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Volumn 21, Issue 4, 2000, Pages 811-816

Inhibitory effect of a flavonoid antioxidant silymarin on benzoyl peroxide-induced tumor promotion, oxidative stress and inflammatory responses in SENCAR mouse skin

Author keywords

[No Author keywords available]

Indexed keywords

ANTIOXIDANT; BENZOYL PEROXIDE; CATALASE; GLUTATHIONE PEROXIDASE; INTERLEUKIN 1; INTERLEUKIN 1ALPHA; MYELOPEROXIDASE; PLANT EXTRACT; SILYMARIN; SUPEROXIDE DISMUTASE;

EID: 0034006962     PISSN: 01433334     EISSN: None     Source Type: Journal    
DOI: 10.1093/carcin/21.4.811     Document Type: Article
Times cited : (117)

References (44)
  • 3
    • 0026467278 scopus 로고
    • Retinoid status and the control of keratin expression and adhesion during the histogenesis of squamous metaplasia of tracheal epithelium
    • Lancillotti, F., Darwiche, N., Celli, G. and De Luca, L.M. (1992) Retinoid status and the control of keratin expression and adhesion during the histogenesis of squamous metaplasia of tracheal epithelium. Cancer Res., 52, 6144-6152.
    • (1992) Cancer Res. , vol.52 , pp. 6144-6152
    • Lancillotti, F.1    Darwiche, N.2    Celli, G.3    De Luca, L.M.4
  • 4
    • 0028351556 scopus 로고
    • The pathogenesis of squamous cell cancer: Lessons learned from studies of skin carcinogenesis - Thirty Third G.H.A. Clowes Memorial Award Lecture
    • Yuspa, S.H. (1994) The pathogenesis of squamous cell cancer: lessons learned from studies of skin carcinogenesis - Thirty Third G.H.A. Clowes Memorial Award Lecture. Cancer Res., 54, 1178-1189.
    • (1994) Cancer Res. , vol.54 , pp. 1178-1189
    • Yuspa, S.H.1
  • 5
    • 0002716925 scopus 로고
    • Cutaneous chemical carcinogenesis
    • Mukhtar, H. (ed.) CRC Press, Boca Raton, FL
    • Agarwal, R. and Mukhtar, H. (1991) Cutaneous chemical carcinogenesis. In Mukhtar, H. (ed.) Pharmacology of the Skin. CRC Press, Boca Raton, FL. pp. 371-387.
    • (1991) Pharmacology of the Skin , pp. 371-387
    • Agarwal, R.1    Mukhtar, H.2
  • 6
    • 0026729695 scopus 로고
    • Multistage carcinogenesis in mouse skin
    • DiGiovanni, J. (1992) Multistage carcinogenesis in mouse skin. Pharmacol. Ther., 54, 63-128.
    • (1992) Pharmacol. Ther. , vol.54 , pp. 63-128
    • DiGiovanni, J.1
  • 8
    • 0027938689 scopus 로고
    • Oxy-radicals and cancer
    • Cerutti, P.A. (1994) Oxy-radicals and cancer. Lancet, 344, 862-863.
    • (1994) Lancet , vol.344 , pp. 862-863
    • Cerutti, P.A.1
  • 9
    • 0024540440 scopus 로고
    • Role of free radicals in tumor promotion and progression
    • Kensler, T.W. and Taffe, B.G. (1989) Role of free radicals in tumor promotion and progression. Prog. Clin. Biol. Res., 298, 233-248.
    • (1989) Prog. Clin. Biol. Res. , vol.298 , pp. 233-248
    • Kensler, T.W.1    Taffe, B.G.2
  • 10
    • 0019890232 scopus 로고
    • Skin tumor promoting activity of benzoyl peroxide, a widely used free radical-generating compound
    • Slaga, T.J., Klein-Szanto, A.J.P., Triplett, L.L. and Yotti, L.P. (1981) Skin tumor promoting activity of benzoyl peroxide, a widely used free radical-generating compound. Science, 213, 1023-1025.
