Breaking of B Cell Tolerance Toward a Highly Conserved Self Protein

Journal of Immunology

Volumn 157, Issue 11, 1996, Pages 4796-4804

  Dalum, Iben ^a,b   Jensen, Martin R ^a   Hindersson, Peter ^a   Elsner, Henrik I ^a   Mouritsen, Søren ^a  

^a M and E A/S   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; AUTOANTIGEN; EPITOPE; H2 ANTIGEN; HYBRID PROTEIN; LYSOZYME; OVALBUMIN; PROTEIN; UBIQUITIN;

AMINO ACID SEQUENCE; ANIMAL; ANTIGEN PRESENTATION; ANTIGEN PRESENTING CELL; ARTICLE; B LYMPHOCYTE; BAGG ALBINO MOUSE; BIOSYNTHESIS; CHICKEN; GENETICS; HELPER CELL; HYBRIDOMA; IMMUNOLOGICAL TOLERANCE; IMMUNOLOGY; ISOLATION AND PURIFICATION; METABOLISM; MOLECULAR GENETICS; MOUSE; NUCLEOTIDE SEQUENCE; PROTEIN BINDING;

AMINO ACID SEQUENCE; ANIMALS; ANTIGEN PRESENTATION; ANTIGEN-PRESENTING CELLS; AUTOANTIBODIES; AUTOANTIGENS; B-LYMPHOCYTES; CHICKENS; CONSERVED SEQUENCE; EPITOPES; H-2 ANTIGENS; HYBRIDOMAS; IMMUNE TOLERANCE; MICE; MICE, INBRED BALB C; MOLECULAR SEQUENCE DATA; MURAMIDASE; OVALBUMIN; PROTEIN BINDING; PROTEINS; RECOMBINANT FUSION PROTEINS; T-LYMPHOCYTES, HELPER-INDUCER; UBIQUITINS;

