Optimization of the Pharmacophore Model for 5-HT7R Antagonism. Design and Synthesis of New Naphtholactam and Naphthosultam Derivatives

Journal of Medicinal Chemistry

Volumn 46, Issue 26, 2003, Pages 5638-5650

  López Rodríguez, María L ^a   Porras, Esther ^a   Morcillo, M José ^b   Benhamú, Bellinda ^a   Soto, Luis J ^a   Lavandera, José L ^a   Ramos, José A ^a   Olivella, Mireia ^c   Campillo, Mercedes ^c   Pardo, Leonardo ^c  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^c INSTITUT DE NEUROCIÈNCIES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 PIPERIDINOBUTYL)BENZO[CD]INDOL 2(1H) ONE; 1 [(4 PHENYLPIPERAZIN 1 YL)METHYL]BENZO[CD]INDOL 2(1H) ONE; 1 [3 (4 PHENYLPIPERAZIN 1 YL)PROPYL]BENZO[CD]INDOL 2(1H) ONE; 1 [3 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PROPYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 CYCLOHEXYLPIPERAZIN 1 YL)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 CYCLOHEXYLPIPERIDINO)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 ISOPROPYLPIPERIDINO)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 METHYLPIPERAZIN 1 YL)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 METHYLPIPERIDINO)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 PHENYL 3,6 DIHYDROPYRIDIN 1(2H) YL)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 (4 PHENYLPIPERIDINO)BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [4 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]BUTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [5 (4 CYCLOHEXYLPIPERAZIN 1 YL)PENTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [5 (4 ISOPROPYLPIPERIDINO)PENTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [5 (4 PHENYLPIPERAZIN 1 YL)PENTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [5 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]PENTYL]BENZO[C,D]INDOL 2(1H) ONE; 1 [5 [4 PHENYL 3,6 DIHYDROPYRIDIN 1(2H) YL]PENTYL]BENZO[CD]INDOL 2(1H) ONE; 1 [6 (4 PHENYLPIPERAZIN 1 YL)HEXYL]BENZO[C,D]INDOL 2(1H) ONE; 1 [6 [4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]HEXYL]BENZO[C,D]INDOL 2(1H) ONE; 1 [[4 (2 METHOXYPHENYL)PIPERAZIN 1 YL]METHYL]BENZO[CD]INDOL 2(1H) ONE; 2 (4 PIPERIDINOBUTYL) 2H NAPHTHO[1,8 CD]ISOTHIAZOLE 1,1 DIOXIDE; 2 [4 (4 METHYLPIPERAZIN 1 YL)BUTYL] 2H NAPHTHO[1,8 CD]ISOTHIAZOLE 1,1 DIOXIDE; 2 [4 (4 METHYLPIPERIDINO)BUTYL] 2H NAPHTHO[1,8 CD]ISOTHIAZOLE 1,1 DIOXIDE; 2 [4 (4 PHENYLPIPERAZIN 1 YL)BUTYL] 2H NAPHTHO[1,8 CD]ISOTHIAZOLE 1,1 DIOXIDE; NAPHTHOLACTAM DERIVATIVE; NAPHTHOSULTAM DERIVATIVE; SEROTONIN 7 RECEPTOR ANTAGONIST; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANIMAL TISSUE; ARTICLE; CALCULATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; MALE; MODEL; NONHUMAN; PHARMACOPHORE; RAT; STRUCTURE ANALYSIS;

ANIMALS; BINDING, COMPETITIVE; COMPUTER SIMULATION; DRUG DESIGN; HYPOTHALAMUS; LACTAMS; LIGANDS; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NAPHTHALENES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES; THIAZOLES;

EID: 10744229658     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm030841r     Document Type: Article

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