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Volumn 105, Issue 1, 2005, Pages 22-30

After chronic myelogenous leukemia: Tyrosine kinase inhibitors in other hematologic malignancies

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DIMETHYL 5 (2 OXO 1H INDOL 3 YLMETHYLENE) 3 PYRROLEPROPIONIC ACID; 4 [6 METHOXY 7 [3 (1 PIPERIDINYL)PROPOXY] 4 QUINAZOLINYL] 1 PIPERAZINECARBOXYLIC ACID (4 ISOPROPOXYPHENYL)AMIDE; 6,7 DIMETHYL 2 PHENYLQUINOXALINE; AC 1296; CEP 701; CT 35318; HERBIMYCIN A; IMATINIB; MIDOSTAURIN; PIPERAZINYLQUINAZOLINE; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; PROTEIN TYROSINE KINASE; PROTEIN TYROSINE KINASE INHIBITOR; RETINOIC ACID; SEMAXANIB; SU 5614; SUNITINIB; TYROSINE; UNCLASSIFIED DRUG; VASCULOTROPIN RECEPTOR 1; VATALANIB;

EID: 11144235822     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2003-11-3896     Document Type: Review
Times cited : (52)

References (147)
  • 1
    • 0015694748 scopus 로고
    • A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining
    • Rowley JD. A new consistent chromosomal abnormality in chronic myelogenous leukaemia identified by quinacrine fluorescence and Giemsa staining [letter]. Nature. 1973;243:290-293.
    • (1973) Nature , vol.243 , pp. 290-293
    • Rowley, J.D.1
  • 2
    • 0027091627 scopus 로고
    • Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: A Cancer and Leukemia Group B Study (8762)
    • Westbrook CA, Hooberman AL, Spino C, et al. Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762). Blood. 1992;80:2983-2990.
    • (1992) Blood , vol.80 , pp. 2983-2990
    • Westbrook, C.A.1    Hooberman, A.L.2    Spino, C.3
  • 3
    • 0031730466 scopus 로고    scopus 로고
    • Biologic heterogeneity in Philadelphia chromosome-positive acute leukemia with myeloid morphology: The Eastern Cooperative Oncology Group experience
    • Paietta E, Racevskis J, Bennett JM, et al. Biologic heterogeneity in Philadelphia chromosome-positive acute leukemia with myeloid morphology: the Eastern Cooperative Oncology Group experience. Leukemia. 1998;12:1881-1885.
    • (1998) Leukemia , vol.12 , pp. 1881-1885
    • Paietta, E.1    Racevskis, J.2    Bennett, J.M.3
  • 4
    • 0028936278 scopus 로고
    • The novel activation of ABL by fusion to an ets-related gene, TEL
    • Papadopoulos P, Ridge SA, Boucher CA, et al. The novel activation of ABL by fusion to an ets-related gene, TEL. Cancer Res. 1995;55:34-38.
    • (1995) Cancer Res , vol.55 , pp. 34-38
    • Papadopoulos, P.1    Ridge, S.A.2    Boucher, C.A.3
  • 5
    • 0029898682 scopus 로고    scopus 로고
    • Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia
    • Golub TR, Goga A, Barker GF, et al. Oligomerization of the ABL tyrosine kinase by the Ets protein TEL in human leukemia. Mol Cell Biol. 1996;16: 4107-4116.
    • (1996) Mol Cell Biol , vol.16 , pp. 4107-4116
    • Golub, T.R.1    Goga, A.2    Barker, G.F.3
  • 7
    • 0028224348 scopus 로고
    • Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation
    • Golub TR, Barker GF, Lovett M, et al. Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. Cell. 1994;77:307-316.
    • (1994) Cell , vol.77 , pp. 307-316
    • Golub, T.R.1    Barker, G.F.2    Lovett, M.3
  • 8
    • 0031864246 scopus 로고    scopus 로고
    • Fusion of Huntington interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33; q11.2)
    • Ross TS, Bernard OA, Berger R, et al. Fusion of Huntington interacting protein 1 to platelet-derived growth factor beta receptor (PDGFbetaR) in chronic myelomonocytic leukemia with t(5;7)(q33; q11.2). Blood. 1998;91:4419-4426.
    • (1998) Blood , vol.91 , pp. 4419-4426
    • Ross, T.S.1    Bernard, O.A.2    Berger, R.3
  • 9
    • 0035877975 scopus 로고    scopus 로고
    • H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5; 10)(q33;q22)
    • Schwaller J, Anastasiadou E, Cain D, et al. H4(D10S170), a gene frequently rearranged in papillary thyroid carcinoma, is fused to the platelet-derived growth factor receptor beta gene in atypical chronic myeloid leukemia with t(5; 10)(q33;q22). Blood. 2001;97:3910-3918.
    • (2001) Blood , vol.97 , pp. 3910-3918
    • Schwaller, J.1    Anastasiadou, E.2    Cain, D.3
  • 10
    • 18344404198 scopus 로고    scopus 로고
    • Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21)
    • Kulkarni S, Heath C, Parker S, et al. Fusion of H4/D10S170 to the platelet-derived growth factor receptor beta in BCR-ABL-negative myeloproliferative disorders with a t(5;10)(q33;q21). Cancer Res. 2000;60:3592-3598.
    • (2000) Cancer Res , vol.60 , pp. 3592-3598
    • Kulkarni, S.1    Heath, C.2    Parker, S.3
  • 11
    • 0035889128 scopus 로고    scopus 로고
    • Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia
    • Magnusson MK, Meade KE, Brown KE, et al. Rabaptin-5 is a novel fusion partner to platelet-derived growth factor beta receptor in chronic myelomonocytic leukemia. Blood. 2001;98:2518-2525.
    • (2001) Blood , vol.98 , pp. 2518-2525
    • Magnusson, M.K.1    Meade, K.E.2    Brown, K.E.3
  • 12
    • 0030669455 scopus 로고    scopus 로고
    • Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution
    • Abe A, Emi N, Tanimoto M, et al. Fusion of the platelet-derived growth factor receptor beta to a novel gene CEV14 in acute myelogenous leukemia after clonal evolution. Blood. 1997;90:4271-4277.
    • (1997) Blood , vol.90 , pp. 4271-4277
    • Abe, A.1    Emi, N.2    Tanimoto, M.3
  • 13
    • 0030852328 scopus 로고    scopus 로고
    • Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9; 12) in a lymphoid and t(9;15;12) in a myeloid leukemia
    • Peeters P, Raynaud SD, Cools J, et al. Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9; 12) in a lymphoid and t(9;15;12) in a myeloid leukemia. Blood. 1997;90:2535-2540.
    • (1997) Blood , vol.90 , pp. 2535-2540
    • Peeters, P.1    Raynaud, S.D.2    Cools, J.3
  • 14
    • 15444339209 scopus 로고    scopus 로고
    • ATEL-JAK2 fusion protein with constitutive kinase activity in human leukemia
    • Lacronique V, Boureux A, Valle VD, et al. ATEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. Science. 1997;278:1309-1312.
    • (1997) Science , vol.278 , pp. 1309-1312
    • Lacronique, V.1    Boureux, A.2    Valle, V.D.3
  • 15
    • 0028198206 scopus 로고
    • Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma
    • Morris SW, Kirstein MN, Valentine MB, et al. Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma. Science. 1994;263:1281-1284.
    • (1994) Science , vol.263 , pp. 1281-1284
    • Morris, S.W.1    Kirstein, M.N.2    Valentine, M.B.3
  • 16
    • 0027303248 scopus 로고
    • Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC
    • Donis-Keller H, Dou S, Chi D, et al. Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC. Hum Mol Genet. 1993;2:851-856.
    • (1993) Hum Mol Genet , vol.2 , pp. 851-856
    • Donis-Keller, H.1    Dou, S.2    Chi, D.3
  • 17
    • 0027231568 scopus 로고
    • Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A
    • Mulligan LM, Kwok JB, Healey CS, et al. Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A. Nature. 1993; 363:458-460.
    • (1993) Nature , vol.363 , pp. 458-460
    • Mulligan, L.M.1    Kwok, J.B.2    Healey, C.S.3
  • 18
    • 84921009389 scopus 로고
    • Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident
    • Io T, Seyama T, Iwamoto KS, et al. Activated RET oncogene in thyroid cancers of children from areas contaminated by Chernobyl accident [letter]. Lancet. 1994;44:259.
    • (1994) Lancet , vol.44 , pp. 259
    • Io, T.1    Seyama, T.2    Iwamoto, K.S.3
  • 19
    • 0034163550 scopus 로고    scopus 로고
    • Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas
    • Frederick L, Wang XY, Eley G, et al. Diversity and frequency of epidermal growth factor receptor mutations in human glioblastomas. Cancer Res. 2000;60:1383-1387.
