Dietary fat interacts with QTLs controlling induction of Pgc-1α and Ucp1 during conversion of white to brown fat

Physiological Genomics

Volumn 14, Issue , 2003, Pages 139-147

  Coulter, Ann Allen ^a   Bearden, Christie M ^a   Liu, Xiaotuan ^a   Koza, Robert A ^a   Kozak, Leslie P ^a  

^a PENNINGTON BIOMEDICAL RESEARCH CENTER   (United States)

Author keywords

Adipocyte; Differentiation; Energy metabolism; Fat pad; Genetics

Indexed keywords

ALLELIC EXCLUSION; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACKCROSSING; BROWN ADIPOSE TISSUE; CHROMOSOME 19; CHROMOSOME 2; CHROMOSOME 3; CHROMOSOME 8; CONTROLLED STUDY; CORRELATION ANALYSIS; ENERGY METABOLISM; FAT INTAKE; GENE; GENE EXPRESSION; GENE EXPRESSION REGULATION; GENE INDUCTION; GENE LOCUS; GENE MAPPING; GENETIC LINKAGE; GENETIC TRAIT; GENETIC VARIABILITY; LINKAGE ANALYSIS; LIPID DIET; LOW FAT DIET; MOUSE; MOUSE STRAIN; NONHUMAN; PEROXISOME PROLIFERATOR ACTIVATOR RECEPTOR GAMMA COACTIVATOR 1ALPHA GENE; PRIORITY JOURNAL; PROGENY; QUANTITATIVE TRAIT LOCUS; REGULATORY MECHANISM; RETROPERITONEUM; THERMOGENESIS; TISSUE DIFFERENTIATION; UNCOUPLING PROTEIN 1 GENE; WHITE ADIPOSE TISSUE; A J MOUSE; ADIPOCYTE; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CELL DIFFERENTIATION; CHEMISTRY; CROSS BREEDING; ENVIRONMENT; FEMALE; GENETICS; MALE; PHYSIOLOGY;

ANIMALIA;

CARRIER PROTEIN; ION CHANNEL; MEMBRANE PROTEIN; MESSENGER RNA; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1; PEROXISOME-PROLIFERATOR-ACTIVATED RECEPTOR-GAMMA COACTIVATOR-1; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR;

ADIPOCYTES; ADIPOSE TISSUE, BROWN; ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CROSSES, GENETIC; DIETARY FATS; ENERGY METABOLISM; ENVIRONMENT; FEMALE; GENE EXPRESSION REGULATION; ION CHANNELS; MALE; MEMBRANE PROTEINS; MICE; MICE, INBRED A; MICE, INBRED C57BL; MITOCHONDRIAL PROTEINS; PROTEIN SUBUNITS; QUANTITATIVE TRAIT LOCI; RETROPERITONEAL SPACE; RNA, MESSENGER; TRANSCRIPTION FACTORS; VARIATION (GENETICS);

EID: 0242365491     PISSN: 15312267     EISSN: None     Source Type: Journal    
DOI: 10.1152/physiolgenomics.00057.2003     Document Type: Article

References (46)

