Cytokine vaccination: Neutralising IL-1α autoantibodies induced by immunisation with homologous IL-1α

Journal of Immunological Methods

Volumn 236, Issue 1-2, 2000, Pages 1-8

  Svenson, Morten ^a   Hansen, Morten B ^a   Thomsen, Allan R ^b   Diamant, Marcus ^a   Nansen, Anneline ^b   Rieneck, Klaus ^a   Otterness, Ivan G ^c   Bendtzen, Klaus ^a  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c PFIZER INC   (United States)

Author keywords

Autoantibodies; Cytokines (interleukin 1 ); In vivo animal model; Interleukin 6; Mice; Vaccination

Indexed keywords

AUTOANTIBODY; BCG VACCINE; CYTOKINE ANTIBODY; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 1ALPHA ANTIBODY; INTERLEUKIN 1BETA; INTERLEUKIN 6; IODINE 125; NEUTRALIZING ANTIBODY; RECOMBINANT INTERLEUKIN 1ALPHA; TUBERCULIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; CONJUGATION; CONTROLLED STUDY; CROSS REACTION; FEMALE; IMMUNIZATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; VACCINATION;

ANIMALS; AUTOANTIBODIES; BCG VACCINE; FEMALE; HUMANS; IMMUNITY, NATURAL; IMMUNIZATION; IMMUNOGLOBULIN G; INFLAMMATION; INTERLEUKIN-1; MICE; MICE, INBRED BALB C; MICE, INBRED C57BL; NEUTRALIZATION TESTS; RECEPTORS, INTERLEUKIN-1; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; VACCINATION;

ANIMALIA; MURINAE;

EID: 0033976230     PISSN: 00221759     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0022-1759(99)00232-X     Document Type: Article

References (31)

