Synthesis and structure-activity relationships of a new model of arylpiperazines. 5. Study of the physicochemical influence of the pharmacophore on 5-HT1A/α1-adrenergic receptor affinity: Synthesis of a new derivative with mixed 5-HT1A/D2 antagonist properties

Journal of Medicinal Chemistry

Volumn 44, Issue 2, 2001, Pages 186-197

  Lopez Rodriguez M L ^a   Morcillo, M J ^c   Fernandez E ^a   Porras, E ^a   Orensanz, L ^d   Beneytez, Ma E ^b   Manzanares, J ^b   Fuentes, J A ^b  

^a UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^b UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

^c UNIVERSIDAD NACIONAL DE EDUCACIÓN A DISTANCIA   (Spain)

^d HOSPITAL RAMÓN Y CAJAL   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

2 [4 [4 [3 (ETHYLSULFONAMIDO)PHENYL]PIPERAZIN 1 YL]BUTYL] 1,3 DIOXOPERHYDROPYRROLO[1,2 C]IMIDAZOLE; ALPHA 1 ADRENERGIC RECEPTOR; AMIDE; AROMATIC COMPOUND; CARBENE; DOPAMINE 2 RECEPTOR; DOPAMINE 2 RECEPTOR BLOCKING AGENT; EF 7412; HYDANTOIN DERIVATIVE; PIPERAZINE DERIVATIVE; PIPERAZINEDIONE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ARTIFICIAL NEURAL NETWORK; BINDING AFFINITY; CONTROLLED STUDY; DOPAMINE RECEPTOR BLOCKING; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SYNTHESIS; MALE; MOUSE; NONHUMAN; PHARMACOPHORE; PHYSICAL CHEMISTRY; POSTSYNAPTIC INHIBITION; PRESYNAPTIC INHIBITION; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RAT; STEREOSPECIFICITY;

ANIMALS; BINDING, COMPETITIVE; BODY TEMPERATURE; BRAIN; COMBINATORIAL CHEMISTRY TECHNIQUES; CORTICOSTERONE; DOPAMINE ANTAGONISTS; MALE; MICE; MOTOR ACTIVITY; PIPERAZINES; POSTURE; RADIOIMMUNOASSAY; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, ALPHA-1; RECEPTORS, DOPAMINE D2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SEROTONIN ANTAGONISTS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFONAMIDES;

EID: 0035905854     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000929u     Document Type: Article

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