    • (2000) Cancer Res , vol.60 , pp. 1383-1387
    • Frederick, L.1    Wang, X.Y.2    Eley, G.3
  • 20
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch TJ, Bell DW, Sordella R, et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med. 2004;350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 21
    • 0026600358 scopus 로고
    • TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas
    • Greco A, Pierotti MA, Bongarzone I, et al. TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas. Oncogene. 1992;7:237-242.
    • (1992) Oncogene , vol.7 , pp. 237-242
    • Greco, A.1    Pierotti, M.A.2    Bongarzone, I.3
  • 22
    • 0025828180 scopus 로고
    • The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions
    • Soman NR, Correa P, Ruiz BA, et al. The TPR-MET oncogenic rearrangement is present and expressed in human gastric carcinoma and precursor lesions. Proc Natl Acad Sci U S A. 1991; 88:4892-4896.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 4892-4896
    • Soman, N.R.1    Correa, P.2    Ruiz, B.A.3
  • 23
    • 0030451722 scopus 로고    scopus 로고
    • Internal tandem duplication of the flt3 gene found in acute myeloid leukemia
    • Nakao M, Yokota S, Iwai T, et al. Internal tandem duplication of the flt3 gene found in acute myeloid leukemia. Leukemia. 1996;10:1911-1918.
    • (1996) Leukemia , vol.10 , pp. 1911-1918
    • Nakao, M.1    Yokota, S.2    Iwai, T.3
  • 24
    • 16944366584 scopus 로고    scopus 로고
    • Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia
    • Horiike S, Yokota S, Nakao M, et al. Tandem duplications of the FLT3 receptor gene are associated with leukemic transformation of myelodysplasia. Leukemia. 1997;11:1442-1446.
    • (1997) Leukemia , vol.11 , pp. 1442-1446
    • Horiike, S.1    Yokota, S.2    Nakao, M.3
  • 25
    • 0344987881 scopus 로고    scopus 로고
    • A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome
    • Cools J, DeAngelo DJ, Gotlib J, et al. A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome. N Engl J Med. 2003;348:1201-1214.
    • (2003) N Engl J Med , vol.348 , pp. 1201-1214
    • Cools, J.1    DeAngelo, D.J.2    Gotlib, J.3
  • 26
    • 10744228486 scopus 로고    scopus 로고
    • CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy
    • Pardanani A, Ketterling RP, Brockman SR, et al. CHIC2 deletion, a surrogate for FIP1L1-PDGFRA fusion, occurs in systemic mastocytosis associated with eosinophilia and predicts response to imatinib mesylate therapy. Blood. 2003;102:3093-3096.
    • (2003) Blood , vol.102 , pp. 3093-3096
    • Pardanani, A.1    Ketterling, R.P.2    Brockman, S.R.3
  • 27
    • 0242670019 scopus 로고    scopus 로고
    • PDGFRA activating mutations in gastrointestinal stromal tumors
    • Heinrich MC, Corless CL, Duensing A, et al. PDGFRA activating mutations in gastrointestinal stromal tumors. Science. 2003;299:708-710.
    • (2003) Science , vol.299 , pp. 708-710
    • Heinrich, M.C.1    Corless, C.L.2    Duensing, A.3
  • 28
    • 0032989226 scopus 로고    scopus 로고
    • c-kit protooncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia
    • Gari M, Goodeve A, Wilson G, et al. c-kit protooncogene exon 8 in-frame deletion plus insertion mutations in acute myeloid leukaemia. Br J Haematol. 1999;105:894-900.
    • (1999) Br J Haematol , vol.105 , pp. 894-900
    • Gari, M.1    Goodeve, A.2    Wilson, G.3
  • 29
    • 0034650957 scopus 로고    scopus 로고
    • C-kit mutations in core binding factor leukemias
    • Beghini A, Peterlongo P, Ripamonti CB, et al. C-kit mutations in core binding factor leukemias. Blood. 2000;95:726-727.
    • (2000) Blood , vol.95 , pp. 726-727
    • Beghini, A.1    Peterlongo, P.2    Ripamonti, C.B.3
  • 30
    • 0033749308 scopus 로고    scopus 로고
    • Mast cell disease associated with acute myeloid leukemia: Detection of a new c-kit mutation Asp816His
    • Pullarkat VA, Pullarkat ST, Calverley DC, et al. Mast cell disease associated with acute myeloid leukemia: detection of a new c-kit mutation Asp816His. Am J Hematol. 2000;65:307-309.
    • (2000) Am J Hematol , vol.65 , pp. 307-309
    • Pullarkat, V.A.1    Pullarkat, S.T.2    Calverley, D.C.3
  • 31
    • 0032456567 scopus 로고    scopus 로고
    • Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: A possible explanation for divergent clinical behavior
    • Buttner C, Henz BM, Welker P, et al. Identification of activating c-kit mutations in adult-, but not in childhood-onset indolent mastocytosis: a possible explanation for divergent clinical behavior. J Invest Dermatol. 1998;111:1227-1231.
    • (1998) J Invest Dermatol , vol.111 , pp. 1227-1231
    • Buttner, C.1    Henz, B.M.2    Welker, P.3
  • 32
    • 15644363454 scopus 로고    scopus 로고
    • Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors
    • Hirota S, Isozaki K, Moriyama Y, et al. Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors. Science. 1998;279:577-580.
    • (1998) Science , vol.279 , pp. 577-580
    • Hirota, S.1    Isozaki, K.2    Moriyama, Y.3
  • 33
    • 0033883060 scopus 로고    scopus 로고
    • KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors
    • Lux ML, Rubin BP, Biase TL, et al. KIT extracellular and kinase domain mutations in gastrointestinal stromal tumors. Am J Pathol. 2000;156:791-795.
    • (2000) Am J Pathol , vol.156 , pp. 791-795
    • Lux, M.L.1    Rubin, B.P.2    Biase, T.L.3
  • 34
    • 0141988690 scopus 로고    scopus 로고
    • c-MET mutational analysis in small cell lung cancer; novel juxtamembrane domain mutations regulating cytoskeletal functions
    • Ma PC, Kijima T, Maulik G, et al. c-MET mutational analysis in small cell lung cancer; novel juxtamembrane domain mutations regulating cytoskeletal functions. Cancer Res. 2003;63:6272-6281.
    • (2003) Cancer Res , vol.63 , pp. 6272-6281
    • Ma, P.C.1    Kijima, T.2    Maulik, G.3
  • 35
    • 0025190309 scopus 로고
    • FMS mutations in myelodysplastic, leukemic, and normal subjects
    • Ridge SA, Worwood M, Oscier D, et al. FMS mutations in myelodysplastic, leukemic, and normal subjects. Proc Natl Acad Sci USA. 1990;87: 1377-1380.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 1377-1380
    • Ridge, S.A.1    Worwood, M.2    Oscier, D.3
  • 36
    • 0027275594 scopus 로고
    • c-fms point mutations in acute myeloid leukemia: Fact or fiction?
    • Springall F, O'Mara S, Shounan Y, et al. c-fms point mutations in acute myeloid leukemia: fact or fiction? Leukemia. 1993;7:978-985.
    • (1993) Leukemia , vol.7 , pp. 978-985
    • Springall, F.1    O'Mara, S.2    Shounan, Y.3
  • 37
    • 0344530234 scopus 로고    scopus 로고
    • c-FMS mutational analysis in acute myeloid leukaemia
    • Abu-Duhier FM, Goodeve AC, Wilson GA, et al. c-FMS mutational analysis in acute myeloid leukaemia. Br J Haematol. 2003;123:749-750.
    • (2003) Br J Haematol , vol.123 , pp. 749-750
    • Abu-Duhier, F.M.1    Goodeve, A.C.2    Wilson, G.A.3
  • 38
    • 17344371122 scopus 로고    scopus 로고
    • RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: A 10-year follow-up
    • Padua RA, Guinn BA, Al-Sabah AI, et al. RAS, FMS and p53 mutations and poor clinical outcome in myelodysplasias: a 10-year follow-up. Leukemia. 1998;12:887-892.
    • (1998) Leukemia , vol.12 , pp. 887-892
    • Padua, R.A.1    Guinn, B.A.2    Al-Sabah, A.I.3
  • 39
    • 0028941132 scopus 로고
    • A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): Description of a distinctive clinicopathologic entity
    • Inborn RC, Aster JC, Roach SA, et al. A syndrome of lymphoblastic lymphoma, eosinophilia, and myeloid hyperplasia/malignancy associated with t(8;13)(p11;q11): description of a distinctive clinicopathologic entity. Blood. 1995;85:1881-1887.