EID: 0030457726     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. Mouritsen, S., A. S. Hansen, B. L. Petersen, and S. Buus. 1992. pH dependence of the interaction between immunogenic peptides and MHC class II molecules: evidence for an acidic intracellular compartment being the organelle of interaction. J. Immunol. 148:1438.
2. Liu, Z., K. P. Williams, Y.-H. Chang, and J. A. Smith. 1993. Immunodominance: a single amino acid substitution within an antigenic site alters intramolecular selection of T cell determinants. J. Immunol. 151:1852.
3. Gammon, G., N. Shastri, J. Cogswell, S. Wilbur, S. Sadegh-Nasseri, U. Krzych, A. Miller, and E. E. Sercarz. 1987. The choice of T-cell epitopes utilized on a protein antigen depends on multiple factors distant from, as well as at the determinant site. Immunol. Rev. 98:53.
4. Donermeyer, D. L., and P. M. Allen. 1989. Binding to Ia protects an immunogenic peptide from proteolytic degradation. J. Immunol. 142:1063.
5. Mouritsen, S., M. Meldal, O. Werdelin, A. S. Hansen, and S. Buus. 1992. MHC molecules protect T cell epitopes against proteolytic destruction. J. Immunol. 149:1987.
6. Kourilsky, P., G. Chaouat, C. Rabourdin-Combe, and J.-M. Claverie. 1987. Working principles in the immune system implied by the "peptidic self" model. Proc. Natl. Acad. Sci. USA 84:3400.
7. Benichou, G., P. A. Takizawa, P. T. Ho, C. C. Killion, C. A. Olson, M. McMillan, and E. E. Sercarz. 1990. Immunogenicity and tolerogenicity of self-major histocompatibility complex peptides. J. Exp. Med. 172:1341.
8. Rock, K. L., B. Benacerraf, and A. K. Abbas. 1984. Antigen presentation by hapten-specific B lymphocytes. J. Exp. Med. 160:1102.
9. Bretscher, P., and M. Cohn. 1970. A theory of self-nonself discrimination: analysis and induction involve the recognition of one or two determinants as an antigen, respectively. Science 163:1042.
10. Goldstein, G., M. Scheid, U. Hammerling, E. A. Boyse, D. H. Schlesinger, and H. D. Niall. 1975. Isolation of a polypeptide that has lymphocyte-differentiating properties and is probably represented universally in living cells. Proc. Natl. Acad. Sci. USA 72:11.
11. Ecker, D. J., T. R. Butl, J. Marsh, E. J. Sternberg, N. Margolis, B. P. Monia, S. Jonnalagadda, M. I. Khan, P. L. Weber, L. Mueller, and S. T. Crooke. 1987. Gene synthesis, expression, structures, and functional activities of site-specific mutants of ubiquitin. J. Biol. Chem. 262:14213.
12. Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular Cloning: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor.
13. Shatzman, A. R., and M. Rosenberg. 1986. Efficient expression of heterologous genes in Escherichia coli. Ann. NY Acad. Sci. 478:233.
14. Harlow, E., and D. Lane. 1988. Antibodies: A Laboratory Manual. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY.
15. Hershko, A., E. Eytan, and A. Ciechanover. 1982. Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. J. Biol. Chem. 257: 13964.
16. Hindersson, P., J. D. Knudsen, and N. H. Axelsen. 1987. Cloning and expression of Treponema pallidum common antigen (Tp-4) in Escherichia coli K12. J. Gen. Microbiol. 133:587.
17. Smith, P. K., R. I. Krohn, G. T. Hermanson, A. K. Mallia, F. H. Gartner, M. D. Provenzano, E. K. Fujimoto, N. M. Goeke, B. J. Olson, and D. C. Klenk. 1985. Measurement of protein using bicinchoninic acid. Anal. Biochem. 150:76.
18. 131I-labelled human growth hormone of high specific activity. Biochem. J. 89:114.
19. Mouritsen, S., I. Dalum, A. M. Engel, I.-M. Svane, I. Svendsen, O. Werdelin, and H. Elsner. 1994. MHC class II-bound self-peptides can be effectively separated by isoelectric focusing and bind optimally to their MHC class II restriction elements around pH 5.0. Immunology 82:529.
20. Shimonkevitz, R., S. M. Colon, J. W. Kappler, P. Marrack, and H. M. Grey. 1984. Antigen recognition by H-2-restricled T cells. II. A tryptic ovalbumin peptide that substitutes for processed antigen. J. Immunol. 133:2067.
21. Mouritsen, S., M. Meldal, B. Rubin, A. Holm, and O. Werdelin. 1989. The T-lymphocyte proliferative response to synthetic peptide antigens of defined secondary structure. Scand. J. Immunol. 30:723.
22. Sette, A., S. Buus, S. Colon, J. A. Smith, C. Miles, and H. M. Grey. 1987. Structural characteristics of an antigen required for its interaction with Ia and recognition by T cells. Nature 328:395.
23. Buus, S., A. Sette, S. M. Colon, C. Miles, and H. M. Grey. 1987. The relation between major histocompatibility complex (MHC) restriction and the capacity of Ia to bind immunogenic peptides. Science 235:1353.
24. Allen, P. M., D. J. Strydom, and E. R. Unanue. 1984. Processing of lysozyme by macrophages: identification of the determinant recognized by two T-cell hybridomas. Proc. Natl. Acad. Sci. USA 81:2489.
25. Babbitt, B. P., P. M. Allen, G. R. Matsueda, E. Haber, and E. R. Unanue. 1985. Binding of immunogenic peptides to Ia histocompatibility molecules. Nature 317:359.
26. Nemazee, D. A., and K. Buerki. 1989. Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes. Nature 337:562.
27. Goodnow, C. C., J. Crosbie, S. Adelstein, T. B. Lavoie, S. J. Smith-Gill, R. A. Brink, H. Pritchard-Briscoe, J. S. Wotherspoon, R. H. Loblay, K. Raphael, R. J. Trent, and A. Basten. 1988. Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice. Nature 334:676.
28. French, D. L., R. Laskov, and M. D. Scharff. 1989. The role of somatic hypermutation in the generation of antibody diversity. Science 244:1152.
29. Siegelman, M., M. W. Bond, W. M. Gallatin, T. St. John, H. T. Smith, V. A. Fried, and I. L. Weissman. 1986. Cell surface molecule associated with lymphocyte homing is a ubiquitinated branched-chain glycoprotein. Science 231:823.
30. Leung, D. W., S. A. Spencer, G. Cachianes, R. G. Hammonds, C. Collins, W. J. Henzel, R. Barnard, M. J. Waters, and W. I. Wood. 1987. Growth hormone receptor and serum binding protein: purification, cloning and expression. Nature 330:537.
31. Vijay-Kumar, S., C. E. Bugg, and W. J. Cook. 1987. Structure of ubiquitin refined at 1.8 Å resolution. J. Mol. Biol. 194:531.
32. Mouritsen, S., M. Meldal, J. Ruud-Hansen, and O. Werdelin. 1991. T-helper-cell determinants in protein antigens are preferentially located in cysteine-rich antigen segments resistant to proteolytic cleavage by calhepsin B, L, and D. Scand. J. Immunol. 34:421.
33. Lehmann, P. V., T. Forsthuber, A. Miller, and E. E. Sercarz. 1992. Spreading of T-cell autoimmunity to cryptic determinants of an autoantigen. Nature 358:155.
34. Elliot, M. J., R. N. Maini, M. Feldman, A. Long-Fox, P. Charles, P. Katsikis, F. M. Brennan, J. Walker, H. Bijl, J. Ghrayeb, and J. N. Woody. 1993. Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis Rheum. 36:1681.
35. Herzog, C., C. Walker, W. Muller, P. Rieber, C. Reiter, G. Riethmuller, P. Wassmer, H. Stockinger, O. Madic, and W. J. Pichler. 1989. Anti-CD4 antibody treatment of patients with rheumatoid arthritis. I. Effect on clinical course and circulating T cells. J. Autoimmun. 2:627.
36. Elliot, M. J., R. N. Maini, M. Feldmann, A. Long-Fox, P. Charles, H. Bijl, and J. N. Woody. 1994. Repeated therapy with monoclonal antibody to tumour necrosis factor α (cA2) in patients with rheumatoid arthritis. Lancet 344:1125.