Role of endogenous interleukin-12 (IL-12) in induced and spontaneous relapses of experimental autoimmune encephalomyelitis in mice

European Cytokine Network

Volumn 10, Issue 2, 1999, Pages 171-179

  Heremans, Hubertine ^a   Dillen, Chris ^a   Groenen, Marleen ^a   Matthys, Patrick ^a   Billiau, Alfons ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

Author keywords

Encephalomyelitis; Interleukin 12; Multiple sclerosis

Indexed keywords

CYTOKINE ANTIBODY; INTERLEUKIN 12;

ALLERGIC ENCEPHALOMYELITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BLOOD LEVEL; CONTROLLED STUDY; MOUSE; NONHUMAN; RELAPSE;

ANIMALS; ANTIBODIES, MONOCLONAL; AUTOIMMUNE DISEASES; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; IMMUNIZATION; INTERLEUKIN-12; MALE; MICE; MICE, INBRED STRAINS; PERIODICITY; RECURRENCE; REPRODUCIBILITY OF RESULTS; SPINAL CORD; TISSUE EXTRACTS;

ANIMALIA;

EID: 0032775094     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. 1. Owens T, Sriram S. 1995. The immunology of multiple sclerosis and its animal model, experimental allergic encephalomyelitis. (Review) Neurol. Clin. 13: 51.
2. 2. Zamvil S S, Steinman L. 1990. The T lymphocyte in experimental allergic encephalomyelitis. Annu. Rev. Immunol. 8: 579.
3. 3. Martin R, McFarland H F, McFarlin D E. 1992. Immunological aspects of demyelinating diseases. (Review) Annu. Rev. Immunol. 10: 153.
4. 4. Brown A M, McFarlin D E. 1981. Relapsing experimental allergic encephalomyelitis in the SJL/J mouse. Lab. Invest. 45: 278.
5. 5. Mokhatarian M K, McFarlin D E, Raine C S. 1984. Adoptive transfer of myelin basic protein-sensitized T cells produces chronic relapsing demyelinating disease in mice. Nature 309: 356.
6. 6. Baker D, O'Neill J K, Gschmeissner S E, Wilcox S E, Butter C, Turk J L. 1990. Induction of chronic relapsing experimental allergic encephalomyelitis in Biozzi mice. J. Neuroimmunol. 28: 261.
7. 7. Khoury S J, Hancock W W, Weiner H L. 1992. Oral tolerance to myelin basic protein and natural recovery from experimental autoimmune encephalomyelitis are associated with downregulation of inflammatory cytokines and differential upregulation of transforming growth factor-β, interleukin-4, and prostaglandin E expression in the brain. J. Exp. Med. 176: 1355.
8. 8. Kennedy M K, Torrance D S, Picha K S, Mohler K M. 1992. Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery. J. Immunol. 149: 2496.
9. 9. Merrill J E, Kono D H, Clayton J, Ando D G, Hinton D R, Hofman F M. 1992. Inflammatory leukocytes and cytokines in the peptide-induced disease of experimental allergic encephalomyelitis in SJL and B10.PL mice. Proc. Natl. Acad. Sci. USA 89: 574.
10. 10. Issazadeh S, Navikas V, Schaub M, Sayegh M, Khoury S. 1998. Kinetics of expression of costimulatory molecules and their ligands in murine relapsing experimental autoimmune encephalomyelitis in viva. J. Immunol. 161: 1104.
11. 11. Issazadeh S, Lorentzen J C, Mustafa M I, Hojeberg B, Mussener A, Olsson T. 1996. Cytokines in relapsing experimental autoimmune encephalomyelitis in DA rats: persistent mRNA expression of proinflammatory cytokines and absent expression of interleukin-10 and transforming growth factor-β. J. Neuroimmunol. 69: 103.
12. 12. Issazadeh S, Ljungdahl A, Hojeberg B, Mustafa M, Olsson T. 1995. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor a and tumor necrosis factor-β. J. Neuroimmunol. 61: 205.
13. 13. Bright J J, Musuro B F, Du C, Sriram S. 1998. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis. J. Neuroimmunol. 82: 22.
14. 14. Tanuma N, Kojima T, Shin T, Aikawa Y, Kohji T, Ishihara Y, Matsumoto Y. 1997. Competitive PCR quantification of pro- and anti-inflammatory cytokine mRNA in the central nervous system during autoimmune encephalomyelitis. J. Neuroimmunol. 73: 197.
15. 15. Lafaille J J, Van de Keere F V, Hsu A L, Baron J L, Haas W, Raine C S, Tonegawa S. 1997. Myelin basic protein-specific T helper 2 (Th2) cells cause experimental autoimmune encephalomyelitis in immunodeficient hosts rather than protect them from the disease. J. Exp. Med. 186: 307.
16. 16. Steinman L. 1996. A few autoreactive cells in an autoimmune infiltrate control a vast population of nonspecific cells: a tale of smart bombs and the infantry. (Review) Proc. Natl. Acad. Sci. USA 93: 2253.
17. 17. Cannella B, Gao Y L, Brosnan C, Raine C S. 1996. IL-10 fails to abrogate experimental autoimmune encephalomyelitis. J. Neurosci. Res. 45: 735.