    • (1995) Blood , vol.85 , pp. 1881-1887
    • Inborn, R.C.1    Aster, J.C.2    Roach, S.A.3
  • 40
    • 0035810147 scopus 로고    scopus 로고
    • Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia
    • Druker BJ, Talpaz M, Resta DJ, et al. Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia. N Engl J Med. 2001;344:1031-1037.
    • (2001) N Engl J Med , vol.344 , pp. 1031-1037
    • Druker, B.J.1    Talpaz, M.2    Resta, D.J.3
  • 41
    • 0037186915 scopus 로고    scopus 로고
    • Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia
    • Kantarjian H, Sawyers C, Hochhaus A, et al. Hematologic and cytogenetic responses to imatinib mesylate in chronic myelogenous leukemia. N Engl J Med. 2002;346:645-652.
    • (2002) N Engl J Med , vol.346 , pp. 645-652
    • Kantarjian, H.1    Sawyers, C.2    Hochhaus, A.3
  • 42
    • 10744233716 scopus 로고    scopus 로고
    • Imatinib compared with Interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia
    • O'Brien SG, Guilhot F, Larson RA, et al. Imatinib compared with Interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia. N Engl J Med. 2003;348:994-1004.
    • (2003) N Engl J Med , vol.348 , pp. 994-1004
    • O'Brien, S.G.1    Guilhot, F.2    Larson, R.A.3
  • 43
    • 0035810142 scopus 로고    scopus 로고
    • Activity of a specific inhibitor of the BC R-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome
    • Druker BJ, Sawyers CL, Kantarjian H, et al. Activity of a specific inhibitor of the BC R-ABL tyrosine kinase in the blast crisis of chronic myeloid leukemia and acute lymphoblastic leukemia with the Philadelphia chromosome. N Engl J Med. 2001; 344:1038-1042.
    • (2001) N Engl J Med , vol.344 , pp. 1038-1042
    • Druker, B.J.1    Sawyers, C.L.2    Kantarjian, H.3
  • 44
    • 0037085785 scopus 로고    scopus 로고
    • Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: Results of a phase 2 study
    • Talpaz M, Silver RT, Druker BJ, et al. Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study. Blood. 2002;99:1928-1937.
    • (2002) Blood , vol.99 , pp. 1928-1937
    • Talpaz, M.1    Silver, R.T.2    Druker, B.J.3
  • 45
    • 0037093092 scopus 로고    scopus 로고
    • Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: Results of a phase II study
    • Sawyers CL, Hochhaus A, Feldman E, et al. Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study. Blood. 2002;99:3530-3539.
    • (2002) Blood , vol.99 , pp. 3530-3539
    • Sawyers, C.L.1    Hochhaus, A.2    Feldman, E.3
  • 46
    • 0037105560 scopus 로고    scopus 로고
    • A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias
    • Ottmann OG, Druker BJ, Sawyers CL, et al. A phase 2 study of imatinib in patients with relapsed or refractory Philadelphia chromosome-positive acute lymphoid leukemias. Blood. 2002;100: 1965-1971.
    • (2002) Blood , vol.100 , pp. 1965-1971
    • Ottmann, O.G.1    Druker, B.J.2    Sawyers, C.L.3
  • 47
    • 0036721320 scopus 로고    scopus 로고
    • Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia
    • Kantarjian HM OBS, Cortes JE, Rios MB, et al. Imatinib mesylate therapy for relapse after allogeneic stem cell transplantation for chronic myelogenous leukemia. Blood. 2002;100:1590-1595.
    • (2002) Blood , vol.100 , pp. 1590-1595
    • Kantarjian, H.M.O.B.S.1    Cortes, J.E.2    Rios, M.B.3
  • 48
    • 79960970521 scopus 로고    scopus 로고
    • Imatinib mesylate (Gleevec) for disease relapse following allogeneic bone marrow transplantation
    • Soiffer RJ, Galinsky I, DeAngelo D. Imatinib mesylate (Gleevec) for disease relapse following allogeneic bone marrow transplantation [abstract]. Blood. 2001;98:400a.
    • (2001) Blood , vol.98
    • Soiffer, R.J.1    Galinsky, I.2    DeAngelo, D.3
  • 49
    • 0037071418 scopus 로고    scopus 로고
    • Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease
    • Scheijen B, Griffin JD. Tyrosine kinase oncogenes in normal hematopoiesis and hematological disease. Oncogene. 2002;21:3314-3333.
    • (2002) Oncogene , vol.21 , pp. 3314-3333
    • Scheijen, B.1    Griffin, J.D.2
  • 50
    • 0037103624 scopus 로고    scopus 로고
    • Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta
    • Apperley JF, Gardembas M, Melo JV, et al. Response to imatinib mesylate in patients with chronic myeloproliferative diseases with rearrangements of the platelet-derived growth factor receptor beta. N Engl J Med. 2002;347:481-487.
    • (2002) N Engl J Med , vol.347 , pp. 481-487
    • Apperley, J.F.1    Gardembas, M.2    Melo, J.V.3
  • 51
    • 5644251199 scopus 로고    scopus 로고
    • NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5; 14)(q33;q24) and an imatinib-responsive myeloproliferative disorder
    • Vizmanos JL, Novo FJ, Roman JP, et al. NIN, a gene encoding a CEP110-like centrosomal protein, is fused to PDGFRB in a patient with a t(5; 14)(q33;q24) and an imatinib-responsive myeloproliferative disorder. Cancer Res. 2004;64:2673-2676.
    • (2004) Cancer Res , vol.64 , pp. 2673-2676
    • Vizmanos, J.L.1    Novo, F.J.2    Roman, J.P.3
  • 52
    • 0344826038 scopus 로고    scopus 로고
    • Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: Involvement of PDGFRB and response to imatinib
    • Wilkinson K, Velloso ER, Lopes LF, et al. Cloning of the t(1;5)(q23;q33) in a myeloproliferative disorder associated with eosinophilia: involvement of PDGFRB and response to imatinib. Blood. 2003:102:4187-4190.
    • (2003) Blood , vol.102 , pp. 4187-4190
    • Wilkinson, K.1    Velloso, E.R.2    Lopes, L.F.3
  • 53
    • 5644284103 scopus 로고    scopus 로고
    • HC-MOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5; 17)(q33;p11.2)
    • Morerio C, Acquila M, Rosanda C, et al. HC-MOGT-1 is a novel fusion partner to PDGFRB in juvenile myelomonocytic leukemia with t(5; 17)(q33;p11.2). Cancer Res. 2004;64:2649-2651.
    • (2004) Cancer Res , vol.64 , pp. 2649-2651
    • Morerio, C.1    Acquila, M.2    Rosanda, C.3
  • 54
    • 0036098784 scopus 로고    scopus 로고
    • Receptor tyrosine kinase mutations in myeloid neoplasms
    • Gupta R, Knight CL, Bain BJ. Receptor tyrosine kinase mutations in myeloid neoplasms. Br J Haematol. 2002;117:489-508.
    • (2002) Br J Haematol , vol.117 , pp. 489-508
    • Gupta, R.1    Knight, C.L.2    Bain, B.J.3
  • 55
    • 0029966854 scopus 로고    scopus 로고
    • The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways
    • Carroll M, Tomasson MH, Barker GF, et al. The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways. Proc Natl Acad Sci U S A. 1996;93:14845-14850.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 14845-14850
    • Carroll, M.1    Tomasson, M.H.2    Barker, G.F.3
  • 56
    • 0032589693 scopus 로고    scopus 로고
    • The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice
    • Ritchie KA, Aprikyan AA, Bowen-Pope DF, et al. The Tel-PDGFRbeta fusion gene produces a chronic myeloproliferative syndrome in transgenic mice. Leukemia. 1999;13:1790-1803.
    • (1999) Leukemia , vol.13 , pp. 1790-1803
    • Ritchie, K.A.1    Aprikyan, A.A.2    Bowen-Pope, D.F.3
  • 57
    • 0033999917 scopus 로고    scopus 로고
    • Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581
    • Tomasson MH, Sternberg DW, Williams IR, et al. Fatal myeloproliferation, induced in mice by TEL/PDGFbetaR expression, depends on PDGFbetaR tyrosines 579/581. J Clin Invest. 2000;105: 423-432.
    • (2000) J Clin Invest , vol.105 , pp. 423-432
    • Tomasson, M.H.1    Sternberg, D.W.2    Williams, I.R.3
  • 58
    • 0031454003 scopus 로고    scopus 로고
    • CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins
    • Carroll M, Ohno-Jones S, Tamura S, et al. CGP 57148, a tyrosine kinase inhibitor, inhibits the growth of cells expressing BCR-ABL, TEL-ABL, and TEL-PDGFR fusion proteins. Blood. 1997;90: 4947-4952.
