; CAROTID ARTERY DISEASES; CATALYTIC DOMAIN; CELL LINE; CLONING, MOLECULAR; COLLAGEN; ENZYME ACTIVATION; FIBROSIS; HUMANS; IN SITU HYBRIDIZATION; MOLECULAR SEQUENCE DATA; MUSCLE, SMOOTH, VASCULAR; ORGAN SPECIFICITY; PROCOLLAGEN-PROLINE DIOXYGENASE; PROTEIN SUBUNITS; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0043075892     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.0000080883.53863.5C     Document Type: Article

References (11)

1. Kivirikko KI, Myllyharju J. Prolyl 4-hydroxylases and their protein disulfide isomerase subunit. Matrix Biol. 1998;16:357-368.
2. Berg RA, Steinmann B, Rennard SI, et al. Ascorbate deficiency results in decreased collagen production: under-hydroxylation of proline leads to increased intracellular degradation. Arch Biochem Biophys. 1983;226:681-686.
3. Li S, Fan YS, Chow LH, et al. Innate diversity of adult human arterial smooth muscle cells: cloning of distinct subtypes from the internal thoracic artery. Circ Res. 2001;89:517-525.
4. Rocnik E, Chow LH, Pickering JG. Heat-shock protein 47 is expressed in fibrous regions of human atheroma and is regulated by growth factors and oxidized low-density lipoprotein. Circulation. 2000;101:1229-1233.
5. Kivirikko KI, Myllyla R. Posttranslational enzymes in the biosynthesis of collagen: intracellular enzymes. Methods Enzymol. 1982;82(pt A):245-304.
6. Helaakoski T, Vuori K, Myllyla R, et al. Molecular cloning of the α-subunit of human prolyl 4-hydroxylase: the complete cDNA-derived amino acid sequence and evidence for alternative splicing of RNA transcripts. Proc Natl Acad Sci U S A. 1989;86:4392-4396.
7. von Heijne G. A new method for predicting signal sequence cleavage sites. Nucleic Acids Res. 1986;14:4683-4690.
8. Myllyharju J, Kivirikko KI. Identification of a novel proline-rich peptide-binding domain in prolyl 4-hydroxylase. EMBO J. 1999;18:306-312.
9. Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 2001;294:1337-1340.
10. 2 tetramer. J Biol Chem. 1997;272:17342-17348.
11. Nissi R, Autio-Harmainen H, Marttila P, et al. Prolyl 4-hydroxylase isoenzymes I and II have different expression patterns in several human tissues. J Histochem Cytochem. 2001;49:1143-1153.