Active vaccination against IL-5 bypasses immunological tolerance and ameliorates experimental asthma

Journal of Immunology

Volumn 167, Issue 7, 2001, Pages 3792-3799

  Hertz, M ^a   Mahalingam, S ^a   Dalum, I ^a   Klysner, S ^a   Mattes, J ^a   Neisig, A ^a   Mouritsen, S ^a   Foster, P S ^a   Gautam, A ^a  

^a Pharmexa A X   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; CYTOKINE; DNA VACCINE; EPITOPE; INTERLEUKIN 5; NEUTRALIZING ANTIBODY; POLYCLONAL ANTIBODY;

AIRWAY; ANIMAL MODEL; ARTICLE; ASTHMA; BRONCHUS HYPERREACTIVITY; CONTROLLED STUDY; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INFLAMMATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; VACCINATION;

EID: 0035478849     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.167.7.3792     Document Type: Article

References (47)

1. Bronchoalveolar eosinophilia during allergen-induced late asthmatic reactions
2. Cellular events in the hronchi in mild asthma and after bronchial provocation
3. Identification of activated T lymphocytes and eosinophils in bronchial biopsics in stable atopic asthma Am
4. Airway hyperresponsiveness, increased intracellular spaces of bronchial epithelium, and increased infiltration of eosinophils and lymphocytes in bronchial mucosa in asthma
5. + T-lymphocytes and interleukin-5 mediate antigeninduced eosinophil infiltration into the mouse trachea
6. Evidence of ongoing mast cell and eosinophil degranulation in symptomatic asthma airway
7. Eosinophils and mast cells in bronchoalveolar lavage in subjects with mild asthma: Relationship to bronchial hyperreactivity
8. Relationships among numbers of bronchoalveolar lavage cells expressing messenger ribonucleic acid for cytokines, asthma symptoms, and airway methacholine responsiveness in atopic asthma
9. Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity
10. Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma
11. + T cells, increased TH2-type cytokine mRNA expression, and eosinophil recruitment in bronchoalveolar lavage after allergen inhalation challenge in patients with atopic asthma
12. Allergic and nonallergic asthmatics have distinct patterns of T-cell activation and cytokine production in peripheral blood and bronchoalveolar lavage
13. Sorting out the cytokines of asthma
14. Eosinophilic inflammation in asthma
15. Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model
16. Effects of an antibody to interleukin-5 in a monkey model of asthma
17. Inhibitory effect of the TRFK-5 anti-IL 5 antibody in a guinea pig model of asthma
18. Therapeutic antibodies elicited by immunization against TNF-α
19. Breaking of B cell tolerance toward a highly conserved self protein
20. Induction of cross-reactive antibodies against a self protein by immunization with a modified self protein containing a foreign T helper epitope
21. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs
22. Universally immunogenic T cell epitopes; promiscuous binding to human MHC class II and promiscuous recognition by T cells
23. A novel T cell-regulated mechanism modulating allergeninduced airways hyperreactivity in BALB/c mice independently of IL-4 and IL-5
24. Noninvasive measurement of airway responsiveness in allergic mice using barometric plethysmography
25. Integrated signals between IL-13 IL-4, and IL-5 regulate airways hyperreactivity
26. Analysis of cytokine mRNA expression during primary granuloma formation induced by eggs of Schistosoma mansoni
27. Mice with STAT6-targeted gene disruption develop a Th1 response and control culaneous leishmaniasis
28. + T cells play a pivotal role in aeroallergen-induced eosinophilia, bronchial hyperreactivity, and lung damage in mice
29. Interleukin 4, but not interleukin interleukin 5 or eosinophils, is required in a murine model of acute airway hyperreactivity
30. The allergen-induced airway hyperresponsiveness in a human-mouse chimera model of asthma is T cell and IL-4 and IL-5 dependent
31. Regulation of TH1- and TH2-type cytokine expression and action in atopic asthmatic sensitized airway smooth muscle
32. Autocrine interaction between IL-5 and IL-1 β mediates altered responsiveness of atopic asthmatic sensitized airway smooth muscle
33. Receptor editing and commitment in B lymphocytes
34. Balancing immunity and tolerance: Deleting and tuning lymphocyte repertoires
35. B-cell antigen receptor competence regulates B-lymphocyte selection and survival
36. Immunostimulatory DNA sequences inhibit IL-5, eosinophilic inflammation, and airway hyperresponsiveness in mice
37. Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma
38. Allergen challenge in asthma: Association of eosinophils and lymphocytes with interleukin-5
39. IL-5 is the predominant eosinophil active cytokine in the antigen-induced pulmonary late-phase reaction
40. Inhibition of pulmonary eosinophilia and hyperreactivity by antibodies to interleukin-5
41. Effect of anti-IL-5 and IL-5 on airway hyperreactivity and eosinophils in guinea pigs
42. Antibody against interleukin-5 prevents antigen-induced eosinophil infiltration and bronchial hyperreactivity in the guinea pig airways
43. Interleukin-5 modulates eosinophil accumulation in allergic guinea pig lung
44. Involvement of IL-5 in a murine model of allergic pulmonary inflammation: Prophylactic and therapeutic effect of an anti-IL-5 antibody
45. Therapeutic efficacy of an anti-IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma
46. Effect of anti-IL-5 monoclonal antibody on allergic bronchial eosinophilia and airway hyperresponsiveness in mice
47. Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsiveness the late asthmatic response