    • (1997) Blood , vol.90 , pp. 4947-4952
    • Carroll, M.1    Ohno-Jones, S.2    Tamura, S.3
  • 59
    • 0036682958 scopus 로고    scopus 로고
    • Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene
    • Magnusson MK, Meade KE, Nakamura R, et al. Activity of STI571 in chronic myelomonocytic leukemia with a platelet-derived growth factor beta receptor fusion oncogene. Blood. 2002;100:1088-1091.
    • (2002) Blood , vol.100 , pp. 1088-1091
    • Magnusson, M.K.1    Meade, K.E.2    Nakamura, R.3
  • 60
    • 0033084227 scopus 로고    scopus 로고
    • TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor
    • Tomasson MH, Williams IR, Hasserjian R, et al. TEL/PDGFbetaR induces hematologic malignancies in mice that respond to a specific tyrosine kinase inhibitor. Blood. 1999;93:1707-1714.
    • (1999) Blood , vol.93 , pp. 1707-1714
    • Tomasson, M.H.1    Williams, I.R.2    Hasserjian, R.3
  • 61
    • 11144221712 scopus 로고    scopus 로고
    • Ph-negative myeloproliferative disorders (MPD) characterized by eosinophilia and/or translocations involving the PDGFRB gene: Response to imatinib
    • Apperley JF, Dmitrijevic S, Brown P, et al. Ph-negative myeloproliferative disorders (MPD) characterized by eosinophilia and/or translocations involving the PDGFRB gene: Response to imatinib [abstract]. Proc Am Soc Clin Oncol. 2003;22:563.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 563
    • Apperley, J.F.1    Dmitrijevic, S.2    Brown, P.3
  • 62
    • 10744229862 scopus 로고    scopus 로고
    • Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders
    • Cortes J, Giles F, O'Brien S, et al. Results of imatinib mesylate therapy in patients with refractory or recurrent acute myeloid leukemia, high-risk myelodysplastic syndrome, and myeloproliferative disorders. Cancer. 2003;97:2760-2766.
    • (2003) Cancer , vol.97 , pp. 2760-2766
    • Cortes, J.1    Giles, F.2    O'Brien, S.3
  • 63
    • 0035929652 scopus 로고    scopus 로고
    • Roots of clinical resistance to STI-571 cancer therapy
    • Hochhaus A, Kreil S, Corbin A, et al. Roots of clinical resistance to STI-571 cancer therapy. Science. 2001;293:2163.
    • (2001) Science , vol.293 , pp. 2163
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.3
  • 64
    • 0030797764 scopus 로고    scopus 로고
    • Molecular characterization of the t(8;13)(p11;q12) translocation associated with an atypical myeloproliferative disorder: Evidence for three discrete loci involved in myeloid leukemias on 8p11
    • Still IH, Chemova O, Hurd D, et al. Molecular characterization of the t(8;13)(p11;q12) translocation associated with an atypical myeloproliferative disorder: evidence for three discrete loci involved in myeloid leukemias on 8p11. Blood. 1997;90: 3136-3141.
    • (1997) Blood , vol.90 , pp. 3136-3141
    • Still, I.H.1    Chemova, O.2    Hurd, D.3
  • 65
    • 1642421743 scopus 로고    scopus 로고
    • Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations
    • Roumiantsev S, Krause DS, Neumann CA, et al. Distinct stem cell myeloproliferative/T lymphoma syndromes induced by ZNF198-FGFR1 and BCR-FGFR1 fusion genes from 8p11 translocations. Cancer Cell. 2004;5:287-298.
    • (2004) Cancer Cell , vol.5 , pp. 287-298
    • Roumiantsev, S.1    Krause, D.S.2    Neumann, C.A.3
  • 66
    • 0036566196 scopus 로고    scopus 로고
    • Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation
    • O'Brien SG, Vieira SA, Connors S, et al. Transient response to imatinib mesylate (STI571) in a patient with the ETV6-ABL t(9;12) translocation. Blood. 2002;99:3465-3467.
    • (2002) Blood , vol.99 , pp. 3465-3467
    • O'Brien, S.G.1    Vieira, S.A.2    Connors, S.3
  • 67
    • 0036720398 scopus 로고    scopus 로고
    • The roles of FLT3 in hematopoiesis and leukemia
    • Gilliland DG, Griffin JD. The roles of FLT3 in hematopoiesis and leukemia. Blood. 2002;100: 1532-1542.
    • (2002) Blood , vol.100 , pp. 1532-1542
    • Gilliland, D.G.1    Griffin, J.D.2
  • 68
    • 9244260192 scopus 로고    scopus 로고
    • Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells
    • Rosnet O, Buhring HJ, Marchetto S, et al. Human FLT3/FLK2 receptor tyrosine kinase is expressed at the surface of normal and malignant hematopoietic cells. Leukemia. 1996;10:238-248.
    • (1996) Leukemia , vol.10 , pp. 238-248
    • Rosnet, O.1    Buhring, H.J.2    Marchetto, S.3
  • 69
    • 0028222367 scopus 로고
    • Expression of the FLT3 gene in human leukemia-lymphoma cell lines
    • DaSilva N, Hu ZB, Ma W, et al. Expression of the FLT3 gene in human leukemia-lymphoma cell lines. Leukemia. 1994;8:885-888.
    • (1994) Leukemia , vol.8 , pp. 885-888
    • DaSilva, N.1    Hu, Z.B.2    Ma, W.3
  • 70
    • 0030002950 scopus 로고    scopus 로고
    • Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells
    • Drexler HG. Expression of FLT3 receptor and response to FLT3 ligand by leukemic cells. Leukemia. 1996;10:588-599.
    • (1996) Leukemia , vol.10 , pp. 588-599
    • Drexler, H.G.1
  • 71
    • 0030956849 scopus 로고    scopus 로고
    • + blood progenitors expressing different levels of c-kit protein
    • + blood progenitors expressing different levels of c-kit protein. Eur J Haematol. 1997;58:257-264.
    • (1997) Eur J Haematol , vol.58 , pp. 257-264
    • Sonoda, Y.1    Kimura, T.2    Sakabe, H.3
  • 72
    • 0036659931 scopus 로고    scopus 로고
    • Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: Correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease
    • Schnittger S, Schoch C, Dugas M, et al. Analysis of FLT3 length mutations in 1003 patients with acute myeloid leukemia: correlation to cytogenetics, FAB subtype, and prognosis in the AMLCG study and usefulness as a marker for the detection of minimal residual disease. Blood. 2002; 100:59-66.
    • (2002) Blood , vol.100 , pp. 59-66
    • Schnittger, S.1    Schoch, C.2    Dugas, M.3
  • 73
    • 0037097716 scopus 로고    scopus 로고
    • Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: Association with FAB subtypes and identification of subgroups with poor prognosis
    • Thiede C, Steudel C, Mohr B, et al. Analysis of FLT3-activating mutations in 979 patients with acute myelogenous leukemia: association with FAB subtypes and identification of subgroups with poor prognosis. Blood. 2002;99:4326-4335.
    • (2002) Blood , vol.99 , pp. 4326-4335
    • Thiede, C.1    Steudel, C.2    Mohr, B.3
  • 74
    • 16944362760 scopus 로고    scopus 로고
    • Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia
    • Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho)
    • Kiyoi H, Naoe T, Yokota S, et al. Internal tandem duplication of FLT3 associated with leukocytosis in acute promyelocytic leukemia. Leukemia Study Group of the Ministry of Health and Welfare (Kohseisho). Leukemia. 1997;11:1447-1452.
    • (1997) Leukemia , vol.11 , pp. 1447-1452
    • Kiyoi, H.1    Naoe, T.2    Yokota, S.3
  • 75
    • 16944365287 scopus 로고    scopus 로고
    • Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines
    • Yokota S, Kiyoi H, Nakao M, et al. Internal tandem duplication of the FLT3 gene is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. A study on a large series of patients and cell lines. Leukemia. 1997;11:1605-1609.
    • (1997) Leukemia , vol.11 , pp. 1605-1609
    • Yokota, S.1    Kiyoi, H.2    Nakao, M.3
  • 76
    • 0035383768 scopus 로고    scopus 로고
    • FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia
    • Stirewalt DL, Kopecky KJ, Meshinchi S, et al. FLT3, RAS, and TP53 mutations in elderly patients with acute myeloid leukemia. Blood. 2001; 97:3589-3595.
    • (2001) Blood , vol.97 , pp. 3589-3595
    • Stirewalt, D.L.1    Kopecky, K.J.2    Meshinchi, S.3
  • 77
    • 0035168677 scopus 로고    scopus 로고
    • Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia
    • Meshinchi S, Woods WG, Stirewalt DL, et al. Prevalence and prognostic significance of Flt3 internal tandem duplication in pediatric acute myeloid leukemia. Blood. 2001;97:89-94.