    • (1981) Science , vol.213 , pp. 1023-1025
    • Slaga, T.J.1    Klein-Szanto, A.J.P.2    Triplett, L.L.3    Yotti, L.P.4
  • 11
    • 0027527396 scopus 로고
    • Cancer chemoprevention: Principles and prospects
    • Morse, M.A. and Stoner, G.D. (1993) Cancer chemoprevention: principles and prospects. Carcinogenesis, 14, 1737-1746.
    • (1993) Carcinogenesis , vol.14 , pp. 1737-1746
    • Morse, M.A.1    Stoner, G.D.2
  • 12
    • 0024437914 scopus 로고
    • Antioxidants and multistage carcinogenesis in mouse skin
    • Perchellet, J.-P. and Perchellet, E.M. (1989) Antioxidants and multistage carcinogenesis in mouse skin. Free Radic. Biol. Med., 7, 377-408.
    • (1989) Free Radic. Biol. Med. , vol.7 , pp. 377-408
    • Perchellet, J.-P.1    Perchellet, E.M.2
  • 13
    • 0031607310 scopus 로고    scopus 로고
    • Natural antioxidants in chemoprevention
    • Dragsted, L.O. (1998) Natural antioxidants in chemoprevention. Arch. Toxicol., 20 (suppl.), 209-226.
    • (1998) Arch. Toxicol. , vol.20 , Issue.SUPPL. , pp. 209-226
    • Dragsted, L.O.1
  • 16
    • 0026643016 scopus 로고
    • Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016
    • Carini, R., Comoglio, A., Albano, E. and Poli, G. (1992) Lipid peroxidation and irreversible damage in the rat hepatocyte model. Protection by the silybin-phospholipid complex IdB 1016. Biochem. Pharmacol., 43, 2111-2115.
    • (1992) Biochem. Pharmacol. , vol.43 , pp. 2111-2115
    • Carini, R.1    Comoglio, A.2    Albano, E.3    Poli, G.4
  • 17
    • 0025190226 scopus 로고
    • An antioxidant drug, silibinin, modulates steroid secretion in human pathological adrenocortical cells
    • Racz, K., Feher, J., Csomos, G., Varga, I., Kiss, R. and Glaz, E. (1990) An antioxidant drug, silibinin, modulates steroid secretion in human pathological adrenocortical cells. J. Endocrinol., 124, 341-345.
    • (1990) J. Endocrinol. , vol.124 , pp. 341-345
    • Racz, K.1    Feher, J.2    Csomos, G.3    Varga, I.4    Kiss, R.5    Glaz, E.6
  • 18
    • 0022872988 scopus 로고
    • Antioxidant properties of the flavonoids silybin and (+)-cyanidanol-3: Comparison with butylated hydroxyanisole and butylated hydroxytoluene
    • Valenzuela, A., Guerra, R. and Videla, L.A. (1986) Antioxidant properties of the flavonoids silybin and (+)-cyanidanol-3: comparison with butylated hydroxyanisole and butylated hydroxytoluene. Planta Med., 5, 438-440.
    • (1986) Planta Med. , vol.5 , pp. 438-440
    • Valenzuela, A.1    Guerra, R.2    Videla, L.A.3
  • 20
    • 0026006786 scopus 로고
    • Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme
    • Muzes, G., Deak, G., Lang, I., Nekam, K., Gergely, P. and Feher, J. (1991) Effect of the bioflavonoid silymarin on the in vitro activity and expression of superoxide dismutase (SOD) enzyme. Acta Phys. Hung., 78, 3-9.
