Tetrahydrobenzindoles: Selective antagonists of the 5-HT7 receptor [1]

Journal of Medicinal Chemistry

Volumn 42, Issue 4, 1999, Pages 533-535

  Kikuchi, Chika ^a   Nagaso, Hiroshi ^a   Hiranuma, Toyokazu ^a   Koyama, Masao ^a  

^a MEIJI SEIKA KAISHA LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INDOLE DERIVATIVE; SEROTONIN 7 RECEPTOR; SEROTONIN ANTAGONIST; TETRAHYDROBENZINDOLE; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BINDING AFFINITY; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; LETTER; REACTION ANALYSIS; RECEPTOR BLOCKING; RECEPTOR DENSITY; SEQUENCE HOMOLOGY; STRUCTURE ACTIVITY RELATION; VASODILATATION;

ANIMALS; CEREBRAL CORTEX; COS CELLS; GUINEA PIGS; HUMANS; INDOLES; NEOSTRIATUM; PYRIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, SEROTONIN; RECOMBINANT PROTEINS; SEROTONIN ANTAGONISTS;

EID: 0033602216     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980519u     Document Type: Letter

References (23)

1. 7 Serotonin Receptor Subtype. J. Biol. Chem. 1993, 268, 18200-18204.
2. 7) Implicated in the Regulation of Mammalian Circadian Rhythms. Neuron 1993, 11, 449-458.
3. 7) Activating cAMP Formation. Proc. Natl. Acad. Sci. U.S.A. 1993, 90, 8547-8551.
4. Plassat, J.-L.; Amlaiky, N.; Hen, R. Molecular Cloning of a Mammalian Serotonin Receptor that Activates Adenylate Cyclase. Mol. Pharmacol. 1993, 44, 229-236.
5. 7) Positively Linked to Adenylate Cyclase. J. Biol. Chem. 1993, 268, 23422-23426.
6. 7 Receptor Positively Coupled to Adenylyl Cyclase. J. Neurochem. 1994, 63, 456-464.
7. 7 Receptors. J. Pharmacol. Exp. Ther. 1994, 268, 1403-1410.
8. 7) Receptor Isoforms in Human and Rat Produced by Alternative Splicing: Species Differences Due to Altered Intron-Exon Organization. J. Neurochem. 1997, 68, 1372-1381.
9. 7(b)). Br. J. Pharmacol. 1997, 122, 126-132.
10. 7 Receptor: Cloning and Pharmacological Characterisation of Two Receptor Variants. FEBS Lett. 1997, 413, 489-494.
11. 7 Receptor Antagonist. J. Med. Chem. 1998, 41, 655-657.
12. 7 Receptors Mediating Direct Relaxation in Cynomolgus Monkey Isolated Jugular Vein. Br. J. Pharmacol. 1996, 117, 926-930.
13. 7 Receptor? Br. J. Pharmacol. 1995, 114, 383P.
14. Walsh, L. K. M.; Pulido-Rios, T. M.; Hamilton, C. D.; Wong, E. H. F.; Eglen, R. M.; Leung, E. Characterization of 5-Hydroxytryptamine (5-HT) Receptors in Cynomolgus Monkey Vasculature in vitro. FASEB J. 1995, 9, 5426.
15. 7 Receptor Ligand, Blocks Serotonin-Induced Relaxation in Canine Coronary Artery. J. Pharmacol. Exp. Ther. 1996, 277, 1560-1566.
16. 7 Receptors in Guinea Pig Brain. Br. J. Pharmacol. 1995, 115, 107-116.
17. 7 Receptor in Rat Brain. Br. J. Pharmacol. 1996, 117, 657-666.
18. 7 and its mRNA in Rat CNS by Radioligand Binding and In Situ Hybridization Histochemistry. Br. J. Pharmacol. 1994, 112, 100P.
19. 7 Receptor Binding Sites in Rat Hypothalamus: Sensitivity to Chronic Antidipressant Treatment. Mol. Pharmacol. 1995, 47, 99-103.
20. Sumova, A.; Maywood, E. S.; Selvage, D.; Ebling, F. J. P.; Hastings, M. H. Serotonergic Antagonists Impair Arousal-induced Phase Shifts of the Circadian System of the Syrian Hamster. Brain Res. 1996, 709, 88-96.
21. 7 Receptors Mediate Serotonergic Effects on Light-Sensitive Suprachiasmatic Nucleus Neurons. Brain Res. 1997, 755, 246-254.
22. Schwartz, W. J. A Clinician's Primer on the Circadian Clock: Its Localization, Function and Resetting. Adv. Int. Med. 1993, 38, 81-106.
23. Meiji Seika Kaisha Ltd. Patent WO 9800400, Jan 8, 1998.