    • (2001) Blood , vol.97 , pp. 89-94
    • Meshinchi, S.1    Woods, W.G.2    Stirewalt, D.L.3
  • 78
    • 0033134792 scopus 로고    scopus 로고
    • Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia
    • Kiyoi H, Naoe T, Nakano Y, et al. Prognostic implication of FLT3 and N-RAS gene mutations in acute myeloid leukemia. Blood. 1999;93:3074-3080.
    • (1999) Blood , vol.93 , pp. 3074-3080
    • Kiyoi, H.1    Naoe, T.2    Nakano, Y.3
  • 79
    • 0035885955 scopus 로고    scopus 로고
    • The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: Analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials
    • Kottaridis PD, Gale RE, Frew ME, et al. The presence of a FLT3 internal tandem duplication in patients with acute myeloid leukemia (AML) adds important prognostic information to cytogenetic risk group and response to the first cycle of chemotherapy: analysis of 854 patients from the United Kingdom Medical Research Council AML 10 and 12 trials. Blood. 2001;98:1752-1759.
    • (2001) Blood , vol.98 , pp. 1752-1759
    • Kottaridis, P.D.1    Gale, R.E.2    Frew, M.E.3
  • 80
    • 3142770699 scopus 로고    scopus 로고
    • The relationship between FLT3 mutation status, biological characteristics and outcome in patients with acute promyelocytic leukaemia
    • Grimwade D, Gale RE, Hills R, et al. The relationship between FLT3 mutation status, biological characteristics and outcome in patients with acute promyelocytic leukaemia [abstract]. Blood. 2003;102:98a.
    • (2003) Blood , vol.102
    • Grimwade, D.1    Gale, R.E.2    Hills, R.3
  • 81
    • 0035476264 scopus 로고    scopus 로고
    • Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: A cancer and leukemia group B study
    • Whitman SP, Archer KJ, Feng L, et al. Absence of the wild-type allele predicts poor prognosis in adult de novo acute myeloid leukemia with normal cytogenetics and the internal tandem duplication of FLT3: a cancer and leukemia group B study. Cancer Res. 2001;61:7233-7239.
    • (2001) Cancer Res , vol.61 , pp. 7233-7239
    • Whitman, S.P.1    Archer, K.J.2    Feng, L.3
  • 82
    • 0035871889 scopus 로고    scopus 로고
    • Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies
    • Yamamoto Y, Kiyoi H, Nakano Y, et al. Activating mutation of D835 within the activation loop of FLT3 in human hematologic malignancies. Blood. 2001;97:2434-2439.
    • (2001) Blood , vol.97 , pp. 2434-2439
    • Yamamoto, Y.1    Kiyoi, H.2    Nakano, Y.3
  • 83
    • 0034936404 scopus 로고    scopus 로고
    • Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia
    • Abu-Duhier FM, Goodeve AC, Wilson GA, et al. Identification of novel FLT-3 Asp835 mutations in adult acute myeloid leukaemia. Br J Haematol. 2001;113:983-988.
    • (2001) Br J Haematol , vol.113 , pp. 983-988
    • Abu-Duhier, F.M.1    Goodeve, A.C.2    Wilson, G.A.3
  • 84
    • 0036839326 scopus 로고    scopus 로고
    • A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia
    • Spiekermann K, Bagrintseva K, Schoch C, et al. A new and recurrent activating length mutation in exon 20 of the FLT3 gene in acute myeloid leukemia. Blood. 2002;100:3423-3425.
    • (2002) Blood , vol.100 , pp. 3423-3425
    • Spiekermann, K.1    Bagrintseva, K.2    Schoch, C.3
  • 85
    • 0013312329 scopus 로고    scopus 로고
    • Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification
    • Armstrong SA, Kung AL, Mabon ME, et al. Inhibition of FLT3 in MLL. Validation of a therapeutic target identified by gene expression based classification. Cancer Cell. 2003;3:173-183.
    • (2003) Cancer Cell , vol.3 , pp. 173-183
    • Armstrong, S.A.1    Kung, A.L.2    Mabon, M.E.3
  • 86
    • 18544375333 scopus 로고    scopus 로고
    • MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia
    • Armstrong SA, Staunton JE, Silverman LB, et al. MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia. Nat Genet. 2002;30:41-47.
    • (2002) Nat Genet , vol.30 , pp. 41-47
    • Armstrong, S.A.1    Staunton, J.E.2    Silverman, L.B.3
  • 87
    • 0034598830 scopus 로고    scopus 로고
    • Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines
    • Hayakawa F, Towatari M, Kiyoi H, et al. Tandem-duplicated Flt3 constitutively activates STAT5 and MAP kinase and introduces autonomous cell growth in IL-3-dependent cell lines. Oncogene. 2000;19:624-631.
    • (2000) Oncogene , vol.19 , pp. 624-631
    • Hayakawa, F.1    Towatari, M.2    Kiyoi, H.3
  • 88
    • 0034554796 scopus 로고    scopus 로고
    • Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STATS pathways
    • Mizuki M, Fenski R, Halfter H, et al. Flt3 mutations from patients with acute myeloid leukemia induce transformation of 32D cells mediated by the Ras and STATS pathways. Blood. 2000;96: 3907-3914.
    • (2000) Blood , vol.96 , pp. 3907-3914
    • Mizuki, M.1    Fenski, R.2    Halfter, H.3
  • 89
    • 0036093475 scopus 로고    scopus 로고
    • FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model
    • Kelly LM, Liu Q, Kutok JL, et al. FLT3 internal tandem duplication mutations associated with human acute myeloid leukemias induce myeloproliferative disease in a murine bone marrow transplant model. Blood. 2002;99:310-318.
    • (2002) Blood , vol.99 , pp. 310-318
    • Kelly, L.M.1    Liu, Q.2    Kutok, J.L.3
  • 90
    • 0037783433 scopus 로고    scopus 로고
    • A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657
    • Sohal J, Phan VT, Chan PV, et al. A model of APL with FLT3 mutation is responsive to retinoic acid and a receptor tyrosine kinase inhibitor, SU11657. Blood. 2003;101:3188-3197.
    • (2003) Blood , vol.101 , pp. 3188-3197
    • Sohal, J.1    Phan, V.T.2    Chan, P.V.3
  • 91
    • 0034093724 scopus 로고    scopus 로고
    • In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor
    • Zhao M, Kiyoi H, Yamamoto Y, et al. In vivo treatment of mutant FLT3-transformed murine leukemia with a tyrosine kinase inhibitor. Leukemia. 2000;14:374-378.
    • (2000) Leukemia , vol.14 , pp. 374-378
    • Zhao, M.1    Kiyoi, H.2    Yamamoto, Y.3
  • 92
    • 0036799356 scopus 로고    scopus 로고
    • Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor
    • Tse KF, Allebach J, Levis M, et al. Inhibition of the transforming activity of FLT3 internal tandem duplication mutants from AML patients by a tyrosine kinase inhibitor. Leukemia. 2002;16:2027-2036.
    • (2002) Leukemia , vol.16 , pp. 2027-2036
    • Tse, K.F.1    Allebach, J.2    Levis, M.3
  • 93
    • 0035437140 scopus 로고    scopus 로고
    • A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations
    • Levis M, Tse KF, Smith BD, et al. A FLT3 tyrosine kinase inhibitor is selectively cytotoxic to acute myeloid leukemia blasts harboring FLT3 internal tandem duplication mutations. Blood. 2001;98: 885-887.
    • (2001) Blood , vol.98 , pp. 885-887
    • Levis, M.1    Tse, K.F.2    Smith, B.D.3
  • 94
    • 0036595143 scopus 로고    scopus 로고
    • Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412
    • Weisberg E, Boulton C, Kelly LM, et al. Inhibition of mutant FLT3 receptors in leukemia cells by the small molecule tyrosine kinase inhibitor PKC412. Cancer Cell. 2002;1:433-443.
    • (2002) Cancer Cell , vol.1 , pp. 433-443
    • Weisberg, E.1    Boulton, C.2    Kelly, L.M.3
  • 95
    • 0035281737 scopus 로고    scopus 로고
    • Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C
    • Propper DJ, McDonald AC, Man A, et al. Phase I and pharmacokinetic study of PKC412, an inhibitor of protein kinase C. J Clin Oncol. 2001;19: 1485-1492.