    • (1991) Acta Phys. Hung. , vol.78 , pp. 3-9
    • Muzes, G.1    Deak, G.2    Lang, I.3    Nekam, K.4    Gergely, P.5    Feher, J.6
  • 21
    • 0016433509 scopus 로고
    • Studies on the pharmacodynamics, including site and mode of action, of silymarin: The antihepatotoxic principle from Silybum mar. (L) Gaertn
    • Vogel, G., Trost, W. and Braatz, R. (1975) Studies on the pharmacodynamics, including site and mode of action, of silymarin: the antihepatotoxic principle from Silybum mar. (L) Gaertn. Arzneimittelforschung, 25, 82-89.
    • (1975) Arzneimittelforschung , vol.25 , pp. 82-89
    • Vogel, G.1    Trost, W.2    Braatz, R.3
  • 22
    • 0014294313 scopus 로고
    • Pharmacology and toxicology of silymarin, the anti-hepatotoxic agent of Silybum marianum (L.) Gaertn
    • Hahn, V.G., Lehmann, H.D., Kurten, M., Uebel, H. and Vogel, G. (1968) Pharmacology and toxicology of silymarin, the anti-hepatotoxic agent of Silybum marianum (L.) Gaertn. Arzneimittelforschung, 18, 698-704.
    • (1968) Arzneimittelforschung , vol.18 , pp. 698-704
    • Hahn, V.G.1    Lehmann, H.D.2    Kurten, M.3    Uebel, H.4    Vogel, G.5
  • 23
    • 0024552331 scopus 로고
    • Dermatologie therapies you've probably never heard of
    • Ely, H. (1989) Dermatologie therapies you've probably never heard of. Dermatol. Clin. 7, 19-35.
    • (1989) Dermatol. Clin. , vol.7 , pp. 19-35
    • Ely, H.1
  • 24
    • 0028283883 scopus 로고
    • Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice
    • Agarwal, R., Katiyar, S.K., Lundgren, D.W. and Mukhtar, H. (1994) Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O-tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis, 15, 1099-1103.
    • (1994) Carcinogenesis , vol.15 , pp. 1099-1103
    • Agarwal, R.1    Katiyar, S.K.2    Lundgren, D.W.3    Mukhtar, H.4
  • 25
    • 0030903321 scopus 로고    scopus 로고
    • Protective effects of silymarin against photocarcinogenesis in mouse skin model
    • Katiyar, S.K., Korman, N.J., Mukhtar, H. and Agarwal, R. (1997) Protective effects of silymarin against photocarcinogenesis in mouse skin model. J. Natl Cancer Inst., 89, 556-566.
    • (1997) J. Natl Cancer Inst. , vol.89 , pp. 556-566
    • Katiyar, S.K.1    Korman, N.J.2    Mukhtar, H.3    Agarwal, R.4
  • 26
    • 0031561420 scopus 로고    scopus 로고
    • Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: Inhibition of mRNA expression of an endogenous tumor promoter TNFa
    • Zi, X., Mukhtar, H. and Agarwal, R. (1997) Novel cancer chemopreventive effects of a flavonoid antioxidant silymarin: inhibition of mRNA expression of an endogenous tumor promoter TNFa. Biochem. Biophys. Res. Commun., 239, 334-339.
    • (1997) Biochem. Biophys. Res. Commun. , vol.239 , pp. 334-339
    • Zi, X.1    Mukhtar, H.2    Agarwal, R.3
  • 27
    • 0033082440 scopus 로고    scopus 로고
    • A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in SENCAR mouse skin tumorigenesis model
    • Lahiri-Chatterjee, M., Katiyar, S.K., Mohan, R.R. and Agarwal, R. (1999) A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in SENCAR mouse skin tumorigenesis model. Cancer Res., 59, 622-632.
    • (1999) Cancer Res. , vol.59 , pp. 622-632
    • Lahiri-Chatterjee, M.1    Katiyar, S.K.2    Mohan, R.R.3    Agarwal, R.4
  • 28
    • 0027692047 scopus 로고
    • Protection against ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a polyphenolic fraction isolated from green tea
    • Agarwal, R., Katiyar, S.K., Khan, S.G. and Mukhtar, H. (1993) Protection against ultraviolet B radiation-induced effects in the skin of SKH-1 hairless mice by a polyphenolic fraction isolated from green tea. Photochem. Photobiol., 58, 695-700.