1. Barbera MJ, Schluter A, Pedraza N, Iglesias R, Villarroya F, and Giralt M. Peroxisome proliferator-activated receptor α activates transcription of the brown fat uncoupling protein-1 gene. A link between regulation of the thermogenic and lipid oxidation pathways in the brown fat cell. J Biol Chem 276: 1486-1493, 2001.
2. Cao W, Medvedev AV, Daniel KW, and Collins S. β-Adrenergic activation of p38 MAP kinase in adipocytes. cAMP induction of the uncoupling protein 1 (UCP1) gene requires P38 MAP kinase. J Biol Chem 276: 27077-27082, 2001.
3. Cederberg A, Gronning LM, Ahren B, Tasken P, Carlsson P, and Enerback S. FOXC2 is a winged helix gene that counteracts obesity, hypertriglyceridemia, and diet-induced insulin resistance. Cell 106: 563-573, 2001.
4. Champigny O and Ricquier D. Evidence from in vitro differentiating cells that adrenoceptor agonists can increase uncoupling protein mRNA level in adipocytes of adult humans: an RT-PCR study. J Lipid Res 37: 1907-1914, 1996.
5. Champigny O, Ricquier D, Blondel O, Mayers RM, Briscoe MG, and Holloway BR. Beta 3-adrenergic receptor stimulation restores message and expression of brown-fat mitochondrial uncoupling protein in adult dogs. Proc Natl Acad Sci USA 88: 10774-10777, 1991.
6. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples. Biotechniques 15: 532-534, 536-537, 1993.
7. Collins S, Daniel KW, Petro AE, and Surwit RS. Strain-specific response to β3-adrenergic receptor agonist treatment of diet-induced obesity in mice. Endocrinology 138: 405-413, 1997.
8. Commins SP, Watson PM, Padgett MA, Dudley A, Argyropoulos G, and Gettys TW. Induction of uncoupling protein expression in brown and white adipose tissue by leptin. Endocrinology 140: 292-300, 1999.
9. Cousin B, Cinti S, Morroni M, Raimbault S, Ricquier D, Pénicaud L, and Casteilla L. Occurrence of brown adipocytes in rat white adipose tissue: molecular and morphological characterization. J Cell Sci 103: 931-942, 1992.
10. Cummings DE, Brandon EP, Planas JV, Motamed K, Idzerda RL, and McKnight GS. Genetically lean mice result from targeted disruption of the RII β-subunit of protein kinase A. Nature 382: 622-626, 1996.
11. Digby JE, Montague CT, Sewter CP, Sanders L, Wilkison WO, O'Rahilly S, and Prins JB. Thiazolidinedione exposure increases the expression of uncoupling protein 1 in cultured human preadipocytes. Diabetes 47: 138-141, 1998.
12. Guerra C, Koza RA, Yamashita H, Walsh K, and Kozak LP. Emergence of brown adipocytes in white fat in mice is under genetic control. Effects on body weight and adiposity. J Clin Invest 102: 412-420, 1998.
13. Gugneja S and Scarpulla RC. Serine phosphorylation within a concise amino-terminal domain in nuclear respiratory factor 1 enhances DNA binding. J Biol Chem 272: 18732-18739, 1997.
14. Herzig S, Long F, Jhala US, Hedrick S, Quinn R, Bauer A, Rudolph D, Schutz G, Yoon C, Puigserver P, Spiegelman B, and Montminy M. CREB regulates hepatic gluconeogenesis through the coactivator PGC-1. Nature 413: 179-183, 2001.
15. Himms-Hagen J, Cui J, Danforth E Jr, Taatjes DJ, Lang SS, Waters BL, and Claus TH. Effect of CL-316,243, a thermogenic β3-agonist, on energy balance and brown and white adipose tissues in rats. Am J Physiol Regul Integr Comp Physiol 266: R1371-R1382, 1994.
16. Himms-Hagen J, Melnyk A, Zingaretti MC, Ceresi E, Barbatelli G, and Cinti S. Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes. Am J Physiol Cell Physiol 279: C670-C681, 2000.
17. Knutti D, Kressler D, and Kralli A. Regulation of the transcriptional coactivator PGC-1 via MAPK-sensitive interaction with a repressor. Proc Natl Acad Sci USA 98: 9713-9718, 2001.
18. Kopecky J, Clarke G, Enerback S, Spiegelman B, and Kozak LP. Expression of the mitochondrial uncoupling protein gene from the aP2 gene promoter prevents genetic obesity. J Clin Invest 96: 2914-2923, 1995.
19. Koza RA, Hohmann SM, Guerra C, Rossmeisl M, and Kozak LP. Synergistic gene interactions control the induction of the mitochondrial uncoupling protein (Ucp1) gene in white fat tissue. J Biol Chem 275: 34486-34492, 2000.
20. Kozak UC, Kopecky J, Teisinger J, Enerback S, Boyer B, and Kozak LP. An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene. Mol Cell Biol 14: 59-67, 1994.
21. Lander ES and Botstein D. Mapping Mendelian factors underlying quantitative traits using RFLP linkage maps. Genetics 121: 185-199, 1989.
22. Lee Y, Yu X, Gonzales F, Mangelsdorf DJ, Wang MY, Richardson C, Witters LA, and Unger RH. PPAR alpha is necessary for the lipopenic action of hyperleptinemia on white adipose and liver tissue. Proc Natl Acad Sci USA 99: 11848-11853, 2002.
23. Lehman JJ, Barger PM, Kovacs A, Saffitz JE, Medeiros DM, and Kelly DP. Peroxisome proliferator-activated receptor gamma coactivator-1 promotes cardiac mitochondrial biogenesis. J Clin Invest 106: 847-856, 2000.