    • (2001) J Clin Oncol , vol.19 , pp. 1485-1492
    • Propper, D.J.1    McDonald, A.C.2    Man, A.3
  • 96
    • 0012774179 scopus 로고    scopus 로고
    • PKC412 an oral FLT3 inhibitor has activity in mutant FLT3 acute myeloid leukemia (AML): A phase II clinical trial
    • Stone R, Klimek V, DeAngelo DJ, et al. PKC412 an oral FLT3 inhibitor has activity in mutant FLT3 acute myeloid leukemia (AML): a phase II clinical trial [abstract]. Blood. 2002;100:86a.
    • (2002) Blood , vol.100
    • Stone, R.1    Klimek, V.2    DeAngelo, D.J.3
  • 97
    • 3042772932 scopus 로고    scopus 로고
    • Oral PKC 412 has activity in patients (pts) with mutant FLT3 acute myeloid leukemia (AML): A phase II trial
    • Stone R, Klimek V, DeAngelo D, et al. Oral PKC 412 has activity in patients (pts) with mutant FLT3 acute myeloid leukemia (AML): a phase II trial [abstract]. Proc Am Soc Clin Oncol. 2003;22:568.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 568
    • Stone, R.1    Klimek, V.2    DeAngelo, D.3
  • 98
    • 0036624916 scopus 로고    scopus 로고
    • A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo
    • Levis M, Allebach J, Tse KF, et al. A FLT3-targeted tyrosine kinase inhibitor is cytotoxic to leukemia cells in vitro and in vivo. Blood. 2002;99: 3885-3891.
    • (2002) Blood , vol.99 , pp. 3885-3891
    • Levis, M.1    Allebach, J.2    Tse, K.F.3
  • 99
    • 1842420032 scopus 로고    scopus 로고
    • Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia
    • Smith BD, Levis M, Beran M, et al. Single-agent CEP-701, a novel FLT3 inhibitor, shows biologic and clinical activity in patients with relapsed or refractory acute myeloid leukemia. Blood. 2004; 103:3669-3676.
    • (2004) Blood , vol.103 , pp. 3669-3676
    • Smith, B.D.1    Levis, M.2    Beran, M.3
  • 100
    • 11144244086 scopus 로고    scopus 로고
    • CEP-701, a selective FLT3 tyrosine kinase inhibitor that is cytotoxic to FLT3/ITD-expressing leukemia cells, is synergistic with chemotherapeutic agents in vitro when used in a time-sequential fashion
    • Levis M, Pham R, Small D. CEP-701, a selective FLT3 tyrosine kinase inhibitor that is cytotoxic to FLT3/ITD-expressing leukemia cells, is synergistic with chemotherapeutic agents in vitro when used in a time-sequential fashion [abstract]. Blood. 2003;102:66a.
    • (2003) Blood , vol.102
    • Levis, M.1    Pham, R.2    Small, D.3
  • 101
    • 0141500350 scopus 로고    scopus 로고
    • Single agent CEP 701, a novel FLT-3 inhibitor shows initial response in patients with refractory acute myeloid leukemia
    • Smith BD, Levis M, Brown P, et al. Single agent CEP 701, a novel FLT-3 inhibitor shows initial response in patients with refractory acute myeloid leukemia [abstract]. Blood. 2002;100:85a.
    • (2002) Blood , vol.100
    • Smith, B.D.1    Levis, M.2    Brown, P.3
  • 102
    • 0033563119 scopus 로고    scopus 로고
    • Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)
    • George DJ, Dionne CA, Jani J, et al. Sustained in vivo regression of Dunning H rat prostate cancers treated with combinations of androgen ablation and Trk tyrosine kinase inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555). Cancer Res. 1999; 59:2395-2401.
    • (1999) Cancer Res , vol.59 , pp. 2395-2401
    • George, D.J.1    Dionne, C.A.2    Jani, J.3
  • 103
    • 0013102301 scopus 로고    scopus 로고
    • CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML)
    • Kelly LM, Yu JC, Boulton CL, et al. CT53518, a novel selective FLT3 antagonist for the treatment of acute myelogenous leukemia (AML). Cancer Cell. 2002;1:421-432.
    • (2002) Cancer Cell , vol.1 , pp. 421-432
    • Kelly, L.M.1    Yu, J.C.2    Boulton, C.L.3
  • 104
    • 4043095240 scopus 로고    scopus 로고
    • Phase I clinical results with MLN518, a novel FLT3 antagonist: Tolerability, pharmacokinetics, and pharmacodynamics
    • DeAngelo DJ, Stone R, Bruner R, et al. Phase I clinical results with MLN518, a novel FLT3 antagonist: tolerability, pharmacokinetics, and pharmacodynamics [abstract]. Blood. 2003;102:65a.
    • (2003) Blood , vol.102
    • DeAngelo, D.J.1    Stone, R.2    Bruner, R.3
  • 105
    • 0012765842 scopus 로고    scopus 로고
    • A "first in man" study of the safety and PK/PD of an oral FLT3 inhibitor (MLN518) in patients with AML or high risk myelodysplasia
    • Heinrich MC, Druker B, Curtin PT, et al. A "first in man" study of the safety and PK/PD of an oral FLT3 inhibitor (MLN518) in patients with AML or high risk myelodysplasia [abstract]. Blood. 2002; 336a.
    • (2002) Blood
    • Heinrich, M.C.1    Druker, B.2    Curtin, P.T.3
  • 106
    • 0037108298 scopus 로고    scopus 로고
    • SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase
    • Yee KW, O'Farrell AM, Smolich BD, et al. SU5416 and SU5614 inhibit kinase activity of wild-type and mutant FLT3 receptor tyrosine kinase. Blood. 2002;100:2941-2949.
    • (2002) Blood , vol.100 , pp. 2941-2949
    • Yee, K.W.1    O'Farrell, A.M.2    Smolich, B.D.3
  • 107
    • 0035282940 scopus 로고    scopus 로고
    • The anti-angiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts
    • Smolich BD, Yuen HA, West KA, et al. The anti-angiogenic protein kinase inhibitors SU5416 and SU6668 inhibit the SCF receptor (c-kit) in a human myeloid leukemia cell line and in acute myeloid leukemia blasts. Blood. 2001;97:1413-1421.
    • (2001) Blood , vol.97 , pp. 1413-1421
    • Smolich, B.D.1    Yuen, H.A.2    West, K.A.3
  • 108
    • 0141993064 scopus 로고    scopus 로고
    • A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia
    • Fiedler W, Mesters R, Tinnefeid H, et al. A phase 2 clinical study of SU5416 in patients with refractory acute myeloid leukemia. Blood. 2003;102: 2763-2767.
    • (2003) Blood , vol.102 , pp. 2763-2767
    • Fiedler, W.1    Mesters, R.2    Tinnefeid, H.3
  • 109
    • 0032893263 scopus 로고    scopus 로고
    • SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types
    • Fong TA, Shawver LK, Sun L, et al. SU5416 is a potent and selective inhibitor of the vascular endothelial growth factor receptor (Flk-1/KDR) that inhibits tyrosine kinase catalysis, tumor vascularization, and growth of multiple tumor types. Cancer Res. 1999;59:99-106.
    • (1999) Cancer Res , vol.59 , pp. 99-106
    • Fong, T.A.1    Shawver, L.K.2    Sun, L.3
  • 110
    • 0038204144 scopus 로고    scopus 로고
    • SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo
    • O'Farrell AM, Abrams TJ, Yuen HA, et al. SU11248 is a novel FLT3 tyrosine kinase inhibitor with potent activity in vitro and in vivo. Blood. 2003;101:3597-3605.
    • (2003) Blood , vol.101 , pp. 3597-3605
    • O'Farrell, A.M.1    Abrams, T.J.2    Yuen, H.A.3
  • 111
    • 0142175216 scopus 로고    scopus 로고
    • An innovative single dose clinical study shows potent inhibition of FLT3 phosphorylation by SU11248 in vivo: A clinical and pharmacodynamic study in AML pts
    • abstract
    • O'Farrell AM, Feidler W, Serve H, et al. An innovative single dose clinical study shows potent inhibition of FLT3 phosphorylation by SU11248 in vivo: a clinical and pharmacodynamic study in AML pts. [abstract]. Blood. 2002;100:559a.
    • (2002) Blood , vol.100
    • O'Farrell, A.M.1    Feidler, W.2    Serve, H.3
  • 112
    • 12244277954 scopus 로고    scopus 로고
    • Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent
    • Mendel DB, Laird AD, Smolich BD, et al. Development of SU5416, a selective small molecule inhibitor of VEGF receptor tyrosine kinase activity, as an anti-angiogenesis agent. Anticancer Drug Des. 2000;15:29-41.