    • (1993) Photochem. Photobiol. , vol.58 , pp. 695-700
    • Agarwal, R.1    Katiyar, S.K.2    Khan, S.G.3    Mukhtar, H.4
  • 29
    • 0017121187 scopus 로고
    • The superoxide dismutase activity of various photosynthetic organisms measured by a new rapid assay technique
    • Henry, L.E.A., Halliwell, B. and Hall, D.D. (1976) The superoxide dismutase activity of various photosynthetic organisms measured by a new rapid assay technique. FEBS Lett., 66, 303-306.
    • (1976) FEBS Lett. , vol.66 , pp. 303-306
    • Henry, L.E.A.1    Halliwell, B.2    Hall, D.D.3
  • 30
    • 0021318441 scopus 로고
    • Catalase in vitro
    • Aebi, H. (1984) Catalase in vitro. Methods Enzymol., 105, 121-126.
    • (1984) Methods Enzymol. , vol.105 , pp. 121-126
    • Aebi, H.1
  • 31
    • 0016769483 scopus 로고
    • Purification and properties of human erythrocyte glutathione peroxidase
    • Awasthi, Y.C. Beutler, E. and Srivastava, S.K. (1975) Purification and properties of human erythrocyte glutathione peroxidase. J. Biol. Chem., 10, 5144-5149.
    • (1975) J. Biol. Chem. , vol.10 , pp. 5144-5149
    • Awasthi, Y.C.1    Beutler, E.2    Srivastava, S.K.3
  • 32
    • 0020051148 scopus 로고
    • Measurement of cutaneous inflammation: Estimation of neutrophil content with an enzyme marker
    • Bradley, P.P., Priebat, D.A., Christensen, R.D. and Rothstein, G. (1982) Measurement of cutaneous inflammation: estimation of neutrophil content with an enzyme marker. J. Invest. Dermatol., 78, 206-209.
    • (1982) J. Invest. Dermatol. , vol.78 , pp. 206-209
    • Bradley, P.P.1    Priebat, D.A.2    Christensen, R.D.3    Rothstein, G.4
  • 33
    • 0027050097 scopus 로고
    • Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea
    • Katiyar, S.K., Agarwal, R., Wood, G.S. and Mukhtar, H. (1992) Inhibition of 12-O-tetradecanoylphorbol-13-acetate-caused tumor promotion in 7,12-dimethylbenz[a]anthracene-initiated SENCAR mouse skin by a polyphenolic fraction isolated from green tea. Cancer Res., 52, 6890-6897.
    • (1992) Cancer Res. , vol.52 , pp. 6890-6897
    • Katiyar, S.K.1    Agarwal, R.2    Wood, G.S.3    Mukhtar, H.4
  • 34
    • 0029059659 scopus 로고
    • Inhibition of 12-O-tetradecanoylphorbol-13-acelate and other skin tumor promoter-caused induction of epidermal inierleukin-1a mRNA and protein expression in SENCAR mice by green tea polyphenols
    • Katiyar, S.K., Rupp, C.O., Korman, N.J., Agarwal, R. and Mukhtar, H. (1995) Inhibition of 12-O-tetradecanoylphorbol-13-acelate and other skin tumor promoter-caused induction of epidermal inierleukin-1a mRNA and protein expression in SENCAR mice by green tea polyphenols. J. Invest. Dermatol., 105, 394-398.
