DR4004, a putative 5-HT7 receptor antagonist, also has functional activity at the dopamine D2 receptor

European Journal of Pharmacology

Volumn 449, Issue 1-2, 2002, Pages 105-111

  Kogan, Helen A ^a   Marsden, Charles A ^a   Fone, Kevin C F ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

5 HT (5 hydroxytryptamine, serotonin); 5 HT7 receptor; 5 HT7 receptor antagonist; Body temperature; Dopamine D2 receptor; Plasma glucose

Indexed keywords

2A [4 (4 PHENYL 1,2,3,6 TETRAHYDROPYRIDYL)BUTYL] 2A,3,4,5 TETRAHYDROBENZO[CD]INDOL 2(1H) ONE; 3 [2 [2 (4 METHYL 1 PIPERIDINYL)ETHYL] 1 PYRROLIDINESULFONYL]PHENOL; 3,N DIMETHYL N [1 METHYL 3 (4 METHYL 1 PIPERIDINYL)PROPYL]BENZENESULFONAMIDE; 8 CHLORO 2,3,4,5 TETRAHYDRO 3 METHYL 5 PHENYL 1H 3 BENZAZEPIN 7 OL HYDROGEN MALEATE; ALPHA 1 ADRENERGIC RECEPTOR; ALPHA 2 ADRENERGIC RECEPTOR; BETA ADRENERGIC RECEPTOR; CYANOIODOPINDOLOL; DOPAMINE 1 RECEPTOR; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; DR 4004; HISTAMINE H1 RECEPTOR; KETANSERIN; MEPYRAMINE; MUSCARINIC RECEPTOR; PRAZOSIN; QUINUCLIDINYL BENZILATE; RACLOPRIDE; RAUWOLSCINE; SEROTONIN; SEROTONIN 2A RECEPTOR; SEROTONIN 2C RECEPTOR; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; UNCLASSIFIED DRUG; 2A (4 (4 PHENYL 1,2,3,6 TETRAHYDROPYRIDYL)BUTYL) 2A,3,4,5 TETRAHYDROBENZO(CD)INDOL 2(1H) ONE; 2A-(4-(4-PHENYL-1,2,3,6-TETRAHYDROPYRIDYL)BUTYL)-2A,3,4,5-TETRAHYDROBENZO(CD)INDOL-2(1H)-ONE; ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; DOPAMINE RECEPTOR BLOCKING AGENT; INDOLE DERIVATIVE; PHENOL DERIVATIVE; PYRIDINE DERIVATIVE; RECEPTOR; SEROTONIN RECEPTOR; SULFONAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING COMPETITION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; HYPERGLYCEMIA; HYPOTHERMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY; ANIMAL; ANIMAL BEHAVIOR; BODY TEMPERATURE; GLUCOSE BLOOD LEVEL; HYPOTHALAMUS; IN VITRO STUDY; KINETICS; METABOLISM;

ADRENERGIC ALPHA-ANTAGONISTS; ANIMAL; BEHAVIOR, ANIMAL; BLOOD GLUCOSE; BODY TEMPERATURE; DOPAMINE ANTAGONISTS; HYPOTHALAMUS; IN VITRO; INDOLES; KINETICS; MALE; PHENOLS; PRAZOSIN; PYRIDINES; RACLOPRIDE; RATS; RECEPTORS, BIOGENIC AMINE; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; SEROTONIN ANTAGONISTS; SULFONAMIDES; SUPPORT, NON-U.S. GOV'T; ANIMALS;

EID: 0037008259     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(02)02003-4     Document Type: Article

References (40)

1. 7) positively coupled to adenylate cyclase
2. 3H]-ketanserin-labelled S2 serotonin receptors
3. 3H-SCH 23390, a selective D1 receptor antagonist ligand, in rat striatum
4. 3H] idazoxan in rat brain
5. Beta adrenergic receptor binding in membrane preparations from mammalian brain
6. The pharmacology of prazosin, a novel antihypertensive agent
7. 50) of an enzymatic reaction
8. 7 receptors in the rat hypothalamus without alteration in exploratory behaviour or neuroendocrine function
9. 7 receptors
10. 7 receptor-mediated depressor responses in rats
11. 1A receptors in discrete regions of the circadian timing system in hamsters
12. Dopamine receptor anatgonists modulate glucose uptake in rat pheochromocytoma (PC12) cells
13. 7 receptor, orphan found
14. 7 receptors in the rodent suprachiasmatic nucleus
15. 3H-prazosin to rat brain alpha-adrenergic receptors
16. 7 receptor antagonist
17. 2 receptor
18. 7) receptor isoforms produced by alternative splicing
19. 7b)
20. A receptor-activated current in cultured rat suprachiasmatic neurones
21. 7 receptor
22. 7 antagonist: (R)-3-(2-(2-(4-methylpiperidin-1-yl)-ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
23. 7) implicated in the regulation of mammalian circadian rhythms
24. 7 receptor regulation in the rat hypothalamus
25. Ligand: A versatile computerized approach for characterization of ligand-binding systems
26. 7 receptors in rat brain by immunohistochemistry, in situ hybridization, and agonist stimulated cFos expression
27. Molecular-cloning of a mammalian serotonin receptor that activates adenylate-cyclase
28. Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors
29. 7) activating cAMP formation
30. 7 serotonin receptor subtype
31. 1A receptor antagonist, on cortical acetylcholine release, electrocorticogram and body temperature in guinea pigs and rats
32. 7 receptor binding sites in rat hypothalamus: Sensitivity to chronic antidepressant treatment
33. Brain alpha 1-adrenergic neurotransmission is necessary for behavioural activation to environmental change in mice
34. 7 receptor (long-form); Antagonist profile of SB-258719
35. 7 receptors in guinea pig brain
36. 3H] mepyramine
37. 7 receptors: Current knowledge and future prospects
38. Effects of the non-selective 5-HT receptor agonist, 5-carboxamidotryptamine, on plasma glucose levels in rats
39. Muscarinic cholinergic binding in rat brain
40. 7 receptor mRNA expression in the rat hippocampus