18. 18. Billiau A, Heremans H, Vandekerckhove F, Dijkmans R, Sobis H, Meulepas E, Carton H. 1988. Enhancement ot experimental allergic encephalomyelitis in mice by antibodies against TFN-γ. J. Immunol. 140: 1506.
19. 19. Heremans H, Dillen C, Groenen M, Martens E, Billiau A. 1996. Chronic relapsing experimental autoimmune encephalomyelitis (CREAE) in mice: enhancement by monoclonal antibodies against IFN-γ. Eur. J. Immunol. 26: 2393.
20. 20. Duong T T, St Louis J, Gilbert J J, Finkelman F D, Strejan G H. 1992. Effect of anti-interferon-γ and anti-interleukin-2 monoclonal antibody treatment on the development of actively and passively induced experimental allergic encephalomyelitis in the SJL/J mouse. J. Neuroimmunol 36: 105.
21. 21. Lublin F D, Knobler R L, Kalman B, Goldhaber M, Marini J, Perrault M, d'Imperio C, Joseph J, Alkan S S, Korngold R. 1993. Monoclonal anti-γ interferon antibodies enhance experimental allergic encephalomyelitis. Autoimmunity 16: 267.
22. 22. Willenborg D O, Fordham S A, Cowden W B, Ramshaw I A. 1995. Cytokines and murine autoimmune encephalomyelitis: inhibition or enhancement of disease with antibodies to select cytokines, or by delivery of exogenous cytokines using a recombinant vaccinia virus system. Scand. J. Immunol. 41: 31.
23. 23. Mattner F, Fischer S, Guekes S, Jin S, Kaulen H, Schmitt E, Rude E, Germann T. 1993. The interleukin-12 subunit p40 specifically inhibits effects of the interleukin-12 heterodimer. Eur. J. Immunol. 23: 2202.
24. 24. Manetti R, Parronchi P, Guidizi M G, Piccini M P, Maggi E, Trinchieri G, Romangani S. 1993. Natural killer cell stimulatory factor (interleukin-12 [IL-12]) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177: 1199.
25. 25. Trinchieri G. 1993. Interleukin 12 and its role in the generation of Th1 cells. (Review) Immunol. Today 14: 335.
26. 26. Waldburger K E, Hastings R C, Schaub R G, Goldman S J, Leonard J P. 1996. Adoptive transfer of experimental allergic encephalomyelitis after in vitro treatment with recombinant murine interleukin-12. Preferential expansion of interferon-γ-producing cells and increased expression of macrophage-associated inducible nitric oxide synthase as immunomodulatory mechanisms. Am. J. Pathol. 148: 375.
27. 27. Segal B M, Shevach E M. 1996. IL-12 unmasks latent autoimmune disease in resistant mice. J. Exp. Med. 184: 771.
28. 28. Leonard J P, Waldburger K E, Goldman S J. 1995. Prevention of experimental autoimmune encephalomyelitis by antibodies against interleukin 12. J. Exp. Med. 181: 381.
29. 29. Segal B M, Dwyer B K, Shevach E M. 1998. An interleukin (IL)-10/IL-12 immunoregulatory circuit controls susceptibility to autoimmune disease. J. Exp. Med. 187: 537.
30. 30. Segal B M, Klinman D M, Shevach E M. 1997. Microbial products induce autoimmune disease by an IL-12-dependent pathway. J. Immunol. 158: 5087.
31. 31. Constantinescu C S, Wysocka M, Hiliard B, Ventura E S, Lavi E, Trinchieri G, Rostami A. 1998. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J. Immunol. 161: 5097.
32. 32. Kozlowski P B, Schuller-Levis G B, Wisniewski H M. 1987. Induction of synchronized relapses in SJL/J mice with chronic relapsing experimental allergic encephalomyelitis. Acta Neuropathol. 74: 163.
33. 33. Wysocka M, Kubin M, Vieira L Q, Ozmen L, Garotta G, Scott P, Trinchieri G. 1995. Interleukin-12 is required for interferon-γ production and lethality in lipopolysaccharide-induced shock in mice. Eur. J. Immunol. 25: 672.
34. 34. Scharton-Kersten T M, Afonso L C, Wysocka M, Trinchieri G, Scott P. 1995. IL-12 is required for natural killer cell activation and subsequent T helper 1 cell development in experimental leishmaniasis. J. Immunol. 154: 5320.
35. + T cells in murine experimental allergic encephalomyelitis. Science 256: 1213.
36. 36. Zhang B, Yamamura T, Kondo T, Fujiwara M, Tabira T. 1997. Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J. Exp. Med. 186: 1677.
37. + T cells in recovery from antigen-induced autoimmune disease. J. Exp. Med. 178: 909.
38. + T line cells. Eur. J. Immunol. 18: 1993.
39. - regulatory T cells and T cell clones presenting TCR peptide. Its implication for TCR vaccination against experimental autoimmune encephalomyelitis. J. Immunol. 157: 1781.
40. 40. Miller A, Hafler D A, Weiner H L. 1991. Tolerance and suppressor mechanisms in experimental autoimmune encephalomyelitis: implications for immunotherapy of human autoimmune diseases. (Review) FASEB J. 5: 2560.
41. 41. Smith T, Hewson A K, Kingsley C I, Leonard J P, Cuzner M L. 1997. IL-12 induces relapses in experimental allergic encephalomyelitis in the Lewis rat. Am. J. Pathol. 150: 1909.