    • (2000) Anticancer Drug Des , vol.15 , pp. 29-41
    • Mendel, D.B.1    Laird, A.D.2    Smolich, B.D.3
  • 113
    • 1842463109 scopus 로고    scopus 로고
    • Randomized phase II trial of the tyrosine kinase inhibitor PKC412 in patients with acute myeloid leukemia/high-risk MDS characterized by wild-type or mutated FLT3
    • Estey E, Fisher T, Giles F, et al. Randomized phase II trial of the tyrosine kinase inhibitor PKC412 in patients with acute myeloid leukemia/high-risk MDS characterized by wild-type or mutated FLT3 [abstract]. Blood. 2003;102:614a.
    • (2003) Blood , vol.102
    • Estey, E.1    Fisher, T.2    Giles, F.3
  • 114
    • 0037087531 scopus 로고    scopus 로고
    • Inhibition of KIT tyrosine kinase activity: A novel molecular approach to the treatment of KIT-positive malignancies
    • Heinrich MC, Blanke CD, Druker BJ, et al. Inhibition of KIT tyrosine kinase activity: a novel molecular approach to the treatment of KIT-positive malignancies. J Clin Oncol. 2002;20:1692-1703.
    • (2002) J Clin Oncol , vol.20 , pp. 1692-1703
    • Heinrich, M.C.1    Blanke, C.D.2    Druker, B.J.3
  • 115
    • 0027359443 scopus 로고
    • Identification of mutations in the coding sequence of the protooncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product
    • Furitsu T, Tsujimura T, Tono T, et al. Identification of mutations in the coding sequence of the protooncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product. J Clin Invest. 1993;92:1736-1744.
    • (1993) J Clin Invest , vol.92 , pp. 1736-1744
    • Furitsu, T.1    Tsujimura, T.2    Tono, T.3
  • 116
    • 0344987886 scopus 로고    scopus 로고
    • Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms
    • Zermati Y, De Sepulveda P, Feger F, et al. Effect of tyrosine kinase inhibitor STI571 on the kinase activity of wild-type and various mutated c-kit receptors found in mast cell neoplasms. Oncogene. 2003;22:660-664.
    • (2003) Oncogene , vol.22 , pp. 660-664
    • Zermati, Y.1    De Sepulveda, P.2    Feger, F.3
  • 117
    • 4243184163 scopus 로고    scopus 로고
    • PKC412, inhibitor of the KIT tyrosine kinase, demonstrates efficacy in mast cell leukemia with the D816V KIT mutation
    • Gotlib J, Berube C, Ruan J, et al. PKC412, inhibitor of the KIT tyrosine kinase, demonstrates efficacy in mast cell leukemia with the D816V KIT mutation [abstract]. Blood. 2003;102:919a.
    • (2003) Blood , vol.102
    • Gotlib, J.1    Berube, C.2    Ruan, J.3
  • 118
    • 0025718579 scopus 로고
    • Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells
    • Ikeda H, Kanakura Y, Tamaki T, et al. Expression and functional role of the proto-oncogene c-kit in acute myeloblastic leukemia cells. Blood. 1991; 78:2962-2968.
    • (1991) Blood , vol.78 , pp. 2962-2968
    • Ikeda, H.1    Kanakura, Y.2    Tamaki, T.3
  • 119
    • 0032528497 scopus 로고    scopus 로고
    • The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias
    • The European Group for the Immunological Classification of Leukemias (EGIL)
    • Bene MC, Bernier M, Casasnovas RO, et al. The reliability and specificity of c-kit for the diagnosis of acute myeloid leukemias and undifferentiated leukemias. The European Group for the Immunological Classification of Leukemias (EGIL). Blood. 1998;92:596-599.
    • (1998) Blood , vol.92 , pp. 596-599
    • Bene, M.C.1    Bernier, M.2    Casasnovas, R.O.3
  • 120
    • 0031437680 scopus 로고    scopus 로고
    • Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias
    • Sperling C, Schwarte S, Buchner T, et al. Expression of the stem cell factor receptor C-KIT (CD117) in acute leukemias. Haematologica. 1997;82:617-621.
    • (1997) Haematologica , vol.82 , pp. 617-621
    • Sperling, C.1    Schwarte, S.2    Buchner, T.3
  • 121
    • 0024438920 scopus 로고
    • The expression of the proto-oncogene C-kit in the blast cells of acute myeloblastic leukemia
    • Wang C, Curtis JE, Geissler EN, et al. The expression of the proto-oncogene C-kit in the blast cells of acute myeloblastic leukemia. Leukemia. 1989;3:699-702.
    • (1989) Leukemia , vol.3 , pp. 699-702
    • Wang, C.1    Curtis, J.E.2    Geissler, E.N.3
  • 122
    • 2342518106 scopus 로고    scopus 로고
    • Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia
    • Kindler T, Breitenbuecher F, Marx A, et al. Efficacy and safety of imatinib in adult patients with c-kit-positive acute myeloid leukemia. Blood. 2004;103:3644-3654.
    • (2004) Blood , vol.103 , pp. 3644-3654
    • Kindler, T.1    Breitenbuecher, F.2    Marx, A.3
  • 123
    • 79960971609 scopus 로고    scopus 로고
    • SU5416 a novel receptor tyrosine kinase inhibitor in the treatment of patients with refractory, c-kit positive, acute myeloid leukemia
    • Abstract 512
    • Fiedler W, Mesters R, Staib P, et al. SU5416 a novel receptor tyrosine kinase inhibitor in the treatment of patients with refractory, c-kit positive, acute myeloid leukemia [abstract]. Blood. 2001; 98. Abstract 512.
    • (2001) Blood , vol.98
    • Fiedler, W.1    Mesters, R.2    Staib, P.3
  • 124
    • 0033998238 scopus 로고    scopus 로고
    • Vascular endothelial growth factor in human colon cancer: Biology and therapeutic implications
    • Ellis LM, Takahashi Y, Liu W, et al. Vascular endothelial growth factor in human colon cancer: biology and therapeutic implications. Oncologist. 2000;5(suppl1):11-15.
    • (2000) Oncologist , vol.5 , Issue.SUPPL. 1 , pp. 11-15
    • Ellis, L.M.1    Takahashi, Y.2    Liu, W.3
  • 125
    • 0029021660 scopus 로고
    • Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium
    • Fong GH, Rossant J, Gertsenstein M, et al. Role of the Flt-1 receptor tyrosine kinase in regulating the assembly of vascular endothelium. Nature. 1995;376:66-70.
    • (1995) Nature , vol.376 , pp. 66-70
    • Fong, G.H.1    Rossant, J.2    Gertsenstein, M.3
  • 126
    • 0029006696 scopus 로고
    • Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice
    • Shalaby F, Rossant J, Yamaguchi TP, et al. Failure of blood-island formation and vasculogenesis in Flk-1-deficient mice. Nature. 1995;376:62-66.
    • (1995) Nature , vol.376 , pp. 62-66
    • Shalaby, F.1    Rossant, J.2    Yamaguchi, T.P.3
  • 127
    • 0032753447 scopus 로고    scopus 로고
    • Angiogenesis in myelodysplastic syndromes
    • Pruneri G, Bertolini F, Soligo D, et al. Angiogenesis in myelodysplastic syndromes. Br J Cancer. 1999;81:1398-1401.
    • (1999) Br J Cancer , vol.81 , pp. 1398-1401
    • Pruneri, G.1    Bertolini, F.2    Soligo, D.3
  • 128
    • 0034655595 scopus 로고    scopus 로고
    • Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
    • Padro T, Ruiz S, Bieker R, et al. Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood. 2000;95:2637-2644.
    • (2000) Blood , vol.95 , pp. 2637-2644
    • Padro, T.1    Ruiz, S.2    Bieker, R.3
  • 129
    • 0036053859 scopus 로고    scopus 로고
    • Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia
    • Padro T, Bieker R, Ruiz S, et al. Overexpression of vascular endothelial growth factor (VEGF) and its cellular receptor KDR (VEGFR-2) in the bone marrow of patients with acute myeloid leukemia. Leukemia. 2002;16:1302-1310.
    • (2002) Leukemia , vol.16 , pp. 1302-1310
    • Padro, T.1    Bieker, R.2    Ruiz, S.3
  • 130
    • 0033485961 scopus 로고    scopus 로고
    • Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia
    • Aguayo A, Estey E, Kantarjian H, et al. Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia. Blood. 1999;94:3717-3721.
    • (1999) Blood , vol.94 , pp. 3717-3721
    • Aguayo, A.1    Estey, E.2    Kantarjian, H.3
  • 131
    • 0043245991 scopus 로고    scopus 로고
    • SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes
    • Giles FJ, Stopeck AT, Silverman LR, et al. SU5416, a small molecule tyrosine kinase receptor inhibitor, has biologic activity in patients with refractory acute myeloid leukemia or myelodysplastic syndromes. Blood. 2003;102:795-801.
