The role of interleukin 12 in the development of atherosclerosis in apoE-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 19, Issue 3, 1999, Pages 734-742

  Lee, Tzong Shyuan ^a   Yen, Hwei Chen ^b   Pan, Ching Chien ^a   Chau, Lee Young ^a  

^a INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Atherosclerosis; Interleukin 12; Oxidized LDL

Indexed keywords

B7 ANTIGEN; CD86 ANTIGEN; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN M; INTERLEUKIN 12; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; GENE EXPRESSION; HYPERLIPOPROTEINEMIA TYPE 3; IMMUNOHISTOCHEMISTRY; MACROPHAGE; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; T LYMPHOCYTE ACTIVATION;

EID: 0032976126     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.19.3.734     Document Type: Article

References (55)

1. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature (Lond). 1993;362:801-809.
2. Jonasson L, Holm J, Skalli O, Bondjers G, Hansson GK. Regional accumulations of T cells, macrophages, and smooth muscle cells in the human atherosclerotic plaque. Arteriosclerosis. 1986;6:131-138.
3. Hansson GK, Holm J, Jonasson L. Detection of activated T lymphocytes in the human atherosclerotic plaque. Am J Pathol. 1989;135:169-175.
4. Hansson GK, Seifert PS, Olsson G, Bondjers G. Immunohistochemical detection of macrophages and T lymphocytes in atherosclerotic lesions of cholesterol-fed rabbits. Arterioscler Thromb. 1991;11:745-750.
5. Hansson GK, Jonasson L, Lojsted B, Stemme S, Kocher O, Gabbiani G. Localization of T lymphocytes and macrophages in fibrous and complicated plaques. Atherosclerosis. 1988;72:135-140.
6. Libby P, Hansson GK. Biology of disease: Involvement of the immune system in human atherosclerosis: current knowledge and unanswered questions. Lab Invest. 1991;64:5-15.
7. Pang AS, Katz A, Minta JO. C3 deposition in cholesterol-induced atherosclerosis in rabbits: a possible etiologic role for complement in atherosclerosis. J Immunol. 1979;123:1117-1123.
8. Hasson GK, Holm J, Kral JG. Accumulation of IgG and complement factor C3 in human arterial endothelium and atherosclerotic lesions. Acta Pathol Microbiol Immunol Scand. 1984;92A:429-435.
9. Parums DV, Mitchinson MJ. Demonstration of immunoglobulin in the neighbourhood of advanced atherosclerotic plaques. Atherosclerosis. 1981;38:211-216.
10. Salonen JT, Ylä-Herttuala S, Yamamoto R, Bulter S, Korpela H, Salonen R, Nyyssonen K, Palinski W, Witztum J. Autoantibody against oxidized LDL and progression of carotid atherosclerosis. Lancet. 1992;339: 883-887.
11. Virella G, Virella I, Leman RB, Pryor MB, Lopes-Virella MF. Antioxidized low-density lipoprotein antibodies in patients with coronary heart disease and normal healthy volunteers. Int J Clin Lab Res. 1993; 23:95-101.
12. Ylä-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb. 1994;14:32-40.
13. Palinski W, Ord VA, Plump AS, Breslow JL, Steinberg D, Witztum JL. ApoE- deficient mice are a model of lipoprotein oxidation in atherogenesis: Demonstration of oxidation-specific epitopes in lesions and high titers of autoantibodies to malondialdehyde-lysine in serum. Arterioscler Thromb. 1994;14:605-616.
14. Xu QB, Oberhuber G, Gruschwitz M, Wick G. Immunology of atherosclerosis: cellular composition and major histocompatibility complex class II antigen expression in aortic intima, fatty streaks, and atherosclerotic plaques in young and aged human specimens. Clin Immunol Immunopathol. 1990;56:344-359.
15. Jonasson L, Holm J, Skalli O, Gabbiani G, Hansson GK. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest. 1985;76:125-131.
