Silymarin protects pancreatic β-cells against cytokine-mediated toxicity: Implication of c-Jun NH2-terminal kinase and Janus kinase/signal transducer and activator of transcription pathways

Endocrinology

Volumn 146, Issue 1, 2005, Pages 175-185

  Matsuda, Takeru ^a,b   Ferreri, Kevin ^a   Todorov, Ivan ^a   Kuroda, Yoshikazu ^c   Smith, Craig V ^a,b   Kandeel, Fouad ^a   Mullen, Yoko ^a,b  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c KOBE UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 1BETA; JANUS KINASE; NITRIC OXIDE; SILYMARIN; STAT PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; CELL DAMAGE; CELL DEATH; CELL LINE; CELL PROTECTION; CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; INSULIN RELEASE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL;

ANIMALS; ANTIOXIDANTS; BIOLOGICAL TRANSPORT; CELL DEATH; CELL LINE; CELL NUCLEUS; CYTOPROTECTION; DNA-BINDING PROTEINS; DRUG COMBINATIONS; ENZYME ACTIVATION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-1; ISLETS OF LANGERHANS; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MILK PROTEINS; MITOGEN-ACTIVATED PROTEIN KINASES; NF-KAPPA B; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; PROTEIN-TYROSINE KINASES; RATS; SIGNAL TRANSDUCTION; SILYMARIN; STAT1 TRANSCRIPTION FACTOR; STAT3 TRANSCRIPTION FACTOR; STAT5 TRANSCRIPTION FACTOR; TISSUE CULTURE TECHNIQUES; TRANS-ACTIVATORS;

EID: 11144237925     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/en.2004-0850     Document Type: Article

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