1. Adelstein S., Pritchard-Briscoe H., Anderson T.A., et al. Induction of self-tolerance in T cells but not B cells of transgenic mice expressing little self antigen. Science. 251:1991;1223.
2. Bendtzen K., Hansen M.B., Ross C., Svenson M. Cytokine autoantibodies. Peter J.B., Shoenfeld Y. Autoantibodies. 1996;209 Elsevier Science, Amsterdam.
3. Bendtzen K., Hansen M.B., Ross C., Svenson M. High-avidity autoantibodies to cytokines. Immunol. Today. 19:1998;209.
4. Bendtzen K., Svenson M., Jnsson V., Hippe E. Autoantibodies to cytokines-friends or foes? Immunol. Today. 11:1990;167.
5. Chen T.T., Levy R. Induction of autoantibody responses to GM-CSF by hyperimmunization with an Id-GM-CSF fusion protein. J. Immunol. 154:1995;3105.
6. Ciapponi L., Maione D., Scoumanne A., et al. Induction of interleukin-6 (IL-6) autoantibodies through vaccination with an engineered IL-6 receptor antagonist. Nature Biotechnol. 15:1997;997.
7. Dalum I., Jensen M.R., Hindersson P., Elsner H.I., Mouritsen S. Breaking of B cell tolerance toward a highly conserved self protein. J. Immunol. 157:1996;4796.
8. Daumy G.O., Merenda J.M., McColl A.S., et al. Isolation and characterization of biologically active murine interleukin-1 alpha derived from expression of a synthetic gene in Escherichia coli. Biochim. Biophys. Acta. 998:1989;32.
9. Del Prete G.F., de Carli M., Ricci M., Romagnani S. Helper activity for immunoglobulin synthesis of T helper type 1 (Th1) and Th2 human T cell clones: the help of Th1 clones is limited by their cytolytic capacity. J. Exp. Med. 174:1991;809.
10. Dinarello C.A. The interleukin-1 family: 10 years of discovery. FASEB J. 8:1994;1314.
11. Dower S.K., Sims J.E., Cerretti D.P., Bird T.A. The interleukin-1 system: Receptors, ligands and signals. Chem. Immunol. 51:1992;33.
12. Finkelman F.D., Madden K.B., Morris S.C., et al. Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes. J. Immunol. 151:1993;1235.
13. Hansen M.B., Svenson M., Abell K., et al. Sex- and age-dependency of IgG auto-antibodies against IL-1α in healthy humans. Eur. J. Clin. Invest. 24:1994;212.
14. Heremans H., Dillen C., Put W., van Damme J., Billiau A. Protective effect of anti-interleukin (IL)-6 antibody against endotoxin, associated with paradoxically increased IL-6 levels. Eur. J. Immunol. 22:1992;2395.
15. Ibsen P.H., Holm A., Raaschou-Nielsen M., Petersen J.W., Capiau C., Heron I. Induction of polyclonal antibodies to the S1 subunit of pertussis toxin by synthetic peptides coupled to PPD: effect of conjugation method, adjuvant, priming and animal species. APMIS. 100:1992;159.
16. Jouvenne P., Fossiez F., Banchereau J., Miossec P. High levels of neutralizing autoantibodies against IL-1α are associated with a better prognosis in chronic polyarthritis: a follow-up study. Scand. J. Immunol. 46:1997;413.
17. Lussow A.R., Barrios C., van Embden J., et al. Mycobacterial heat-shock proteins as carrier molecules. Eur. J. Immunol. 21:1991;2297.
18. Matsiota P., Saron M.F., Guillon J.C., Avrameas S. Mouse natural autoantibodies can interfere with murine alpha and beta interferons. J. Virol. 63:1989;955.
19. May L.T., Neta R., Moldawer L.L., Kenney J.S., Patel K., Sehgal P.B. Antibodies chaperone circulating IL-6: Paradoxical effects of anti-IL-6 'neutralizing' antibodies in vivo. J. Immunol. 151:1993;3225.
20. Mizutani H., Ohmoto Y., Kupper T.S., Shimizu M. Endogenous neutralizing anti-IL-1α autoantibodies in inflammatory skin diseases: possible natural inhibitor for over expressed epidermal IL-1. J. Dermatol. Sci. 20:1998;63.
21. Mukerjee R., Chaturvedi U.C. Effect of adjuvants on immunization with dengue virus-induced cytotoxic factor. Clin. Exp. Immunol. 102:1995;496.
22. Novick D., Shulman L.M., Chen L., Revel M. Enhancement of interleukin 6 cytostatic effect on human breast carcinoma cells by soluble IL-6 receptor from urine and reversion by monoclonal antibody. Cytokine. 4:1992;6.
23. Rook G.A., Stanford J.L. Give us this day our daily germs. Immunol. Today. 19:1998;113.
24. Sperber S.J., Gocke D.J., Haberzettl C., Kuk R., Schwartz B., Pestka S. Anti-HIV-1 activity of recombinant and hybrid species of interferon-α J. Interferon Res. 12:1992;363.
25. Steinhoff U., Burkhart C., Arnheiter H., Hengartner H., Zinkernagel R. Virus or a hapten-carrier complex can activate autoreactive B cells by providing linked T help. Eur. J. Immunol. 24:1994;773.
26. Sunder-Plassmann G., Sedlacek P.L., Sunder-Plassmann R., et al. Anti-interleukin-1α autoantibodies in hemodialysis patients. Kidney Int. 40:1991;787.
27. Svenson M., Hansen M.B., Bendtzen K. Binding of cytokines to pharmaceutically prepared human immunoglobulin. J. Clin. Invest. 92:1993;2533.
28. Svenson M., Hansen M.B., Heegaard P., Abell K., Bendtzen K. Specific binding of interleukin 1 (IL-1)β and IL-1 receptor antagonist (IL-1ra) to human serum. High-affinity binding of IL-1ra to soluble IL-1 receptor type I. Cytokine. 5:1993;427.
29. Svenson M., Hansen M.B., Kayser L., et al. Effects of human anti-IL-1α autoantibodies on receptor binding and biological activities of IL-1. Cytokine. 4:1992;125.
30. Tabata M., Kobayashi K., Kaga S., et al. Antibodies to interleukin 2 in sera of autoimmune-prone mice. Scand. J. Rheumatol. 19:1990;183.
31. Wysocka M., Kubin M., Vieira L.Q., et al. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25:1995;672.