    • (2003) Blood , vol.102 , pp. 795-801
    • Giles, F.J.1    Stopeck, A.T.2    Silverman, L.R.3
  • 132
    • 0043020929 scopus 로고    scopus 로고
    • Phase I trial of PTK787/zk222584 (PTK/ZK) an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, in acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS)
    • Roboz G, Giles F, List A, et al. Phase I trial of PTK787/zk222584 (PTK/ZK) an inhibitor of vascular endothelial growth factor receptor tyrosine kinases, in acute myelogenous leukemia (AML) and myelodysplastic syndromes (MDS) [abstract]. Proc Am Soc Clin Oncol. 2003;22:568.
    • (2003) Proc Am Soc Clin Oncol , vol.22 , pp. 568
    • Roboz, G.1    Giles, F.2    List, A.3
  • 133
    • 79960971151 scopus 로고    scopus 로고
    • Effects of SU5416 on angiogenic factors, proliferation and apoptosis in patients with hematologic malignancies
    • Abstract 464
    • Albitar M, Smolich BD, Cherrington JM, et al. Effects of SU5416 on angiogenic factors, proliferation and apoptosis in patients with hematologic malignancies [abstract]. Blood. 2001;98:110a. Abstract 464.
    • (2001) Blood , vol.98
    • Albitar, M.1    Smolich, B.D.2    Cherrington, J.M.3
  • 134
    • 0035360833 scopus 로고    scopus 로고
    • Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma
    • Monestiroli S, Mancuso P, Burlini A, et al. Kinetics and viability of circulating endothelial cells as surrogate angiogenesis marker in an animal model of human lymphoma. Cancer Res. 2001;61:4341-4344.
    • (2001) Cancer Res , vol.61 , pp. 4341-4344
    • Monestiroli, S.1    Mancuso, P.2    Burlini, A.3
  • 135
    • 0034903286 scopus 로고    scopus 로고
    • Thalidomide in multiple myeloma, myelodysplastic syndromes and histiocytosis. Analysis of clinical results and of surrogate angiogenesis markers
    • Bertolini F, Mingrone W, Alietti A, et al. Thalidomide in multiple myeloma, myelodysplastic syndromes and histiocytosis. Analysis of clinical results and of surrogate angiogenesis markers. Ann Oncol. 2001;12:987-990.
    • (2001) Ann Oncol , vol.12 , pp. 987-990
    • Bertolini, F.1    Mingrone, W.2    Alietti, A.3
  • 136
    • 0038599016 scopus 로고    scopus 로고
    • Clinical evaluation of the novel vascular-targeting agent, ZD6126: Assessment of toxicity and surrogate markers of vascular damage
    • Radema SA, Beeerepoot LV, Witteveen Po, et al. Clinical evaluation of the novel vascular-targeting agent, ZD6126: assessment of toxicity and surrogate markers of vascular damage [abstract]. Proc Am Soc Clin Oncol. 2002;21:110a.
    • (2002) Proc Am Soc Clin Oncol , vol.21
    • Radema, S.A.1    Beeerepoot, L.V.2    Witteveen, P.O.3
  • 137
    • 1642301466 scopus 로고    scopus 로고
    • Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: A comparative analysis of 120 paired diagnostic and relapse bone marrow samples
    • Shih LY, Huang CF, Wu JH, et al. Heterogeneous patterns of FLT3 Asp(835) mutations in relapsed de novo acute myeloid leukemia: a comparative analysis of 120 paired diagnostic and relapse bone marrow samples. Clin Cancer Res. 2004; 10:1326-1332.
    • (2004) Clin Cancer Res , vol.10 , pp. 1326-1332
    • Shih, L.Y.1    Huang, C.F.2    Wu, J.H.3
  • 138
    • 0036785393 scopus 로고    scopus 로고
    • Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: Implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors
    • Kottaridis PD, Gale RE, Langabeer SE, et al. Studies of FLT3 mutations in paired presentation and relapse samples from patients with acute myeloid leukemia: implications for the role of FLT3 mutations in leukemogenesis, minimal residual disease detection, and possible therapy with FLT3 inhibitors. Blood. 2002;100:2393-2398.
    • (2002) Blood , vol.100 , pp. 2393-2398
    • Kottaridis, P.D.1    Gale, R.E.2    Langabeer, S.E.3
  • 139
    • 0342546626 scopus 로고    scopus 로고
    • Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296
    • Kovalenko M, Ronnstrand L, Heldin CH, et al. Phosphorylation site-specific inhibition of platelet-derived growth factor beta-receptor autophosphorylation by the receptor blocking tyrphostin AG1296. Biochemistry. 1997;36:6260-6269.
    • (1997) Biochemistry , vol.36 , pp. 6260-6269
    • Kovalenko, M.1    Ronnstrand, L.2    Heldin, C.H.3
  • 140
    • 0032474915 scopus 로고    scopus 로고
    • Synthesis and biological evaluations of 3-substituted indolin-2-ones: A novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases
    • Sun L, Tran N, Tang F, et al. Synthesis and biological evaluations of 3-substituted indolin-2-ones: a novel class of tyrosine kinase inhibitors that exhibit selectivity toward particular receptor tyrosine kinases. J Med Chem. 1998;41:2588-2603.
    • (1998) J Med Chem , vol.41 , pp. 2588-2603
    • Sun, L.1    Tran, N.2    Tang, F.3
  • 141
    • 0036850514 scopus 로고    scopus 로고
    • Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy
    • Hochhaus A, Kreil S, Corbin AS, et al. Molecular and chromosomal mechanisms of resistance to imatinib (STI571) therapy. Leukemia. 2002;16: 2190-2196.
    • (2002) Leukemia , vol.16 , pp. 2190-2196
    • Hochhaus, A.1    Kreil, S.2    Corbin, A.S.3
  • 142
    • 0035800507 scopus 로고    scopus 로고
    • Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification
    • Gorre ME, Mohammed M, Ellwood K, et al. Clinical resistance to STI-571 cancer therapy caused by BCR-ABL gene mutation or amplification. Science. 2001;293:876-880.
    • (2001) Science , vol.293 , pp. 876-880
    • Gorre, M.E.1    Mohammed, M.2    Ellwood, K.3
  • 143
    • 0001686739 scopus 로고    scopus 로고
    • Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia
    • Shah NP, Nicoll JM, Nagar B, et al. Multiple BCR-ABL kinase domain mutations confer polyclonal resistance to the tyrosine kinase inhibitor imatinib (STI571) in chronic phase and blast crisis chronic myeloid leukemia. Cancer Cell. 2002;2:117-125.
    • (2002) Cancer Cell , vol.2 , pp. 117-125
    • Shah, N.P.1    Nicoll, J.M.2    Nagar, B.3
  • 144
    • 0036682481 scopus 로고    scopus 로고
    • Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment
    • Roche-Lestienne C, Soenen-Comu V, Grardel-Duflos N, et al. Several types of mutations of the Abl gene can be found in chronic myeloid leukemia patients resistant to STI571, and they can pre-exist to the onset of treatment. Blood. 2002; 100:1014-1018.
    • (2002) Blood , vol.100 , pp. 1014-1018
    • Roche-Lestienne, C.1    Soenen-Comu, V.2    Grardel-Duflos, N.3
  • 145
    • 0037045583 scopus 로고    scopus 로고
    • BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: A prospective study
    • von Bubnoff N, Schneller F, Peschel C, et al. BCR-ABL gene mutations in relation to clinical resistance of Philadelphia-chromosome-positive leukaemia to STI571: a prospective study. Lancet. 2002;359:487-491.
    • (2002) Lancet , vol.359 , pp. 487-491
    • Von Bubnoff, N.1    Schneller, F.2    Peschel, C.3
  • 146
    • 1542313903 scopus 로고    scopus 로고
    • Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells
    • Bagrintseva K, Schwab R, Kohl TM, et al. Mutations in the tyrosine kinase domain of FLT3 define a new molecular mechanism of acquired drug resistance to PTK inhibitors in FLT3-ITD-transformed hematopoietic cells. Blood. 2004;103: 2266-2275.
    • (2004) Blood , vol.103 , pp. 2266-2275
    • Bagrintseva, K.1    Schwab, R.2    Kohl, T.M.3
  • 147
    • 0038156174 scopus 로고    scopus 로고
    • Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor
    • Grundler R, Thiede C, Miething C, et al. Sensitivity toward tyrosine kinase inhibitors varies between different activating mutations of the FLT3 receptor. Blood. 2003;102:646-651.
    • (2003) Blood , vol.102 , pp. 646-651
    • Grundler, R.1    Thiede, C.2    Miething, C.3


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