16. Roselaar SE, Schonfeld G, Daugherty A. Enhanced development of atherosclerosis in cholesterol-fed rabbits by suppression of cell-mediated immunity. J Clin Invest. 1995;96:1389-1394.
17. Emeson EE, Shen ML. Accelerated atherosclerosis in hyperlipidemic C57BL/6 mice treated with cyclosporin A. Am J Pathol. 1993;142: 1906-1915.
18. Fyfe AI, Qiao J-H, Lusis A. Immune-deficient mice develop typical atherosclerotic fatty streaks when fed an atherogenic diet. J Clin Invest. 1994;94:2516-2520.
19. Trinchieri G. Interleukin-12: a cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cells type 1 and cytotoxic lymphocytes. Blood. 1994;84:4008-4027.
20. Moore KW, O'Garra A, de Waal Malefyt R, Vieira P, Mosmann TR. Interleukin 10. Annu Rev Immunol. 1993;11:165-190.
21. Uyemura K, Demer LL, Castle SC, Jullien D, Berliner JA, Gately MK, Warrier RR, Pham N, Fogelman AM, Modlin RL. Cross-regulatory roles of interleukin (IL)-12 and IL-10 in atherosclerosis. J Clin Invest. 1996; 97:2130-2138.
22. Plump AS, Smith JD, Hayek T, Aalto-Setala K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992;71:343-353.
23. Zhang SH, Reddick RL, Piedrahita JA, Maeda N. Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science. 1992;258:468-471.
24. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apoE-evaluation of lesional development and progression. Arterioscler Thromb. 1994;14:141-147.
25. Nakashima Y, Plump AS, Raines EW, Breslow JL, Ross R. ApoE-deficient mice develop lesions of all phases of atherosclerosis throughout the arterial tree. Arterioscler Thromb. 1994;14:133-140.
26. Germann T, Bongartz M, Dlugonska H, Hess H, Schmitt E, Kolbe L, Kölsch E, Podlaski FJ, Gately MK, Rüde E. Interleukin 12 profoundly up-regulates the synthesis of antigen-specific complement-fixing IgG2a, IgG2b, and IgG3 antibody subclasses in vivo. Eur J Immunol. 1995;25:823-829.
27. Morris SC, Madden KB, Adamovicz JJ, Gause WC, Hubbard BR, Gately MK, Finkelman FD. Effects of IL-12 on in vivo cytokine gene expression and Ig isotype selection. J Immunol. 1994;152:1047-1056.
28. Berliner JA, Navab M, Fogelman AM, Frank JS, Demer LL, Edward PA, Watson AD, Lusis AJ. Atherosclerosis: basic mechanisms, oxidation, inflammation, and Genetics. Circulation. 1995 91;2488-2496.
29. Stemme S, Faber B, Holm J, Wiklund O, Witztum JL, Hansson GK. T lymphocytes from human atherosclerotic plaques recognize oxidized low density lipoprotein. Proc Natl Acad Sci U S A. 1995;92:3893-3897.
30. Lenschow DJ, Walunas TL, Bluestone JA. CD28/B7 system of T cell costimulation. Annu Rev Immunol. 1996;14:233-258.
31. Rudd CE. Upstream-downstream CD28 cosignaling pathways and T cell function. Immunity. 1996;4:527-534.
32. Chomczynski P, Sacchi N. Single-step method of RNA isolated by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
33. Jones M, Cordell JL, Beyers AD, Tse AGD, Mason DY. Detection of T and B cells in many animal species using cross-reactive antipeptide antibodies. J Immunol. 1993;150:5429-5435.
34. Shu S, Ju G, Fan L. The glucose oxidase-DAB-nickel method in peroxidase histochemistry of the nervous system. Neurosci Lett. 1988;85: 169-171.
35. Pang J-H S, Jiang M-J, Chen Y-L, Wang F-W, Wang DL, Chu S-H, Chau L-Y. Increased ferritin gene expression in atherosclerotic lesions. J Clin Invest. 1996;97:2204-2212.
36. Zhou X, Stemme S, Hansson GK. Evidence for a local immune response in atherosclerosis: CD4+ T cells infiltrate lesions of apoE-deficient mice. Am J Pathol. 1996;149:359-366.
37. Roselaar SE, Kakkanathu PX, Daugherty A. Lymphocyte populations in atherosclerotic lesions of ApoE-/- and LDL receptor -/-mice. Decreasing density with disease progression. Arterioscler Thromb Vase Biol. 1996; 16:1013-1018.