24. Levine JA, Eberhardt NL, and Jensen MD. Role of nonexercise activity thermogenesis in resistance to fat gain in humans. Science 283: 212-214, 1999.
25. Loncar D. Convertible adipose tissue in mice. Cell Tissue Res 266: 149-161, 1991.
26. Louet JF, Hayhurst G, Gonzalez FJ, Girard J, and Decaux JF. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyltransferase I gene expression by cAMP in combination with HNF4a and CREB. J Biol Chem 277: 37991-38000, 2002.
27. Lowell BB and Spiegelman BM. Towards a molecular understanding of adaptive thermogenesis. Nature 404: 652-660, 2000.
28. Manly KF and Olson JM. Overview of QTL mapping software and introduction to map manager QT. Mamm Genome 10: 327-334, 1999.
29. Michael LF, Wu Z, Cheatham RB, Puigserver P, Adelmant G, Lehman JJ, Kelly DP, and Spiegelman BM. Restoration of insulin-sensitive glucose transporter (GLUT4) gene expression in muscle cells by the transcriptional coactivator PGC-1. Proc Natl Acad Sci USA 98: 3820-3825, 2001.
30. Oberkofler H, Esterbauer H, Linnemayr V, Strosberg AD, Krempler F, and Patsch W. Peroxisome proliferator-activated receptor (PPAR) gamma coactivator-1 recruitment regulates PPAR subtype specificity. J Biol Chem 277: 16750-16757, 2002.
31. Puigserver P, Wu Z, Park CW, Graves R, Wright M, and Spiegelman BM. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92: 829-839, 1998.
32. Rim JS and Kozak LP. Regulatory motifs for CREB-binding protein and Nfe2l2 transcription factors in the upstream enhancer of the mitochondrial uncoupling protein 1 gene. J Biol Chem 277: 34589-34600, 2002.
33. Scarpulla RC. Nuclear control of respiratory chain expression in mammalian cells. J Bioenerg Biomembr 29: 109-119, 1997.
34. Schadt EE, Monks SA, Drake TA, Lusis AJ, Che N, Colinayo V, Ruff TG, Milligan SB, Lamb JR, Cavet G, Linsley PS, Mao M, Stoughton RB, and Friend SH. Genetics of gene expression surveyed in maize, mouse and man. Nature 422: 297-302, 2003.
35. Soeder KJ, Snedden SK, Cao W, Della Rocca GJ, Daniel KW, Luttrell LM, and Collins S. The β3-adrenergic receptor activates mitogen-activated protein kinase in adipocytes through a Gi-dependent mechanism. J Biol Chem 274: 12017-12022, 1999.
36. Soloveva V, Graves RA, Rasenick MM, Spiegelman BM, and Ross SR. Transgenic mice overexpressing the β1-adrenergic receptor in adipose tissue are resistant to obesity. Mol Endocrinol 11: 27-38, 1997.
37. Tsukiyama-Kohara K, Poulin F, Kohara M, DeMaria CT, Cheng A, Wu Z, Gingras AC, Katsume A, Elchebly M, Spiegelman BM, Harper ME, Tremblay ML, and Sonenberg N. Adipose tissue reduction in mice lacking the translational inhibitor 4E-BP1. Nat Med 7: 1128-1132, 2001.
38. Vega RB, Huss JM, and Kelly DP. The coactivator PGC-1 cooperates with peroxisome proliferator-activated receptor α in transcriptional control of nuclear genes encoding mitochondrial fatty acid oxidation enzymes, Mol Cell Biol 20: 1868-1876, 2000.
39. Virbasius JV and Scarpulla RC. Activation of the human mitochondrial transcription factor A gene by nuclear respiratory factors: a potential regulatory link between nuclear and mitochondrial gene expression in organelle biogenesis. Proc Natl Acad Sci USA 91: 1309-1313, 1994.
40. Watson PM, Commins SP, Beiler RJ, Hatcher HC, and Gettys TW. Differential regulation of leptin expression and function in A/J vs. C57BL/6J mice during diet-induced obesity. Am J Physiol Endocrinol Metab 279: E356-E365, 2000.
41. Wu H, Kanatous SB, Thurmond FA, Gallardo T, Isotani E, Bassel-Duby R, and Williams RS. Regulation of mitochondrial biogenesis in skeletal muscle by CaMK. Science 296: 349-352, 2002.
42. Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, Mootha V, Troy A, Cinti S, Lowell B, Scarpulla RC, and Spiegelman BM. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98: 115-124, 1999.
43. Xu HE, Lambert MH, Montana VG, Parks DJ, Blanchard SG, Brown PJ, Sternbach DD, Lehmann JM, Wisely GB, Willson TM, Kliewer SA, and Milburn MV. Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol Cell 3: 397-403, 1999.
44. Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, Rhee J, Adelmant G, Stafford J, Kahn CR, Granner DK, Newgard CB, and Spiegelman BM. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413: 131-138, 2001.
45. Young P, Arch JRS, and Ashwell M. Brown adipose tissue in the parametrial fat pad of the mouse. FEBS Lett 167: 10-14, 1984.
46. Yubero P, Barbera MJ, Alvarez R, Vinas O, Mampel T, Iglesias R, Villarroya F, and Giralt M. Dominant negative regulation by c-Jun of transcription of the uncoupling protein-1 gene through a proximal cAMP-regulatory element: a mechanism for repressing basal and norepinephrine-induced expression of the gene before brown adipocyte differentiation. Mol Endocrinol 12: 1023-1037, 1998.