    • (1995) J. Invest. Dermatol. , vol.105 , pp. 394-398
    • Katiyar, S.K.1    Rupp, C.O.2    Korman, N.J.3    Agarwal, R.4    Mukhtar, H.5
  • 35
    • 0024350865 scopus 로고
    • Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo
    • Perchellet, E.M. and Perchellet, J.P. (1989) Characterization of the hydroperoxide response observed in mouse skin treated with tumor promoters in vivo. Cancer Res., 49, 6193-6201.
    • (1989) Cancer Res. , vol.49 , pp. 6193-6201
    • Perchellet, E.M.1    Perchellet, J.P.2
  • 36
    • 0019995464 scopus 로고
    • Effects of peroxides on rodent skin: Epidermal hyperplasia and tumor promotion
    • Klein-Szanto, A.J.P. and Slaga, T.J. (1982) Effects of peroxides on rodent skin: epidermal hyperplasia and tumor promotion. J. Invest. Dermatol., 79, 30-34.
    • (1982) J. Invest. Dermatol. , vol.79 , pp. 30-34
    • Klein-Szanto, A.J.P.1    Slaga, T.J.2
  • 37
    • 0022336547 scopus 로고
    • Mechanisms of lipid peroxidation
    • Girotti, A.W. (1985) Mechanisms of lipid peroxidation. J. Free Radic. Biol. Med., 1, 87-95.
    • (1985) J. Free Radic. Biol. Med. , vol.1 , pp. 87-95
    • Girotti, A.W.1
  • 38
    • 0026577281 scopus 로고
    • Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA
    • Park, J.W. and Floyd, R.A. (1992) Lipid peroxidation products mediate the formation of 8-hydroxydeoxyguanosine in DNA. Free Radic. Biol. Med., 12, 245-250.
    • (1992) Free Radic. Biol. Med. , vol.12 , pp. 245-250
    • Park, J.W.1    Floyd, R.A.2
  • 39
    • 0023188926 scopus 로고
    • Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes
    • Frenkel, K. and Chrzan, K. (1987) Hydrogen peroxide formation and DNA base modification by tumor promoter-activated polymorphonuclear leukocytes. Carcinogenesis, 8, 455-460.
    • (1987) Carcinogenesis , vol.8 , pp. 455-460
    • Frenkel, K.1    Chrzan, K.2
  • 40
    • 0023030615 scopus 로고
    • Enhanced release of hydrogen peroxide and metabolites of arachidonic acid by macrophages from SENCAR mice following stimulation with phorbol esters
    • Lewis, J.G. and Adams, D.O. (1986) Enhanced release of hydrogen peroxide and metabolites of arachidonic acid by macrophages from SENCAR mice following stimulation with phorbol esters. Cancer Res., 46, 5696-5700.
    • (1986) Cancer Res. , vol.46 , pp. 5696-5700
    • Lewis, J.G.1    Adams, D.O.2
  • 41
    • 0023234750 scopus 로고
    • Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposure to 12-O-tetradecanoylphorbol-13-acetate
    • Lewis, J.G. and Adams, D.O. (1987) Early inflammatory changes in the skin of SENCAR and C57BL/6 mice following exposure to 12-O-tetradecanoylphorbol-13-acetate. Carcinogenesis, 8, 889-898.
    • (1987) Carcinogenesis , vol.8 , pp. 889-898
    • Lewis, J.G.1    Adams, D.O.2
  • 42
    • 0027153961 scopus 로고
    • Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters
    • Wei, H. and Frenkel, K. (1993) Relationship of oxidative events and DNA oxidation in SENCAR mice to in vivo promoting activity of phorbol ester-type tumor promoters. Carcinogenesis, 14, 1195-1201.
    • (1993) Carcinogenesis , vol.14 , pp. 1195-1201
    • Wei, H.1    Frenkel, K.2
  • 44
    • 0003964361 scopus 로고    scopus 로고
    • American Cancer Society, www.cancer.org
    • American Cancer Society (1998) Cancer Facts and Figures-1998. American Cancer Society, www.cancer.org.
    • (1998) Cancer Facts and Figures-1998


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