New Method for Genotyping the Mouse Lepob Mutation, Using a Polymerase Chain Reaction Assay

Laboratory Animal Science

Volumn 48, Issue 1, 1998, Pages 103-104

  Namae, Misako ^a   Mori, Yasumiti ^b   Yasuda, Kazuki ^b   Kadowaki, Takashi ^b   Kanazawa, Yasunori ^c   Komeda, Kajuro ^a  

^a TOKYO MEDICAL UNIVERSITY   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

^c JICHI MEDICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN;

ANIMAL; ARTICLE; C57BL MOUSE; FEMALE; GENETICS; GENOTYPE; HOMOZYGOTE; MALE; MOUSE; MOUSE MUTANT; MUTATION; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; POLYMERASE CHAIN REACTION;

ANIMALS; DIABETES MELLITUS, TYPE 2; FEMALE; GENOTYPE; HOMOZYGOTE; LEPTIN; MALE; MICE; MICE, INBRED C57BL; MICE, OBESE; MUTATION; OBESITY; POLYMERASE CHAIN REACTION; PROTEINS;

EID: 0031992120     PISSN: 00236764     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (6)

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2. Bray, G. A., and D. A. York. 1979. Hypothalamic and genetic obesity in experimental animals: an autonomic and endocrine hypothesis. Physiol. Rev. 59:719-809.
3. Zhang, Y., R. Proenca, M. Maffei, et al. 1994. Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.
4. Pelleymounter, M. A., M. J. Cullen, M. B. Baker, et al. 1995. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543.
5. Chehab, F. F., M. E. Lim, and R. Lu. 1996. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Natl. Genet. 12:318-320.
6. Erickson, J. C., G. Hollopeter, and R D. Palmiter. 1996. Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704-1707.