38. Geng YJ, Holm J, Nygren S, Bruzelius M, Stemme S, Hansson GK. Expression of the macrophage scavenger receptor in atheroma: Relationship to immune activation and the T cell cytokine Interferon-γ. Arterioscler Thromb Vase Biol. 1995;15:1995-2002.
39. Palinski W, Rosenfeld ME, Ylä-Herttuala S, Gurtner GC, Socher SS, Butler SW, Parthasarathy S, Carew TE, Steinberg D, Witztum JL. Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci U S A. 1989;86:1372-1376.
40. Murphy EE, Terres G, Macatonia SE, Hsieh C-S, Mattson J, Lanier L, Wysocka M, Trinchieri G, Murphy K, O'Garra A. B7 and interleukin 12 cooperate for proliferation and Interferon γ production by mouse T helper clones that are unresponsive to B7 costimulation. J Exp Med. 1994;180: 223-231.
41. Kubin M, Kamoun M, Trinchieri G. Interleukin12 synergizes with B7/CD28 interaction in inducing efficient proliferation and cytokine production of human T cells. J Exp Med. 1994;180:211-222.
42. Zhou X, Paulsson G, Stemme S, Hansson GK. Hypercholesterolemia is associated with a T helper (Th)1/Th2 switch of the autoimmune response in atherosclerotic apoE-knockout mice. J Clin Invest. 1998;101: 1717-1725.
43. Dansky HM, Charlton SA, Harper MM, Smith JD. T and B lymphocytes play a minor role in atherosclerotic plaque formation in the apolipoprotein E-deficient mouse. Proc. Natl Acad Sci U S A. 1997;94:4642-4646.
44. Daugherty A, Pure E, Delfel-Butteiger D, Chen s, Leferovich J, Roselaar SE, Rader DJ. The effects of total lymphocyte deficiency on the extent of atherosclerosis in apolipoprotein E -/-mice. J Clin Invest. 1997;100: 1575-1580.
45. Mironova M, Virella G, Lopes-Virella M-F. Isolation and characterization of human antioxidized LDL autoantibodies. Arterioscler Thromb Vasc Biol. 1996;16:222-229.
46. Bruggeman M, Williams GT, Bindon C, Clarke M, Walker M, Jefferies R, Waldmann H, Neuberger M. Comparison of the effector functions of human Immunoglobins using a matched set of chimeric antibodies. J Exp Med. 1987;166:1351-1358.
47. Oi VT, Vuong TM, Hardy R, Reider J, Dangler J, Herzenberg LA, Stryer L. Correlation between segmental flexibility and effector function of antibodies. Nature. 1984;307:136.
48. Li H, Cybulsky MI, Gimbrone MA, Libby P. An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb. 1993;13:197-204.
49. Jonasson GK, Holm J, Skalli O, Gabbiani G, Hansson GK. Expression of class II transplantation antigen on vascular smooth muscle cells in human atherosclerosis. J Clin Invest. 1985;76:125-131.
50. Li H, Freeman MW, Libby P. Regulation of smooth muscle cell scavenger receptor expression in vivo by atherogenic diets and in vitro by cytokines. J Clin Invest. 1995;95:122-133.
51. Gupta S, Pablo AM, Jiang X-C, Wang N, Tall AR, Schindler C. IFN-γ potentiates atherosclerosis in apoE knock-out mice. J Clin Invest. 1997; 99:2752-2761.
52. Nagano H, Mitchell RN, Taylor MK, Hasegawa S, Tilney NL, Libby P. Interferon-7 deficiency prevents coronary arteriosclerosis but not myocardial rejection in transplanted mouse hearts. J Clin Invest. 1997;100: 550-557.
53. Trembleau S, Penna G, Bosi E, Mortara A, Gately MK, Adorini L. Interleukin12 administration induces T helper type 1 cells and accelerates autoimmune diabetes in NOD mice. J Exp Med. 1995 181;817-821.
54. Huang F-P, Feng G-J, Lindop G, Stott DI, Liew FY. The role of interleukin 12 and nitric oxide in the development of spontaneous autoimmune disease in MRL/MP -Ipr/lpr mice. J Exp Med. 1996;183:1447-1459.
55. Germann T, Szeliga J, Hess H, Storkel S, Podlaski FJ, Gately MK, Schmitt E, Rude E. Administration of interleukin-12 in combination with type II collagen induces severe arthritis in DBA/1 mice. Proc Natl Acad Sci U S A. 1995;92:4823-4827.